Figure 1.

Acute cutaneous changes in mice infected with MHV-1 (7 days post-infection). There is thinning of the epidermis (red arrow in (B)) with the absence of stratum corneum (dark blue arrow), papillomatosis (black arrow), and dying keratinocyte (light blue arrow) in MHV-1 infected mice. In contrast, the epidermal layer is preserved in healthy mice ((A), asterisk). The adipose tissue is replaced by fibrosis and collagen deposition in MHV-1 infected mice (black asterisk in (D)), as compared to the control ((C), asterisk). Additionally, extensive collagen deposition is observed in MHV-1-infected mice ((D), blue asterisk), and the number of hair follicles is increased, as compared to the controls (A,C). (A,B) = 66×; (C,D) = 23× in Figure 1 and Figure 2 below, (n = 16).