Figure 2.
Immune Cell Composition Changes in Idiopathic Gastroparesis and Markers for Myeloid Cells
(A) The proportion of cells making up an individual’s total cell count for either control (blue) or patients with gastroparesis (orange). Dots represent individual patients. p > 0.05 for all cell-types, heteroscedastic unpaired Student’s t test.
(B) Bubble plot showing the expression (color, yellow high, purple low) of genes previously associated with myeloid cells and fraction of cells expressing those genes (log TP10K+1 > 0.5, size of bubble). Monocytes, macrophages and DCs show the highest average expression level and the expression in largest proportion of cells. The data represents expression for cells from both IG and controls.
(C) Bubble plots of genes associated with specific cell types, in order: monocytes, macrophages, mast cells, dendritic cells. Expression (log TP10K+1) is represented by color (yellow high, purple low) and fraction of cells expressing (log TP10K+1 > 0.5) is represented by size of the bubble. Genes were selected by calculating a Z score for the associated cell type against all other cell types, and genes with the highest Z score were plotted.