Abstract
Objective: To test that a positive family history and ApoE e4 genotype are prevalent among dementia patients with onset before 70 years of age compared with healthy spousal controls. Methods: A total of 210 patients with dementia and 82 spousal control participants. Neuropsychiatric examination, Consortium to establish a registry on Alzheimer’s disease test battery, Clock-drawing Test, and ApoE genotyping were performed in patients and controls. Results: Of the 131 patients with Alzheimer dementia, 25 were homozygous for Apo e4. Among dementia patients with a positive family history (n = 83), homozygosity for the Apo e4 genotype was found in 19 (22.9%). A positive family history was highest among Apo e4 homozygous Alzheimer dementia patients (72.0%) and lowest among the cognitively normal spousal controls (9.3%). Conclusions: In our sample of patients with Alzheimer dementia, approximately 3 of 4 (72.0%) were homozygous for the genotype Apo e4 when they had a positive family history.
Keywords: dementia, Alzheimer’s disease, ApoE, family history
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Contributor Information
Maria Zintl, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg School of Medicine, Regensburg, Germany, maria.zintl@web.de .
Gerd Schmitz, Department of Institut for Clinical Chemistry and Laboratory Medicine, University of Regensburg School of Medicine, Regensburg, Germany.
Göran Hajak, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg School of Medicine, Regensburg, Germany.
Hans-Hermann Klünemann, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg School of Medicine, Regensburg, Germany.
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