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[Preprint]. 2024 Jan 2:2024.01.02.573710. [Version 1] doi: 10.1101/2024.01.02.573710

Figure 4. Inferring DNA methylation and tissues-of-origin from cfDNA ULP-WGS.

Figure 4.

a. Average ground truth (ULP-WGBS) and predicted (ULP-WGS) DNA methylation level from cancer and healthy individuals at CpG island promoter regions. b. T-SNE plot by using the DNA methylation level in the 100kb non-overlapped window in autosomes but only summarized from CGI and CGI shore regions in the ground truth (ULP-WGBS) and predicted (ULP-WGS) results from cancer and healthy individuals. c. the concordance of prostate or breast related cell type fractions with tumor fraction estimated by ichorCNA in both healthy and cancers.