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. 2024 Feb 5;12:20. doi: 10.1186/s40168-023-01734-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Efects of Lactobacillus reuteri and Lactobacillus amylovorus on PEDV infection in piglets. Lactobacillus reuteri and Lactobacillus amylovorus alleviate PEDV infection. A Protective model of Lactobacillus reuteri and Lactobacillus amylovorus in piglets (Am, Min pigs gavaged with Lactobacillus amylovorus; Re, Min pigs gavaged with Lactobacillus reuteri; Am/Re, Min pigs gavaged with Lactobacillus amylovorus and Lactobacillus reuteri; PBS, Min pigs gavaged with PBS; NC, normal control group). Comparative analysis of survival (B), weight loss (C), and diarrhea (D) in each group of piglets. E Analysis of average fluorescence intensity. F Comparison of histopathological changes (H&E staining) and PEDV viral load in the jejunum of piglets on day 8 post-infection. The left image is scanned at a magnification of 40×, and the right image is scanned at a magnification of 200×. G Histopathological scoring of tissues. The results are presented as the means ± SD, and statistical significance was calculated by one-way ANOVA. *P < 0.05; **P < 0.01; ****P < 0.0001