Extended Data Fig. 7. Effect s of CMV status on induced cytokines is modified by blood cell subsets and effect of smoking on induced cytokines is modified by specific CpGs associated with induced levels of IL2 following SEB stimulation.

a, Heatmap showing associations of the cytomegalovirus (CMV) serostatus with each induced cytokine following SEB stimulation, with either no cellular covariate (top line) or each of 76 cell subsets passed as covariates in the models. Significance of the BY adj-pval likelihood ratio test is marked with stars (*P < 0.05, **P < 0.01, ***P < 0.001). b, Heatmap showing associations of the smoking status with each induced cytokine following SEB stimulation when either no methylation probe (top line) or each individual methylation probe associated with IL-2 concentration levels in SEB stimulation is passed as a covariate in the models. Significance of the BY adj-pval likelihood ratio test is marked with stars (*P < 0.05, **P < 0.01, ***P < 0.001).