Abstract
A quantitative assessment of post-ischaemic paraesthesiae has been made in 50 diabetic subjects and in a group of healthy age-matched controls. The results show a highly significant diminution of the paraesthetic response in the diabetic subjects. The degree of depression of the paraesthetic response was associated with the duration of the disease and the severity of the metabolic abnormality as determined by the degree of insulin dependence. Diabetics with the juvenile onset type of the disease were more adversely affected than those with the maturity onset type. There was no consistent relationship between the degree of depression of the paraesthesiae and the presence of peripheral neuropathy. The significance of these results is discussed in relation to the factors which determine the composition of the ionic micro-environment of myelinated nerve and the level of electrical excitability of the nerve fibre.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Christensen N. J., Orskov H. Vibratory perception during ischaemia in uraemic patients and in subjects with mild carbohydrate intolerance. J Neurol Neurosurg Psychiatry. 1969 Dec;32(6):519–524. doi: 10.1136/jnnp.32.6.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FRANKENHAEUSER B., HODGKIN A. L. The action of calcium on the electrical properties of squid axons. J Physiol. 1957 Jul 11;137(2):218–244. doi: 10.1113/jphysiol.1957.sp005808. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gregersen G. A study of the peripheral nerves in diabetic subjects during ischaemia. J Neurol Neurosurg Psychiatry. 1968 Apr;31(2):175–181. doi: 10.1136/jnnp.31.2.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gregersen G., Pilgaard S. The effect of ischaemia on vibration sense in hypo- or hypercalcaemia and in demyelinated nerves. Acta Neurol Scand. 1971;47(1):71–79. doi: 10.1111/j.1600-0404.1971.tb07465.x. [DOI] [PubMed] [Google Scholar]
- POOLE E. W. Ischaemic and post-ischaemic paraesthesiae; normal responses in the upper limb with special reference to the effect of age. J Neurol Neurosurg Psychiatry. 1956 May;19(2):148–154. doi: 10.1136/jnnp.19.2.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STEINESS I. Influence of diabetic status on vibratory perception during ischaemia. Acta Med Scand. 1961 Sep;170:319–338. doi: 10.1111/j.0954-6820.1961.tb00245.x. [DOI] [PubMed] [Google Scholar]
- Seneviratne K. N., Peiris O. A. Peripheral nerve function in chronic liver disease. J Neurol Neurosurg Psychiatry. 1970 Oct;33(5):609–614. doi: 10.1136/jnnp.33.5.609. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Seneviratne K. N., Peiris O. A. The effect of ischaemia on the excitability of human sensory nerve. J Neurol Neurosurg Psychiatry. 1968 Aug;31(4):338–347. doi: 10.1136/jnnp.31.4.338. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Seneviratne K. N., Peiris O. A. The effect of ischaemia on the excitability of sensory nerves in diabetes mellitus. J Neurol Neurosurg Psychiatry. 1968 Aug;31(4):348–353. doi: 10.1136/jnnp.31.4.348. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Seneviratne K. N., Peiris O. A. The effects of hypoxia on the excitability of the isolated peripheral nerves of alloxan-diabetic rats. J Neurol Neurosurg Psychiatry. 1969 Oct;32(5):462–469. doi: 10.1136/jnnp.32.5.462. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Seneviratne K. N., Peiris O. A. The role of diffusion barriers in determining the excitability of peripheral nerve. J Neurol Neurosurg Psychiatry. 1970 Jun;33(3):310–318. doi: 10.1136/jnnp.33.3.310. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Seneviratne K. N., Peiris O. A., Weerasuriya A. Effects of hyperkalaemia on the excitability of peripheral nerve. J Neurol Neurosurg Psychiatry. 1972 Apr;35(2):149–155. doi: 10.1136/jnnp.35.2.149. [DOI] [PMC free article] [PubMed] [Google Scholar]