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Proposed mechanism by which OLE-JGF protects against hepatocellular lipid dysmetabolism. OLE-JGF may downregulate the expression of SREBP-1c by the activation of LKB1, resulting in the downregulation of FAS and ACC, thereby inhibiting lipogenesis. On the other hand, LKB1 may directly activate PGC-1α to enhance the expressions of Nrf2, Tfam, and UCP2, which promote energy expenditure.
