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. 2023 Dec 2;32(1):257–259. doi: 10.1016/j.ymthe.2023.11.024

A trans-amplifying RNA simplified to essential elements is highly replicative and robustly immunogenic in mice

Mario Perkovic, Stefanie Gawletta, Tina Hempel, Silke Brill, Evelin Nett, Ugur Sahin , Tim Beissert ∗∗
PMCID: PMC10787165  PMID: 38043532

Main text

(Molecular Therapy 31, 1636–1646; June 2023)

In the originally published version of this article, a single nucleotide was misspelled within the short sequence stretch shown in Figure 2D displaying the evolved SFV-STR 5’end. The correct 5’end equals 5’-AUAAAA(A)GATGGC-3’. An updated Figure 2 has been provided here and incorporated in the original article online.

Furthermore, in the first erratum a sequence error was overseen by the authors within the SFVSTR. Therefore, this error has been corrected in Table S1.

The authors apologize for these errors and any confusion they may have caused.

graphic file with name gr2o.jpg

Figure 2. The SINV-STR is preferentially amplified by the SFV-replicase, but it is outcompeted by a 5’-modified SFV-STR upon directed evolution. (original)

graphic file with name gr2c.jpg

Figure 2. The SINV-STR is preferentially amplified by the SFV-replicase, but it is outcompeted by a 5’-modified SFV-STR upon directed evolution. (corrected)

Contributor Information

Ugur Sahin, Email: ugur.sahin@biontech.de.

Tim Beissert, Email: tim.beissert@tron-mainz.de.


Articles from Molecular Therapy are provided here courtesy of The American Society of Gene & Cell Therapy

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