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[Preprint]. 2023 Dec 11:2023.12.11.23299806. [Version 1] doi: 10.1101/2023.12.11.23299806

Extended Data Table 6.

Demographic characteristics of the BLSA-Neuropathology cohort

Controls Asymptomatic AD
Sample size 12 15 20
Age, y 76.40 ± 15.47 84.50 ± 8.507 82.71 ± 9.873
Plasma – death interval 4.450 ± 2.767 2.871 ± 2.295 5.022 ± 3.464
Sex, F, n (%) 2/12 (16.7%) 5/15 (33.3%) 11/20 (55%)
Neuritic Plaques: Low/None 12/12 (100%) 0/15 (0%) 0/20 (0%)
Neuritic Plaques: Moderate 0/12 (0%) 3/15 (20%) 4/20 (25%)
Neuritic Plaques: High 0/12 (0%) 12/15 (80%) 16/20 (75%)
BRAAK 0-II 4/12 (33.3%) 1/15 (6.7%) 0/20 (0%)
BRAAK III-IV 8/12 (66.7%) 13/15 (86.7%) 6/20 (30%)
BRAAK V-VI 0/12 (0%) 1/15 (6.7%) 14/20 (70%)
Plasma p-tau181, pg/ml 7.7 (5.1 – 10.7)c 6.84 (4.3–13.8) 14.2 (9.4–18.4)a
Plasma p-tau231, pg/ml 10.8 (8.7–18.4)c 10.23 (8.1–19.2) 18.75 (11.8–23.9)a
Plasma p-tau212 (Simoa), pg/ml 1.2 (0.7–1.5)c 1.012 (0.8–2.1)c 4.022 (2.2–4.9)a,b
a

– Different from Controls

b

– Different from ASYMAD

c

– Different from AD