Fig. 3. All mice with the approximately 0.25-affinity ETS-A are indistinguishable in terms of the penetrance, laterality and severity of polydactyly.
a, Penetrance and laterality of phenotypes seen in French 2, Indian 2 and Syn 0.25 heterozygous (Het) and homozygous (Homo) mice. There is no significant difference in penetrance and laterality between heterozygotes and between homozygotes of French 2, Indian 2 and Syn 0.25 mice (Fisher’s exact test). Polydactyly occurs more frequently on the right hindlimb in both heterozygotes and homozygotes. In Syn 0.25/LOF mice, polydactyly is less penetrant than in heterozygous Syn 0.25 mice (Syn 0.25/WT). NS, not significant. b, Polydactyly phenotypes seen in French 2, Indian 2 and Syn 0.25 heterozygotes (dashed lines) and homozygotes (solid lines), as well as in Syn 0.25/LOF mice. There is no significant difference in the phenotypes seen between the French 2, Indian 2 and Syn 0.25 lines (Fisher’s exact test). TT, triphalangeal toe. Biorender.com was used to generate images in this figure.