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The Cochrane Database of Systematic Reviews logoLink to The Cochrane Database of Systematic Reviews
. 2010 Jan 20;2010(1):CD000933. doi: 10.1002/14651858.CD000933.pub2

Antibiotic prophylaxis for cesarean section

G Justus Hofmeyr 1, Fiona M Smaill 2,
Editor: Cochrane Pregnancy and Childbirth Group
PMCID: PMC10798422  PMID: 20091509

Reason for withdrawal from publication

This review has been withdrawn from publication because it is out of date. It has been updated by a new review first published in Issue 1, 2010 of The Cochrane Librarysee the review entitled 'Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section' by FM Smaill and GML Gyte in the Cochrane Database of Systematic Reviews.

The editorial group responsible for this previously published document have withdrawn it from publication.

Keywords: Female, Humans, Pregnancy, Antibiotic Prophylaxis, Cesarean Section, Cesarean Section/adverse effects, Endometritis, Endometritis/prevention & control, Randomized Controlled Trials as Topic, Surgical Wound Infection, Surgical Wound Infection/prevention & control, Urinary Tract Infections, Urinary Tract Infections/prevention & control

Feedback

Griffin, July 1999

Summary

It has been stated that manual removal of the placenta during caesarean section increases the risk of endometritis, when compared to cord traction for placental delivery. Occlusive dressings also increase wound healing and decrease the risk of wound infection. Would it be better to adopt these simple measures first and then trial antibiotic therapy again?

Summary of comments from Chris Griffin, July 1999.

Reply

Infection following caesarean section may be reduced by the use of cord traction to remove the placenta and occlusive wound dressings. Most trials of prophylactic antibiotic therapy do not specify the methods of placental removal and wound care, and may represent a mixture of various methods. Given the clinically important reduction of infection with antibiotic use in general, support for a policy of not using antibiotics would require evidence from randomized trials that in the context of placental removal by cord traction and occlusive wound dressings, antibiotic therapy confers no additional benefit.

Contributors

Summary of response from Fiona Smaill and Justus Hofmeyr, October 1999.

What's new

Date Event Description
8 November 2009 Amended Review withdrawn from publication.

History

Protocol first published: Issue 1, 1999
 Review first published: Issue 2, 1999

Date Event Description
15 June 2008 Amended Converted to new review format.
Added a note about the updating of the review.
5 March 2002 New citation required but conclusions have not changed Fifteen additional trials have been added to the review. The overall conclusion remains unchanged. Antibiotic prophylaxis will reduce infectious complications following both an elective and non‐elective cesarean section.
30 June 1999 Feedback has been incorporated Added feedback from Chris Griffin and response from authors.

Sources of support

Internal sources

  • University of the Witwatersrand, South Africa.

External sources

  • UNDP/UNFPA/WHO/World Bank (HRP), Switzerland.

Withdrawn from publication for reasons stated in the review


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