Table 2.
Anti-inflammatory activity of oleuropein solution and oleuropein entrapped in chitosan nanoparticles measured through the stabilization of red blood cell membranes and the inhibition of lipoxygenase enzyme.
| Membrane Stabilization | Lipoxygenase Inhibitory % | ||||
|---|---|---|---|---|---|
| Sample Concentration (µg/ mL) |
Oleuropein Solution | Oleuropein CS NPs | Sample Concentration (µg/ mL) |
Oleuropein Solution | Oleuropein CS NPs |
| 1000 | 89.32 ± 2.3 | 92.34 ± 0.11 | 125 | 81.64 ± 0.34 | 97.83 ± 1.6 |
| 500 | 80.19 ± 1.5 | 86.35 ± 3.20 | 62.5 | 74.09 ± 0.64 | 91.15 ± 2.1 |
| 250 | 72.98 ± 1.3 | 79.38 ± 0.34 | 31.25 | 61.91 ± 0.72 | 86.37 ± 0.92 |
| 125 | 68.91 ± 0.58 | 71.82 ± 0.92 | 15.63 | 50.08 ± 0.89 | 76.35 ± 1.41 |
| 62.5 | 61.80 ± 1.5 | 68.24 ± 1.73 | 7.81 | 31.25 ± 1.37 | 55.08 ± 0.58 |
| 31.25 | 56.32 ± 3.1 | 59.73 ± 2.41 | 3.9 | 24.69 ± 2.64 | 23.13 ± 2.64 |
| 15.63 | 38.94 ± 2.5 | 42.19 ± 2.03 | 1.95 | 15.62 ± 1.7 | 18.95 ± 1.7 |
| 7.81 | 21.06 ± 1.5 | 35.76 ± 1.04 | 0.98 | 7.2 ± 0.63 | 8.21 ± 2.1 |
| 0 | 0 | 0 | 0 | 0 | 0 |
| IC50 | 25.6 | 22.6 | IC50 | 15.6 | 7.17 |