Table 3.

Cox regression models of selected immune marker z-score, intracranial large artery stenosis, and longitudinal outcomes

Outcome	Characteristic	Model 1 HR (95% CI)	Model 2 HR (95% CI)	Model 3 HR (95% CI)	Interaction term p-value
Any death (n=454)	Immune marker z-score	1.09 (1.06–1.12)	1.08 (1.05–1.12)	1.08 (1.05–1.11)	0.17
	≥50% ICAS*	2.10 (1.54–2.85)	1.52 (1.12–2.07)	1.47 (1.08–2.01)
Vascular death (n=200)	Immune marker z-score	1.11 (1.07–1.15)	1.12 (1.07–1.16)	1.11 (1.06–1.16)	0.33
	≥50% ICAS*	2.95 (1.95–4.45)	2.06 (1.36–3.13)	1.94 (1.27–2.95)
Any vascular event (n=324)	Immune marker z-score	1.07 (1.04–1.11)	1.06 (1.02–1.10)	1.05 (1.01–1.09)	0.72
	≥50% ICAS*	1.86 (1.29–2.69)	1.39 (0.96–2.02)	1.33 (0.91–1.93)

HR = hazard ratio; CI = confidence interval; ICAS = intracranial larger artery stenosis

^*Reference not ≥50% ICAS.

Model 1 includes only immune marker z-score and ICAS.

Model 2 additionally includes age, sex, race, ethnicity.

Model 3 additionally includes hypertension, hyperlipidemia, diabetes mellitus, and smoking history.