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. Author manuscript; available in PMC: 2024 Aug 7.
Published in final edited form as: Nature. 2024 Feb 7;626(8000):799–807. doi: 10.1038/s41586-024-07022-x

Fig. 2. CAD genes converge on 5 programs in endothelial cells.

Fig. 2.

a. Path to the convergence of 5 V2G2P programs and 41 V2G2P genes for coronary artery disease.

b. Identification of V2G2P programs for CAD. The 50 programs are ordered (y-axis) by the number of program genes linked to CAD variants (x-axis). We define the 5 programs with FDR < 0.05 as V2G2P programs. Gray dashed line: the number of genes linked to CAD variants that would be expected by chance.

c. Relationships among the 41 V2G2P genes for CAD and the 5 V2G2P programs. Top: 6 V2G2P genes were regulators of one or more V2G2P programs (FDR < 0.05). Light blue boxes indicate positive regulators (genes where loss-of-function leads to a decrease in program expression); dark blue indicates negative regulators (genes where loss-of-function leads to an increase in program expression). Bottom: 36 V2G2P genes for CAD were co-regulated genes in one or more V2G2P program. Cross hatching indicates members of the 8 gold standard EC CAD genes, previously known to affect CAD risk through effects in ECs (Supplementary Table 16).