Extended Data Table 2 |.

Neuropsychological battery

DOMAIN	MEASURE	COMPONENT TASKS/SUBTESTS
Overall cognition	Mini Mental State Exam (MMSE)	Global cognition
Intelligence	Hopkins Adult Reading Test	Estimates of premorbid intelligence
Attention	WAIS – Digit Span	Simple aural attention and working memory
Cognitive speed	WAIS – Digit Symbol Substitution Test	Timed coding
Language	Verbal Fluency	Timed letter-cued and category-cued word generation
	Boston Naming Test – 30	Confrontation naming
Episodic memory	Free and Cued Selective Reminding Test Immediate and delayed recall	Episodic memory
Verbal memory	Hopkins Verbal Learning Test-Revised WMS Logical Memory	Verbal list learning, recall, and recognition Learning, recall, and recognition of stories
Visual memory	Brief Visual Memory Test – Revised	Learning and recall of simple geometric figures
Executive function	Trail Making Test (A & B)	Visual sequencing and mental flexibility
Mood	Geriatric Depression Scale	Self-report measures of depression in adults >50
Disease staging	Clinical Dementia Rating Scale	Semi-structured interview designed to assess domains of cognitive and functional performance