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. 2023 Dec 28;149(11):860–884. doi: 10.1161/CIRCULATIONAHA.123.065517

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© 2023 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 2. — Integrated proteome/interactome analysis indicates broad remodeling of kidney metabolite transport by SGLT2i. A, Volcano plot quantification of proteomics analysis of kidney cortex. Overlapping significant proteins (false discovery rate <0.05) between wild-type (WT) and Akita mice upon SGLT2i (sodium-glucose cotransporter 2 inhibitor) treatment are labeled with their gene name. B, Enrichment of Gene Ontology Biological Process (GOBP) terms in WT kidney cortex (kidney cortex proteome was used as background). C, Nephron localization of altered transmembrane transporters of the solute carrier group (SLC). D, Mass spectrometry–based interactome analysis of mouse SGLT2i. SGLT2 interacts with membrane transporters that mediate the reabsorption or secretion of sodium, amino acids, urate, protons, anions, and multiple other compounds. E, Human tissue atlas of selected putative human SGLT2 interactors (source: The Human Proteome Atlas; https://www.proteinatlas.org).