Figure 4.

A. Therapeutic efficacy of J-71 and J-80 compared to chloroquine in mice infected with P. berghei luciferase (Pb-Luc). Dose 1 was administered intravenously when parasitemia reached 0.5% on Day 5 and 3 subsequent doses were given in 12 h intervals. Parasitemia was estimated from May Grunwald-Giemsa-stained blood smears (x1000 magnification) and a paired T-test was performed to determine the significance in parasitemia reduction on Day 8, 9 and 10 (*<0.05, **<0.001, ***<0.0005) compared to control. B. Survival curve of mice infected with Pb-Luc parasites for 25 days after infection. Comparison of infected mouse survival between the untreated (control) and treated groups (J-71, J-80 and chloroquine). Colors used in the survival curves match panel A. Four mice were used in each treatment group.