Figure 2. Middle age presentation of ovarian and peritoneal tumors.

(A) Lifespan data from mice euthanized due to tumor burden criteria. # indicates the Pax8 and p53+/− model survival curve data were assessed from previous publications (see Methods) and are displayed for qualitative comparison. OvTrpMyc data originate from this study. (B) example of a dissected reproductive tract from a mouse with obvious macroscopic ovarian tumors. (C) examples of widespread intra-abdominal disease, including liver invasion (L), peritoneal tumors (P), splenic tumor (S), and ovarian tumors (Ov).