Abstract
Necropsy studies were done on six patients with idiopathic paralysis agitans, one with multiple system atrophy including features of Parkinsonism, and one control. Autonomic functions had been evaluated during life to a varying degree. Intra-arterial blood pressure studies were carried out on two patients with paralysis agitans (cases 4 and 6) and the one with multiple system atrophy (case 7). Lewy bodies with or without cell loss were seen in the sympathetic ganglia of five cases of paralysis agitans. Three of these had orthostatic hypotension and the severity of the lesion approximately correlated with the degree of hypotension. It is concluded that the lesions of the sympathetic ganglia may play a major role in the production of orthostatic hypotension in idiopathic paralysis agitans.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aminoff M. J., Wilcox C. S. Assessment of autonomic function in patients with a Parkinsonian syndrome. Br Med J. 1971 Oct 9;4(5779):80–84. doi: 10.1136/bmj.4.5779.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Appenzeller O., Goss J. E. Autonomic deficits in Parkinson's syndrome. Arch Neurol. 1971 Jan;24(1):50–57. doi: 10.1001/archneur.1971.00480310078007. [DOI] [PubMed] [Google Scholar]
- Bannister R. Degeneration of the autonomic nervous system. Lancet. 1971 Jul 24;2(7717):175–179. doi: 10.1016/s0140-6736(71)90893-2. [DOI] [PubMed] [Google Scholar]
- Bannister R., Oppenheimer D. R. Degenerative diseases of the nervous system associated with autonomic failure. Brain. 1972;95(3):457–474. doi: 10.1093/brain/95.3.457. [DOI] [PubMed] [Google Scholar]
- Chokroverty S., Barron K. D., Katz F. H., Del Greco F., Sharp J. T. The syndrome of primary orthostatic hypotension. Brain. 1969;92(4):743–768. doi: 10.1093/brain/92.4.743. [DOI] [PubMed] [Google Scholar]
- Gross M., Bannister R., Godwin-Austen R. Orthostatic hypotension in Parkinson's disease. Lancet. 1972 Jan 22;1(7743):174–176. doi: 10.1016/s0140-6736(72)90571-5. [DOI] [PubMed] [Google Scholar]
- Hoehn M. M., Yahr M. D. Parkinsonism: onset, progression and mortality. Neurology. 1967 May;17(5):427–442. doi: 10.1212/wnl.17.5.427. [DOI] [PubMed] [Google Scholar]
- Johnson R. H., Lee G. de J., Oppenheimer D. R., Spalding J. M. Autonomic failure with orthostatic hypotension due to intermediolateral column degeneration. A report of two cases with autopsies. Q J Med. 1966 Apr;35(138):276–292. [PubMed] [Google Scholar]
- Rajput A. H. Levodopa in dystonia musculorum deformans. Lancet. 1973 Feb 24;1(7800):432–432. doi: 10.1016/s0140-6736(73)90296-1. [DOI] [PubMed] [Google Scholar]
- SHY G. M., DRAGER G. A. A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study. Arch Neurol. 1960 May;2:511–527. doi: 10.1001/archneur.1960.03840110025004. [DOI] [PubMed] [Google Scholar]
- Schwarz G. A. The orthostatic hypotension syndrome of Shy-Drager. A clinicopathologic report. Arch Neurol. 1967 Feb;16(2):123–139. doi: 10.1001/archneur.1967.00470200011002. [DOI] [PubMed] [Google Scholar]
- Vanderhaeghen J. J., Périer O., Sternon J. E. Pathological findings in idiopathic orthostatic hypotension. Its relationship with Parkinson's disease. Arch Neurol. 1970 Mar;22(3):207–214. doi: 10.1001/archneur.1970.00480210017002. [DOI] [PubMed] [Google Scholar]
- Webster D. D. Critical analysis of the disability in Parkinson's disease. Mod Treat. 1968 Mar;5(2):257–282. [PubMed] [Google Scholar]
- den HARTOG JAGER W. A., BETHLEM J. The distribution of Lewy bodies in the central and autonomic nervous systems in idiopathic paralysis agitans. J Neurol Neurosurg Psychiatry. 1960 Nov;23:283–290. doi: 10.1136/jnnp.23.4.283. [DOI] [PMC free article] [PubMed] [Google Scholar]