Table 1.

Comparison of healthy controls, MS patients with a functional ANS (MS I) and MS patients with a dysfunctional ANS (MS II)

	Co	MS I	MS II	$p_{C-I}$	$p_{C-II}$	$p_{I-II}$
N	23	27	24
Female	13 (57%)	21 (78%)	13 (38%)	0.115	0.882	0.079
SPMS	0 (0%)	4 (15%)	4 (17%)			0.580
RRMS	0 (0%)	23 (85%)	20 (83%)			0.869
Age	33.9 (10.7)	34.3 (7.9)	39.1 (11.3)	0.487	0.095	0.125
VAS	3.8 (1.0)	3.6 (1.4)	4.5 (1.5)	0.271	0.083	0.026
FSMC	30.9 (9.0)	47.3 (20.3)	63.2 (18.7)	0.193	0.002	0.037
FSMC: cognitive	15.6 (3.4)	21.9 (9.5)	32.9 (10.2)	0.395	0.009	0.003
FSMC: motoric	15.2 (5.9)	25.4 (11.0)	30.3 (10.1)	0.089	0.013	0.199
Handgrip (kg)	27.4 (3.6)	21.6 (6.0)	26.6 (9.4)	0.004	0.480	0.053
9-hole PT (s)	17.2 (1.6)	20.1 (4.9)	24.8 (7.3)	0.071	0.001	0.001
EDSS		1.9 (1.5)	2.7 (1.4)			0.021
ARMSS		4.1 (2.4)	5.0 (1.8)			0.177
Disease Duration (y)	0 (0)	6.7 (6.8)	10.4 (8.8)			0.150

Percentages and standard deviations are provided in brackets in the first and second part of the table, respectively. The p values corresponding to distribution-free Wilcoxon signed rank tests testing for mean differences between Co and MS I, Co and MS II, and MS I and MS II are given in columns $p_{C-I}$, $p_{C-II}$, and $p_{I-II}$, respectively. SPMS and RRMS refer to the number of participants with Secondary Progressive MS and Relapse Remitting MS, respectively. Overall scores on the FSMC are presented, as well as the scores on the cognitive and motoric subparts. Only 8 participants of the control group completed the FSMC, the handgrip strength, and the 9-hole peg (9-hole PT) test. Participants of the control group were not scored on the EDSS or the ARMSS. Further information about MS patients can be found in Tables S1–S3. Figure S2 shows the distribution of VAS fatigue ratings.