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. 2023 Aug 29;20(1):114–130. doi: 10.1080/15548627.2023.2249762

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 7. — In colorectal cancer cells, high histone lactylation level induced by aerobic glycolysis promotes the transcription of RUBCNL, which enhances autophagy through promoting autophagasome maturation, and contributes to colorectal cancer tumorigenesis and progression. When receiving bevacizumab, the glycolysis of cancer cell in hypoxic regions may be further enhanced, followed by higher levels of histone lactylation and RUBCNL is transcriptionally upregulated by histone lactylation, which contributes to colorectal cancer cells survival and therapy resistance.