Table 1.

iSCORE-PD cell line collection summary (targeted genes, mutations generated, genetic inheritance, editing approach, number of cell lines and their genotype).

				CELLS IN COLLECTION
╲	MUTATION	INHERITANCE	EDITING	MONOALLELIC - HETEROZYGOUS	BIALLELIC - HOMOZYGOUS
SNCA (PARK1)	A53T	Autosomal dominant	Prime editing	3	-
	A30P	Autosomal dominant	Prime editing	3	1
PRKN (PARK2)	EX3DEL	Autosomal recessive	CRISPR/Cas9 (dual guide)	-	3
PINK1 (PARK6)	Q129X	Autosomal recessive	CRISPR/Cas9 (HDR)	-	3
DJ1 (PARK7)	EX1–5DEL	Autosomal recessive	CRISPR/Cas9 (dual guide)	-	3
LRRK2 (PARK8)	G2019S	Autosomal dominant	Prime editing, TALEN and CRISPR/Cas9 (HDR)	4	1
ATP13A2 (PARK9)	FS	Autosomal recessive	CRISPR/Cas9 (HDR)	-	5
FBXO7 (PARK15)	R498X/FS	Autosomal recessive	CRISPR/Cas9 (HDR)	-	1
DNAJC6 (PARK19)	c.801–2 A>G/FS	Autosomal recessive	CRISPR/Cas9 (HDR)	-	2
SYNJ1 (PARK20)	R258Q/FS	Autosomal recessive	CRISPR/Cas9 (HDR)	-	2
VPS13c (PARK23)	W395C/FS	Autosomal recessive	CRISPR/Cas9 (HDR)	-	4
	A444P/FS	Autosomal recessive	CRISPR/Cas9 (HDR)	1	2
GBA1	IVS2+1/FS	Autosomal dominant1	CRISPR/Cas9 (HDR)	4	2
Wild type	-	-		Parental + 3 independent clones
Edited wild type (EWT)	-	-	Prime editing	Prime editing (6) + CRISPR/Cas9 (2)

¹mixed inheritance.