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. 2024 Jan 30;16(2):1981–1982. doi: 10.18632/aging.204906

Retraction: MiR-27a promotes the autophagy and apoptosis of IL-1β treated-articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling

Chen Cai 1,*, Shaoxiong Min 1,*, Bo Yan 2, Wen Liu 3, Xiao Yang 1, Liuxun Li 1, Ting Wang 3, Anmin Jin 1,
PMCID: PMC10866444  PMID: 38289967

This article has been retracted: Aging has completed its investigation of this paper. We found that four images of immunofluorescent staining in Figure 5A were previously published as Figure 6A in a 2012 paper by different authors [1]. In addition, Western blot bands in Figure 5B show internal duplication with bands in Figures 7B and Figure 2C in an earlier published paper from Huang et al [2] as well as Figure 6A in an unrelated paper [3]. There are also multiple overlaps between Western blot bands in Figures 6G and 7B with figures in unrelated papers all published in 2019 [46]. The authors informed the journal that they cannot reproduce the data published in the paper. As a result, all authors agreed that the article should be retracted.

REFERENCES

  • 1.Kumari S, Mehta SL, Li PA. Glutamate induces mitochondrial dynamic imbalance and autophagy activation: preventive effects of selenium. PLoS One. 2012; 7:e39382. 10.1371/journal.pone.0039382 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Huang YH, Sun Y, Huang FY, Li YN, Wang CC, Mei WL, Dai HF, Tan GH, Huang C. Toxicarioside O induces protective autophagy in a sirtuin-1-dependent manner in colorectal cancer cells. Oncotarget. 2017; 8:52783–91. 10.18632/oncotarget.17189 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Huang L, Jian Z, Gao Y, Zhou P, Zhang G, Jiang B, Lv Y. RPN2 promotes metastasis of hepatocellular carcinoma cell and inhibits autophagy via STAT3 and NF-κB pathways. Aging (Albany NY). 2019; 11:6674–90. 10.18632/aging.102167 [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]
  • 4.Liang M, Shao A, Tang X, Feng M, Wang J, Qiu Y. MiR-34a affects dexmedetomidine-inhibited chronic inflammatory visceral pain by targeting to HDAC2. BMC Anesthesiol. 2019; 19:131. 10.1186/s12871-019-0801-z [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Li G, Tan W, Fang Y, Wu X, Zhou W, Zhang C, Zhang Y, Liu Y, Jiu G, Liu D. circFADS2 protects LPS-treated chondrocytes from apoptosis acting as an interceptor of miR-498/mTOR cross-talking. Aging (Albany NY). 2019; 11:3348–61. 10.18632/aging.101986 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Chen T, Zhang Y, Liu Y, Zhu D, Yu J, Li G, Sun Z, Wang W, Jiang H, Hong Z. MiR-27a promotes insulin resistance and mediates glucose metabolism by targeting PPAR-γ-mediated PI3K/AKT signaling. Aging (Albany NY). 2019; 11:7510–24. 10.18632/aging.102263 [DOI] [PMC free article] [PubMed] [Google Scholar]

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