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. 2024 Mar 2;15:1951. doi: 10.1038/s41467-024-46188-w

Silver-catalyzed direct conversion of epoxides into cyclopropanes using N-triftosylhydrazones

Linxuan Li 1, Paramasivam Sivaguru 1, Dandan Wei 1, Menglin Liu 1, Qingwen Zhu 1, Shuai Dong 1, Emanuele Casali 2, Nan Li 1, Giuseppe Zanoni 2, Xihe Bi 1,3,✉
PMCID: PMC10908805  PMID: 38431716

Abstract

Epoxides, as a prominent small ring O-heterocyclic and the privileged pharmacophores for medicinal chemistry, have recently represented an ideal substrate for the development of single-atom replacements. The previous O-to-C replacement strategy for epoxides to date typically requires high temperatures to achieve low yields and lacks substrate range and functional group tolerance, so achieving this oxygen-carbon exchange remains a formidable challenge. Here, we report a silver-catalyzed direct conversion of epoxides into trifluoromethylcyclopropanes in a single step using trifluoromethyl N-triftosylhydrazones as carbene precursors, thereby achieving oxygen-carbon exchange via a tandem deoxygenation/[2 + 1] cycloaddition. The reaction shows broad tolerance of functional groups, allowing routine cheletropic olefin synthesis in a strategy for the net oxygen-carbon exchange reaction. The utility of this method is further showcased with the late-stage diversification of epoxides derived from bioactive natural products and drugs. Mechanistic experiments and DFT calculations elucidate the reaction mechanism and the origin of the chemo- and stereoselectivity.

Subject terms: Reaction mechanisms, Synthetic chemistry methodology, Catalyst synthesis

Epoxides are prominent small-ring O-heterocycles found in a variety of bioactive natural products and pharmaceuticals. Here, the authors report a silver carbene strategy to achieve O-to-C atom exchange of epoxides in a single step, affording diverse fluoroalkylcyclopropanes.

Introduction

Epoxides are prominent small-ring O-heterocycles found in a variety of bioactive natural products and pharmaceuticals1–3. Moreover, they are often used as efficient structural linkers in the polymerization process4–6 and versatile building blocks for the synthesis of complex molecules3,7,8. In light of their value, the transformation and utilization of readily accessible epoxides is of utmost importance in synthetic chemistry and includes the direct conversion into other three-membered (hetero)cyclic compounds such as thiiranes9–15, aziridines16–20, and cyclopropanes without altering the ring structure21–24. Given the importance of cyclopropanes in synthetic and medicinal chemistry, the conversion of epoxides to cyclopropanes (i.e., oxygen to carbon exchange) has received renewed attention. To date, four strategies have been developed to achieve this oxygen-carbon exchange in epoxides. In 1961, Wadsworth and Emmons demonstrated the first oxygen-carbon exchange in epoxides using phosphonate carbanions as the carbon source (Fig. 1a1)25–29. Subsequently, Denney and coworkers achieved this transformation by heating epoxides with Wittig reagent at 200 °C (Fig. 1a2)30. Despite these advances, existing strategies generally require a high temperature to achieve oxygen-carbon exchange with low yields while lacking substrate scope and functional group tolerance. Recently, the Hong and Cho groups independently synthesized enantioenriched cyclopropylboronates via a two-step three-component reaction of chiral epoxides with lithiated gem-diboronates and diphenyl chlorophosphate (Fig. 1a3)31,32. Noyori realized the only example of an oxygen-carbon exchange reaction by heating with ethyl diazoacetate at 130–140 °C, where small amounts of competing C–O and C–H insertion products were also formed (Fig. 1a4)33,34.

Fig. 1. Development of catalytic oxygen-carbon exchange reaction using carbenes.

Fig. 1

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a Literature reports: Conversion of epoxides into cyclopropanes. b This work: Silver-catalyzed conversion of epoxides into cyclopropanes.

To broaden the scope of this transformation and generalize the conditions for the synthesis of polyfunctionalized cyclopropanes, we here report a silver-catalyzed oxygen-carbon exchange strategy for the direct conversion of epoxides to cyclopropanes using fluoroalkyl N-triftosylhydrazones35 under mild conditions (Fig. 1b). In contrast to existing strategies (which involve nucleophilic ring-opening of epoxides followed by ring closure with the elimination of a leaving group), this one-step process proceeds through sequential epoxides deoxygenation to furnish an alkene intermediate followed by cyclopropanation with silver carbene and the same catalyst. This protocol is operationally simple and scalable, providing trifluoromethylcyclopropanes in high yields and high diastereoselectivity with excellent functional group compatibility. Fluorinated cyclopropyl motifs are attractive synthons for the synthesis of new bioactive molecules of medicinal interest owing to the conformational rigidity of the three-membered ring combined with the unique properties imparted by the presence of fluorinated substituent36–41.

Results

Optimization of the reaction conditions

At the outset, our investigations focused on the reaction of (2,3-epoxypropyl)-benzene (1a) and trifluoromethyl phenyl N-triftosylhydrazone (2a, 2.0 equiv.). A reaction system composed of catalytic TpBr3Ag(thf) and NaH (2.5 equiv.) at 60 °C in dichloromethane (DCM) provided the desired cyclopropane 3 in 58% yield and 10:1 diastereomeric ratio (d.r.) along with 90% deoxygenation product, trifluoroacetophenone 3’ (Table 1, entry 1), without the formation of competing C–O or C–H bond insertion products35,42–48. Control experiments revealed that the amounts of 2a and NaH were crucial to improving the efficiency, and the best result (92% isolated yield of 3 and quantitative trifluoroacetophenone 3’) was indeed obtained with 4.0 equiv. of 2a and 4.5 equiv. of NaH (entries 1, 2 vs 3). Other silver catalysts, such as AgOTf, AgOAc, Tp(CF3)2Ag(thf), and Tp*Ag, resulted in diminished yields and diastereoselectivity (entries 4–7). This unusual reactivity of TpBr3Ag(thf) is mainly due to the presence of a substantial steric hindrance scorpion ligand (TpBr3), which not only hinders the occurrence of a competitive carbene dimerization process but also enhances non-enantioselectivity. To our surprise, no conversion of 1a was observed when using TpBr3Cu(MeCN), Pd(OAc)2, and FeTPPCl as catalysts (entries 8–10). The use of Rh2(OAc)4 as catalysts results in modest efficiency in the deoxidation process, thus obtaining 3 in poor yield and selectivity (entry 11). The reaction yield and stereoselectivity could not be improved by decreasing (40 °C) or increasing (80 °C) the reaction temperature (entries 12 and 13). The substituents and positions on N-sulfonylhydrazones were also critical, as lower yields were observed with 4-methylphenyl- and 2,4,6-triisopropylphenyl N-sulfonylhydrazones (2b and 2c) (entries 14 and 15). Note that the easy decomposition of o-trifluoromethyl N-triftosylhydrazones compared to other functional groups substituted N-sulfonylhydrazones enabled the rapid deoxidation process35.

Table 1.

Optimization of the reaction conditionsaInline graphic

Entry 2 (equiv.) Cat. (5 mol%) NaH (equiv.) Yield of 3’ (%) Yield of 3 (%) d.r. of 3
1 2a (2.0) TpBr3Ag(thf) 2.5 90 58 10:1
2 2a (3.0) TpBr3Ag(thf) 3.5 99 82 10:1
3 2a (4.0) TpBr3Ag(thf) 4.5 99 95 (92)d 10:1
4 2a (4.0) AgOTf 4.5 30 12 5:1
5 2a (4.0) AgOAc 4.5 43 32 7:1
6 2a (4.0) Tp(CF3)2Ag(thf) 4.5 82 60 7:1
7 2a (4.0) Tp*Ag 4.5 60 22 7:1
8 2a (4.0) TpBr3Cu(MeCN) 4.5 56 0 –
9 2a (4.0) Pd(OAc)2 4.5 0 0 –
10 2a (4.0) FeTPPCl 4.5 8 Trace –
11 2a (4.0) Rh2(OAc)4 4.5 60 10 4:1
12b 2a (4.0) TpBr3Ag(thf) 4.5 89 28 10:1
13c 2a (4.0) TpBr3Ag(thf) 4.5 95 76 9:1
14 2b (4.0) TpBr3Ag(thf) 4.5 67 37 10:1
15 2c (4.0) TpBr3Ag(thf) 4.5 62 33 8:1
graphic file with name 41467_2024_46188_Tabb_HTML.gif
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aReaction conditions: 1 (0.15 mmol), 2 (0.6 mmol), NaH (0.68 mmol), Cat. (5 mol%) in DCM (4.0 mL) at 60 °C under N2 for 6 h.

b40 °C instead of 60 °C.

c80 °C instead of 60 °C.

dIsolated yields. The yields and the diastereomeric ratio (d.r.) were determined by the relative integration of 19F NMR spectra.

Substrate scope

With the optimized conditions in hand, we explored the scope and limitations of this transformation with a range of epoxides and N-triftosylhydrazone (Fig. 2). We first probed the reactivity of various epoxides for this oxygen-carbon exchange protocol using 4-chlorophenyl trifluoromethyl N-triftosylhydrazone as a carbon component (Fig. 2a). Mono-substituted epoxides with methyl, n-butyl, n-decyl, benzyl, and 2-phenethyl groups readily transformed into corresponding cyclopropane products 4–8 with good to excellent yields and good diastereomeric ratio (d.r.). Dialkyl ether and alkylaryl ether-tethered epoxides were tolerated well, giving rise to cyclopropane products 9–12 in good yields and diastereoselectivities (>20:1 d.r.), except for product 9 (7:1 d.r.). Pleasingly, functional groups such as ester, chloro, and tosylate groups at the terminus of alkyl epoxides underwent smooth reaction, affording cyclopropane products 13–15 in good yields and diastereoselectivities. 3-Phenyl-2,2′-bisepoxide was transformed into biscyclopropane 16 with high diastereoselectivity albeit in lower yield under modified conditions for 24 h.

Fig. 2. Scope of single-atom transmutation of epoxides with fluoroalkyl N-triftosylhydrazones.

Fig. 2

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a Scope of epoxides. b Scope of N-triftosylhydrazones. c Gram-scale synthesis. Reaction conditions: a1 (0.15 mmol, 1.0 equiv.), 2 (0.6 mmol, 4.0 equiv.), NaH (0.68 mmol, 4.5 equiv.) and TpBr3Ag(thf) (10 mol%) in DCM (4.0 mL) at 60 °C for 6–12 h. bExtend reaction time to 24 h. cUsing 6.0 equiv. of 2. d1 (0.15 mmol, 1.0 equiv.), 2 (0.38 mmol, 2.5 equiv.), NaH (0.38 mmol, 2.5 equiv.) and TpBr3Ag(thf) (2.5–5 mol%) in DCM (4.0 mL) at 60 °C for 0.5–6 h. e1 (0.15 mmol, 1.0 equiv.), 2 (0.45 mmol, 3.0 equiv.), NaH (0.45 mmol, 3.0 equiv.) and TpBr3Ag(thf) (5 mol%) in DCM (4.0 mL) at 60 °C for 10 h. f1b (1.2 g, 10 mmol), 2a (9.9 g, 25 mmol), NaH (1.0 g, 25 mmol) and TpBr3Ag(thf) (219 mg, 2 mol%) in DCM (80.0 mL) at 60 °C for 2 h. Yields of the isolated product are given. Diastereomeric ratio (d.r.) determination by relative integration of 19F NMR spectra. PCP, 4-chlorophenyl. PMP, 4-methoxyphenyl.

This catalytic protocol also operates effectively with 2-(phenylethynyl)oxirane to furnish cyclopropane 17 (54% yield and >20:1 d.r.), where the internal alkynyl remains intact for [2 + 1] cycloaddition with carbenes. Under standard conditions, 1,2,7,8-diepoxyoctane readily converted to n-hexene-substituted cyclopropane 18 (80% yield and >12:1 d.r.) but produced the expected 1,4-dicyclopropylbutane 19 (74% yield and 8:1 d.r.) with 6 equiv. of 4-chlorophenyl trifluoromethyl N-triftosylhydrazone. Next, an array of aryl-substituted oxiranes was subjected to the reaction system. Aryl epoxides with various substitution groups (e.g., methyl, phenyl, chloro, methoxy, and trifluoromethyl) and electronic properties were well tolerated with this transformation, affording cyclopropanes 20–28 in high yields (62–93%) and excellent diastereoselectivities (>20:1 d.r.). Similarly, disubstituted phenyl-, naphthyl-, and 2-thienyl-substituted epoxides were converted into cyclopropanes 29–31 in good yield with >20:1 d.r. The scope of various disubstituted oxiranes was then examined. Several 2,2-disubstituted epoxides, including 2,2-dimethyl, sterically hindered 2,2-diaryl, and 2-(cyclo)alkyl-2-aryl-substituted epoxides, as well as cyclohexyl ketal, pyran, N-Cbz protected piperidine fused epoxides proved compatible, leading to highly substituted cyclopropanes 32–40 in high yields with d.r. as high as 16:1. Similarly, various 2,3-disubstituted epoxides (e.g., cyclopentane, 2,3-dihydro indene oxirane, 2,3-dialkyl-, 2-alkyl-3-aryl-, and 2,3-diaryl-substituted epoxides) afforded the corresponding cyclopropanes 41–45 with good to excellent yields and moderate to good d.r.

Finally, we explored the scope of fluoroalkyl N-triftosylhydrazones with the representative styrene oxide or 4-methoxystyrene oxide (Fig. 2b). Under optimized conditions, both electron-rich and electron-poor aryl trifluoromethyl N-triftosylhydrazones were well tolerated with this transformation, furnishing cyclopropane products 46–55 in high yields and excellent d.r. Similarly, disubstituted phenyl-, naphthyl-, and furyl-substituted trifluoromethyl N-triftosylhydrazones reacted smoothly to afford corresponding cyclopropanes 56–58 in 53–78% yield and >20:1 d.r. N-Triftosylhydrazones derived from trifluoromethyl vinyl/1,3-dienyl ketones were also found to be suitable carbene precursors, affording the corresponding alkenyl/dienyl substituted cyclopropanes 59–62 in high yields (75–89%) with excellent diastereoselectivity. We also attempted to use alkyl N-triftosylhydrazones as carbene precursors (For details, please see Supplementary Fig. 1b), but no cyclopropane product was observed owing to the in situ generated alkyl trifluoromethyl silver carbene more prone to undergo β-hydrogen elimination to yield trifluoromethyl substituted olefins. Even methyl trifluoromethyl N-triftosylhydrazone also failed to yield the cyclopropanization product, likely due to the low reactivity of alkyl trifluoromethyl silver carbene. Interestingly, N-triftosylhydrazone derived from pentafluoroethyl phenyl ketone was successfully converted into pentafluoroethyl cyclopropane 63 in 74% yield with a d.r. of >20:1, demonstrating the capability of the present work in divergent synthesis. This protocol also successfully extended to N-triftosylhydrazones derived from ethyl phenylglyoxylate with good yield and excellent selectivity. Aside from trifluoromethyl ketones derived N-triftosylhydrazones, those derived from aromatic aldehydes performed well to afford desired 1,2-diaryl cyclopropanes 65–67 in moderate diastereoselectivities. To demonstrate the robustness and scalability of this protocol, we performed a 10.0 mmol scale transformation to prepare cyclopropane 46 without lowering the yield or diastereoselectivity of the reaction (Fig. 2c). The relative configuration of 46 was confirmed with X-ray crystallography.

Given the importance of trifluoromethylcyclopropane motifs in bioactive molecules, epoxides derived from natural products and drugs were synthesized to showcase the versatility of the protocol (Fig. 3). Under standard conditions, epoxides derived from cocal, fenbufen, zingerone, nabumetone, and fenofibrate readily transformed into corresponding trifluoromethylcyclopropane products 68–72 in moderate to high yield and diastereoselectivities. Similarly, the trifluoromethylcyclopropane functionality could be successfully installed onto the sulfonamide anti-gout drug probenecid 73 (63% yield and 17:1 d.r.). We attempted to use allose-derived epoxides as substrates for the reaction because the steric hindrance of the trisubstituted olefin intermediates prevented further conversion of cyclopropane. The derivatives of scopolamine, due to their alkalinity, result in catalyst deactivation and failure to obtain the corresponding cyclopropane product (For details, please see Supplementary Fig. 1b). The anti-gout drug probenecid was used to treat severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection49,50. Moreover, N-triftosylhydrazones derived from bioactive natural products (e.g., citronellol, cholesterol, and DL-menthol) and nonsteroidal anti-inflammatory drugs (e.g., indometacin and ibuprofen) effectively underwent this oxygen-carbon exchange reaction to afford cyclopropane products 74–78 in high yields with excellent stereocontrol.

Fig. 3. Late-stage skeletal editing to access trifluoromethylcyclopropane containing quaternary carbon centers.

Fig. 3

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a, b Scope of epoxides derived from natural products and drugs. c Scope of N-triftosylhydrazones derived from natural products and drugs. Reaction conditions: a1 (0.15 mmol, 1.0 equiv.), 2d (0.6 mmol, 4.0 equiv.), NaH (0.68 mmol, 4.5 equiv.) and TpBr3Ag(thf) (10 mol%) in DCM (4.0 mL) at 60 °C for 2–10 h. b1b (0.15 mmol, 1.0 equiv.), 2 (0.38 mmol, 2.5 equiv.), NaH (0.38 mmol, 2.5 equiv.) and TpBr3Ag(thf) (5 mol%) in DCM (4.0 mL) at 60 °C for 2 h. Yields of the isolated product are given. Diastereomeric ratio (d.r.) determination by relative integration of 19F NMR spectra.

Mechanistic investigations

We next conducted control experiments to gain some insights into the reaction mechanism (Fig. 4a). First, subjecting (2,3-epoxypropyl)-benzene or styrene oxide to standard conditions without N-triftosylhydrazones leads to no reaction and recovered epoxides in quantitative yields (Fig. 4a, eq. i), indicating the high stability of epoxides in basic conditions and N-triftosylhydrazone is necessary for deoxygenation process. However, the model reaction in the presence of N-triftosylhydrazones, both (2,3-epoxypropyl)-benzene and styrene oxide disappeared within 5 mins and produced olefin intermediate and cyclopropane, suggesting that the in situ-generated silver carbene may induce this sequential deoxygenation and cycloaddition process. When the reaction lasted for 30 mins, (2,3-epoxypropyl)-benzene produced allylbenzene (30%) along with the expected cyclopropane product 3 (68%), whereas styrene oxide gave the cyclopropane product 46 in 78% yield (Fig. 4a, eq. ii and iii), owing to the higher reactivity of aryl olefins toward cyclopropanation than alkyl olefins. After 6 hours of reaction, allylbenzene was completely consumed and converted to cyclopropane product 3 (92%, d.r. = 10:1) (Fig. 4a, eq. ii). Based on the control experiments, we proposed a reasonable deoxygenation and cycloaddition mechanism in Fig. 4b.

Fig. 4. Mechanism investigation.

Fig. 4

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a Control experiments. b Proposed mechanism. c Computed fragmentation/[2 + 1] cycloaddition mechanism. Energies are given in kcal mol−1 and most H atoms in 3D structures are omitted for clarity.

To gain a better understanding of the reaction mechanism and the specific interactions responsible for the experimentally observed stereoselectivity, we performed systematic density functional theory (DFT) calculations for the reaction between trifluoromethyl phenyl diazomethane 2a’ and (2,3-epoxypropyl)-benzene at the B3LYP/6-31 G(d,p)-GD3(BJ)-SDD (Ag,Br) level using PCM (CH2Cl2) solvent model. The calculations indicated that the most favorable pathway was net oxygen-carbon exchange via cycloaddition of the in situ generated olefin from deoxygenation of epoxides with excess silver carbene. Figure 4c depicts the calculated free energy profiles for the catalytic cycle. First, the dinitrogen extrusion from 2a’ occurs in the presence of an Ag catalyst via the transition state TS1’ (∆G≠ = 8.6 kcal mol−1) to form an electrophilic silver carbene Int1 (For details, please see Supplementary Fig. 2a). Then the Int1 either binds to (2,3-epoxypropyl)-benzene 1a to form Int2 (TS1, ∆G≠ = 1.3 kcal mol−1) or reacts with excess 2a’ to provide the Pr’ via TS4 (∆G≠ = 4.7 kcal mol−1) (For details, please see Supplementary Fig. 2b), which is consistent with the experimental results. However, the calculations suggest that the formation of Int2 is preferable due to the low energy barrier required. As a result, Int2 readily undergoes intramolecular ring-opening isomerization via TS2 (∆G≠ = 2.9 kcal mol−1) to form trifluoromethyl acetophenone 3a and allylbenzene Int3. Finally, the concerted [2 + 1] cycloaddition of Int3 with the excess silver carbene Int1 yields the cyclopropane product 3-syn (∆G≠ = 4.7 kcal mol−1) and 3-anti (∆G≠ = 1.0 kcal mol−1). Note that competitive allylic C–H bond insertion might occur to some extent due to the presence of allylic C–H bond51. Our calculations demonstrated that the C–H bond insertion reaction at the allylic position occurs via the three-membered ring transition state formed by Int1 and Int3 (TS5, ∆G≠ = 3.7 kcal mol−1). When compared to the C–H insertion process, the [2 + 1] cycloaddition is both thermodynamically and kinetically favored and thus produces cyclopropane products 3-anti and 3-syn.

The cyclopropane (3-anti and 3-syn) formation transition states TS3 and TS3’ are shown in Fig. 5. According to our calculations, the number of C–H---F hydrogen bonding interactions in TS3’ is more than that of TS3, resulting in a sterically more hindered configuration of TS3’ (Fig. 5). The color-filled reduced density gradient (RDG) analysis52,53 for the cyclopropanation process demonstrated that TS3 has a stronger non-covalent interaction of mutual attraction, while a stronger steric hindrance exists in TS3’. Thus, the formation of 3-anti is highly favorable over 3-syn.

Fig. 5. The number of C–H---F hydrogen bonding interactions (left).

Fig. 5

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color-filled reduced density gradient (RDG) isosurface for TS3 and TS3’ (isovalue set to 0.5): (blue) areas of attraction (covalent bonding); (green) vdW interaction; (red) areas of repulsion (steric and ring effects) (right).

Discussion

In summary, we have demonstrated the use of fluoroalkyl N-triftosylhydrazones as competent one-carbon atom reagents for the one-step conversion of epoxides to cyclopropanes under mild conditions. The oxygen-carbon exchange method described herein provides rapid access to diverse valuable fluoroalkyl cyclopropanes in high yields and diastereoselectivity and shows good functional group compatibility. This method can be successfully extended to the late-stage functionalization and diversification of pharmaceutically relevant bioactive natural products and drugs. Examination of the reaction mechanism by DFT supports the ylide fragmentation-cycloaddition sequence initiated by fluoroalkyl carbene in an unusual concerted process. This report represents an important example of the emerging concept of “single-atom skeletal editing”.

Methods

General procedure for the synthesis of fluoroalkyl N-triftosylhydrazones

Under air conditions, fluoroalkyl ketone (11 mmol, 1.1 equiv.) and 20.0 mL ethyl acetate were added in an oven-dried 50.0 mL round-bottomed flask and then TfsNHNH2 (10 mmol, 1.0 equiv.) was added and the reaction mixture was stirred at 40 °C. Upon complete dissolution, 2.0 mL of boron trifluoride ether (48 wt% BF3) was added. After complete consumption of the starting material (as evidenced by TLC), saturated sodium chloride solution was added and then extracted with ethyl acetate (20.0 mL × 3). The combined organic layers were dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 10/1) to obtain the product with a white solid.

General procedure oxygen-carbon exchange reaction of alkyl substituted epoxides

In the glove box, N-sulfonylhydrazones derived from aryl trifluoromethyl ketone (0.60 mmol, 4.0 equiv.), NaH (0.68 mmol, 4.5 equiv.), and 4.0 mL of DCM were added to the dry-sealed tube. Then the alkyl-substituted epoxides (0.15 mmol) and TpBr3Ag(thf) (10 mol%) were added under stirring conditions. The resulting mixture was sealed and heated to 60 °C. After the reaction was completed and cooled to room temperature, the reaction mixture was filtered through diatomaceous earth under reduced pressure and the filter pad was washed with DCM (5.0 mL × 3). The combined residue was then concentrated under reduced pressure and the crude residue was purified by flash silica gel column chromatography (petroleum ether as eluent) to give cyclopropanation products.

General procedure oxygen-carbon exchange reaction of aryl-substituted epoxides

In the glove box, N-sulfonylhydrazones derived from aryl trifluoromethyl ketone (0.38 mmol, 2.5 equiv.), NaH (0.38 mmol, 2.5 equiv.), and 4.0 mL of DCM were added to the dry-sealed tube. Then the aryl-substituted epoxides (0.15 mmol) and TpBr3Ag(thf) (2.5–5 mol%) were added under stirring conditions. The resulting mixture was sealed and heated to 60 °C. After the reaction was completed and cooled to room temperature, the reaction mixture was filtered through diatomaceous earth under reduced pressure and the filter pad was washed with DCM (5.0 mL × 3). The combined residue was then concentrated under reduced pressure and the crude residue was purified by flash silica gel column chromatography (petroleum ether as eluent) to give cyclopropanation products.

General procedure oxygen-carbon exchange reaction of N-triftosylhydrazones derived from aryl aldehyde

In the glove box, N-triftosylhydrazones derived from aryl aldehyde (0.45 mmol, 3.0 equiv.), NaH (0.45 mmol, 3.0 equiv.), and 4.0 mL of DCM were added to the dry-sealed tube. Then the aryl-substituted epoxides (0.15 mmol) and TpBr3Ag(thf) (5 mol%) were added under stirring conditions. The resulting mixture was sealed and heated to 60 °C. After the reaction was completed and cooled to room temperature, the reaction mixture was filtered through diatomaceous earth under reduced pressure and the filter pad was washed with DCM (5.0 mL × 3). The combined residue was then concentrated under reduced pressure and the crude residue was purified by flash silica gel column chromatography (petroleum ether as eluent) to give cyclopropanation products.

Supplementary information

Supplementary Information (14.8MB, pdf)
Peer Review File (5.5MB, pdf)
41467_2024_46188_MOESM3_ESM.pdf (70.6KB, pdf)

Description of Additional Supplementary Files

Supplementary Data 1 (979.6KB, xlsx)

Acknowledgements

We acknowledge the National Natural Science Foundation of China (NSFC) (grant No. 22331004 to X.B.) for financial support.

Author contributions

L.L., M.L., Q.Z., S.D., and N.L. performed the experimental investigations and D.W. carried out the theoretical calculations. L.L. and X.B. conceived the concept, designed the project, analyzed the data, and together with E.C., P.S., and G.Z. discussed the results and prepared this manuscript.

Peer review

Peer review information

Nature Communications thanks Shingo Harada and the other anonymous reviewer(s) for their contribution to the peer review of this work. A peer review file is available.

Data availability

The data reported in this paper are available in the main text or the Supplementary Information. The Cartesian coordinates of all optimized structures are available from the Supplementary Data 1. Crystallographic data for the structures reported in this Article have been deposited at the Cambridge Crystallographic Data Centre, under deposition numbers CCDC 2247410 (compound 46), and 2281663 (compound 69). Copies of the data can be obtained free of charge via https://www.ccdc.cam.ac.uk/structures/. All other data are available in the main text or the Supplementary Information. All data are available from the corresponding author upon request.

Competing interests

The authors declare no competing interests.

Footnotes

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

The online version contains supplementary material available at 10.1038/s41467-024-46188-w.

References

  • 1.Marco-Contelles J, Molina MT, Anjum S. Naturally occurring cyclohexane epoxides: sources, biological activities, and synthesis. Chem. Rev. 2004;104:2857–2900. doi: 10.1021/cr980013j. [DOI] [PubMed] [Google Scholar]
  • 2.Zhu Y, Wang Q, Cornwall RG, Shi Y. Organocatalytic asymmetric epoxidation and aziridination of olefins and their synthetic applications. Chem. Rev. 2014;114:8199–8256. doi: 10.1021/cr500064w. [DOI] [PubMed] [Google Scholar]
  • 3.Heravi MM, Lashaki TB, Poorahmad N. Applications of sharpless asymmetric epoxidation in total synthesis. Tetrahedron: Asymmetry. 2015;26:405–495. doi: 10.1016/j.tetasy.2015.03.006. [DOI] [Google Scholar]
  • 4.Lu X-B, Darensbourg DJ. Cobalt catalysts for the coupling of CO2 and epoxides to provide polycarbonates and cyclic carbonates. Chem. Soc. Rev. 2012;41:1462–1484. doi: 10.1039/C1CS15142H. [DOI] [PubMed] [Google Scholar]
  • 5.Klaus S, Lehenmeier MW, Anderson CE, Rieger B. Recent advances in CO2/epoxide copolymerization-new strategies and cooperative mechanisms. Coord. Chem. Rev. 2011;255:1460–1479. doi: 10.1016/j.ccr.2010.12.002. [DOI] [Google Scholar]
  • 6.Bhat GA, Darensbourg DJ. Progress in the catalytic reactions of CO2 and epoxides to selectively provide cyclic or polymeric carbonates. Green. Chem. 2022;24:5007–5034. doi: 10.1039/D2GC01422J. [DOI] [Google Scholar]
  • 7.Remete AM, Kiss L. Synthesis of fluorine-containing molecular entities through fluoride ring opening of oxiranes and aziridines. Eur. J. Org. Chem. 2019;2019:5574–5602. doi: 10.1002/ejoc.201900981. [DOI] [Google Scholar]
  • 8.Delost MD, Smith DT, Anderson BJ, Njardarson JT. From oxiranes to oligomers: architectures of U.S. FDA approved pharmaceuticals containing oxygen heterocycles. J. Med. Chem. 2018;61:10996–11020. doi: 10.1021/acs.jmedchem.8b00876. [DOI] [PubMed] [Google Scholar]
  • 9.Takido T, Kobayashi Y, Itabashi K. A convenient synthesis of thiirans by the use of dimethylthioformamide. Synthesis. 1986;1986:779–780. doi: 10.1055/s-1986-31778. [DOI] [Google Scholar]
  • 10.Chan TH, Finkenbine JR. Facile conversion of oxiranes to thiiranes by phosphine sulfides. scope, stereochemistry, and mechanism. J. Am. Chem. Soc. 1972;94:2880–2882. doi: 10.1021/ja00763a068. [DOI] [Google Scholar]
  • 11.van Tamelen EE. The formation and ring-opening of alkene sulfides. J. Am. Chem. Soc. 1951;73:3444–3448. doi: 10.1021/ja01151a132. [DOI] [Google Scholar]
  • 12.Kleiner CM, Horst L, Würtele C, Wende R, Schreiner PR. Isolation of the key intermediates in the catalyst-free conversion of oxiranes to thiiranes in water at ambient temperature. Org. Biomol. Chem. 2009;7:1397–1403. doi: 10.1039/b820232j. [DOI] [PubMed] [Google Scholar]
  • 13.Mohammadpoor-Baltork I, Khosropour A. Bi(TFA)3 and Bi(OTf)3 catalyzed conversions of epoxides to thiiranes with ammonium thiocyanate and thiourea under non-aqueous conditions. Molecules. 2001;6:996–1000. doi: 10.3390/61200996. [DOI] [Google Scholar]
  • 14.Duan M, et al. Chiral phosphoric acid catalyzed conversion of epoxides into thiiranes: mechanism, stereochemical model, and new catalyst design. Angew. Chem. Int. Ed. 2022;61:e202113204. doi: 10.1002/anie.202113204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15.Liao S, Leutzsch M, Monaco MR, List B. Catalytic enantioselective conversion of epoxides to thiiranes. J. Am. Chem. Soc. 2016;138:5230–5233. doi: 10.1021/jacs.6b01960. [DOI] [PubMed] [Google Scholar]
  • 16.Shahak I, Ittah Y, Blum J. A new one-step synthesis of aziridines from oxiranes. Tetrahedron Lett. 1976;17:4003–4004. doi: 10.1016/S0040-4039(00)92560-7. [DOI] [Google Scholar]
  • 17.Tsuchiya Y, Kumamoto T, Ishikawa T. Guanidines as a nitrogen source for direct conversion of epoxides to aziridines. J. Org. Chem. 2004;69:8504–8505. doi: 10.1021/jo048813j. [DOI] [PubMed] [Google Scholar]
  • 18.Watson IDG, Yudin AK. Ring-opening reactions of nonactivated aziridines catalyzed by tris(pentafluorophenyl)borane. J. Org. Chem. 2003;68:5160–5167. doi: 10.1021/jo0343578. [DOI] [PubMed] [Google Scholar]
  • 19.Géant P-Y, Grenet E, Martínez J, Salom-Roig XJ. Stereoselective divergent synthesis of 1,2-aminoalcohol-containing heterocycles from a common chiral nonracemic building block. Tetrahedron: Asymmetry. 2016;27:22–30. doi: 10.1016/j.tetasy.2015.11.008. [DOI] [Google Scholar]
  • 20.Vaidergorn MM, et al. β-Amino alcohols and their respective 2-phenyl-N-alkyl aziridines as potential DNA minor groove binders. Eur. J. Med. Chem. 2018;157:657–664. doi: 10.1016/j.ejmech.2018.07.055. [DOI] [PubMed] [Google Scholar]
  • 21.Fallah-Mehrjardi M, Kiasat AR, Niknam K. Nucleophilic ring-opening of epoxides: trends in β-substituted alcohols synthesis. J. Iran. Chem. Soc. 2018;15:2033–2081. doi: 10.1007/s13738-018-1400-5. [DOI] [Google Scholar]
  • 22.Kolb HC, Finn MG, Sharpless KB. Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 2001;40:2004–2021. doi: 10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5. [DOI] [PubMed] [Google Scholar]
  • 23.Wang C. Electrophilic ring opening of small heterocycles. Synthesis. 2017;49:5307–5319. doi: 10.1055/s-0036-1589102. [DOI] [Google Scholar]
  • 24.Moser BR, Cermak SC, Doll KM, Kenar JA, Sharma BK. A review of fatty epoxide ring opening reactions: chemistry, recent advances, and applications. J. Am. Oil Chem. Soc. 2022;99:801–842. doi: 10.1002/aocs.12623. [DOI] [Google Scholar]
  • 25.Wadsworth WS, Emmons WD. The utility of phosphonate carbanions in olefin synthesis. J. Am. Chem. Soc. 1961;83:1733–1738. doi: 10.1021/ja01468a042. [DOI] [Google Scholar]
  • 26.Singh AK, et al. Development of a practical, safe, and high-yielding process for the preparation of enantiomerically pure trans-cyclopropane carboxylic acid. Org. Process Res. Dev. 2002;6:618–620. doi: 10.1021/op0202033. [DOI] [Google Scholar]
  • 27.Delhaye L, Merschaert A, Delbeke P, Briône W. A short and efficient synthesis of (R,R)-2-methylcyclopropanecarboxylic acid. Org. Process Res. Dev. 2007;11:689–692. doi: 10.1021/op060249m. [DOI] [Google Scholar]
  • 28.Bray CD, de Faveri G. Stereocontrolled synthesis of trans-cyclopropyl sulfones from terminal epoxides. J. Org. Chem. 2010;75:4652–4655. doi: 10.1021/jo100844g. [DOI] [PubMed] [Google Scholar]
  • 29.Pieroni M, et al. Rational design, synthesis, and preliminary structure–activity relationships of α-substituted-2-phenylcyclopropane carboxylic acids as inhibitors of Salmonella typhimurium O-acetylserine sulfhydrylase. J. Med. Chem. 2016;59:2567–2578. doi: 10.1021/acs.jmedchem.5b01775. [DOI] [PubMed] [Google Scholar]
  • 30.Denney DB, Vill JJ, Boskin MJ. A new synthesis of cyclopropanecarboxylic acids. J. Am. Chem. Soc. 1962;84:3944–3946. doi: 10.1021/ja00879a028. [DOI] [Google Scholar]
  • 31.Chen X, Gao F, Ning P, Wei Y, Hong K. Facile access to cyclopropylboronates via stereospecific deborylative cyclization: a leaving group-assisted activation of geminal diborons. Angew. Chem. Int. Ed. 2023;62:e202302638. doi: 10.1002/anie.202302638. [DOI] [PubMed] [Google Scholar]
  • 32.Kim G, Kim M, Ryu C, Choi J, Cho SH. Anion-mediated, stereospecific synthesis of secondary and tertiary cyclopropylboronates from chiral epoxides and gem-diborylalkanes. Org. Lett. 2023;25:4130–4134. doi: 10.1021/acs.orglett.3c01395. [DOI] [PubMed] [Google Scholar]
  • 33.Nozaki H, Takaya H, Noyori R. The reaction of ethyl diazoacetate with styrene oxide. Tetrahedron Lett. 1965;6:2563–2567. doi: 10.1016/S0040-4039(00)90208-9. [DOI] [Google Scholar]
  • 34.Nozaki H, Takaya H, Noyori R. Reaction of carbethoxycarbene with 2-phenyloxirane and 2-phenyloxetane. Tetrahedron. 1966;22:3393–3401. doi: 10.1016/S0040-4020(01)92527-X. [DOI] [Google Scholar]
  • 35.Sivaguru P, Bi X. Fluoroalkyl N-sulfonyl hydrazones: an efficient reagent for the synthesis of fluoroalkylated compounds. Sci. China Chem. 2021;64:1614–1629. doi: 10.1007/s11426-021-1052-7. [DOI] [Google Scholar]
  • 36.de Meijere A, et al. (2R,1’S,2’R)- and (2S,1’S,2’R)-3-[2-mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues. Beilstein J. Org. Chem. 2014;10:2844–2857. doi: 10.3762/bjoc.10.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 37.Duncton MAJ, et al. Dibutyl 2-(trifluoromethyl)cyclopropylboronate as a useful (trifluoromethyl)cyclopropyl donor: application to antagonists of TRPV1. Tetrahedron Lett. 2010;51:1009–1011. doi: 10.1016/j.tetlet.2009.12.073. [DOI] [Google Scholar]
  • 38.Bezençon O, et al. Selective T-type calcium channel blocker as a drug candidate for the treatment of generalized epilepsies. J. Med. Chem. 2017;60:9769–9789. doi: 10.1021/acs.jmedchem.7b01236. [DOI] [PubMed] [Google Scholar]
  • 39.Marek I, Simaan S, Masarwa A. Enantiomerically enriched cyclopropene derivatives: versatile building blocks in asymmetric synthesis. Angew. Chem. Int. Ed. 2007;46:7364–7376. doi: 10.1002/anie.200604774. [DOI] [PubMed] [Google Scholar]
  • 40.Bos M, Poisson T, Pannecoucke X, Charette AB, Jubault P. Recent progress toward the synthesis of trifluoromethyl- and difluoromethyl-substituted cyclopropanes. Chem. - A Eur. J. 2017;23:4950–4961. doi: 10.1002/chem.201604564. [DOI] [PubMed] [Google Scholar]
  • 41.Liu G, et al. Discovery and optimization of a highly efficacious class of 5-aryl-2-aminopyridines as FMS-like tyrosine kinase 3 (FLT3) inhibitors. Bioorg. Med. Chem. Lett. 2015;25:3436–3441. doi: 10.1016/j.bmcl.2015.07.023. [DOI] [PubMed] [Google Scholar]
  • 42.Muñoz-Molina JM, Belderrain TR, Pérez PJ. Group 11 tris(pyrazolyl)methane complexes: structural features and catalytic applications. Dalton Trans. 2019;48:10772–10781. doi: 10.1039/C9DT01661A. [DOI] [PubMed] [Google Scholar]
  • 43.Álvarez M, Molina F, Pérez PJ. Carbene-controlled regioselective functionalization of linear alkanes under silver catalysis. J. Am. Chem. Soc. 2022;144:23275–23279. doi: 10.1021/jacs.2c11707. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 44.Rodríguez MR, et al. Intermolecular allene functionalization by silver-nitrene catalysis. J. Am. Chem. Soc. 2020;142:13062–13071. doi: 10.1021/jacs.0c04395. [DOI] [PubMed] [Google Scholar]
  • 45.Liu Z, et al. Site-selective C–H benzylation of alkanes with N-triftosylhydrazones leading to alkyl aromatics. Chem. 2020;6:2110–2124. doi: 10.1016/j.chempr.2020.06.031. [DOI] [Google Scholar]
  • 46.Yang YS, et al. Site-selective C−H allylation of alkanes: facile access to allylic quaternary sp3-carbon centers. Angew. Chem. Int. Ed. 2023;62:e202214519. doi: 10.1002/anie.202214519. [DOI] [PubMed] [Google Scholar]
  • 47.Liu Z, et al. Chemoselective carbene insertion into the N−H bonds of NH3·H2O. Nat. Commun. 2022;13:7649. doi: 10.1038/s41467-022-35394-z. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 48.Li L, et al. Carbodefluorination of fluoroalkyl ketones via a carbene-initiated rearrangement strategy. Nat. Commun. 2022;13:4280. doi: 10.1038/s41467-022-31976-z. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 49.Ehrlich, A. et al. The SARS-CoV-2 transcriptional metabolic signature in lung epithelium. SSRN Electron. J. 10.2139/ssrn.3650499 (2020).
  • 50.Murray J, et al. Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro. Sci. Rep. 2021;11:18085. doi: 10.1038/s41598-021-97658-w. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 51.Vaitla J, Boni YT, Davies HML. Distal allylic/benzylic C−H functionalization of silyl ethers using donor/acceptor rhodium(II) carbenes. Angew. Chem. Int. Ed. 2020;59:7397–7402. doi: 10.1002/anie.201916530. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 52.Johnson ER, et al. Revealing noncovalent interactions. J. Am. Chem. Soc. 2010;132:6498–6506. doi: 10.1021/ja100936w. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 53.Lu T, Chen F. Multiwfn: a multifunctional wavefunction analyzer. J. Comput. Chem. 2012;33:580–592. doi: 10.1002/jcc.22885. [DOI] [PubMed] [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

Supplementary Information (14.8MB, pdf)
Peer Review File (5.5MB, pdf)
41467_2024_46188_MOESM3_ESM.pdf (70.6KB, pdf)

Description of Additional Supplementary Files

Supplementary Data 1 (979.6KB, xlsx)

Data Availability Statement

The data reported in this paper are available in the main text or the Supplementary Information. The Cartesian coordinates of all optimized structures are available from the Supplementary Data 1. Crystallographic data for the structures reported in this Article have been deposited at the Cambridge Crystallographic Data Centre, under deposition numbers CCDC 2247410 (compound 46), and 2281663 (compound 69). Copies of the data can be obtained free of charge via https://www.ccdc.cam.ac.uk/structures/. All other data are available in the main text or the Supplementary Information. All data are available from the corresponding author upon request.

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