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. 2010 Jun;25(4):362–366. doi: 10.1177/1533317510365343

Diabetes Mellitus Predicts Cognitive Impairment in Patients With Ischemic Stroke

Eliyahu Hayim Mizrahi 1, Ana Waitzman 2, Tzvia Blumstein 3, Marina Arad 4, Abraham Adunsky 5
PMCID: PMC10845612  PMID: 20360596

Abstract

Background: Non-insulin-dependent diabetes mellitus (NIDDM) is associated with an increased incidence of cognitive impairment. Methods: A retrospective chart review study involving 707 patients admitted for rehabilitation after an ischemic stroke. Cognitive status was assessed by the Mini-Mental State Examination (MMSE), and scores lower than 24 points were considered suggestive of cognitive impairment. Results: Age, gender, NIDDM, dementia, and previous stroke emerged as the only statistically significant parameters differing between those with MMSE score lower than 24 or higher. After adjusting for confounding variables, NIDDM (odds ratio 1.46, 95% CI 1.05-2.05, P = .02) was associated with an increased risk of cognitive impairment. Conclusions: Our findings suggest that NIDDM is independently associated with lower MMSE scores in ischemic stroke patients. It identifies individuals in need of specifically targeted interventions and may assist in selecting and developing resources for cognitively impaired diabetic patients.

Keywords: cognitive impairment, diabetes mellitus, ischemic stroke, vascular risk factors

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Contributor Information

Eliyahu Hayim Mizrahi, Department of Geriatric Medicine & Rehabilitation, Sheba Medical Center, Tel Hashomer, Israel, The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, exm42@sheba.health.gov.il .

Ana Waitzman, Department of Geriatric Medicine & Rehabilitation, Sheba Medical Center, Tel Hashomer, Israel.

Tzvia Blumstein, The Gertner Institute for Epidemiology and Health Policy Research, Chaim Sheba Medical Center, Tel Hashomer, Israel.

Marina Arad, Department of Geriatric Medicine & Rehabilitation, Sheba Medical Center, Tel Hashomer, Israel, The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Abraham Adunsky, Department of Geriatric Medicine & Rehabilitation, Sheba Medical Center, Tel Hashomer, Israel, The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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