Abstract
A 20-year-old girl developed a subacute neurological illness characterized by seizures and epilepsia partialis continua, which resulted in her death within 10 weeks of her first symptom. Although she had a history of unusual reactions to viral infections, there was no evidence of any underlying disorder resulting in immunosuppression. Histopathology demonstrated the presence of dense infection with measles virus. The unusual clinical features of this cases suggest that measles virus may be responsible for a wide spectrum of neurological disease ranging from measles inclusion body encephalitis on the one hand to subacute sclerosing panencephalitis on the other.
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- Agamanolis D. P., Tan J. S., Parker D. L. Immunosuppressive measles encephalitis in a patient with a renal transplant. Arch Neurol. 1979 Nov;36(11):686–690. doi: 10.1001/archneur.1979.00500470056011. [DOI] [PubMed] [Google Scholar]
- Aicardi J., Goutieres F., Arsenio-Nunes M. L., Lebon P. Acute measles encephalitis in children with immunosuppression. Pediatrics. 1977 Feb;59(2):232–239. [PubMed] [Google Scholar]
- Bellman M. H., Dick G. W. Surveillance of subacute sclerosing panencephalitis. J R Coll Physicians Lond. 1978 Apr;12(3):256–261. [PMC free article] [PubMed] [Google Scholar]
- Campbell R. H., Marshall W. C., Chessells J. M. Neurological complications of childhood leukaemia. Arch Dis Child. 1977 Nov;52(11):850–858. doi: 10.1136/adc.52.11.850. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Choppin P. W. Measles virus and chronic neurological diseases. Ann Neurol. 1981 Jan;9(1):17–20. doi: 10.1002/ana.410090104. [DOI] [PubMed] [Google Scholar]
- Coulter J. B., Balch N., Best P. V. Subacute sclerosing panencephalitis after drug-induced immunosuppression. Arch Dis Child. 1979 Aug;54(8):640–642. doi: 10.1136/adc.54.8.640. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Drysdale H. C., Jones L. F., Oppenheimer D. R., Tomlinson A. H. Measles inclusion-body encephalitis in a child with treated acute lymphoblastic leukaemia. J Clin Pathol. 1976 Oct;29(10):865–872. doi: 10.1136/jcp.29.10.865. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gilden D. H., Rorke L. B., Tanaka R. Acute SSPE. Arch Neurol. 1975 Sep;32(9):644–646. doi: 10.1001/archneur.1975.00490510100013. [DOI] [PubMed] [Google Scholar]
- Jabbour J. T., Garcia J. H., Lemmi H., Ragland J., Duenas D. A., Sever J. L. Subacute sclerosing panencephalitis. A multidisciplinary study of eight cases. JAMA. 1969 Mar 24;207(12):2248–2254. doi: 10.1001/jama.207.12.2248. [DOI] [PubMed] [Google Scholar]
- Lyon G. Examen ultra-structural du cerveau dans trois encephalopathies aigues et chroniques au cours de deficits immunitaires. Arch Fr Pediatr. 1972 Jun-Jul;29(6):641–654. [PubMed] [Google Scholar]
- Lyon G., Ponsot G., Lebon P. Acute measles encephalitis of the delayed type. Ann Neurol. 1977 Oct;2(4):322–327. doi: 10.1002/ana.410020411. [DOI] [PubMed] [Google Scholar]
- Mandelbaum D. E., Hall W. W., Paneth N., Wolff R. R., DeVivo D. C. SSPE, measles virus, and the matrix protein: report of a case with unusual immunochemical findings. Ann Neurol. 1981 Oct;10(4):351–354. doi: 10.1002/ana.410100406. [DOI] [PubMed] [Google Scholar]
- Mellor D. H., Purcell M. Unusual encephalitic illnesses in a child with acute leukaemia in remission: possible role of measles virus and Toxoplasma gondii. Neuropadiatrie. 1976 Nov;7(4):423–430. doi: 10.1055/s-0028-1091642. [DOI] [PubMed] [Google Scholar]
- Murphy J. V., Yunis E. J. Encephalopathy following measles infection in children with chronic illness. J Pediatr. 1976 Jun;88(6):937–942. doi: 10.1016/s0022-3476(76)81045-1. [DOI] [PubMed] [Google Scholar]
- Pedersen F. K., Schiøtz P. O., Valerius N. H., Hertz H. Immunosuppressive measles encephalopathy. Acta Paediatr Scand. 1978 Jan;67(1):109–112. doi: 10.1111/j.1651-2227.1978.tb16286.x. [DOI] [PubMed] [Google Scholar]
- Pullan C. R., Noble T. C., Scott D. J., Wisniewsk K., Gardner P. S. Atypical measles infections in leukaemic children on immunosuppressive treatment. Br Med J. 1976 Jun 26;1(6025):1562–1565. doi: 10.1136/bmj.1.6025.1562. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roos R. P., Graves M. C., Wollmann R. L., Chilcote R. R., Nixon J. Immunologic and virologic studies of measles inclusion body encephalitis in an immunosuppressed host: the relationship to subacute sclerosing panencephalitis. Neurology. 1981 Oct;31(10):1263–1270. doi: 10.1212/wnl.31.10.1263. [DOI] [PubMed] [Google Scholar]
- Silva C. A., Paula-Barbosa M. M., Pereira S., Cruz C. Two cases of rapidly progressive subacute sclerosing panencephalitis. Neuropathological findings. Arch Neurol. 1981 Feb;38(2):109–113. doi: 10.1001/archneur.1981.00510020067010. [DOI] [PubMed] [Google Scholar]
- Smyth D., Tripp J. H., Brett E. M., Marshall W. C., Almeida J., Dayan A. D., Coleman J. C., Dayton R. Letter: Atypical measles encephalitis in leukaemic children in remission. Lancet. 1976 Sep 11;2(7985):574–574. doi: 10.1016/s0140-6736(76)91821-3. [DOI] [PubMed] [Google Scholar]
- Thomas J. E., Reagan T. J., Klass D. W. Epilepsia partialis continua. A review of 32 cases. Arch Neurol. 1977 May;34(5):266–275. doi: 10.1001/archneur.1977.00500170020003. [DOI] [PubMed] [Google Scholar]
- Wolinsky J. S., Swoveland P., Johnson K. P., Baringer J. R. Subacute measles encephalitis complicating Hodgkin's disease in an adult. Ann Neurol. 1977 May;1(5):452–457. doi: 10.1002/ana.410010508. [DOI] [PubMed] [Google Scholar]