Table 1.

Burden analysis of rare variants in Parkinson’s disease

Gene	All non-synonymous, P			All functional, P			CADD score ≥20, P
	UKBB	AMP-PD	Meta-analysis	UKBB	AMP-PD	Meta-analysis	UKBB	AMP-PD	Meta-analysis
AXL	0.84	0.27	0.48	0.83	0.27	0.48	0.45	0.85	0.54
MERTK	0.2	0.92	0.81	0.21	1	0.78	0.002	0.67	0.28

Bold text represents statistically significant value (P < 0.05). AMP-PD = Accelerating Medicines Partnership-Parkinson’s Disease; CADD = combined annotation dependent depletion; UKBB = UK Biobank.