Table 2. Ongoing clinical trial registered on the Clinical Trials Registry - India, ClinicalTrials.gov, and Chinese Clinical Trial Register until January 21, 2024, evaluating the safety and/or efficacy of APS for the management of knee osteoarthritis.

Study Identifier	Biologic	Study Phase; Estimated Enrollment (N)	Primary Outcome Measure(s)	Recruitment Status	Study Location(s)
NCT03182374	APS vs. hylauronic acid	Not applicable; N=246	Comparing autologous protein solution (APS) with hyaluronic acid (HA) intra-articular injections - Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) LK 3.1 pain score (time frame: 12 months).	Unknown	Belgium, Denmark, Germany, Italy, Netherlands, Norway, Spain, Switzerland, Turkey, United Kingdom