Figure 1.

The workflow of the entire study

Eleven distinct melanoma T_RM signatures reflective of T_RM infiltration have been extracted utilizing multiple independent single-cell RNA-seq data from human melanoma samples. The role of T_RM infiltration in the TIME and the prognosis of the melanoma patients were systematically investigated. A LASSO Cox regression prognostic model for survival was developed and tested against the TCGA dataset and independently validated across multiple melanoma cohorts. The effects of the T_RM infiltration on melanoma patient TIME were also investigated. Figure created with BioRender.com.