Skip to main content
PMC home page
Thorax logoLink to Thorax
. 1996 Nov;51(11):1155–1157. doi: 10.1136/thx.51.11.1155

Selectins and their counter receptors: a bitter sweet attraction.

F A Symon 1, A J Wardlaw 1
PMCID: PMC1090529  PMID: 8958901

Abstract

Selectins are adhesion receptors expressed by leucocytes, platelets, and endothelial cells. They mediate the initial binding of leucocytes to vascular endothelium in the post-capillary venules. This is an essential first step in leucocyte migration into tissue. The selectin family of adhesion receptors consists of three C-type lectins (E, P, and L selectin). Their ligands (counter structures) are sialylated and fucosylated carbohydrate molecules which, in most cases, decorate mucin-like glycoprotein membrane receptors. Studies using blocking monoclonal antibodies have shown that inhibition of selectin function can ameliorate a range of inflammatory processes, offering the possibility that antagonists of selectin function may be useful in the treatment of inflammatory lung diseases such as asthma.

Full text

PDF
1155

Images in this article

1155Image
on p.1155

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Donnelly S. C., Haslett C., Dransfield I., Robertson C. E., Carter D. C., Ross J. A., Grant I. S., Tedder T. F. Role of selectins in development of adult respiratory distress syndrome. Lancet. 1994 Jul 23;344(8917):215–219. doi: 10.1016/s0140-6736(94)92995-5. [DOI] [PubMed] [Google Scholar]
  2. Etzioni A., Frydman M., Pollack S., Avidor I., Phillips M. L., Paulson J. C., Gershoni-Baruch R. Brief report: recurrent severe infections caused by a novel leukocyte adhesion deficiency. N Engl J Med. 1992 Dec 17;327(25):1789–1792. doi: 10.1056/NEJM199212173272505. [DOI] [PubMed] [Google Scholar]
  3. Frenette P. S., Mayadas T. N., Rayburn H., Hynes R. O., Wagner D. D. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell. 1996 Feb 23;84(4):563–574. doi: 10.1016/s0092-8674(00)81032-6. [DOI] [PubMed] [Google Scholar]
  4. Gearing A. J., Newman W. Circulating adhesion molecules in disease. Immunol Today. 1993 Oct;14(10):506–512. doi: 10.1016/0167-5699(93)90267-O. [DOI] [PubMed] [Google Scholar]
  5. Geng J. G., Bevilacqua M. P., Moore K. L., McIntyre T. M., Prescott S. M., Kim J. M., Bliss G. A., Zimmerman G. A., McEver R. P. Rapid neutrophil adhesion to activated endothelium mediated by GMP-140. Nature. 1990 Feb 22;343(6260):757–760. doi: 10.1038/343757a0. [DOI] [PubMed] [Google Scholar]
  6. Gundel R. H., Wegner C. D., Torcellini C. A., Clarke C. C., Haynes N., Rothlein R., Smith C. W., Letts L. G. Endothelial leukocyte adhesion molecule-1 mediates antigen-induced acute airway inflammation and late-phase airway obstruction in monkeys. J Clin Invest. 1991 Oct;88(4):1407–1411. doi: 10.1172/JCI115447. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Montefort S., Gratziou C., Goulding D., Polosa R., Haskard D. O., Howarth P. H., Holgate S. T., Carroll M. P. Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways. J Clin Invest. 1994 Apr;93(4):1411–1421. doi: 10.1172/JCI117118. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Picker L. J., Martin R. J., Trumble A., Newman L. S., Collins P. A., Bergstresser P. R., Leung D. Y. Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites. Eur J Immunol. 1994 Jun;24(6):1269–1277. doi: 10.1002/eji.1830240605. [DOI] [PubMed] [Google Scholar]
  9. Sako D., Chang X. J., Barone K. M., Vachino G., White H. M., Shaw G., Veldman G. M., Bean K. M., Ahern T. J., Furie B. Expression cloning of a functional glycoprotein ligand for P-selectin. Cell. 1993 Dec 17;75(6):1179–1186. doi: 10.1016/0092-8674(93)90327-m. [DOI] [PubMed] [Google Scholar]
  10. Symon F. A., Walsh G. M., Watson S. R., Wardlaw A. J. Eosinophil adhesion to nasal polyp endothelium is P-selectin-dependent. J Exp Med. 1994 Jul 1;180(1):371–376. doi: 10.1084/jem.180.1.371. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Tedder T. F., Steeber D. A., Chen A., Engel P. The selectins: vascular adhesion molecules. FASEB J. 1995 Jul;9(10):866–873. [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES