Table 1:
Comparison of demographics, admission laboratory results, and outcome between different causes of acute liver failure in the Acute Liver Failure Study Group Registry
| Paracetamol (n=1195) | Ischaemia (n=181) | Drug-induced liver injury (n=283) | Autoimmunity (n=173) | Hepatitis B virus (n=188) | Hepatitis A virus (n=39) | Pregnancy (n=27) | All other causes (n=528) | |
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Age (median, years) | 37 | 53 | 47 | 46 | 45 | 50 | 31 | 40 |
| Women (%) | 75% | 58% | 67% | 81% | 45% | 44% | 100% | 64% |
| Jaundice coma (median, days) | 1 | 2 | 12 | 16 | 8 | 4 | 7 | 7 |
| Hepatic encephalopathy grade 3 or higher (%) | 54% | 56% | 36% | 27% | 51% | 54% | 54% | 44% |
| Alanine aminotransferase (median, IU/L) | 3780 | 2311 | 654 | 404 | 1410 | 2229 | 43 | 758 |
| Bilirubin (median, mg/dL) | 4·3 | 3·8 | 19·6 | 22·8 | 19·2 | 12·0 | 9·0 | 16·2 |
| Transplanted* (%) | 9% | 2% | 39% | 57% | 40% | 33% | 4% | 36% |
| Transplant-free survival* (%) | 65% | 57% | 24% | 14% | 19% | 51% | 78% | 22% |
| Overall survival* (%) | 72% | 58% | 58% | 63% | 53% | 77% | 82% | 55% |
Data were collected between Jan 1, 1998, and March 31, 2019. Total number of patients=2614.
*
Represents outcomes 21 days after admission to the Acute Liver Failure Study Group Registry.