Abstract
It has been suggested that the effect of ACTH in myasthenia gravis may be ascribed to an action involving neuromuscular transmission which favours repolarization processes, with a tendency towards hyperpolarization of the membranes of muscle fibres and motor nerve endings. A similar mechanism has been postulated for the action of ACTH in epilepsy (Klein, 1970). A direct or indirect action on nerve membrane would interfere with depolarization. There is evidence of raised concentration of intracellular potassium and increased outflow of sodium ions which would cause hyperpolarization of the membrane. This paper studies the effect of ACTH on the late block of neuromuscular transmission caused by acetylcholine (ACTH).
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- ELMQVIST D., HOFMANN W. W., KUGELBERG J., QUASTEL D. M. AN ELECTROPHYSIOLOGICAL INVESTIGATION OF NEUROMUSCULAR TRANSMISSION IN MYASTHENIA GRAVIS. J Physiol. 1964 Nov;174:417–434. doi: 10.1113/jphysiol.1964.sp007495. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GROB D., HARVEY A. M., JOHNS R. J. Studies in neuromuscular function. IV. Stimulating and depressant effects of acetylcholine and choline in patients with myasthenia gravis, and their relationship to the defect in neuromuscular transmission. Bull Johns Hopkins Hosp. 1956 Sep;99(3):153–181. [PubMed] [Google Scholar]
- Gambi D., Tonali P. Il test di Grob nella miastenia: discussione di un caso atipico. Riv Neurol. 1971 May-Jun;41(3):161–169. [PubMed] [Google Scholar]
- Gissen A. J., Nastuk W. L. The mechanisms underlying neuromuscular block following prolonged exposure to depolarizing agents. Ann N Y Acad Sci. 1966 Jan 26;135(1):184–194. doi: 10.1111/j.1749-6632.1966.tb45472.x. [DOI] [PubMed] [Google Scholar]
- Klein R. The effects of ACTH and corticosteroids on epileptiform disorders. Prog Brain Res. 1970;32:263–269. doi: 10.1016/S0079-6123(08)61544-7. [DOI] [PubMed] [Google Scholar]
- Pinelli P., Tonali P., Gambi D., Pelliccioli G. Sul blocco neuromuscolare da introduzione endoarteriosa di acetilcolina. Effetti di trattamenti preliminari con ACTH. Riv Neurol. 1970 Jul-Aug;40(4):203–212. [PubMed] [Google Scholar]
- Thesleff S. Acetylcholine utulization in myasthenia gravis. Ann N Y Acad Sci. 1966 Jan 26;135(1):195–208. doi: 10.1111/j.1749-6632.1966.tb45473.x. [DOI] [PubMed] [Google Scholar]
- Tonali P., Gambi D. Neuromuscular block after intra-arterially injected acetylcholine. 1. Introduction, methods, and technique. J Neurol Neurosurg Psychiatry. 1973 Apr;36(2):265–270. doi: 10.1136/jnnp.36.2.265. [DOI] [PMC free article] [PubMed] [Google Scholar]