Fig. 6.

Generation of TLS score. a. Venn diagram showing the intersected genes after dimension reduction based on six machine learning algorithms. b. Correlation coefficients of intersected genes based on LASSO-LR algorithm for the generation of TLS score. c. The survival of patients with high TLS-scores was compared with those with low TLS-scores using the Kaplan–Meier survival curve in pan-cancer. A log-rank test assessed statistical significance. d. Forest plot showing the prognostic value of TLS score in pan-cancer. e. The butterfly plot shows the correlation between TLS score, metabolism, and cancer immunity cycle.