Table 6.
NOEC, I(E)C20 and I(E)C50 values obtained in fish cell lines (PLHC-1 and RTH-149), Daphnia magna and Oncorhynchus mykiss exposed to uncoated and coated NPs. The results expressed as mg core NPs/L (mean ± SEM) corrected to the measured concentrations. The assays with fish cell lines and invertebrates were performed at least in triplicate.
| PLHC-1 (mg/L) |
RTH-149 (mg/L) |
Daphnia magna (mg/L) |
Oncorhynchus mykiss (mg/L) |
|
|---|---|---|---|---|
| TiO2-UNC | NOEC > 71.1 | NOEC > 71.1 | NOEC = 0.60; EC20 = 1.7 ± 0.98; EC50 = 2.3 ± 1.09 |
NOEC > 72.0 |
| TiO2-CIT | NOEC > 72.48 | NOEC > 72.4 | NOEC > 170.4 | NOEC > 89.7 |
| TiO2-PEG | NOEC > 68.8 | NOEC > 68.8 | NOEC > 82.6 | NOEC > 89.0 |
| TiO2-DDPA | NOEC > 0.28 | NOEC > 0.28 | NOEC > 0.17 | Not tested |
| CeO2-UNC | NOEC ≥ 32.5 | NOEC = 16.2; IC20 = 27.1 ± 4.8 |
NOEC = 0.023; EC20 = 0.72 ± 0.40; EC50 = 5.4 ± 1.8 |
NOEC > 40.8 |
| CeO2-CIT | NOEC > 84.7 | NOEC = 10.6 | NOEC > 49.4 | NOEC > 82.7 |
| CeO2-PEG | NOEC > 52.8 | NOEC > 52.8 | NOEC > 29.6 | NOEC > 32.8 |
| CeO2-DDPA | NOEC > 0.39 | NOEC > 0.39 | NOEC > 1.1 | Not tested |
| Ag-CIT | NOEC > 9.9 | NOEC = 0.62; IC20 = 3.6 ± 0.31; IC50 = 6.1 ± 0.63 |
NOEC = 0.015; EC20 = 0.07 ± 0.02; EC50 = 0.08 ± 0.02 |
NOEC > 0.035 |
| Ag-PEG | NOEC > 0.96 | NOEC = 0.24; IC20 = 0.56 ± 0.03; IC50 = 0.73 ± 0.04 |
NOEC = 0.000027; EC20 = 0.006 ± 0.001; EC50 = 0.008 ± 0.002 |
NOEC > 0.08 |
| Ag-OAM | NOEC = 0.10; IC20 = 0.16 ± 0.04; IC50 = 0.21 ± 0.01 |
NOEC = 0.025; IC20 = 0.034 ± 0.007; IC50 = 0.056 ± 0.005 |
NOEC = 0.00016; EC20 = 0.002 ± 0.0006; EC50 = 0.003 ± 0.0005 |
Not tested |