Abstract
In central nervous system diseases, abnormal aggregation of one protein is often associated with aggregation of other proteins. To begin to assess whether ß-amyloid (Aß) is associated with α-synuclein (AS) aggregation [secondary Lewy body (LB) formation], we used immunohistochemical techniques to compare the amygdala of 11 subjects with pathological aging and 18 with Alzheimer's disease. Overall, Aß-40 plaque level was greater in cases with secondary AS aggregates. Aß42 plaque level was not associated with AS aggregation. Aß-40 plaque levels cannot be ruled out as a factor involved in secondary LB formation.
Keywords: Alzheimer's disease, ß-amyloid, α-synuclein, Lewy body, pathological aging
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Contributor Information
Carol F. Lippa, Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania..
Hiroshi Mori, Osaka City University Medical School, Osaka, Japan..
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