Retraction: A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation

This article (1) has been retracted at the request of the editors. Following an institutional review by The Ohio State University (Columbus, OH), the primary affiliation for several of the authors, it was determined that:

• In Fig. 4A, the same image was used to represent the P16-U-R1 PCR band in the SGI-1027–12d and SGI-1027–15d lanes. In addition, the same image was used to represent the P16-M-R2 PCR band in the Control, Decitabine-12d, and Decitabine-15d lanes.

• In Fig. 4B, the same image was used to represent the TIMP-3-M PCR band in the Decitabine-7d and SGI-1027–5d lanes.

• In Fig. 5B, the same image was used to represent the GAPDH Western blot band in the untreated, SGI-1027 6 h, and SGI-1027 12 h lanes.

As a result of these findings, the institution recommended retraction and, upon internal review, the editors agreed with this recommendation.

A copy of this Retraction Notice was sent to the last known e-mail addresses for 8 of the 8 authors. One author (Samson T. Jacob) did not agree to the retraction; 7 authors (Jharna Datta, Kalpana Ghoshal, William A. Denny, Swarna A. Gamage, Darby G. Brooke, Pasit Phiasivongsa, and Sanjeev Redkar) did not respond. Samson T. Jacob did not agree to the retraction and stands by the reproducibility of the experimental data and the conclusions of the article.