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. 2024 Feb 2;13(3):278. doi: 10.3390/cells13030278

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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FAK activation in FLNC^KO hiPSC-CMs. (A) GO cellular component analysis in FLNC knockout and isogenic control iPSC-CMs shows the activation of focal adhesion signaling pathway (hsa04510). (B) Downregulation of genes involved in sarcomere cytoskeleton formation in FLNC^KO iPSC-CMs. (C) Increased expression levels of p-FAK (Y397) in FLNC^KO compared to wildtype iPSC-CMs as assessed by IB. (D) Quantitative representation of the blots in B. (E) IF stanning of FAK in FLNC^KO compared to isogenic control iPSC-CMs. (F) Quantitative representation of the fluorescence signal of FAK in cytoplasm and nucleus.