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Philosophical Transactions of the Royal Society B: Biological Sciences logoLink to Philosophical Transactions of the Royal Society B: Biological Sciences
. 2001 Jan 29;356(1405):61–66. doi: 10.1098/rstb.2000.0749

The reverse transcriptase model of somatic hypermutation.

E J Steele 1, R V Blanden 1
PMCID: PMC1087692  PMID: 11205332

Abstract

The evidence supporting the reverse transcriptase model of somatic hypermutation is critically reviewed. The model provides a coherent explanation for many apparently unrelated findings. We also show that the somatic hypermutation pattern in the human BCL-6 gene can be interpreted in terms of the reverse transcriptase model and the notion of feedback of somatically mutated sequences to the germline over evolutionary time.

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Selected References

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