Skip to main content
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1975 Jul;38(7):650–656. doi: 10.1136/jnnp.38.7.650

Responses of isolated human basilar arteries to 5-hydroxytryptamine, noradrenaline, serum, platelets, and erythrocytes.

L M Starling, D J Boullin, D G Grahame-Smith, C B Adams, R S Gye
PMCID: PMC1083243  PMID: 1159436

Abstract

The isolated human basilar artery suspended in Kreb's solution contracts to 5-hydroxy-tryptamine, noradrenaline, and histamine, which stimulate specific receptors. Normal human serum contains an unidentified contractile substance, and erythrocytes relax the artery. Serum and erythrocytes potentiate 5-HT contractions. This preparation is suitable for studying vasoactive substances released during vasospasm after subarachnoid haemorrhage.

Full text

PDF
650

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahtee L., Boullin D. J., Paasonen M. K. Transport of taurine by normal human blood platelets. Br J Pharmacol. 1974 Oct;52(2):245–251. doi: 10.1111/j.1476-5381.1974.tb09707.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Allen G. S., Gold L. H., Chou S. N., French L. A. Cerebral arterial spasm. 3. In vivo intracisternal production of spasm by serotonin and blood and its reversal by phenoxybenzamine. J Neurosurg. 1974 Apr;40(4):451–458. doi: 10.3171/jns.1974.40.4.0451. [DOI] [PubMed] [Google Scholar]
  3. Allen G. S., Henderson L. M., Chou S. N., French L. A. Cerebral arterial spasm. 1. In vitro contractile activity of vasoactive agents on canine basilar and middle cerebral arteries. J Neurosurg. 1974 Apr;40(4):433–441. doi: 10.3171/jns.1974.40.4.0433. [DOI] [PubMed] [Google Scholar]
  4. Allen G. S., Henderson L. M., Chou S. N., French L. A. Cerebral arterial spasm. 2. In vitro contractile activity of serotonin in human serum and CSF on the canine basilar artery, and its blockage by methylsergide and phenoxybenzamine. J Neurosurg. 1974 Apr;40(4):442–450. doi: 10.3171/jns.1974.40.4.0442. [DOI] [PubMed] [Google Scholar]
  5. BOHR D. F., GOULET P. L., TAQUINI A. C., Jr Direct tension recording from smooth muscle of resistance vessels from various organs. Angiology. 1961 Oct;12:478–485. doi: 10.1177/000331976101201009. [DOI] [PubMed] [Google Scholar]
  6. Boullin D. J., O'Brien R. A. Abnormalities of 5-hydroxytryptamine uptake and binding by blood platelets from children with Down's syndrome. J Physiol. 1971 Jan;212(2):287–297. doi: 10.1113/jphysiol.1971.sp009325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Echlin F. A. Current concepts in the etiology and treatment of vasospasm. Clin Neurosurg. 1968;15:133–160. doi: 10.1093/neurosurgery/15.cn_suppl_1.133. [DOI] [PubMed] [Google Scholar]
  8. Echlin F. A. Spasm of basilar and vertebral arteries caused by experimental subarachnoid hemorrhage. J Neurosurg. 1965 Jul;23(1):1–11. doi: 10.3171/jns.1965.23.1.0001. [DOI] [PubMed] [Google Scholar]
  9. Echlin F. Experimental vasospasm, acute and chronic, due to blood in the subarachnoid space. J Neurosurg. 1971 Dec;35(6):646–656. doi: 10.3171/jns.1971.35.6.0646. [DOI] [PubMed] [Google Scholar]
  10. Nielsen K. C., Owman C. Contractile response and amine receptor mechanisms in isolated middle cerebral artery of the cat. Brain Res. 1971 Mar 19;27(1):33–42. doi: 10.1016/0006-8993(71)90370-2. [DOI] [PubMed] [Google Scholar]
  11. RAYNOR R. B., McMURTRY J. G., POOL J. L. Cerebrovascular effects of topically applied serotonin in the cat. Neurology. 1961 Mar;11:190–195. doi: 10.1212/wnl.11.3.190. [DOI] [PubMed] [Google Scholar]
  12. Toda N., Fujita Y. Responsiveness of isolated cerebral and peripheral arteries to serotonin, norepinephrine, and transmural electrical stimulation. Circ Res. 1973 Jul;33(1):98–104. doi: 10.1161/01.res.33.1.98. [DOI] [PubMed] [Google Scholar]
  13. Wilkins R. H., Wilkins G. K., Gunnells J. C., Odom G. L. Experimental studies of intracranial arterial spasm using aortic strip assays. J Neurosurg. 1967 Dec;27(6):490–500. doi: 10.3171/jns.1967.27.6.0490. [DOI] [PubMed] [Google Scholar]
  14. Zervas N. T., Kuwayama A., Rosoff C. B., Salzman E. W. Cerebral arterial spasm. Modification by inhibition of platelet function. Arch Neurol. 1973 Jun;28(6):400–404. doi: 10.1001/archneur.1973.00490240060010. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES