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. 1996 Apr;51(4):351–353. doi: 10.1136/thx.51.4.351

Beta 2 adrenoceptor polymorphisms: are they clinically important?

I P Hall
PMCID: PMC1090666  PMID: 8733483

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Goldie R. G., Spina D., Henry P. J., Lulich K. M., Paterson J. W. In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta-adrenoceptor agonists and theophylline. Br J Clin Pharmacol. 1986 Dec;22(6):669–676. doi: 10.1111/j.1365-2125.1986.tb02956.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Green S. A., Cole G., Jacinto M., Innis M., Liggett S. B. A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J Biol Chem. 1993 Nov 5;268(31):23116–23121. [PubMed] [Google Scholar]
  3. Green S. A., Turki J., Bejarano P., Hall I. P., Liggett S. B. Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol. 1995 Jul;13(1):25–33. doi: 10.1165/ajrcmb.13.1.7598936. [DOI] [PubMed] [Google Scholar]
  4. Green S. A., Turki J., Innis M., Liggett S. B. Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry. 1994 Aug 16;33(32):9414–9419. doi: 10.1021/bi00198a006. [DOI] [PubMed] [Google Scholar]
  5. Hall I. P., Wheatley A., Wilding P., Liggett S. B. Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet. 1995 May 13;345(8959):1213–1214. doi: 10.1016/s0140-6736(95)91994-5. [DOI] [PubMed] [Google Scholar]
  6. Hausdorff W. P., Caron M. G., Lefkowitz R. J. Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB J. 1990 Aug;4(11):2881–2889. [PubMed] [Google Scholar]
  7. Kobilka B. K., Dixon R. A., Frielle T., Dohlman H. G., Bolanowski M. A., Sigal I. S., Yang-Feng T. L., Francke U., Caron M. G., Lefkowitz R. J. cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci U S A. 1987 Jan;84(1):46–50. doi: 10.1073/pnas.84.1.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kume H., Hall I. P., Washabau R. J., Takagi K., Kotlikoff M. I. Beta-adrenergic agonists regulate KCa channels in airway smooth muscle by cAMP-dependent and -independent mechanisms. J Clin Invest. 1994 Jan;93(1):371–379. doi: 10.1172/JCI116969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Marsh D. G., Neely J. D., Breazeale D. R., Ghosh B., Freidhoff L. R., Ehrlich-Kautzky E., Schou C., Krishnaswamy G., Beaty T. H. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science. 1994 May 20;264(5162):1152–1156. doi: 10.1126/science.8178175. [DOI] [PubMed] [Google Scholar]
  10. Nelson H. S. Beta-adrenergic bronchodilators. N Engl J Med. 1995 Aug 24;333(8):499–506. doi: 10.1056/NEJM199508243330807. [DOI] [PubMed] [Google Scholar]
  11. Ohe M., Munakata M., Hizawa N., Itoh A., Doi I., Yamaguchi E., Homma Y., Kawakami Y. Beta 2 adrenergic receptor gene restriction fragment length polymorphism and bronchial asthma. Thorax. 1995 Apr;50(4):353–359. doi: 10.1136/thx.50.4.353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Postma D. S., Bleecker E. R., Amelung P. J., Holroyd K. J., Xu J., Panhuysen C. I., Meyers D. A., Levitt R. C. Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med. 1995 Oct 5;333(14):894–900. doi: 10.1056/NEJM199510053331402. [DOI] [PubMed] [Google Scholar]
  13. Reihsaus E., Innis M., MacIntyre N., Liggett S. B. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol. 1993 Mar;8(3):334–339. doi: 10.1165/ajrcmb/8.3.334. [DOI] [PubMed] [Google Scholar]
  14. Sandford A. J., Shirakawa T., Moffatt M. F., Daniels S. E., Ra C., Faux J. A., Young R. P., Nakamura Y., Lathrop G. M., Cookson W. O. Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. Lancet. 1993 Feb 6;341(8841):332–334. doi: 10.1016/0140-6736(93)90136-5. [DOI] [PubMed] [Google Scholar]
  15. Shirakawa T., Li A., Dubowitz M., Dekker J. W., Shaw A. E., Faux J. A., Ra C., Cookson W. O., Hopkin J. M. Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor. Nat Genet. 1994 Jun;7(2):125–129. doi: 10.1038/ng0694-125. [DOI] [PubMed] [Google Scholar]
  16. Strader C. D., Candelore M. R., Hill W. S., Sigal I. S., Dixon R. A. Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor. J Biol Chem. 1989 Aug 15;264(23):13572–13578. [PubMed] [Google Scholar]
  17. Szefler S. J., Ando R., Cicutto L. C., Surs W., Hill M. R., Martin R. J. Plasma histamine, epinephrine, cortisol, and leukocyte beta-adrenergic receptors in nocturnal asthma. Clin Pharmacol Ther. 1991 Jan;49(1):59–68. doi: 10.1038/clpt.1991.11. [DOI] [PubMed] [Google Scholar]
  18. Tattersfield A. E. Tolerance to beta-agonists. Bull Eur Physiopathol Respir. 1985 Sep-Oct;21(5):1s–5s. [PubMed] [Google Scholar]
  19. Turki J., Pak J., Green S. A., Martin R. J., Liggett S. B. Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. J Clin Invest. 1995 Apr;95(4):1635–1641. doi: 10.1172/JCI117838. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Vathenen A. S., Knox A. J., Higgins B. G., Britton J. R., Tattersfield A. E. Rebound increase in bronchial responsiveness after treatment with inhaled terbutaline. Lancet. 1988 Mar 12;1(8585):554–558. doi: 10.1016/s0140-6736(88)91352-9. [DOI] [PubMed] [Google Scholar]
  21. Whicker S. D., Armour C. L., Black J. L. Responsiveness of bronchial smooth muscle from asthmatic patients to relaxant and contractile agonists. Pulm Pharmacol. 1988;1(1):25–31. doi: 10.1016/0952-0600(88)90007-5. [DOI] [PubMed] [Google Scholar]

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