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. 1982 Aug;45(8):675–679. doi: 10.1136/jnnp.45.8.675

The treatment of inflammatory polyneuropathy by plasma exchange.

M L Gross, N J Legg, M C Lockwood, C Pallis
PMCID: PMC1083155  PMID: 7130991

Abstract

Observations are reported on six patients with inflammatory polyneuropathy who were treated by plasma exchange. In four cases the polyneuropathy was acute and in two it was chronic or relapsing. Two acute cases and one chronic relapsing case had plasma exchange during a rapidly progressive phase of the disease, and showed a prompt and substantial recovery of function. The other three patients were exchanged when disease activity had reached a plateau. Only minor degrees of improvement were seen in two of these cases. One patient showed an initial mild deterioration before subsequent recovery. There were no significant side effects. These findings are discussed in relation to the pathogenesis and clinical management of inflammatory polyneuropathy.

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Selected References

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  1. Adams D., Festenstein H., Gibson J. D., Hughes R. A., Jaraquemada J., Papasteriadis C., Sachs J., Thomas P. K. HLA antigens in chronic relapsing idiopathic inflammatory polyneuropathy. J Neurol Neurosurg Psychiatry. 1979 Feb;42(2):184–186. doi: 10.1136/jnnp.42.2.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Adams D., Gibson J. D., Thomas P. K., Batchelor J. R., Hughes R. A., Kennedy L., Festenstein H., Sachs J. HLA antigens in Guillain-Barré syndrome. Lancet. 1977 Sep 3;2(8036):504–505. doi: 10.1016/s0140-6736(77)91626-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cook S. D., Dowling P. C., Murray M. R., Whitaker J. N. Circulating demyelinating factors in acute idiopathic polyneuropathy. Arch Neurol. 1971 Feb;24(2):136–144. doi: 10.1001/archneur.1971.00480320064006. [DOI] [PubMed] [Google Scholar]
  4. Dowling P. C., Bosch V. V., Cook S. D. Possible beneficial effect of high-dose intravenous steroid therapy in acute demyelinating disease and transverse myelitis. Neurology. 1980 Jul;30(7 Pt 2):33–36. doi: 10.1212/wnl.30.7_part_2.33. [DOI] [PubMed] [Google Scholar]
  5. Drachman D. A., Paterson P. Y., Berlin B. S., Roguska J. Immunosuppression and the Guillain-Barré syndrome. Arch Neurol. 1970 Nov;23(5):385–393. doi: 10.1001/archneur.1970.00480290005001. [DOI] [PubMed] [Google Scholar]
  6. Faber V., Balslov J. T. Immuno-fluorescent studies of renal biopsies in acute polyradiculitis. Acta Pathol Microbiol Scand B Microbiol Immunol. 1970;78(5):655–656. doi: 10.1111/j.1699-0463.1970.tb04353.x. [DOI] [PubMed] [Google Scholar]
  7. Goust J. M., Chenais F., Carnes J. E., Hames C. G., Fudenberg H. H., Hogan E. L. Abnormal T cell subpopulations and circulating immune complexes in the Guillain-Barré syndrome and multiple sclerosis. Neurology. 1978 May;28(5):421–425. doi: 10.1212/wnl.28.5.421. [DOI] [PubMed] [Google Scholar]
  8. Gross M. L., Thomas P. K. The treatment of chronic relapsing and chronic progressive idiopathic inflammatory polyneuropathy by plasma exchange. J Neurol Sci. 1981 Oct;52(1):69–78. doi: 10.1016/0022-510x(81)90135-0. [DOI] [PubMed] [Google Scholar]
  9. Hahn A. F., Gilbert J. J., Feasby T. E. Passive transfer of demyelination by experimental allergic neuritis serum. Acta Neuropathol. 1980;49(3):169–176. doi: 10.1007/BF00707103. [DOI] [PubMed] [Google Scholar]
  10. Hughes R. A., Newsom-Davis J. M., Perkin G. D., Pierce J. M. Controlled trial prednisolone in acute polyneuropathy. Lancet. 1978 Oct 7;2(8093):750–753. doi: 10.1016/s0140-6736(78)92644-2. [DOI] [PubMed] [Google Scholar]
  11. Julien J., Vital C., Aupy G., Lagueny A., Darriet D., Brechenmacher C. Guillain-Barré syndrome and Hodgkin's disease--ultrastructural study of a peripheral nerve. J Neurol Sci. 1980 Feb;45(1):23–27. doi: 10.1016/s0022-510x(80)80003-7. [DOI] [PubMed] [Google Scholar]
  12. Levy R. L., Newkirk R., Ochoa J. Treatment of chronic relapsing Guillain-Barré syndrome by plasma exchange. Lancet. 1979 Oct 6;2(8145):741–741. doi: 10.1016/s0140-6736(79)90665-2. [DOI] [PubMed] [Google Scholar]
  13. Lockwood C. M., Rees A. J., Pearson T. A., Evans D. J., Peters D. K., Wilson C. B. Immunosuppression and plasma-exchange in the treatment of Goodpasture's syndrome. Lancet. 1976 Apr 3;1(7962):711–715. doi: 10.1016/s0140-6736(76)93089-0. [DOI] [PubMed] [Google Scholar]
  14. Luijten J. A., Baart de la Faille-Kuyp The occurrence of IgM and complement factors along myelin sheaths of peripheral nerves. An immunohistochemical study of the Guillain-Barré syndrome. Preliminary communication. J Neurol Sci. 1972 Feb;15(2):219–224. doi: 10.1016/0022-510x(72)90009-3. [DOI] [PubMed] [Google Scholar]
  15. MELNICK S. C. Thirty-eight cases of the Guillain-Barre syndrome: an immunological study. Br Med J. 1963 Feb 9;1(5327):368–373. doi: 10.1136/bmj.1.5327.368. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Nyland H., Aarli J. A. Guillain-Barré syndrome: demonstration of antibodies to peripheral nerve tissue. Acta Neurol Scand. 1978 Jul;58(1):35–43. doi: 10.1111/j.1600-0404.1978.tb02857.x. [DOI] [PubMed] [Google Scholar]
  17. PALMER K. N. POLYRADICULONEUROPATHY (GUILLAIN-BARR'E SYNDROME) TREATED WITH 6-MERCAPTOPURINE. Lancet. 1965 Apr 3;1(7388):733–734. doi: 10.1016/s0140-6736(65)92091-x. [DOI] [PubMed] [Google Scholar]
  18. Rail D., Stark R., Swash M., Newland A. Improvement in nerve condition after plasma exchange for Guillain-Barré syndrome. J Neurol Neurosurg Psychiatry. 1980 Dec;43(12):1147–1147. doi: 10.1136/jnnp.43.12.1147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Raine C. S., Bornstein M. B. Experimental allergic neuritis. Ultrastructure of serum-induced myelin aberrations in peripheral nervous system cultures. Lab Invest. 1979 Apr;40(4):423–432. [PubMed] [Google Scholar]
  20. Rosen A. D., Vastola E. F. Clinical effects of cyclophosphamide in Guillain-Barré polyneuritis. J Neurol Sci. 1976 Nov;30(1):179–187. doi: 10.1016/0022-510x(76)90265-3. [DOI] [PubMed] [Google Scholar]
  21. Rumpl E., Mayr U., Gerstenbrand F., Hackl J. M., Rosmanith P., Aichner F. Treatment of Guillain-Barré syndrome by plasma exchange. J Neurol. 1981;225(3):207–217. doi: 10.1007/BF00313750. [DOI] [PubMed] [Google Scholar]
  22. Saida T., Saida K., Silberberg D. H., Brown M. J. Transfer of demyelination by intraneural injection of experimental allergic neuritis serum. Nature. 1978 Apr 13;272(5654):639–641. doi: 10.1038/272639a0. [DOI] [PubMed] [Google Scholar]
  23. Server A. C., Lefkowith J., Braine H., McKhann G. M. Treatment of chronic relapsing inflammatory polyradiculoneuropathy by plasma exchange. Ann Neurol. 1979 Sep;6(3):258–261. doi: 10.1002/ana.410060313. [DOI] [PubMed] [Google Scholar]
  24. Tachovsky T. G., Lisak R. P., Koprowski H., Theofilopoulos A. N., Dixon F. J. Circulating immune complexes in multiple sclerosis and other neurological diseases. Lancet. 1976 Nov 6;2(7993):997–999. doi: 10.1016/s0140-6736(76)90835-7. [DOI] [PubMed] [Google Scholar]
  25. Tse K. S., Arbesman C. E., Tomasi T. B., Jr, Tourville D. Demonstration of antimyelin antibodies by immunofluorescence in Guillain-Barré syndrome. Clin Exp Immunol. 1971 Jun;8(6):881–887. [PMC free article] [PubMed] [Google Scholar]
  26. WAKSMAN B. H., ADAMS R. D. Allergic neuritis: an experimental disease of rabbits induced by the injection of peripheral nervous tissue and adjuvants. J Exp Med. 1955 Aug 1;102(2):213–236. doi: 10.1084/jem.102.2.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Yuill G. M., Swinburn W. R., Liversedge L. A. Treatment of polyneuropathy with azathioprine. Lancet. 1970 Oct 24;2(7678):854–856. doi: 10.1016/s0140-6736(70)92019-2. [DOI] [PubMed] [Google Scholar]

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