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. 1971 Jun;34(3):308–315. doi: 10.1136/jnnp.34.3.308

Spontaneous canine hydrocephalus: cerebrospinal fluid dynamics1

A Sahar 1,2,2, G M Hochwald 1,2,3, W J Kay 1,2,4, J Ransohoff 1,2
PMCID: PMC1083469  PMID: 5571319

Abstract

Cerebrospinal fluid dynamics were studied in 14 dogs with spontaneous hydrocephalus. In nine of the dogs aqueductal obstruction was observed and the remainder had a `communicating type' hydrocephalus. The major histological findings consisted of severe ependymal destruction, spongy changes in the periventricular white matter, increased density of capillaries in this area, and varying degrees of thickening, fibrosis, and fusion of the choroid villi. The formation and absorption of CSF were studied by perfusion of the cerebral ventricles. The rate of formation of CSF was found to decrease with perfusion pressure by Vf = 0·02595−0·00022 P ml./min (P = pressure in cm H2O). The absorption of spinal fluid was found to increase linearly with pressure by Va = 0·0165 + 0·00050 P. The various factors influencing the formation and absorption of the spinal fluid are discussed. The meaning and attainment of `arrest' of the hydrocephalic process in terms of the measured rates of CSF formation and absorption in these animals are considered.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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