Figure 5. Heatmap analysis uncovered that deficiency of Cbfβ in cartilage resulted in decreased chondrocyte genes expression and decreased TGF-β and Hippo signaling, but increased Wnt signaling.

(A) Heatmap for chondrocyte gene expression in (1) 6-weeks-old male Cbfβ^f/f mice hip articular cartilage, (2) 6-weeks-old male Cbfβ^f/fCol2α1-CreER^T mice hip articular cartilage, (3) 12-weeks-old male oil injected Cbfβ^f/fAggrecan-CreER^T mice knee joint articular cartilage, and (4) 12-weeks-old male Cbfβ^f/fAggrecan-CreER^T mice (TMX injected at 6-weeks-old) knee joint articular cartilage. (B) Heatmap showing Wnt signaling-related gene expression. (C) Heatmap showing TGF-β signaling-related gene expression. (D) Heatmap showing Hippo signaling-related gene expression.