Figure 2. Mapping of validated pangenomic variants against phenotypes in GeneNetwork.

(A-B) PheWAS and results for two variants in the long non-coding RNAs gene Zfp958l1 and the annotated gene LOC685157, which is similar to Pilrb1l1. Colors refer to phenotype classes, the dashed horizontal line indicates threshold for significance in the PheWAS. Stars mark genotype-phenotype associations that were validated also through Spearman correlation analysis (adjusted p-value < 0.05) reported in (C-E). In F we propose a hypothesis that reconciles our genotype-specific findings with what is known in literature about these genes and their relationship.