Skip to main content
NCBI home page
Cureus logoLink to Cureus
. 2024 Feb 1;16(2):e53411. doi: 10.7759/cureus.53411

Risk Factors of Cardiovascular and Cerebrovascular Events in Patients With Uraemia Complicated With Hypertension During Maintenance Haemodialysis Treatment

Awais Ahmed Nizami 1, Waqar Mustafa 2, Mamoon Qadir 3, Maria Shahzad 3, Hamid Iqbal 3, Anwar Ali 4, Sarosh Khan Jadoon 5,✉, Amna Akbar 6, Sabahat Tasneem 7, Mohammad Saleem Khan 8
Editors: Alexander Muacevic, John R Adler
PMCID: PMC10908417  PMID: 38435216

Abstract

Introduction: This study aimed to investigate the risk factors associated with major adverse cardiovascular (group of events that affect heart and blood vessels) and cerebrovascular (events affecting blood vessels supplying the brain) events (MACCE) in patients with uraemia complicated with hypertension who required maintenance haemodialysis (MHD) treatment.

Methodology: Clinical data and laboratory indicators of 156 uraemia patients complicated with hypertension were collected and retrospectively analysed. The patients were admitted to a tertiary care hospital (Abbas Institute of Medical Sciences AIMS) in Muzaffarabad, Pakistan, from February 2018 to February 2022. The data was collected through consecutive sampling and patients were recruited after following the inclusion and exclusion criteria.

Results: Eighty-one out of 156 patients were not complicated with MACCE, and 75 patients were complicated with MACCE during the MHD treatment cycle, with an incidence of 48.08%. Compared to the non-MACCE group, the MACCE group’s diabetes, body mass growth rate, triglyceride (TG), NT-proBNP, standard deviation and coefficient of variance for systolic and diastolic blood pressure (SBP-SD, SBP-CV, DBP-SD, and DBP-CV) showed significant differences (P<0.05) between the groups. Diabetes, body mass growth rate, TG, NT-proBNP, SBP-SD, SBP-CV, DBP-SD, and DBP-CV with odds ratios of 3.074, 3.202, 2.188, 2.512, 2.357, 2.431, 2.299, and 2.062 respectively were risk factors for MACCE in uraemia patients with hypertension.

Conclusion: From the results of this study, we inferred that patients with uraemia and hypertension complicated by MACCE in the treatment cycle of MHD were related to diabetes, body mass growth rate, TG, NT-proBNP, SBP-SD, SBP-CV, DBP-SD, and DBP-CV.

Keywords: risk factors, cardiovascular and cerebrovascular events, maintenance haemodialysis, hypertension, uraemia

Introduction

Uraemia, short for the uremic stage of chronic kidney disease, is the terminal stage of the development of chronic renal failure and is also a common clinical syndrome in the advanced stages of various kidney diseases [1]. Haemodialysis can replace the human kidney to complete the body's metabolism, remove metabolic waste in the body, and maintain the balance of water, electrolytes, acids, and bases, ultimately ensuring the stability of the internal environment and achieving the purpose of prolonging the survival of patients. Haemodialysis is a widely used and effective method for the treatment of uraemia [2]. With the continuous development of blood purification technology, the survival rate of patients with uraemia has improved significantly [3]. However, in the process of maintenance haemodialysis (MHD), patients often develop hypertension (chronic rise in blood pressure). It increases the incidence of major adverse cardiovascular and cerebrovascular events (MACCE) and mortality [4]. Relevant research findings showed that cardiovascular disease and cerebrovascular diseases are important risk factors for death in MHD patients, with mortality risks of 36% and 11%, respectively [5]. In the treatment cycle of MHD, there are many factors that cause MACCE in uraemia patients with hypertension, but there has been no unified understanding thus far. Reducing the occurrence of MACCE in the treatment cycle of MHD is an urgent problem that needs to be solved. Analysis of the factors related to cardiovascular and cerebrovascular events in uraemia patients with hypertension is of great significance for guiding clinical preventive measures and reducing the occurrence of MACCE in the treatment cycle of MHD. Currently, there are few reports on MACCE in patients with uraemia and hypertension [6]. Therefore, this study retrospectively analysed the occurrence and influencing factors of MACCE in uraemia patients with hypertension treated with MHD. Data was obtained for the time period that ranged from February 2018 to February 2022 at a tertiary care hospital in Muzaffarabad, Pakistan. This study aimed to provide a more theoretical basis for the clinical treatment of uraemia and to guide clinical intervention measures to reduce the occurrence of MACCE. This can help improve the quality of life of MHD patients and reduce their mortality rates.

Materials and methods

Clinical data and laboratory indicators of 156 patients admitted to a tertiary care hospital (Abbas Institute of Medical Sciences AIMS) in Muzaffarabad, Pakistan, from February 2018 to February 2022 were collected for retrospective analysis. Patients suffering from uraemia complicated with hypertension are patients with insufficient renal function and diagnosed with hypertension on the basis of World Health Organization (WHO) criteria [7-8].

Inclusion/exclusion criteria

Inclusion criteria were as follows: (1) confirmation of chronic kidney disease (CKD) stage 5 diagnostic criteria [7] and hypertension diagnostic criteria established by the World Health Organization (WHO) [8]; (2) indication for MHD and receiving MHD treatment; and (3) haemodialysis time > 12 months and haemodialysis performed three times a week for four hours each time. The exclusion criteria were as follows: (1) severe liver disease or chronic infectious wasting disease, (2) severe bleeding tendency, (3) mental disorders, (4) low treatment compliance, and (5) missing clinical information, blood biochemical indexes, blood lipid indexes, and blood pressure parameters. 

The timing and scheme of maintenance dialysis therapy: (1) Timing: K/DOQI recommended that when patients with an estimated glomerular filtration rate (eGFR) less than 15 ml/min/1.73 m2 or weekly urea Kt/V less than 2.0, at stage 5 of CKD, the nephrologist evaluated the benefits, risks, and disadvantages of initiating renal replacement therapy and began preparation for dialysis therapy. However, it is generally recommended that non-diabetic patients with eGFR less than 10 (mL/min/1.73 m2) should start dialysis, diabetic patients with eGFR less than 15 (ml/min/1.73 m2) should start dialysis, and some patients with renal failure with special comorbidities may need to start dialysis earlier [9]. (2) Dialysis regimen: haemodialysis was performed three times a week for 4 h each time. The blood flow rate was 200 - 250 ml/min and the dialysate flow rate of 500 ml/min. Vascular access included an autologous arteriovenous fistula or long-term jugular vein catheter.

Data collection

Patient medical records were reviewed, and clinical data and laboratory indicators, including sex, diabetes, hyperlipidaemias, hyperphosphatemia, smoking history, history of alcohol consumption, age, course of disease, BMI, percentage change in body mass during the study, dialysis age, plasma albumin, haemoglobin, blood calcium, serum inorganic phosphorus, serum sodium, calcium-phosphorus product, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), serum creatinine, urea, uric acid, N-Terminal Pro-B-type natriuretic peptide (NT-proBNP), systolic blood pressure (SBP), systolic blood pressure-standard deviation (SBP-SD), systolic blood pressure-coefficient of variation (SBP-CV), diastolic blood pressure (DBP), diastolic blood pressure-standard deviation (DBP-SD), diastolic blood pressure-coefficient of variation (DBP-CV), and adiponectin, were recorded. SBP and DBP are measured at each patient visit and the values are noted on the patient history sheet. The values were obtained from the sheets and a mean of these values was used, standard deviation (SD) and coefficient of variation was then calculated.

Diagnostic criteria and grouping

Hypertension Diagnostic Criteria

Systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg following repeated examinations should be referred to as hypertension according to the diagnostic criteria of the 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Patients in whom SBP ≥ 140 mmHg and DBP ≥ 90 mmHg were persistent even after the use of antihypertensives were diagnosed with chronic hypertension [10].

Diagnostic Criteria for MACCE

Cardiovascular events were diagnosed according to the K/DOQI and clinical diagnosis and treatment guidelines, including myocardial infarction, unstable angina pectoris, coronary artery bypass grafting, heart failure requiring hospitalization, percutaneous coronary intervention, ischemic heart disease, malignant arrhythmia, and congestive heart failure (CHF). Cerebrovascular events included cerebral haemorrhage and stroke, cerebral ischemic stroke, cerebral infarction, and transient cerebral ischemia.

Grouping

During the treatment cycle, the number of patients with MACCE was counted. Patients with MACCE were included in the MACCE group, and those without MACCE were included in the non-MACCE group. The death toll was not included in the study.

Detection methods of relevant indicators

Blood Biochemical Indices and Serum Adiponectin

Six millilitres of fasting blood was extracted in the morning, and 0.3 mL of 3.84% citrate was added to 3 mL of the blood samples and centrifuged at 3000 revolutions per minute for 10 min. The plasma was then separated and stored at -30 degrees Celsius for examination. Blood lipid indices (total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol) were determined by enzyme colourimetry. Electrolytes (blood sodium, blood calcium, blood phosphorus), renal function indices (urea and blood creatinine), uric acid, and serum NT- proBNP were detected by conventional methods. Adiponectin levels were determined using radioimmunoassay.

Blood Pressure Variability (BPV)

Ambulatory blood pressure monitoring (ABPM to measure SBP and DBP) was performed at each patient dialysis visit and the values were noted on a patient history sheet as a routine protocol of the hospital. According to the data, the blood pressure during the daytime was measured every 30 min from 09:00 to 22:00 at each dialysis visit. Referring to the research method of Rothwell et al. [11], the variability of systolic blood pressure (SBP) and diastolic blood pressure (DBP) was determined by the SD and coefficient of variability (CV). The standard deviation of the mean blood pressure values measured three times was denoted as SD, and CV= SD/mean blood pressure. According to the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH: 24h mean blood pressure ≥ 130/80 mmHg, daytime mean blood pressure ≥ 135/85 mmHg, night mean blood pressure ≥ 120/70 mmHg, or night mean systolic blood pressure ≥ 125 mmHg. Dipper-type blood pressure was defined as nocturnal mean blood pressure ≥ 10% lower than diurnal mean blood pressure, whereas non-dipper-type blood pressure was defined as decreased blood pressure <10% [12]. The summary of the methodology is given in Figure 1.

Figure 1. The technical roadmap of this study.

Figure 1

Open in a new tab

MACCE: Major adverse cardiovascular and cerebrovascular events

Statistical Methods

IBM SPSS Statistics for Windows, Version 22 (Released 2013; IBM Corp., Armonk, New York, United States) was used for data analysis. Qualitative data were expressed as [n (%)], quantitative data were expressed as (x ± s), and t-tests were performed. Univariate and multivariate logistic regression models were applied to investigate the factors related to MACCE in patients with uraemia complicated by hypertension during the MHD treatment cycle, and P< 0.05 was statistically significant.

Results

Following inclusion and exclusion criteria, a total of 156 patients were chosen from 246 patients for this study, of which 81 patients were not complicated with MACCE and 75 patients were complicated with MACCE during the MHD treatment cycle, with an incidence of 48.08% (Figure 1). Comparisons of sex, hyperlipidaemias, hyperphosphatemia, smoking history, drinking history, age, course of disease, BMI, dialysis age, plasma albumin, haemoglobin, blood calcium, blood phosphorus, blood sodium, calcium-phosphorus product, TC, LDL-C, HDL-C, urea, serum creatinine, uric acid, SBP, DBP, and adiponectin between the MACCE group and non-MACCE group (P> 0.05). Compared with the non-MACCE group, MACCE group’s diabetes, body mass growth rate, TG, NT-proBNP, SBP-SD, SBP-CV, DBP-SD, and DBP-CV showed significant differences (P< 0.05). The results of the statistical analysis are shown in Table 1.

Table 1. Univariate analysis of MACCE in uremic patients with hypertension.

SD: Standard deviation; CV: coefficient of variation; MACCE: major adverse cardiovascular and cerebrovascular events; NT-proBNP: N-terminal Pro-B-type natriuretic peptide; SBP-SD: systolic blood pressure-standard deviation; SBP-CV: systolic blood pressure-coefficient of variation; DPP-SD:  diastolic blood pressure-standard deviation; DBP-CV: diastolic blood pressure-coefficient of variation

Influence factor MACCE group(n=75) non-MACCE group(n=81) t/c2 P
Gender (Female/male) 28/47 29/52 0.039 0.843
Concomitant disease        
Diabetes 24(32.00) 4(4.94) 19.365 ＜0.001
Hyperlipidemia 18(24.00) 23(28.40) 0.388 0.533
Hyperphosphatemia 8(10.67) 7(8.64) 0.184 0.668
Smoking history 25(33.33) 29(35.80) 0.105 0.746
Age(year) 54.22±8.39 53.87±7.16 0.281 0.779
Course of disease(year) 2.58±0.57 2.61±0.42 0.376 0.707
BMI (kg/m2) 22.53±2.04 22.49±2.13 0.120 0.905
Growth rate of body mass (%) 7.02±1.33 4.86±1.25 10.430 <0.001
Dialysis age(month) 8.43±2.34 8.52±2.16 0.250 0.803
Blood biochemical indexes        
Plasma-albumin (g/L) 38.22±3.39 38.41±3.10 0.366 0.715
Hemoglobin (g/L) 113.25±12.48 112.59±13.32 0.319 0.750
Blood calcium (mmol/L) 2.28±0.22 2.31±0.17 0.957 0.340
Serum inorganic phosphorus (mmol/L) 2.48±0.52 2.42±0.43 0.788 0.432
Serum sodium (mmol/L) 137.28±4.19 136.85±4.25 0.636 0.526
Calcium*phosphorus (mmol2 /L2) 5.48±0.62 5.39±0.47 1.026 0.306
TG (mmol/L) 1.29±0.42 1.13±0.30 2.753 0.007
TC (mmol/L) 4.42±0.58 4.38±0.29 0.551 0.583
LDL-C(mmol/L) 2.74±0.92 2.66±1.03 0.510 0.611
HDL-C(mmol/L) 1.01±0.11 0.99±0.08 1.306 0.194
Urea(mmol/L) 34.25±6.38 33.74±7.41 0.459 0.647
Serum creatinine(μmol/L) 915.26±25.18 917.02±20.27 0.483 0.630
Uric Acid(μmol/L) 402.55±33.16 405.19±28.87 0.531 0.596
NT-proBNP(ng/L) 6.28±0.47 5.88±0.62 4.514 <0.001
Blood-pressure parameter acquisition        
SBP 143.45±12.28 142.89±11.47 0.295 0.769
DBP 96.21±8.84 95.52±9.13 0.479 0.633
SBP-SD 19.33±4.26 9.25±3.02 17.150 <0.001
SBP-CV 13.17±3.21 5.87±1.85 17.560 <0.001
DBP-SD 10.82±3.29 5.44±1.62 13.100 <0.001
DBP-CV 14.16±4.23 6.24±2.05 15.050 <0.001
Adiponectin 5.37±1.64 5.42±1.38 0.2066 0.837
Open in a new tab

Diabetes distribution and body weight growth rate, TG, NT-proBNP, SBP-SD, SBP-CV, DPP-SD, and DBP-CV in the two groups are shown in Figure 2.

Figure 2. Diabetes distribution and the levels of body weight growth rate, TG, NT-proBNP, SBP-SD, SBP-CV, DPP-SD, and DBP-CV in the two groups.

Figure 2

Open in a new tab

MACCE: Major adverse cardiovascular and cerebrovascular events; TG: triglycerides; NT-proBNP: N-terminal Pro-B-type natriuretic peptide; SBP-SD: systolic blood pressure-standard deviation; SBP-CV: systolic blood pressure-coefficient of variation; DPP-SD:  diastolic blood pressure-standard deviation; DBP-CV: diastolic blood pressure-coefficient of variation

The items with statistical significance in single-factor analysis (diabetes, body mass growth rate, TG, NT-proBNP, SBP-SD, SBP-CV, DPP-SD, and DBP-CV) were taken as independent variables, and the ROC curve was used to find the optimal truncation value of continuous variables in the independent variables. The ROC curve analysis results are shown in Figure 3.

Figure 3. Receivers' operating curve.

Figure 3

Open in a new tab

MACCE: Major adverse cardiovascular and cerebrovascular events

The optimal truncation value and assignment of the independent variables are shown in Table 2. 

Table 2. Risk factors and evaluation of MACCE in uraemia patients with hypertension.

MACCE: Major adverse cardiovascular and cerebrovascular events; TG: triglycerides; NT-proBNP: N-terminal Pro-B-type natriuretic peptide; SBP-SD: systolic blood pressure-standard deviation; SBP-CV: systolic blood pressure-coefficient of variation; DPP-SD:  diastolic blood pressure-standard deviation; DBP-CV: diastolic blood pressure-coefficient of variation

Factor Code  Assignment
Diabetes X1 0=Have，1=Not have
Growth rate of body mass X2 0=<5.54%，1=≥5.54%
TG X3 0=<1.40 mmol/L，1=≥1.40 mmol/L
NT-proBNP X4 0=<5.82 ng/L,1=≥5.82 ng/L
SBP-SD X5 0=<13.52，1=≥13.52
SBP-CV X6 0=<8.63，1=≥8.63
DBP-SD X7 0=<8.14, 1=≥8.14
DBP-CV X8 0=<8.82, 1=≥8.82
Open in a new tab

Using multivariate logistic regression analysis, diabetes, body mass growth rate ≥5.54%, TG ≥1.40 mmol/L, NT-proBNP ≥5.82 ng/L, SBP-SD ≥13.52, SBP-CV ≥ 8.63, DBP- SD ≥8.14, and DBP-CV ≥8.82) were risk factors for MACCE in uraemia patients with hypertension, and the differences were statistically significant (p<0.05) as shown in Table 3.

Table 3. Multivariate logistic regression analysis results .

TG: Triglycerides; NT-proBNP: N-terminal Pro-B-type natriuretic peptide; SBP-SD: systolic blood pressure-standard deviation; SBP-CV: systolic blood pressure-coefficient of variation; DPP-SD:  diastolic blood pressure-standard deviation; DBP-CV: diastolic blood pressure-coefficient of variation

Independent variable β Waldχ2 P OR(95%CI)
Diabetes 3.074 12.458 <0.001 21.633(3.924–119.263)
Growth rate of body mass 3.202 21.268 <0.001 24.578(6.303–95.835)
TG 2.188 7.428 0.006 8.917(1.849–43.007)
NT-proBNP 2.512 13.148 <0.001 12.329(3.171–47.926)
SBP-SD 2.357 13.149 <0.001 10.560(2.954–37.756)
SBP-CV 2.431 12.233 <0.001 11.370(2.912–44.397)
DBP-SD 2.299 11.138 0.001 9.967(2.583–38.460)
DBP-CV 2.062 10.202 0.001 7.860(2.218–27.852)
Open in a new tab

Discussion

Hypertension in haemodialysis patients is related to renal failure and damage and it is important to investigate essential hypertension and renal hypertension caused by kidney disease as well as factors related to haemodialysis [13]. Blood pressure during dialysis treatment was related to the risk of death; high or low systolic blood pressure after dialysis was associated with an increased risk of cardiovascular death, and mortality was significantly increased when the diastolic blood pressure was greater than 109 mmHg [14]. Currently, MACCE is one of the main causes of death in uraemia patients during MHD treatment [15]. In the present study, patients with uraemia complicated by hypertension were included, and the incidence of MACCE was found to be 48.08% indicating higher blood pressure in the group.

The results of this study showed that diabetes body mass growth rate ≥ 5.54%, TG ≥ 1.40 mmol/ L, NT-proBNP ≥ 5.82 ng/L, SBP-SD ≥ 13.52, SBP-CV ≥ 8.63, DBP-SD ≥8.14, and DBP-CV ≥ 8.82 were risk factors for MACCE in uraemia patients with hypertension. Patients with diabetes are more prone to developing MACCE [16]. Hypertension has been proven to be a cardiovascular risk factor [17]. Other studies have shown that diabetes increases the risk of vascular diseases [13]. Under the double impact of hypertension and diabetes, the risk of MACCE in patients with uraemia has greatly increased. Hypertension is related to body mass index and cardiovascular and cerebrovascular diseases [18]. Hypertension promotes an increase in the body mass of patients, and the incidence of MACCE is related to an increase in body mass index, which could increase the incidence of hypertension, hyperlipidaemias, arteriosclerosis, and diabetes, thus causing the formation of MACCE [19]. This indicates that weight gain increases the risk of MACCE. The results of this study showed that the risk of MACCE was significantly increased when the growth rate of body mass exceeded 5.54%. Lipid and complex carbohydrate accumulation, haemorrhage, thrombosis, fibrous hyperplasia, and calcareous deposition are the basis of atherosclerosis [20]. TG is an important component of lipid substances, and increased TG levels indicate increased lipid accumulation, promoting the formation and development of atherosclerosis and leading to an increase in the incidence of MACCE. NT-proBNP is a serum marker that is synthesized mainly by cardiomyocytes. When the ventricular wall tension is too high, it accelerates the synthesis and secretion of NT-proBNP by cardiomyocytes. The discharge capacity of NT-proBNP in patients with uraemia decreases, so the concentration of NT-proBNP in the plasma increases. Decreased renal function in haemodialysis patients significantly increases the risk of cardiovascular events [21].

BPV is a clinical indicator reflecting the degree of blood pressure fluctuation over a certain period. The clinical blood pressure SD and coefficient of variation (CV) are commonly used to reflect the size of the BPV. Recent studies have found that BPV is significantly positively correlated with the occurrence of MACCE [22-23]. The results of this study showed that SBP-SD, SBP-CV, DBP-SD, and DBP-CV were risk factors for MACCE in patients with uraemia complicated by hypertension during the treatment cycle of MHD, which was consistent with relevant research results [24]. BPV is an important risk factor for target organ damage in patients with hypertension, and SBP-SD and DBP-SD are the main indices reflecting BPV. The instability of SBP-SD and DBP-SD increases the risk of cardiovascular adverse events [25,26]. Insufficient data exist explaining the correlation between blood pressure levels and prognosis in dialysis patients. Blood pressure regulation is imperative both in pre-and post-procedures but also during dialysis [27]. Therefore, we guessed that timely and effective intervention measures for high-risk individuals could reduce the incidence of MACCE so that we could ensure the safety of dialysis and reach a better prognosis.

Limitations

This was a single-centre, retrospective study with a limited number of cases. This may have led to a bias in the statistical results and there is no external validation for the study. Therefore, a multicentre study with many samples should be conducted to improve the reliability of the research conclusions.

Conclusions

Patients with uraemia and hypertension complicated with MACCE in the treatment cycle of MHD were related to diabetes, body mass growth rate, TG, TC, NT pro-BNP, SBP-SD, SBP-CV, DBP-SD, and DBP-CV. Therefore, early screening of high-risk patients and positive intervention measures should be performed to reduce the risk of MACCE and ensure dialysis safety. Blood pressure variability can be used as a clinical indicator to monitor fluctuation in BP. The treatment regimens should focus on maintaining systolic and diastolic blood pressure keeping the risk factors in check.

Appendices

Table 4. Data Set.

age-1 age-2 sex-1 sex-2 Diabetes-1 Diabetes-2 Hyperlipidemia-1 Hyperlipidemia-2 Hyperphosphatemia-1 Hyperphosphatemia-2 Smoking history-1 Smoking history-2 TIME-1 year TIME-2 year SBP-1 SBP-2 DBP-1 DBP-2 BMI_1 BMI_2 DIALYSIS MONTHS-1 DIALYSIS MONTHS-2 NT-proBNP-1 NT-proBNP-2 Hemoglobin(g/L) PG Hemoglobin(g/L) CG plasma Albumin-1 plasma Albumin-2 SerumNa-1 SerumNa-2 TC(mmol/L)-1 TC(mmol/L)-2 TG(mmol/L)-1 TG(mmol/L)-2 HDL-C(mmol)-1 HDL-C(mmol/L)-2 LDL-C(mmol/L)-1 LDL-C(mmol/L)-2 Blood calcium(mmol/L) PG Blood calcium(mmol/L) CG Serum potassium(mmol/L)-1 Serum potassium(mmol/L)-2 phosphorus(mmol/L)-1 phosphorus(mmol/L)-2 UA(μmol/L)-1 UA(μmol/L)-2 urea-1 Urea-2 creatinine-1 creatinine-2
42 49 M F 0 1 1 1 0 1 1 0 2.4 1.3 136 140 92 60 24.69 22.92 13 14 4500 1615 125.6 125.4 40.82 39.53 114.946 100.25 4.88 4.99 2.06 1.5 1.51 1.8 2.377 2.897 2.21 2.37 4.35 3.61 5.2 4.59 232.02 209.27 34.59 33.92 547.06 1012.33
38 52 M M 1 0 1 0 0 0 0 1 1.7 1.4 127 132 95 65 31.65 22.76 14 13 5250 1200 113.6 116.3 39.52 40.97 150.314 106.104 5.16 4.15 1.88 1.8 1.7 1.92 2.027 2.597 2.36 2.28 3.91 3.39 4.66 4.89 212.27 203.97 34.42 36.99 1165.56 1116.50
48 59 M M 1 1 1 1 0 0 1 1 2.6 1.2 133 138 77 62 23.83 23.2 13 14 4635 1740 125.4 118.2 42.38 42.53 150.314 123.788 4.16 3.94 0.93 1.62 1.8 1.56 2.757 2.247 2.22 2.22 4.24 3.21 4.8 4.59 182.07 195.94 35.56 34.7 583.33 1217.46
69 51 M M 1 1 1 1 1 1 1 1 2.4 1.2 128 133 70 70 27.98 21.48 13 14 4920 2000 119.6 125.4 42.21 42.77 141.472 106.104 5.02 4.54 2.06 0.67 1.52 1.75 1.787 2.007 2.23 2.46 3.96 3.26 4.91 4.84 168.87 150.87 34.15 33.65 1364.24 561.86
63 57 M F 1 1 1 1 0 1 1 1 2.4 1.2 130 135 71 79 25.69 21.32 13 14 4605 1625 121.6 129.4 42.58 39.67 114.946 97.262 4.08 4.85 2.06 1.24 1.7 1.85 2.027 2.977 2.46 2.18 3.91 3.21 4.66 4.73 221.97 194.27 33.7 34.25 1236.84 849.27
46 69 F F 0 1 1 1 1 0 0 0 1.9 1.3 129 134 78 80 24.26 26.83 14 13 3315 1650 113.6 118.2 42.38 39.53 106.104 100.25 4.11 4.54 0.93 1.62 1.8 2.06 2.377 2.247 2.22 2.22 4.12 3.53 5.2 4.86 191.77 203.97 35.2 34.09 550.80 965.41
43 63 M M 0 0 0 0 1 0 0 1 2.1 1.2 135 139 80 66 22.01 21.48 14 13 5445 1830 132.6 113.6 40.81 42.36 107.56 79.578 4.71 4.85 2.06 1.01 1.85 1.56 2.677 2.927 2.18 2.36 3.96 3.26 4.8 4.92 168.87 164.07 34.59 33.92 1044.44 826.44
44 60 M M 1 0 1 1 1 1 1 1 1.8 1.3 135 138 90 69 29.11 22.01 14 13 4605 1650 125.4 125.4 42.21 42.77 106.104 123.788 5.02 4.54 1.05 0.79 1.51 1.8 2.027 2.597 2.22 2.34 3.91 3.26 4.93 4.59 168.87 194.27 37.49 35.06 810.81 617.89
42 52 F M 1 1 1 1 1 0 0 1 2.4 1.3 126 131 95 60 24.11 22.4 15 13 6135 1840 118.2 119.6 42.38 42.73 108.25 79.578 3.99 4.99 0.93 1.62 1.7 1.85 1.787 2.247 2.21 2.22 4.09 3.54 4.8 5.13 221.97 206.05 34.15 33.65 1044.44 1054.68
56 59 M M 0 0 1 0 0 0 1 1 1.8 1.2 135 139 95 80 32.8 22.92 12 12 4830 1600 125.4 121.6 40.82 39.75 114.946 100.25 5.02 4.54 1.76 1.8 1.51 1.73 2.707 2.977 2.18 2.21 3.91 3.26 4.66 4.84 168.87 195.94 34.42 33.2 1035.29 1219.46
44 87 M M 0 1 1 1 0 0 1 1 1.7 1.2 128 133 72 66 29.58 24.8 13 14 3900 1615 116.3 113.6 39.6 40.97 109.52 97.262 5.16 3.94 1.05 1.5 1.8 1.56 2.027 3.047 2.36 2.36 4.16 3.42 4.96 4.86 212.27 164.07 35.2 34.7 1236.84 1140.54
63 42 F F 1 1 1 1 1 1 0 0 2.0 1.3 125 130 95 69 34.4 22.36 13 14 5775 2000 119.6 125.4 42.58 42.53 106.104 88.42 5.16 4.39 1.78 0.79 1.68 1.56 2.707 2.717 2.46 2.46 3.91 3.21 3.16 3.09 168.87 203.97 36.59 34.09 1113.51 965.41
46 71 M M 1 1 1 1 1 0 1 1 1.8 1.2 129 135 95 60 25.3 22.76 14 12 4890 1640 114.9 116.3 39.38 42.36 159.156 114.946 4.88 4.71 1.5 0.67 1.85 1.75 2.027 2.007 2.28 2.18 3.96 3.46 4.66 4.59 168.87 194.27 37.24 36.99 1085.53 561.86
46 54 M M 1 1 1 1 1 0 1 1 2.4 1.3 135 140 77 80 27.73 22.66 12 12 4590 2010 116.3 118.2 42.21 42.53 132.63 114.946 4.08 4.99 0.93 0.77 1.7 1.85 1.787 2.597 2.22 2.22 4.24 3.21 5.2 4.59 212.27 173.77 34.15 33.65 516.67 657.26
32 59 F M 0 0 0 0 1 1 0 1 1.8 1.2 127 132 76 70 24.81 24.71 12 12 4590 1915 125.4 125.4 40.82 41.73 95.45 61.894 5.02 3.91 2.06 1.39 1.8 1.61 2.377 2.247 2.18 2.21 3.96 3.26 5.14 4.82 191.77 150.87 35.2 33.92 970.59 1210.85
56 56 F M 0 0 1 0 1 1 1 1 2.1 1.2 135 139 78 73 20.59 25.2 11 12 4480 1530 125.6 129.4 42.62 40.96 132.63 97.262 4.11 3.82 1.88 1.62 1.87 1.85 2.027 2.977 2.36 2.33 3.91 3.21 4.8 4.73 182.07 164.07 34.42 34.7 695.36 826.44
51 59 F M 0 0 0 0 0 0 0 1 1.4 1.2 130 135 80 70 24.89 24.54 14 12 4298 2000 127.6 118.2 40.81 42.53 114.946 100.25 4.56 3.91 1.65 1.62 2.01 1.92 1.787 2.007 2.46 2.22 4.31 3.42 4.66 5.13 221.97 203.97 37.49 36.09 512.44 1151.97
76 45 M M 1 0 1 1 1 0 1 0 2.6 1.2 122 127 72 80 28.06 26 11 12 5446 1825 125.4 119.6 42.38 40.97 106.104 97.262 3.99 4.99 1.03 0.79 1.51 1.73 2.757 2.977 2.33 2.18 3.91 3.21 4.93 3.09 224.05 150.87 33.7 36.74 1092.72 1022.75
44 77 M M 1 1 1 1 0 1 1 1 1.8 1.2 130 135 73 69 31.25 22.13 11 12 4872 1635 116.3 114.9 40.82 42.73 79.578 123.788 5.16 4.54 1.05 1.39 1.8 1.9 2.027 2.007 2.18 2.37 4.12 3.61 4.93 4.86 212.27 194.27 34.15 33.65 1101.60 682.18
73 57 M F 1 1 1 1 0 0 1 0 1.7 1.3 129 133 95 80 25.78 22 13 14 4550 1800 119.6 127.6 41.58 39.75 114.946 132.63 5.16 4.99 2.06 1.8 1.75 1.75 1.787 2.597 2.34 2.22 4.19 3.21 4.66 5.07 168.87 203.17 37.22 34.7 679.14 1064.35
86 43 M F 1 0 1 1 1 0 1 1 1.8 1.2 133 138 94 60 25.65 23.58 13 14 4242 1805 132.6 132.6 42.38 42.53 150.314 100.25 4.11 4.52 0.93 1.62 1.56 1.85 2.377 2.247 2.46 2.08 4.24 3.26 3.16 4.86 232.02 164.07 34.59 33.92 572.22 1217.46
51 72 M M 1 1 0 1 0 1 1 1 2.4 1.3 130 135 79 65 22.83 26.83 14 12 5082 1910 125.4 125.4 39.6 40.97 108.45 97.262 4.71 4.85 1.88 0.98 1.51 1.92 2.027 2.897 2.37 2.22 3.96 3.54 5.21 4.59 182.07 214.02 33.7 36.99 970.59 1036.14
74 77 F F 1 0 1 0 0 1 1 0 2.0 1.2 127 132 77 62 23.75 22.53 14 12 4312 1455 118.2 118.2 42.21 42.73 114.946 114.946 4.16 4.54 1.76 0.67 1.7 2.06 1.787 2.597 2.22 2.28 4.23 3.21 4.8 5.13 221.97 203.97 37.21 33.2 1320.51 1126.37
66 51 M F 1 1 1 1 1 0 1 0 1.8 1.3 128 133 74 70 23.32 26.4 11 12 5124 1830 116.3 125.4 42.38 42.36 79.578 77.8096 4.88 4.39 1.27 1.8 1.52 1.56 2.677 2.247 2.18 2.46 3.91 3.46 4.91 5.14 182.07 194.27 34.15 33.65 561.50 1054.68
68 68 F M 1 1 1 1 0 0 0 1 2.6 1.2 135 140 95 80 27.85 21.74 11 12 4844 1640 137.8 116.3 42.58 42.53 114.946 100.25 4.71 3.91 1.27 1.8 1.8 1.85 2.027 2.007 2.18 2.22 3.96 3.42 4.66 4.59 221.17 164.07 34.42 36.72 1113.51 973.87
68 72 M M 1 1 1 1 0 1 1 1 1.4 2.4 127 132 74 60 23.83 23.44 11 12 4312 1555 125.6 119.6 40.81 42.77 150.314 115.49 4.08 4.99 2.06 0.67 1.51 1.8 2.827 2.247 2.22 2.36 4.31 3.21 4.93 3.09 212.27 150.87 33.7 34.09 1105.88 719.37
41 61 M F 1 1 0 1 0 1 1 1 1.6 1.9 125 129 95 65 27.07 25.6 11 12 4500 1900 119.6 114.9 42.38 42.36 132.63 70.736 3.99 4.54 1.65 1.8 2.01 1.61 1.787 2.007 2.36 2.18 4.12 3.26 5.2 4.86 168.87 173.77 34.75 33.2 516.67 965.41
48 59 M M 0 0 0 0 0 1 1 1 1.8 2.1 126 130 75 62 34.58 25.2 14 12 5250 1540 132.6 116.3 40.82 40.97 106.104 123.788 4.71 3.91 1.88 0.79 1.87 1.56 2.027 2.597 2.46 2.22 4.24 3.21 4.66 3.09 212.27 194.27 37.24 36.71 935.32 590.46
56 49 M F 1 1 1 0 1 1 1 0 2.4 1.4 128 132 95 80 27.27 22.76 11 12 4635 1750 124.8 125.4 39.52 42.36 123.788 106.104 4.11 3.82 0.93 0.67 1.68 1.75 2.757 2.247 2.33 2.34 3.91 3.21 4.89 4.73 182.47 203.97 34.15 33.65 1165.56 1332.85
40 77 M F 1 1 1 1 1 0 0 1 2.5 1.8 128 133 76 69 23.33 25.1 14 12 4920 1730 116.3 125.6 42.38 39.67 132.63 97.262 4.56 4.85 1.05 1.5 1.8 1.57 2.377 2.977 2.22 2.23 4.09 3.54 3.16 4.59 212.27 194.27 34.75 33.92 1364.24 1104.71
39 69 F M 1 0 0 0 1 0 0 0 2.7 1.7 135 140 78 65 24 26.09 14 12 4605 1615 118.2 127.6 39.38 42.73 150.314 79.578 4.71 3.99 1.76 0.79 1.85 1.85 2.027 2.007 2.18 2.22 3.91 3.54 5.14 5.13 182.07 150.87 35.56 33.2 802.14 566.28
54 58 M M 1 1 0 1 1 0 1 1 1.7 1.8 128 132 78 80 23.05 24.9 14 12 3315 1550 132.6 125.4 42.21 39.75 123.788 100.25 5.16 4.99 2.06 1.8 1.87 1.56 1.787 2.247 2.08 2.18 4.17 3.56 4.66 4.84 221.97 194.27 34.42 34.25 547.06 989.81
56 72 F F 1 1 1 1 1 1 0 0 1.8 2.4 133 138 79 66 27.73 23.58 11 12 5445 1830 125.4 116.3 42.38 40.96 141.472 123.788 5.16 4.39 1.5 1.62 1.52 2.06 2.827 2.597 2.46 2.36 4.24 3.42 4.8 4.74 182.07 164.07 36.59 36.74 567.57 1217.46
40 62 F F 1 1 1 1 0 1 0 1 2.5 2.4 130 136 80 69 24.58 26 13 14 4605 2025 116.3 119.6 40.81 42.53 106.104 115.49 4.71 3.91 1.88 0.77 1.52 1.92 2.027 2.897 2.22 2.37 4.12 3.21 4.93 4.86 182.07 194.27 34.15 33.65 627.78 951.22
51 87 M M 1 1 1 1 0 0 1 1 2.6 2.1 127 132 80 60 26.17 25.78 14 12 6135 1600 113.6 132.6 42.58 41.73 106.104 123.788 3.99 3.94 1.05 1.62 1.7 1.73 1.787 2.247 2.18 2.46 3.91 3.42 3.16 3.09 212.27 194.27 37.22 34.25 550.80 580.04
44 57 F F 0 0 0 0 0 0 0 0 2.2 1.2 136 141 75 79 29.54 23.58 13 12 4830 1740 125.6 125.4 42.38 42.53 114.946 100.25 4.88 4.2 0.93 1.24 1.8 1.85 2.677 2.007 2.36 2.22 3.96 3.21 4.91 4.59 227.27 150.87 34.59 35.06 1355.26 965.41
38 77 M M 1 0 0 0 1 1 1 1 2.4 1.3 135 139 77 66 26.88 24 13 13 3900 1600 127.6 118.2 39.6 40.97 97.262 106.104 4.71 4.85 1.13 1.62 1.52 1.9 2.027 2.927 2.28 2.08 3.91 3.54 4.8 5.13 191.77 203.17 36.39 33.92 1035.29 1207.57
44 51 M M 0 0 0 0 1 0 1 1 2.4 2.1 130 135 95 69 28.8 25.3 13 13 5775 1845 132.6 116.3 40.82 42.53 132.63 88.42 4.69 4.99 2.06 1.5 1.52 1.92 2.377 2.247 2.22 2.33 4.16 3.26 4.66 5.07 168.87 194.27 34.42 36.09 561.50 710.58
76 85 M F 1 1 1 0 1 1 0 1 1.6 2.6 130 135 76 60 30.45 21.88 11 12 4890 1820 118.2 137.8 42.38 39.75 150.314 115.49 4.08 3.91 1.65 1.62 1.75 1.57 1.787 2.597 2.23 2.22 4.24 3.46 5.2 4.59 221.17 164.07 33.7 33.65 833.33 1054.68
48 80 F F 1 1 1 1 0 1 0 0 2.0 2.6 132 139 95 80 27.1 22.39 13 13 4590 1545 121.9 125.6 41.54 42.53 97.262 100.25 4.71 3.91 1.88 1.8 1.87 1.59 2.027 2.007 2.46 2.18 4.35 3.21 4.93 4.73 182.07 209.27 37.21 36.72 625.00 566.28
58 71 F M 1 1 1 1 0 1 0 1 6.1 4.3 127 132 75 66 25.65 20.45 13 13 4590 1700 125.4 119.6 40.81 42.73 106.104 97.262 3.99 4.99 1.76 1.39 1.51 1.75 2.757 2.247 2.18 2.23 4.31 3.42 5.21 4.92 221.97 203.97 35.2 34.09 941.18 594.79
70 42 M M 1 1 1 0 1 0 1 0 4.8 5.3 126 130 95 69 26.4 23.98 11 12 4256 1625 124.6 132.6 42.21 42.53 114.946 106.104 5.02 4.39 1.5 0.67 1.7 1.85 2.707 2.977 2.22 2.34 4.24 3.54 3.16 3.09 168.87 214.02 35.56 35.89 695.36 1217.46
61 77 M M 0 1 0 1 0 1 1 1 6.0 5.5 130 135 75 60 23.63 25.6 13 13 4242 1600 125.6 124.8 42.62 42.77 159.156 123.788 5.16 4.54 0.93 1.39 1.8 1.57 2.027 2.927 2.46 2.22 4.12 3.21 4.66 4.84 182.07 194.27 36.59 33.92 1245.03 895.76
61 64 F F 1 1 1 1 0 0 0 0 5.6 4.4 126 131 76 66 24.69 26.4 11 12 3416 2000 131.2 116.3 40.82 42.53 141.472 132.63 5.16 4.99 1.88 0.79 2.01 1.52 1.787 2.247 2.22 2.36 3.91 3.61 4.99 5.13 212.27 164.07 34.15 33.2 970.59 1207.57
39 77 M M 1 1 1 1 1 1 1 0 3.7 6.8 125 129 77 70 26.48 22.3 13 13 5376 1810 137.8 118.2 42.58 39.75 106.104 97.262 4.56 4.85 2.06 0.77 1.51 1.43 2.377 2.007 2.36 2.46 4.19 3.46 4.91 4.59 224.05 194.27 34.42 36.71 1236.84 1031.63
42 57 M M 1 1 1 1 1 0 1 1 5.9 21.1 127 131 75 80 29.11 25.61 13 13 4494 1930 118.2 132.6 42.21 42.53 96.3778 79.578 4.88 3.82 1.88 1.39 1.75 1.56 2.027 2.897 2.22 2.28 4.23 3.42 4.66 4.86 168.87 173.77 35.2 34.7 615.89 736.69
48 63 M F 0 0 0 0 1 1 1 1 26.8 14.5 156 160 76 60 26.75 20.82 11 12 3360 1250 119.6 125.4 39.6 40.96 141.472 106.104 4.11 4.54 1.05 1.8 1.8 1.75 1.787 2.247 2.37 2.22 4.24 3.21 4.93 5.13 168.87 150.87 37.22 35.06 1044.44 930.35
58 77 F M 1 1 1 1 1 0 0 1 14.0 4.8 135 140 95 65 22.4 25.2 14 13 2912 1800 121.9 116.3 40.81 42.53 132.63 97.262 5.02 3.99 1.76 1.01 1.68 1.85 2.497 2.597 2.33 2.18 4.16 3.21 4.8 4.73 191.77 194.27 34.59 36.09 550.80 527.96
61 62 M F 1 1 1 1 0 1 1 1 5.6 6.7 126 131 94 62 25.37 26 11 12 3472 1500 125.4 113.6 41.54 42.53 97.262 123.788 3.99 3.91 1.88 0.77 1.51 1.57 2.027 2.007 2.22 2.37 4.24 3.26 5.2 5.14 182.07 194.27 34.15 33.65 1245.03 822.31
46 70 F F 0 1 0 1 0 1 0 0 8.5 9.5 132 138 75 70 29.69 22.27 14 13 4564 1815 124.6 125.6 42.38 41.69 114.946 100.25 4.16 4.99 1.65 1.39 2.01 1.75 2.757 2.247 2.18 2.22 3.91 3.65 4.66 4.59 212.27 164.07 35.2 33.92 725.71 1052.79
56 44 M M 0 0 1 0 1 0 1 0 5.1 6.9 126 131 93 80 23.63 26.4 14 13 4074 2000 125.6 127.6 39.38 39.75 150.314 106.104 4.08 4.54 0.93 1.8 1.7 1.85 1.787 2.977 2.34 2.21 4.12 3.26 5.21 3.09 221.97 209.27 34.42 34.7 1105.88 1104.71
48 53 F M 1 1 1 0 0 1 0 1 2.6 2.5 152 112 80 60 27.27 24.9 15 13 4650 2000 132.6 132.6 42.21 40.97 105.25 70.736 4.11 3.94 2.06 0.79 1.56 1.9 2.027 2.717 2.22 2.18 4.31 3.21 3.16 4.84 232.02 194.27 33.7 36.72 682.12 594.79
58 56 M M 1 0 0 1 1 1 1 1 1.4 2.7 153 124 80 65 27.57 24 14 13 2235 1657 118.2 118.2 42.58 42.73 114.946 125.5 5.16 4.71 1.76 1.8 1.52 1.56 2.677 2.007 2.23 2.22 4.35 3.54 4.93 4.59 168.87 164.07 34.75 34.09 1236.84 1000.62
70 63 M M 1 0 1 1 1 1 1 1 1.4 2.9 170 115 80 62 24.54 24.11 15 13 3900 1720 119.6 121.9 40.82 39.2 123.788 114.946 5.16 4.85 1.88 1.62 1.51 1.75 2.827 2.597 2.46 2.08 4.16 3.21 4.99 5.13 212.27 203.97 34.15 33.65 695.36 949.19
61 81 M M 0 1 1 1 1 1 1 1 2.7 2.9 160 110 79 80 25.39 23.05 13 14 1890 1745 127.6 125.4 40.81 39.2 105.25 106.104 4.71 4.39 1.27 0.67 1.8 1.56 2.027 2.927 2.22 2.37 3.91 3.46 4.8 4.86 182.07 150.87 37.22 34.7 1044.44 566.28
61 47 M F 0 0 1 1 1 0 1 0 1.7 2.8 156 130 78 69 22.43 25 14 13 4800 1919 116.3 124.6 39.52 40.96 114.946 97.262 5.02 4.39 1.05 1.62 1.87 1.85 1.787 2.007 2.21 2.22 4.24 3.21 4.91 3.09 221.97 203.97 33.7 33.92 1101.60 1126.37
39 81 F M 0 0 1 1 0 1 0 1 1.8 2.5 145 128 79 66 26.95 26.4 11 12 4815 1746 125.4 125.6 41.58 42.36 123.788 70.736 4.37 4.99 0.93 1.5 1.52 1.56 1.787 2.597 2.22 2.36 3.91 3.26 4.93 5.19 168.87 150.87 37.21 33.2 1016.22 1104.71
42 54 M F 0 0 0 1 1 0 1 0 1.4 2.4 138 111 79 62 25.74 24.51 13 14 4545 1931 124.6 131.2 42.21 39.75 125.5 125.5 4.11 4.39 2.06 1.8 1.52 1.57 2.027 2.977 2.46 2.46 4.12 3.42 4.66 5.13 182.07 194.27 34.75 34.25 1085.53 1070.03
48 65 M M 0 0 1 1 1 1 1 1 1.7 2.1 150 120 95 80 25.78 23.72 11 12 6030 2000 121.9 137.8 42.62 41.73 141.472 61.894 4.88 3.82 1.88 1.24 1.51 1.92 2.757 2.247 2.18 2.34 3.91 3.26 5.2 3.09 182.47 164.47 34.15 33.65 1105.88 580.04
58 52 F M 0 1 1 1 0 1 0 1 1.4 2.4 151 115 75 60 25.74 25.3 12 13 3900 1728 124.8 118.2 42.58 42.73 141.472 123.788 4.56 4.85 1.5 0.67 1.7 1.85 2.377 2.007 2.36 2.18 4.09 3.21 3.16 4.59 212.27 164.07 34.42 36.72 977.78 606.03
61 63 M M 1 0 1 1 1 1 1 1 1.4 2.3 152 130 95 68 25.61 23.72 13 14 4500 1633 118.2 119.6 40.81 39.67 106.104 97.262 4.08 3.91 1.65 0.79 1.85 1.9 2.027 2.897 2.28 2.22 3.91 3.53 4.66 4.82 182.07 150.87 35.2 33.2 1005.35 1126.37
46 91 M M 0 0 1 1 1 1 1 1 1.4 2.5 130 113 75 80 25.87 26.4 12 13 5250 1736 119.6 121.9 40.82 42.77 114.946 79.578 5.02 4.99 1.76 0.87 1.8 1.85 2.707 2.247 2.22 2.33 4.16 3.26 4.81 4.73 191.77 194.27 35.56 36.71 746.27 608.49
56 46 M F 0 1 0 0 1 0 1 0 1.4 2.3 150 120 95 67 25.6 24.51 14 13 4635 2022 125.6 125.4 41.58 42.36 114.946 97.262 4.11 4.71 0.93 0.77 1.51 1.75 1.787 2.007 2.33 2.28 4.24 3.42 4.93 4.59 168.87 194.27 36.39 34.25 1355.26 1210.85
45 75 M M 1 0 1 1 1 1 1 1 2.1 2.4 154 119 76 62 28.69 25.3 13 14 4920 2012 116.3 124.6 42.38 40.96 97.262 88.42 4.16 3.91 1.88 1.8 1.56 1.57 2.027 2.927 2.34 2.21 4.31 3.26 4.8 3.09 212.27 194.27 34.15 33.65 1059.52 907.16
41 58 M M 0 0 1 1 1 1 1 1 1.8 3.0 140 129 77 64 21.88 25.78 12 13 4605 1821 125.4 125.6 42.21 40.97 114.946 125.5 5.16 4.99 2.06 1.5 2.01 1.9 2.377 2.247 2.22 2.22 4.24 3.21 3.16 5.13 182.07 194.27 35.2 33.92 695.36 756.14
51 63 F M 1 0 0 1 0 1 0 1 1.4 2.7 138 112 78 70 22.3 22.3 15 13 3315 1633 124.6 132.6 41.58 39.53 141.472 106.104 3.99 3.94 1.05 0.79 1.87 1.57 2.677 2.007 2.46 2.21 4.12 3.46 4.66 5.14 221.97 164.07 37.25 34.7 547.06 826.44
72 60 M M 1 1 1 1 1 1 1 1 1.4 1.7 133 120 76 72 28.75 26.02 15 13 5445 2000 132.6 118.2 39.05 39.75 150.314 114.946 4.88 4.54 1.05 1.24 1.51 1.85 2.027 2.597 2.46 2.36 3.91 3.65 4.8 4.84 227.27 214.02 34.59 35.06 1092.72 1297.01
66 63 M M 1 0 1 1 1 1 1 1 1.6 2.7 136 121 77 73 27 26.09 14 13 4605 1913 121.9 119.6 42.58 42.73 125.5 61.894 4.11 4.85 1.03 0.79 1.7 1.75 1.787 2.247 2.18 2.22 4.09 3.21 5.14 5.07 212.27 194.27 35.2 35.89 1144.44 930.35
49 49 M F 0 1 1 0 1 0 1 0 1.4 2.5 144 130 78 80 24.9 24.51 12 12 6135 1805 118.2 127.6 40.81 42.36 114.946 125.5 5.02 4.99 1.88 1.5 1.68 1.56 2.377 3.017 2.22 2.18 4.23 3.54 4.66 5.13 182.07 164.07 33.7 33.65 1165.56 965.41
46 81 M M 0 0 1 1 1 1 1 1 1.4 2.4 128 122 79 70 27.57 24.39 14 12 4830 1914 119.6 116.3 42.62 42.53 106.104 88.42 5.16 3.82 0.93 0.79 1.8 2.06 1.787 2.007 2.08 2.46 4.31 3.21 4.93 3.09 236.72 150.87 37.21 34.7 611.84 608.49
47 61 M M 0 1 1 0 1 1 1 1 1.7 2.1 150 130 80 60 28.86 26.09 14 12 3900 1900 116.3 125.4 42.21 42.36 88.42 106.104 4.71 4.54 2.06 1.62 1.51 1.56 2.377 2.247 2.37 2.37 4.24 3.61 4.91 4.59 212.27 203.97 35.56 36.75 682.12 682.18
45 47 M F 0 0 1 1 1 0 1 0 1.4 2.5 152 112 81 80 29.54 25.6 13 14 5775 1940 121.6 124.6 40.82 41.73 125.5 70.736 4.08 4.52 1.65 1.39 1.75 1.92 1.787 2.977 2.36 2.22 4.35 3.21 4.66 4.86 168.87 173.77 35.2 34.09 724.36 960.25
59 76 M M 0 1 1 1 1 1 1 1 2.6 2.9 138 124 82 66 30 26.83 14 12 4890 2000 125.4 121.9 42.21 42.53 97.262 79.578 4.56 3.94 1.5 1.62 1.87 1.92 2.027 2.007 2.33 2.34 3.91 3.26 4.93 4.59 221.97 150.87 33.7 34.7 1245.03 1207.57
47 81 M M 0 0 1 1 1 1 1 1 1.4 2.2 133 115 78 80 28.4 24.51 14 12 4590 1904 124.6 124.8 39.52 42.77 150.314 125.5 5.16 4.39 1.88 0.67 2.01 1.85 1.787 2.247 2.22 2.08 4.12 3.54 4.8 5.14 182.07 150.87 34.15 33.2 1024.88 895.76
66 55 M M 0 1 1 0 1 1 1 1 1.4 2.5 143 110 87 69 27.85 26.09 14 12 4590 1719 137.8 118.2 42.58 40.96 70.736 106.104 4.71 4.54 1.76 1.62 1.7 1.75 2.377 2.597 2.21 2.21 3.91 3.42 3.16 5.13 191.77 203.97 34.75 36.71 1245.03 1217.46
49 72 M F 1 0 0 1 1 0 1 0 1.8 2.1 154 129 75 63 25.93 26.02 13 14 3690 1643 125.6 119.6 39.6 42.53 106.104 114.946 4.08 3.82 0.93 0.77 1.85 1.61 2.027 2.007 2.22 2.18 4.24 3.39 5.2 4.73 168.87 150.87 37.22 35.06 596.15 606.03
49 76 M M 0 1 1 1 1 1 1 1 1.6 2.5 140 124 76 70 25.74 25.78 12 12 4650 2013 118.2 125.6 40.81 40.97 167.998 114.946 5.16 4.85 2.06 1.62 1.8 1.92 2.027 2.247 2.28 2.28 4.17 3.26 5.26 4.84 224.05 194.27 37.24 34.7 1245.03 605.75
35 65 M M 0 0 1 1 1 1 1 1 1.8 2.0 153 115 78 72 27.67 24.39 14 12 5115 1656 119.6 116.3 42.38 42.36 97.262 167.998 5.16 3.91 1.05 1.01 1.68 1.9 2.757 2.897 2.18 2.22 3.91 3.21 4.66 4.92 182.07 150.87 36.59 33.2 583.33 636.89
59 63 M M 0 1 1 1 1 1 1 1 2.1 2.7 130 110 75 74 23.63 26.02 14 12 4620 1824 116.3 125.4 41.58 42.53 125.5 88.42 4.71 4.54 1.88 1.62 1.85 1.75 1.787 2.007 2.46 2.46 4.16 3.46 4.99 4.86 182.47 150.87 34.15 33.65 1105.88 1052.79
54 53 M M 0 0 1 0 1 1 1 1 2.5 2.4 154 127 79 80 23.05 26.09 15 13 5100 1813 121.9 124.6 42.38 41.69 106.104 114.946 4.11 3.94 1.5 0.77 1.51 1.85 2.027 2.977 2.34 2.36 4.24 3.26 4.66 4.59 212.27 194.27 34.42 34.25 891.89 973.29
79 81 F F 1 1 0 1 0 0 0 0 1.7 2.6 138 125 95 69 32.92 26.17 13 14 3705 1730 125.4 118.2 40.82 42.73 123.788 79.578 5.16 4.99 1.65 1.62 1.68 2.06 2.797 2.007 2.37 2.33 4.31 3.47 3.16 4.52 221.97 173.77 35.2 36.72 1044.44 1054.68
47 73 M M 0 0 1 0 1 1 1 1 1.4 2.7 132 115 76 66 26.34 23.05 12 13 2730 2000 124.6 119.6 42.38 39.75 106.104 70.736 5.02 3.99 0.93 0.79 1.7 1.56 1.787 2.597 2.36 2.37 3.91 3.26 5.21 3.09 232.02 164.07 34.59 36.74 977.78 1140.54
76 62 M M 0 0 1 1 1 1 1 1 1.4 2.0 120 130 80 63 26 24 13 14 5820 1904 131.2 137.8 39.6 39.67 125.5 88.42 4.71 4.54 2.06 1.62 1.85 1.56 2.027 2.007 2.22 2.18 4.12 3.54 4.66 4.84 168.87 203.97 37.49 36.09 1005.35 968.81
89 76 F F 0 1 0 1 0 0 0 0 1.4 2.6 125 124 81 80 22.13 25.3 13 14 6735 2127 132.6 116.3 42.38 42.77 132.63 97.262 4.16 4.2 1.88 1.8 1.51 1.92 2.757 2.717 2.33 2.22 4.35 3.21 4.8 5.13 212.27 206.05 34.15 34.7 1144.44 561.86
54 66 M M 1 0 1 1 1 1 1 1 2.6 2.8 122 115 95 69 27.03 26.4 12 13 6000 4500 118.2 124.6 42.58 42.36 97.262 79.578 4.88 4.85 1.27 1.62 1.8 1.75 2.377 2.977 2.18 2.36 4.31 3.61 5.2 5.14 182.07 194.27 35.56 34.25 1119.05 1217.46
77 91 M M 0 0 1 1 1 1 1 1 2.1 2.4 121 110 80 66 28.27 25.2 13 14 6330 5250 119.6 121.9 42.38 42.53 70.736 125.5 4.11 3.94 1.76 1.39 1.87 1.9 2.027 2.247 2.21 2.34 4.23 3.26 4.66 4.84 191.77 150.87 33.7 34.75 516.67 1332.85
69 61 M M 0 1 1 0 1 1 1 1 2.4 2.4 120 129 78 63 26.95 26.09 13 14 5490 4635 116.3 125.4 42.62 41.73 97.262 70.736 4.08 4.99 1.5 1.62 1.52 1.85 1.787 2.927 2.23 2.23 4.24 3.46 4.93 4.59 212.27 214.02 34.42 33.92 935.32 1210.85
71 81 M M 1 0 1 1 1 1 1 1 1.8 2.5 128 124 82 80 24.81 26.02 15 13 4905 4920 121.9 124.8 42.38 40.96 123.788 97.262 3.99 4.54 0.93 1.5 2.01 1.92 2.497 2.597 2.22 2.46 4.31 3.54 4.91 4.86 168.87 164.07 35.2 36.99 882.35 590.46
71 55 M M 0 0 1 1 1 1 1 1 2.5 2.3 154 115 95 60 27.2 23.44 12 13 6300 4605 124.6 118.2 39.6 40.97 114.946 106.104 5.02 3.91 1.88 1.62 1.7 1.57 2.027 2.247 2.37 2.23 4.12 3.42 4.93 4.73 227.27 203.97 33.7 33.2 1178.81 989.81
44 89 F F 0 0 0 1 0 0 0 0 1.9 2.3 122 110 94 80 26.34 23.6 13 14 5490 3315 125.4 132 42.38 42.73 79.578 79.578 4.56 4.39 2.06 1.24 1.85 1.75 2.677 3.047 2.28 2.18 3.91 3.21 3.16 3.09 212.27 164.07 37.49 34.7 1016.22 1217.46
51 84 M M 1 1 1 1 1 1 1 1 1.4 2.0 152 130 93 63 28.27 24.11 13 14 5220 5445 125.6 129 40.81 42.36 150.314 125.5 4.11 4.99 1.05 1.8 1.8 1.92 1.787 2.597 2.22 2.22 4.16 3.26 4.66 4.59 182.07 203.17 37.24 33.92 695.36 910.58
59 75 M M 0 1 1 1 1 1 1 1 1.7 2.3 130 112 75 69 27.5 23.2 12 13 5250 4605 121.6 112.8 42.38 42.36 132.63 114.946 5.16 3.82 1.65 1.52 1.56 1.85 2.027 2.247 2.46 2.21 4.24 3.53 5.2 4.74 221.97 194.27 33.7 33.2 1144.44 541.16
43 46 M M 1 0 1 0 1 1 1 1 2.1 2.4 153 124 76 80 25.69 24.39 12 13 4590 6135 118.2 117.5 42.38 42.53 125.5 106.104 4.37 4.85 1.27 0.79 1.68 1.73 2.377 2.977 2.18 2.28 4.12 3.39 4.89 4.92 224.05 150.87 36.39 34.25 1245.03 1332.85
42 81 M M 0 0 1 1 1 1 1 1 2.6 2.5 134 115 80 69 27.24 24.54 13 14 4815 4830 119.6 125.4 41.54 39.75 97.262 70.736 5.16 4.71 1.88 0.67 1.85 1.92 2.757 2.597 2.22 2.18 4.19 3.54 3.16 3.09 212.27 164.07 34.15 34.75 497.33 1036.14
57 68 M M 1 0 1 1 1 1 1 1 1.9 3.0 132 110 79 66 29.22 22.36 15 13 4800 3900 137.8 122.3 39.6 39.2 114.946 88.42 4.88 4.99 0.93 1.39 1.7 1.56 2.027 2.247 2.36 2.36 4.24 3.26 4.66 5.14 168.87 164.07 33.7 33.2 1092.72 1054.68
59 81 M M 1 0 1 0 1 1 1 1 2.1 2.8 135 116 78 63 29.2 22.53 12 13 5550 5775 116.3 121.9 40.82 42.36 110.525 106.104 4.71 3.99 2.06 1.8 1.51 1.56 1.787 2.007 2.34 2.37 3.91 3.21 4.8 4.59 221.97 150.87 34.42 33.92 1074.29 724.95
43 61 M M 0 1 1 1 1 1 1 1 2.4 2.4 136 130 94 80 29.11 25.6 13 13 3030 4890 124.6 116.3 42.58 42.73 119.367 61.894 3.97 4.85 1.76 1.5 1.87 1.75 2.427 2.977 2.22 2.22 4.24 3.46 5.14 4.86 182.07 203.97 35.2 34.25 1165.56 590.46
54 67 M M 0 0 1 1 1 1 1 1 2.5 2.3 125 112 75 69 26 26.09 12 13 4800 4590 121.9 125.6 39.05 40.97 111.4092 88.42 5.16 3.91 1.78 0.67 1.8 1.57 2.027 2.247 2.21 2.46 4.12 3.42 4.93 4.84 212.27 194.27 33.7 33.2 550.80 541.16
47 81 M M 0 0 1 1 1 1 1 1 1.4 2.8 151 124 95 66 26.48 25.6 12 13 5160 4590 125.4 137.8 39.05 42.36 106.104 125.5 4.32 3.94 1.88 0.77 1.85 1.56 2.377 2.007 2.36 2.34 4.26 3.54 5.2 3.09 236.72 206.05 34.15 36.99 1245.03 1219.46
41 66 M M 0 0 1 1 1 1 1 1 1.7 2.7 152 115 80 63 28.86 23.72 13 13 3960 1703 124.8 127.6 40.81 39.75 106.104 97.262 4.11 4.54 2.06 0.87 1.51 1.85 1.787 2.897 2.46 2.36 4.12 3.26 4.66 4.73 221.97 164.07 34.59 33.92 1144.44 1054.68
47 74 F F 1 0 0 1 0 0 0 0 2.4 2.3 125 110 95 80 26.95 22.92 13 13 4560 1857 118.2 118.2 42.21 39.2 123.788 44.21 4.71 4.85 0.93 1.62 1.52 1.92 2.027 2.247 2.18 2.33 3.91 3.26 4.96 5.07 182.07 214.02 33.7 33.2 547.06 780.94
79 48 M M 0 0 1 0 1 1 1 1 2.0 2.5 154 128 94 69 24.81 24.8 13 13 4605 2000 119.6 125.4 39.6 39.67 125.5 132.63 5.02 3.82 1.03 1.8 2.01 1.56 2.677 2.007 2.22 2.22 4.09 3.21 4.66 4.59 168.87 150.87 36.39 34.25 1236.84 973.29
51 58 F F 0 1 0 1 1 0 0 0 2.6 2.2 129 124 81 66 20.82 22.13 13 13     125.6 124.6 41.58 42.53 125.4 132.6 4.71 4.85 1.05 1.62 1.7 1.8 2.377 3.047 2.21 2.18 4.24 3.49 4.91 5.14 191.77 194.27 35.56 34.09 604.28 1140.54
61 71 M M 1 0 1 1 1 1 1 1 2.4 2.5 130 115 83 63 25 26.83 12 13     124.6 124.8 42.58 41.73 119.6 125.4 5.02 4.99 1.88 0.67 1.51 1.75 2.027 2.247 2.33 2.21 4.31 3.61 4.8 3.09 212.27 164.07 33.7 33.2 617.65 531.63
73 65 F M 0 0 1 1 1 1 0 1 1.4 1.3 134 110 77 70 24.91 26.17 13 13     116.3 121.9 39.52 42.53 132.6 118.2 4.71 3.94 2.06 1.62 1.56 1.56 1.787 2.007 2.22 2.08 4.12 3.21 4.93 4.86 224.05 203.97 34.42 33.92 1074.29 1217.46
64 60 M F 0 0 1 1 1 1 1 0 1.6 3.0 139 130 79 80 27.6 23.94 11 12     118.2 125.6 36.59 36.99 124.6 116.3 5.16 4.54 1.65 0.79 1.8 1.57 2.757 2.597 2.18 2.46 3.91 3.54 4.99 4.59 232.02 150.87 35.2 34.25 941.18 1151.97
64 52 F F 1 1 1 0 1 1 0 0 2.5 2.7 140 124 76 69 27.92 22.4 13 13     132.6 122.3 35.2 35.06 131.2 137.8 4.71 4.99 0.93 1.62 2.01 1.56 1.787 2.247 2.37 2.37 4.19 3.26 4.66 4.73 182.07 173.77 33.7 33.2 1101.60 685.41
42 58 M F 0 0 0 1 0 0 1 0 1.6 1.7 115 115 80 66 28.86 22.53 13 13     125.4 118.2 34.15 33.2 125.6 125.6 4.11 3.99 1.76 1.39 1.51 1.85 2.677 2.007 2.22 2.22 4.24 3.42 5.2 4.82 212.27 164.07 37.24 35.06 1245.03 590.46
45 70 M F 0 0 1 0 1 1 1 0 1.7 2.7 110 110 75 63 28.46 26.02 11 12     118.2 127.6 37.24 34.7 137.8 119.6 4.71 4.71 1.88 1.62 1.52 1.92 2.377 2.977 2.08 2.28 4.16 3.26 4.91 4.73 221.97 150.87 34.15 33.92 611.84 672.59
51 64 F M 1 0 1 1 1 1 0 1 1.9 2.5 154 130 76 80 25.37 24.54 13 14     121.9 125.4 34.42 36.99 119.6 132.6 4.88 4.85 2.06 1.5 1.87 1.9 2.027 2.247 2.22 2.18 4.35 3.65 4.93 3.09 213.94 194.27 33.7 33.2 993.38 1079.00
61 47 F F 0 1 0 1 0 0 0 0 1.8 2.4 116 125 77 69 27.92 20.68 11 12     118.2 119.6 37.49 36.09 125.4 124.8 4.71 3.94 1.76 1.62 1.7 1.57 1.787 2.007 2.28 2.36 3.91 3.21 3.16 4.84 168.87 173.77 37.21 34.25 1044.44 608.49
64 47 F F 1 0 1 1 1 1 0 0 2.4 2.1 153 115 78 66 29.54 23.17 13 14     119.6 132.6 35.2 34.7 122.3 116.3 5.02 4.39 1.03 1.8 1.68 1.75 2.707 2.597 2.46 2.34 4.31 3.54 4.66 3.09 191.77 164.07 35.56 34.7 841.06 1116.50
49 55 F F 1 1 1 1 1 1 0 0 2.4 2.5 126 129 75 63 24.9 25.6 11 12     121.6 124.6 34.15 33.65 127.6 118.2 4.71 3.91 0.93 1.62 1.51 1.85 2.757 2.247 2.22 2.21 4.12 3.26 4.66 5.19 168.87 203.97 33.7 33.65 617.65 1070.03
59 75 M F 1 0 1 0 1 1 1 0 2.1 2.9 152 112 76 70 24.63 25.19 11 12     116.3 131.2 34.75 36.74 118.2 132.6 4.11 4.54 1.88 0.67 1.8 1.92 1.787 2.007 2.36 2.22 4.23 3.21 4.89 4.59 212.27 194.27 34.15 33.2 1245.03 849.27
48 55 F F 0 1 1 1 1 1 0 0 1.6 2.2 140 124 79 80 25.65 24.9 13 14     124.6 125.6 34.59 33.92 131.2 125.4 4.71 4.39 2.06 1.62 1.52 2.06 2.377 2.927 2.18 2.37 4.31 3.42 4.8 4.86 182.07 209.27 34.42 34.25 1101.60 1104.71
47 63 F M 0 1 1 1 1 1 0 1 2.4 2.5 139 115 75 69 26.17 22.4 13 14     137.8 137.8 34.42 36.99 124.6 116.3 5.16 4.99 1.76 1.24 1.85 1.57 2.027 2.247 2.22 2.46 3.91 3.26 5.2 4.84 212.27 195.94 33.7 33.65 1165.56 1134.41
56 48 M F 1 1 0 1 0 0 1 0 1.8 2.1 135 110 76 66 26.25 23.68 13 14     125.4 119.6 35.56 34.7 121.6 113.6 4.71 3.94 1.05 1.52 2.01 1.73 2.677 2.007 2.34 2.18 4.24 3.21 3.16 4.59 221.97 164.07 34.75 36.09 1016.22 527.96
75 54 F F 0 1 1 1 1 1 0 0 1.7 2.5 132 125 79 63 28.27 25.3 11 12     118.2 125.4 34.15 33.65 125.6 125.6 4.88 3.82 2.06 1.62 1.7 1.56 1.787 2.977 2.23 2.33 4.17 3.39 4.93 4.73 212.27 150.87 35.2 33.2 1059.52 1207.57
55 47 F F 1 0 1 1 1 1 0 0 1.4 2.0 130 115 80 80 27.6 22.4 11 12     125.6 122.3 33.7 34.25 125.4 127.6 4.11 4.85 1.88 0.79 1.8 1.75 2.497 2.247 2.22 2.23 4.26 3.21 5.14 4.74 182.47 194.27 33.7 33.92 572.22 617.89
64 59 M M 0 0 1 0 1 1 1 1 2.6 2.7 125 128 95 69 27.24 22.53 13 14     121.9 127.6 35.2 34.09 118.2 132.6 5.02 4.71 0.93 1.8 1.51 1.56 1.787 2.597 2.18 2.22 4.12 3.46 4.93 3.09 224.05 203.97 34.59 33.65 1245.03 1022.75
49 67 F F 1 0 1 1 1 1 0 0 2.1 2.4 129 125 80 66 26.95 23.42 11 12     122.3 118.2 34.59 33.92 132.6 118.2 4.71 4.99 1.65 1.62 1.52 1.85 2.377 2.897 2.36 2.36 3.91 3.21 4.66 4.84 212.27 164.07 36.59 34.25 679.14 824.83
55 54 F F 0 0 1 1 1 1 0 0 1.8 2.6 122 115 95 63 25.87 25.3 14 13     124.6 131.2 37.49 35.06 137.8 121.9 5.16 3.94 1.78 0.67 1.7 1.56 2.027 2.247 2.37 2.23 4.24 3.26 5.2 5.07 227.27 206.05 34.42 33.2 1364.24 1070.03
47 60 M F 0 1 1 0 1 1 1 0 2.4 2.7 115 130 95 80 25.74 24.54 14 13     116.3 124.6 34.15 33.65 127.6 125.4 4.11 4.99 1.76 1.39 1.51 1.57 2.757 2.007 2.46 2.28 4.12 3.54 5.21 4.86 168.87 150.87 35.56 34.7 1236.84 605.75
60 52 F M 1 0 1 1 1 1 0 1 1.6 2.0 110 117 79 69 27.08 22.92 14 13     132.6 121.6 34.42 33.2 131.2 124.6 4.88 4.71 1.88 1.62 1.51 1.56 1.787 2.717 2.22 2.46 4.16 3.26 4.66 3.09 182.07 194.27 34.15 33.65 695.36 1332.85
68 47 M F 0 1 1 1 1 1 1 0 1.7 2.6 119 130 80 66 24.61 24 14 13     121.9 125.6 35.2 34.7 124.6 125.6 4.71 4.39 1.05 1.5 1.52 1.61 2.757 2.247 2.08 2.18 4.31 3.21 3.16 4.59 191.77 164.47 37.25 34.25 970.59 1054.68
55 58 M M 1 0 1 1 1 1 1 1 2.5 2.8 120 112 79 63 26.8 22.13 14 12     125.4 125.6 36.59 34.09 116.3 131.2 5.02 4.85 0.93 0.77 1.87 1.56 1.787 2.977 2.33 2.22 3.91 3.61 4.93 4.73 212.27 164.07 37.21 33.2 1245.03 826.44
61 57 M F 0 1 1 0 0 1 1 0 2.4 2.4 125 124 80 80 27.27 22.06 13 14     118.2 113.6 37.24 36.99 121.6 137.8 4.11 4.54 1.03 1.62 1.8 2.06 2.377 2.597 2.22 2.34 4.24 3.21 3.16 4.92 212.27 203.97 36.39 34.09 977.78 1036.14
52 62 F M 1 0 0 1 1 1 0 1 2.6 2.4 121 115 81 66 26.17 25 13 14     125.6 125.4 34.15 33.65 125.6 118.2 4.08 4.99 1.65 1.8 1.51 1.56 2.027 2.247 2.18 2.33 4.09 3.42 4.8 4.59 221.97 194.27 34.42 33.65 1364.24 973.87
48 62 F M 0 1 1 1 1 1 0 1 2.4 2.5 126 110 76 69 29.11 21.37 11 12     131.2 119.6 35.2 33.92 122.3 119.6 4.71 4.99 1.88 0.67 1.85 1.61 2.677 3.017 2.23 2.22 4.12 3.49 4.66 4.89 212.27 150.87 34.15 33.92 1005.35 527.96
58 67 F M 1 0 1 1 1 1 0 1 1.8 2.3 130 119 79 80 25.87 24.4 14 12     124.6 121.6 34.42 34.7 119.6 121.9 4.56 3.94 1.88 1.62 1.8 1.56 2.377 2.007 2.34 2.28 4.35 3.54 5.2 3.09 168.87 164.07 34.59 33.2 993.38 1217.46
57 66 F F 0 0 1 1 1 0 0 0 1.6 2.3 138 129 80 70 28.75 24.39 11 12     121.6 113.6 37.49 36.09 121.9 125.4 5.02 4.71 1.05 0.87 1.51 1.85 2.027 2.247 2.22 2.08 3.91 3.26 4.91 5.14 212.27 173.77 37.21 34.25 604.28 1126.37
63 63 F F 1 1 1 1 0 1 0 0 1.9 2.0 154 124 95 60 26.42 26.09 13 14     132.6 125.4 33.7 36.74 127.6 123.788 4.11 3.94 1.65 0.79 1.7 1.75 1.787 2.597 2.36 2.36 4.23 3.53 4.81 4.73 182.07 209.27 37.22 34.7 1245.03 685.41
63 77 F F 0 0 0 1 1 0 0 0 1.7 2.3 125 115 79 80 25.74 22.53 14 12     137.8 118.2 34.15 33.65 119.6 123.788 4.71 4.85 2.06 1.62 1.8 1.9 2.027 2.977 2.46 2.18 4.31 3.21 4.93 4.86 212.27 164.07 37.21 34.25 522.39 930.35
67 60 F F 0 1 1 1 1 1 0 0 1.6 2.4 130 110 78 63 26.48 27.24 11 12     125.4 125.4 37.22 34.7 131.2 141.472 4.56 4.54 1.88 1.05 1.51 1.85 1.787 2.247 2.28 2.46 4.12 3.26 3.16 4.73 212.27 194.27 33.7 33.2 1144.44 826.44
67 70 F M 1 1 1 1 0 1 0 1 2.4 2.5 122 128 76 68 26.95 26.09 14 12     125.6 116.3 34.59 33.92 118.2 141.472 4.88 3.94 1.92 0.93 1.67 2.02 1.82 2.11 2.22 2.22 4.19 3.61 4.66 4.59 168.87 173.77 36.59 35.06 1236.84 1022.75
64 72 M F 0 1 1 1 1 1 1 0 2.5 3.0 153 124 75 80 27.41 24.8 14 12     121.9 119.6 33.7 36.99 124.6 106.104 4.71 4.71 1.88 0.67 1.52 1.75 1.787 2.007 2.18 2.37 3.91 3.42 5.2 4.92 221.17 203.97 35.56 33.92 615.89 608.49
78 53 F F 0 0 1 1 1 1 0 0 2.4 2.8 115 115 80 69 30 24.61 13 14     124.6 114.9 37.21 33.2 125.6 114.946 5.16 4.54 1.03 0.77 1.87 1.61 2.027 2.597 2.37 2.33 4.09 3.54 5.14 4.84 212.27 164.07 34.59 34.25 1035.29 1325.50
61 55 F M 0 1 0 0 1 0 0 1 2.1 2.4 119 110 81 66 29.96 22.43 14 12     131.2 116.3 34.15 33.65 132.6 114.946 4.16 4.85 1.88 1.62 1.8 1.57 2.757 2.247 2.22 2.34 4.12 3.21 4.66 3.09 182.07 150.87 37.21 33.2 1005.35 1140.54
70 54 M F 1 0 1 1 1 1 1 0 1.4 2.3 110 129 80 63 25.39 25.78 11 12     122.3 125.4 34.42 36.72 121.9 97.262 4.88 4.54 1.5 1.01 1.85 1.56 2.707 2.717 2.21 2.28 4.24 3.39 4.8 5.07 227.27 206.05 34.15 36.74 916.67 1047.57
72 60 F F 0 1 1 1 1 1 0 0 2.2 2.8 154 117 75 80 24.91 22.8 14 12     116.3 125.6 33.7 34.09 118.2 114.946 5.02 3.94 1.88 1.8 1.8 1.85 2.027 2.977 2.18 2.18 4.31 3.21 4.99 4.92 221.97 194.27 37.49 33.65 682.12 1217.46
53 56 M F 0 1 0 1 0 1 1 0 1.8 2.7 152 130 95 70 29.58 22.13 11 12     125.6 127.6 34.75 33.2 137.8 141.472 4.11 4.54 1.76 1.62 1.7 1.92 1.787 2.247 2.22 2.22 3.91 3.47 3.16 3.09 232.02 150.87 34.75 34.7 1016.22 1151.97
56 58 M M 0 1 1 1 1 1 1 1 1.7 2.3 151 125 75 60 30 25.6 14 12     125.4 125.4 37.24 36.71 137.8 150.314 4.56 4.99 1.88 0.79 1.52 1.57 2.677 2.597 2.08 2.21 4.23 3.54 4.91 4.59 212.27 214.02 35.2 35.89 1355.26 608.49
55 66 M F 1 0 1 1 1 1 1 0 2.6 1.2 139 115 79 80 26.09 25.78 13 14     118.2 116.3 34.15 33.65 125.6 97.262 4.08 4.54 2.06 1.39 1.85 1.57 2.027 2.897 2.37 2.46 4.12 3.42 5.2 4.86 182.07 164.07 36.39 33.92 679.14 580.04
61 53 F M 0 0 1 0 1 0 0 1 2.4 1.2 134 130 80 63 25.74 24.39 13 14     121.9 119.6 34.75 33.92 124.6 114.946 4.71 4.71 1.65 1.62 1.52 1.56 2.377 2.247 2.22 2.36 4.16 3.21 4.66 4.84 212.27 194.27 34.15 33.65 1245.03 685.41
56 71 F F 1 0 1 1 1 1 0 0 1.9 1.3 132 125 76 69 25 23.28 12 12     124.6 132.6 35.56 33.2 127.6 106.104 4.56 3.94 0.93 1.5 1.8 1.75 1.787 2.007 2.36 2.23 4.12 3.26 4.93 4.82 191.77 203.97 37.21 34.09 547.06 1022.75
58 52 F M 0 1 1 0 1 1 0 1 1.6 1.3 130 115 78 80 23.75 24.8 13 14     132.6 125.4 34.42 34.25 121.9 88.42 5.16 4.85 1.65 1.8 1.7 1.9 2.027 2.597 2.46 2.37 3.91 3.21 5.2 4.73 168.87 218.72 33.7 34.7 938.09 1332.85
66 59 F F 0 0 1 1 1 0 0 0 1.8 1.2 139 116 77 80 21.93 26.09 13 14     121.6 118.2 36.59 36.74 122.3 88.42 4.11 4.54 1.05 1.62 1.51 1.85 2.757 2.247 2.34 2.22 4.31 3.46 4.8 4.59 212.27 164.07 34.42 36.71 1236.84 853.76
53 49 F M 1 1 1 1 1 1 0 1 2.4 1.1 154 130 75 69 32.07 26.02 13 14     118.2 116.3 34.15 33.65 124.6 97.262 3.99 4.99 1.03 1.24 2.01 1.56 2.497 3.017 2.18 2.18 4.35 3.54 5.21 3.09 212.27 150.87 37.49 33.65 993.38 541.16
71 82 F F 0 0 1 1 1 1 0 0 2.6 1.3 125 124 75 66 22.13 27.24 12 12     116.3 137.8 37.22 34.25 116.3 150.314 5.02 3.94 1.65 0.87 1.51 1.61 1.787 2.977 2.22 2.08 3.91 3.65 4.66 4.59 182.07 194.27 34.59 35.06 1320.51 1134.41
53 66 F M 1 0 1 1 1 1 0 1 1.7 1.3 153 115 79 63 29.69 25.78 13 14     125.4 125.6 34.59 35.06 121.6 70.736 4.88 4.71 2.06 1.62 1.87 2.06 2.377 2.247 2.33 2.34 4.31 3.61 3.16 5.07 227.27 164.47 37.24 33.92 1044.44 1217.46
60 66 M F 0 0 1 1 1 1 1 0 2.1 1.3 130 110 75 80 27.85 23.44 12 12     125.6 119.6 36.39 33.92 118.2 106.104 5.16 4.54 1.27 0.79 1.87 1.92 2.707 2.597 2.28 2.46 4.12 3.54 4.91 5.19 212.27 150.87 37.25 34.7 562.19 1207.57
50 58 F M 0 0 0 0 0 0 0 1 1.9 1.2 153 129 76 67 27.57 23.58 12 12     127.6 132.6 34.42 36.09 119.6 167.998 4.11 4.85 1.03 1.8 1.8 1.56 1.787 2.927 2.21 2.21 4.24 3.42 4.66 3.09 182.07 164.07 34.42 33.65 1092.72 960.25
83 71 F F 1 0 1 1 1 1 0 0 2.2 1.2 152 124 80 65 29.11 23.32 13 14     121.9 124.8 33.7 33.65 125.6 97.262 5.16 3.94 1.65 1.62 1.7 1.75 2.377 2.247 2.22 2.22 4.17 3.21 5.2 4.86 221.97 203.97 36.59 36.09 547.06 595.22
66 64 F M 0 1 0 1 0 1 0 1 1.6 1.3 115 115 94 80 26.8 22.13 13 14     132.6 116.3 37.21 36.72 124.6 123.788 4.88 3.91 2.06 0.67 1.56 1.73 2.757 2.007 2.21 2.36 3.91 3.49 4.93 4.73 168.87 194.27 35.56 33.2 705.56 608.49
67 60 F F 1 1 1 0 1 1 0 0 1.4 1.2 120 110 75 68 27.34 23.58 13 14     118.2 118.2 35.2 34.09 118.2 106.104 4.56 4.54 1.05 1.5 1.87 1.85 2.027 3.017 2.36 2.18 4.12 3.53 3.16 4.84 221.97 203.17 37.24 34.09 1320.51 1031.63
65 59 M M 1 0 0 1 1 0 1 1 2.5 1.3 132 115 80 67 26 24.22 13 14     124.6 132.6 35.56 35.89 132.6 123.788 5.02 4.39 2.06 1.62 1.85 1.56 1.787 2.247 2.22 2.28 4.31 3.39 5.26 3.09 168.87 206.05 34.59 33.65 1044.44 1325.50
Open in a new tab

The authors have declared that no competing interests exist.

Author Contributions

Concept and design:  Sarosh Khan Jadoon, Awais Ahmed Nizami, Waqar Mustafa, Mamoon Qadir, Maria Shahzad, Hamid Iqbal, Anwar Ali, Amna Akbar, Sabahat Tasneem, Mohammad Saleem Khan

Acquisition, analysis, or interpretation of data:  Sarosh Khan Jadoon, Awais Ahmed Nizami, Waqar Mustafa, Mamoon Qadir, Maria Shahzad, Hamid Iqbal, Anwar Ali, Amna Akbar, Sabahat Tasneem, Mohammad Saleem Khan

Drafting of the manuscript:  Sarosh Khan Jadoon, Awais Ahmed Nizami, Waqar Mustafa, Mamoon Qadir, Maria Shahzad, Hamid Iqbal, Anwar Ali, Amna Akbar, Sabahat Tasneem, Mohammad Saleem Khan

Critical review of the manuscript for important intellectual content:  Sarosh Khan Jadoon, Awais Ahmed Nizami, Waqar Mustafa, Mamoon Qadir, Maria Shahzad, Hamid Iqbal, Anwar Ali, Amna Akbar, Sabahat Tasneem, Mohammad Saleem Khan

Supervision:  Awais Ahmed Nizami, Mamoon Qadir, Mohammad Saleem Khan

Human Ethics

Consent was obtained or waived by all participants in this study. Abbas Institute of Medical Sciences (AIMS) issued approval reference number: 1451

Animal Ethics

Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue.

References

  • 1.Uremia-associated ageing of the thymus and adaptive immune responses. Betjes MG. Toxins (Basel) 2020;12 doi: 10.3390/toxins12040224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Hemoperfusion combined with hemodialysis filtration can effectively improve uremia complicated with bone and mineral disorders. Tang X, Wang J, Li H, et al. Panminerva Med. 2021;63:394–395. doi: 10.23736/S0031-0808.19.03702-9. [DOI] [PubMed] [Google Scholar]
  • 3.Clinical significance of hemodialysis quality of care indicators in very elderly patients with end stage kidney disease. Kim HW, Jhee JH, Joo YS, et al. J Nephrol. 2022;35:2351–2361. doi: 10.1007/s40620-022-01356-3. [DOI] [PubMed] [Google Scholar]
  • 4.Endothelial dysfunction is associated with cerebrovascular events in pre-dialysis CKD patients: a prospective study. Cerqueira A, Quelhas-Santos J, Sampaio S, et al. Life (Basel) 2021;11 doi: 10.3390/life11020128. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.The uraemic hypertensive patient: a therapeutic challenge-right you are (if you think so) Cice G, Monzo L, Calo L. Eur Heart J Suppl. 2020;22:0–8. doi: 10.1093/eurheartj/suaa133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Diagnosis and treatment of chronic kidney disease (Article in German) Girndt M. Internist (Berl) 2017;58:243–256. doi: 10.1007/s00108-017-0195-2. [DOI] [PubMed] [Google Scholar]
  • 7.Impact of the new criteria of the ACC/AHA on the diagnostic prevalence of hypertension. Baena Díez JM, Carrera Morodo M, Corral Roca M, Calatayud Subías E, Flores Jiménez I, de la Arada Acebes AM. Med Clin (Barc) 2020;154:254–256. doi: 10.1016/j.medcli.2019.06.021. [DOI] [PubMed] [Google Scholar]
  • 8.KDOQI clinical practice guideline for hemodialysis adequacy: 2015 update. Am J Kidney Dis. 2015;66:884–930. doi: 10.1053/j.ajkd.2015.07.015. [DOI] [PubMed] [Google Scholar]
  • 9.2020 International Society of Hypertension Global Hypertension practice guidelines. Unger T, Borghi C, Charchar F, et al. Hypertension. 2020;75:1334–1357. doi: 10.1161/HYPERTENSIONAHA.120.15026. [DOI] [PubMed] [Google Scholar]
  • 10.Risk prediction of bleeding and MACCE by PRECISE-DAPT score post-PCI. Dannenberg L, Afzal S, Czychy N, et al. Int J Cardiol Heart Vasc. 2021;33:100750. doi: 10.1016/j.ijcha.2021.100750. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Rothwell PM, Howard SC, Dolan E, et al. Lancet. 2010;375:895–905. doi: 10.1016/S0140-6736(10)60308-X. [DOI] [PubMed] [Google Scholar]
  • 12.2018 ESC/ESH Guidelines for the management of arterial hypertension. Williams B, Mancia G, Spiering W, et al. Eur Heart J. 2018;39:3021–3104. doi: 10.1093/eurheartj/ehy339. [DOI] [PubMed] [Google Scholar]
  • 13.Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomized controlled trial. Ueki K, Sasako T, Okazaki Y, et al. Lancet Diabetes Endocrinol. 2017;5:951–964. doi: 10.1016/S2213-8587(17)30327-3. [DOI] [PubMed] [Google Scholar]
  • 14.Impact of age at type 2 diabetes mellitus diagnosis on mortality and vascular complications: systematic review and meta-analyses. Nanayakkara N, Curtis AJ, Heritier S, et al. Diabetologia. 2021;64:275–287. doi: 10.1007/s00125-020-05319-w. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15.Haemodiafiltration and mortality in end-stage kidney disease patients: a pooled individual participant data analysis from four randomized controlled trials. Peters SA, Bots ML, Canaud B, et al. Nephrol Dial Transplant. 2016;31:978–984. doi: 10.1093/ndt/gfv349. [DOI] [PubMed] [Google Scholar]
  • 16.Spironolactone reduces cardiovascular and cerebrovascular morbidity and mortality in hemodialysis patients. Matsumoto Y, Mori Y, Kageyama S, et al. J Am Coll Cardiol. 2014;63:528–536. doi: 10.1016/j.jacc.2013.09.056. [DOI] [PubMed] [Google Scholar]
  • 17.Predictive value of women's weight trajectories in determining familial cardiovascular disorders: a family-based longitudinal study. Naseri P, Amiri P, Zareie Shab-Khaneh A, Azizi F. Sci Rep. 2021;11:17317. doi: 10.1038/s41598-021-96154-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Hypertension, BMI, and cardiovascular and cerebrovascular diseases. Qiao W, Zhang X, Kan B, et al. Open Med (Wars) 2021;16:149–155. doi: 10.1515/med-2021-0014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19.Body mass index, intensive blood pressure management, and cardiovascular events in the SPRINT trial. Oxlund CS, Pareek M, Rasmussen BS, et al. Am J Med. 2019;132:840–846. doi: 10.1016/j.amjmed.2019.01.024. [DOI] [PubMed] [Google Scholar]
  • 20.Triglyceride-rich lipoprotein cholesterol, small dense LDL cholesterol, and incident cardiovascular disease. Duran EK, Aday AW, Cook NR, Buring JE, Ridker PM, Pradhan AD. J Am Coll Cardiol. 2020;75:2122–2135. doi: 10.1016/j.jacc.2020.02.059. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Perindopril-based blood pressure-lowering therapy reduces amino-terminal-pro-B-type natriuretic peptide in individuals with cerebrovascular disease. Campbell DJ, Woodward M, Chalmers JP, et al. J Hypertens. 2007;25:699–705. doi: 10.1097/HJH.0b013e328013c581. [DOI] [PubMed] [Google Scholar]
  • 22.Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT. Mezue K, Goyal A, Pressman GS, Matthew R, Horrow JC, Rangaswami J. J Clin Hypertens (Greenwich) 2018;20:1247–1252. doi: 10.1111/jch.13346. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Blood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis. Kim Y, Lim JS, Oh MS, et al. https://doi.org/10.1038/s41598-021-83945-z. Sci Rep. 2021;11:5049. doi: 10.1038/s41598-021-83945-z. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24.Interindividual relationships between blood pressure and cerebral blood flow variability with intact and blunted cerebrovascular control. Tzeng YC, MacRae BA. J Appl Physiol (1985) 2013;114:888–895. doi: 10.1152/japplphysiol.01388.2012. [DOI] [PubMed] [Google Scholar]
  • 25.Blood pressure control and clinical outcomes in acute intracerebral haemorrhage: a preplanned pooled analysis of individual participant data. Moullaali TJ, Wang X, Martin RH, et al. Lancet Neurol. 2019;18:857–864. doi: 10.1016/S1474-4422(19)30196-6. [DOI] [PubMed] [Google Scholar]
  • 26.Blood pressure variability and outcome in acute severe stroke: a post hoc analysis of CHASE-a randomized controlled trial. Zhao J, Yuan F, Fu F, et al. J Clin Hypertens (Greenwich) 2021;23:96–102. doi: 10.1111/jch.14090. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27.Blood pressure management in hemodialysis patients. Hirawa N. https://doi.org/10.1038/s41440-023-01279-x. Hypertens Res. 2023;46:1807–1809. doi: 10.1038/s41440-023-01279-x. [DOI] [PubMed] [Google Scholar]

Articles from Cureus are provided here courtesy of Cureus Inc.

RESOURCES