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Signaling mediators downstream of MRGPRs. MRGPRX1, MRGPRX2, MRGPRX4 and MRGPRD can mediate Gαq11 dependent pathways leading to phospholipase C (PLC) driven calcium responses. MRGPRX1, MRGPRX2 and MRGPRD can additionally engage Gαi and MRGPRD can recruit Gαs that drives cAMP production. In addition to G-proteins, β-arrestin signaling is engaged by MRGPRs and selectively other cell-surface receptor like RAMP-2 can inhibit MRGPRX4 expression and basal or agonist-induced activation.
