Abstract
Flavonoid evolution in land plants is discussed from an enzymic point of view, based on the present day distribution of the major subgroups of flavonoids in bryophytes, lower and higher vascular plants. The importance of varied functions in the origin of pathways with a series of sequential steps leading to end-products is considered; it is argued that the initial function is that of an internal regulatory agent, rather than as a filter against ultraviolet irradiation. The basic synthases, hydroxylases, and reductases of flavonoid pathways are presumed to have evolved from enzymes of primary metabolism. A speculative scheme is presented of flavonoid evolution within a primitive group of algae derived from a Charophycean rather than a Chlorophycean line, as a land environment was invaded. Flavonoid evolution was preceded by that of the phenylpropanoid and malonyl-coenzyme A pathways, but evolved prior to the lignin pathway.
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- Britsch L. Purification and characterization of flavone synthase I, a 2-oxoglutarate-dependent desaturase. Arch Biochem Biophys. 1990 Oct;282(1):152–160. doi: 10.1016/0003-9861(90)90099-k. [DOI] [PubMed] [Google Scholar]
- Fischer D., Ebenau-Jehle C., Grisebach H. Phytoalexin synthesis in soybean: purification and characterization of NADPH:2'-hydroxydaidzein oxidoreductase from elicitor-challenged soybean cell cultures. Arch Biochem Biophys. 1990 Feb 1;276(2):390–395. doi: 10.1016/0003-9861(90)90737-j. [DOI] [PubMed] [Google Scholar]
- Hartl D. L. Evolving theories of enzyme evolution. Genetics. 1989 May;122(1):1–6. doi: 10.1093/genetics/122.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Horowitz N. H. On the Evolution of Biochemical Syntheses. Proc Natl Acad Sci U S A. 1945 Jun;31(6):153–157. doi: 10.1073/pnas.31.6.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jacobs M., Rubery P. H. Naturally occurring auxin transport regulators. Science. 1988 Jul 15;241(4863):346–349. doi: 10.1126/science.241.4863.346. [DOI] [PubMed] [Google Scholar]
- Marchelli R., Vining L. C. The biosynthetic origin of chlorflavonin, a flavonoid antibiotic from Aspergillus candidus. Can J Biochem. 1973 Dec;51(12):1624–1629. doi: 10.1139/o73-218. [DOI] [PubMed] [Google Scholar]
- Melchior F., Kindl H. Grapevine stilbene synthase cDNA only slightly differing from chalcone synthase cDNA is expressed in Escherichia coli into a catalytically active enzyme. FEBS Lett. 1990 Jul 30;268(1):17–20. doi: 10.1016/0014-5793(90)80961-h. [DOI] [PubMed] [Google Scholar]
- Schüz R., Heller W., Hahlbrock K. Substrate specificity of chalcone synthase from Petroselinum hortense. Formation of phloroglucinol derivatives from aliphatic substrates. J Biol Chem. 1983 Jun 10;258(11):6730–6734. [PubMed] [Google Scholar]
- Snyder B. A., Nicholson R. L. Synthesis of phytoalexins in sorghum as a site-specific response to fungal ingress. Science. 1990 Jun 29;248(4963):1637–1639. doi: 10.1126/science.248.4963.1637. [DOI] [PubMed] [Google Scholar]