Skip to main content
American Journal of Alzheimer's Disease and Other Dementias logoLink to American Journal of Alzheimer's Disease and Other Dementias
. 2007 Aug-Sep;22(4):313–318. doi: 10.1177/1533317507303198

A Quick Test for Cognitive Speed: A Measure of Cognitive Speed in Dementia With Lewy Bodies

Maria Andersson 1, Elisabeth H Wiig 2, Lennart Minthon 3, Elisabet Londos 4
PMCID: PMC10846159  PMID: 17712162

Abstract

The purpose of this article is to investigate how patients with dementia with Lewy bodies (DLB) perform on A Quick Test for Cognitive Speed (AQT) compared with patients with Alzheimer's disease (AD) and age- and sex-matched controls and to see whether this test might be helpful in distinguishing DLB from AD at comparable cognitive levels. Twenty-three patients with DLB, 18 patients with AD, and 24 controls were included. The time in seconds to complete the AQT was recorded for the 3 independent study groups according to standard directives. The DLB patients had significantly longer reading times than the AD patients at equivalent and relatively high Mini-Mental State Examination levels. We suggest that slow performance on the AQT at relatively high Mini-Mental State Examination levels could be one way of distinguishing DLB from AD. This may have clinical implications for treatment as well as for understanding the neuropathological properties of the disease.

Keywords: A Quick Test for Cognitive Speed, dementia, Lewy bodies, cognitive speed, subcortical

Full Text

The Full Text of this article is available as a PDF (100.4 KB).

Contributor Information

Maria Andersson, Neuropsychiatric Clinic, Malmö University Hospital, Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden, maria_a.andersson@med.lu.se .

Elisabeth H. Wiig, Knowledge Research Institute, Arlington, Texas.

Lennart Minthon, Neuropsychiatric Clinic, Malmö University Hospital, Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.

Elisabet Londos, Neuropsychiatric Clinic, Malmö University Hospital, Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.

References

  1. Zaccai J., McCracken C., Brayne C. A systematic review of prevalence and incidence studies of dementia with Lewy bodies. Age Ageing. 2005;34:561-566. [DOI] [PubMed] [Google Scholar]
  2. Ballard CG Definition and diagnosis of dementia with Lewy bodies. Dement Geriatr Cogn Dis. 2004;17(suppl 1):15-24. [DOI] [PubMed] [Google Scholar]
  3. McKeith IG, Dickson DW, Lowe J., et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology. 2005. ;65:1863-1872. [DOI] [PubMed] [Google Scholar]
  4. McKeith IG, Galasko D., Kosaka K., et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology. 1996;47:1113-1124. [DOI] [PubMed] [Google Scholar]
  5. McKeith IG, Perry EK, Perry RH Report of the second dementia with Lewy body international workshop: diagnosis and treatment: consortium on dementia with Lewy bodies. Neurology . 1999;53:902-905. [DOI] [PubMed] [Google Scholar]
  6. Geser F., Wenning GK, Poewe W., McKeith I. How to diagnose dementia with Lewy bodies: state of the art. Mov Disord. 2005;20:S11. [DOI] [PubMed] [Google Scholar]
  7. Nielsen NP, Wiig EH, Warkentin S., Minthon L. Clinical utility of color-form naming in Alzheimer's disease: preliminary evidence. Percept Mot Skills. 2004;99:1201-1204. [DOI] [PubMed] [Google Scholar]
  8. Nielsen NP, Wiig EH Alzheimer's Quick Test cognitive screening criteria for West African speakers of Krio. Age Ageing. 2006;35:503-507. [DOI] [PubMed] [Google Scholar]
  9. Jacobson JM, Nielsen NP, Minthon L., Warkentin S., Wiig EH Multiple automatic naming measures of cognition: normal performance and effects of aging. Percept Mot Skills. 2004;98:739-753. [DOI] [PubMed] [Google Scholar]
  10. Wiig EH, Nielsen NP, Minthon L., McPeek D., Said K., Warkentin S. Parietal lobe activation in rapid, automatized naming by adults. Percept Mot Skills. 2002;94:1230-1244. [DOI] [PubMed] [Google Scholar]
  11. Stroop J. Studies of interference in serial verbal reactions. J Exp Psychol. 1935;18:643-662. [Google Scholar]
  12. Folstein MF , Folstein SE, McHugh PR “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-198. [DOI] [PubMed] [Google Scholar]
  13. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan EM Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34: 939-944. [DOI] [PubMed] [Google Scholar]
  14. Wiig EH, Nielsen NP, Minthon L., Warkentin S. Alzheimer's Quick Test: Assessment of Parietal Function. San Antonio, Tex: Harcourt; /PsychCorp; 2002. [Google Scholar]
  15. Wiig EH, Nielsen NP, Minthon L., Warkentin S. Alzheimer's Quick Test: Assessement of Parietal Function. Stockholm, Sweden: Psykologiforlaget; 2003. [Google Scholar]
  16. Walker MP, Ayre GA, Perry EK, et al. Quantification and characterisation of fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease. Dement Geriatr Cog Disord. 2000;11:327. [DOI] [PubMed] [Google Scholar]
  17. Mondon K., Gochard A., Marque A., et al. Visual recognition memory differentiates dementia with Lewy bodies and Parkinson's disease dementia. J Neurol Neurosurg Psychiatry. 2007: jnnp.2006.104257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Janvin CC, Aarsland D., Larsen JP, Hugdahl K. Neuropsychological profile of patients with Parkinson's disease without dementia . Dement Geriatr Cog Disord. 2003;15:126-131. [DOI] [PubMed] [Google Scholar]
  19. Janvin CC, Larsen JP, Salmon DP, Galasko D., Hugdahl K., Aarsland D. Cognitive profiles of individual patients with Parkinson's disease and dementia: comparison with dementia with Lewy bodies and Alzheimer's disease. Mov Disord 2006;21:337-342. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Alzheimer's Disease and Other Dementias are provided here courtesy of SAGE Publications

RESOURCES