Saturday, February 3, 2024
Poster Session 1
1:00 p.m.—3:00 p.m.
Marquis Ballroom
S1. Effects of Chronic Stress on Selective Attention to Auditory Stimuli With Background Noise in Humans
Felipe Munoz*1, Pablo Moya2, Jean-Gabriel Minonzio3, Paulo Barraza4, Gonzalo Terreros5
1Universidad de Valparaíso, 2Centro Interdisciplinario de Neurociencia de Valparaíso, Instituto de Fisiología, Universidad de Valparaíso 3Centro de Investigación y Desarrollo en Ingeniería en Salud, Universidad de Valparaíso, 4Center for Advanced Research in Education (CIAE), Institute for Advanced Studies in Education (IE), University of Chile, 5Instituto de Ciencias de La Salud, Universidad de O’Higgins
S2. Neurofeedback Training of Auditory Spatial Attention Changes Oscillatory Activity of Parietal Cortex
Hwan Shim*1, Akira Takeuchi1, Inyong Choi2, Sungyoung Kim1
1 Rochester Institute of Technology, 2 University of Iowa
S3. Self-Vocalizations Evoke Neural Activity in the Auditory Cortex of Neonatal Mice
Didhiti Mukherjee*1, Chih-Ting Chen1, Patrick O. Kanold1
1 Johns Hopkins University
S4. Auditory Cortical Coding of Task-Relevant Variables During Active Listening
Nathan Schneider1, Michael Malina2, Rebecca Krall1, Ross Williamson*1
1 University of Pittsburgh, 2 Carnegie-Mellon University
S5. In-Vivo Holographic Stimulation Reveals Functionally Interacting Subnetworks in the Auditory Cortex
HiJee Kang*1, Travis Babola1, Patrick Kanold1
1 Johns Hopkins University
S6. Unsupervised Analysis of Attention Level-Dependent Temporal Coherence Processing Reveals Auditory Cortical Specializations for Acoustic and Cognitive Coding
Kunpeng Yu*1, Hemant Kumar Srivastava1, Justin Fine1, Ben Hayden1, Kit Jaspe1, Nikolas A. Scarcelli1, Hong Jiang1, Matthew J. McGinley1
1 Baylor College of Medicine
S7. Auditory Cortex Processing of Vocalizations in Natural Bouts
Estelle in 't Zandt*1, Dan Sanes1
1 New York University
S8. Probing AMPA Receptors Activity at Ribbon Synapses in the Mammalian Cochlea by Glutamate Uncaging
Juan Goutman*1, Mona Jawad2, James Huettner2, Mark Rutherford2
1 INGEBI (CONICET), 2 Washington University in St. Louis
S9. Cx30 (GJB6) is Required for Neural Development and Distribution in the Cochlea
Liman Liu*1, Tian-Ying Zhai1, Yang Yang1, Yi-Ding Yu1, Yong Kong2, Hong-Bo Zhao1
1 Yale University Medical School, 2 Yale School of Public Health
S10. Inferred Neural Deficits Associated With Difficult Word-Recognition Tasks are Consistent With a Preferential Loss of Low- And Medium-SR Fibers in Normal-Hearing Subjects
Viacheslav Vasilkov*1, M. Charles Liberman1, Stéphane F. Maison1
1 Harvard Medical School / Mass Eye and Ear
S11. Peripheral Speech Encoding Mechanisms: Comparative Analysis Between Simulations and Human and Gerbil Empirical Measures
Morgan Thienpont*1, Marjoleen Wouters2, Francois Deloche2, Daniil Kiselev3, Xavier Dubernard4, Arthur Seidermann4, Jean Luc Puel5, Jerome Bourien3, Etienne Gaudrain6, Sarah Verhulst2
1Ugent, 2Ghent University, 3Institute for Neurosciences Montpellier, University of Montpellier, Institut National de la Santé et de la Recherche Médicale, 4University Hospital of Reims, 5INSERM U 1051, 6CNRS
S12. Neural Response Recovery Despite Persistent Synapse Loss in the Noise-Exposed Gerbil: Characterization in Ears With and Without Hair Cell Loss
Penelope Jeffers*1, Jerome Bourien2, Artem Diuba2, Kenneth E. Hancock3, Jean-Luc Puel2, Sharon G. Kujawa4
1Harvard University, 2Institute for Neurosciences Montpellier, University of Montpellier, Institut National de la Santé et de la Recherche Médicale, 3Eaton-Peabody Laboratories, Massachusetts Eye and Ear, 4Eaton-Peabody Laboratories, Massachusetts Eye and Ear; Harvard Medical School; Speech and Hearing Bioscience and Technology, Harvard University
S13. Differential Proteomics Analyses of the Young and Aging Auditory and Vestibular Neurons
Ebenezer Yamoah1, Liao Yen-Chen2, Jeong Han Lee1, Maria C. Lisa M. Bramer2, Sarah M. Williams2, Pasa-Tolic Ljiiljana2, Jeong Han Lee*3
1University of Nevada School of Medicine, 2Pacific Northwest National Laboratory, 3Physiology and Cell Biology, School of Medicine, University of Nevada, Reno
S14. Hyperpolarization-Activated Cation Channels Confer Tonotopic Specializations in the Cochlear Nucleus
Kwame Owusu-Nyantakyi*1, Lashaka Hamlette1, Stefan Oline1, Paul Asadourian1, R. Michael Burger1
1 Lehigh University
S15. Characteristics of Suprathreshold Parallel Auditory Brainstem Responses (pABR)
Isabel Herb*1, Melissa Polonenko1
1 University of Minnesota
S16. Neuropeptide Y mRNA Has Altered Expression With Age in the Inferior Colliculus in Fischer Brown Norway Rats
Laila Almassri*1, Kristen Crane2, Sean Hergenrother1, Milena Iafrate1, Nick Tokar1, Andrew Ohl1, Jeffrey Mellott1
1NEOMED, 2Akron University, NEOMED
S17. Effects of Noise-Induced Hearing Loss on Dorsal Cochlear Nucleus Neurons in Late Adolescent NF107:Ai32 Mice
Paul Manis*1, Michael Kasten2, Reginald Edwards2, Tessa-Jonne Ropp3, Kendall Hutson2
1UNC Chapel Hill, Otolaryngology-Head and Neck Surgery, 2University of North Carolina—Chapel Hill, 3UNC Chapel Hill, Otolaryngology-Head and Neck Surgery and Neuroscience Center
S18. Glutamatergic Pathway-Specific Loss-Of-Function of mGluR5 Disrupts the Development of Synaptic Excitatory Transmission Onto Mouse MNTB Neurons
Huimei Wang*1, Yong Lu2
1Northeast Ohio Medica University, 2Northeast Ohio Medical University
Supported by NIH R56DC016054
S19. Age-Dependent Characterization of Fusiform Cells
Reginald Edwards*1, Michael Kasten2, Kendall Hutson2, Paul Manis2
1UNC Chapel Hill, 2UNC Chapel Hill, Otolarygology-Head and Neck Surgery
S20. Three-Dimensional Imaging of Granule Cell Regions in Cochlear Nucleus of NF107:Ai32 Mice
Kendall A. Hutson*1, Michael R. Kasten1, Reginald J. Edwards1, Paul B. Manis1
1 University of North Carolina
S21. Influences of Sensory-Motor and Predictive Mechanisms on the Frequency Following Response (FFR): Listening While Playing the Organ
Isabelle Arseneau-Bruneau*1, Marcel Farres Franch1, Lucy Core1, Amy Li1, Emily Chen1, Emily Issa2, Alexandre Payoma3, Nayemur Rahman2, Sebastian Kolde1, Martha Liu1, Patrick Bermudez4, Fernando Llanos5, Emily B.J. Coffey3, Robert J. Zatorre1
1Montreal Neurological Institute—McGill University, 2Dawson College, 3Concordia University, 4Canadian Open Neuroscience Platform, 5University of Texas at Austin
S22. Compartmental-Specific CD47 and Microglial SIRP-ɒ Expression in the Developing Lateral Cortex of the Inferior Colliculus
Maddie Book*1, Sophie Khadr1, Sophia Lindauer1, Mark Gabriele1
1 James Madison University
S23. Cholinergic Excitation and Inhibition of NPY Neurons in the Inferior Colliculus
Elie Huez*1, Marina Silveira1, Michael Roberts1
1 University of Michigan, Kresge Hearing Research Institute
S24. Altered Predictive Processing in the Inferior Colliculus of a Rat Model of Autism
Sara Cacciato Salcedo*1, Ana Belén Lao-Rodriguez1, Manuel Sánchez Malmierca1
1 Cognitive and Auditory Neuroscience Laboratory (CANELAB), Institute of Neuroscience of Castilla y León (INCYL), University of Salamanca
S25. Subcortical Plasticity During Auditory Perceptual Learning
Rose Ying*1, Daniel Stolzberg2, Melissa Caras3
1University of Maryland—College Park, 2Otolith Labs, Inc., 3University of Maryland
S26. Probing Correlations between Different Types of Feature Selectivity in Inferior Colliculus of Awake Rabbit
Chenyang Li1, Kylie E. Roloson1, Swapna Agarwalla1, Daniel R. Guest1, Laurel H. Carney1, Chenyang Li*1
1 University of Rochester
S27. Investigating Potential Sources of Modulation Enhancement in Noise Through Physiologically Recorded and Model Neural Responses
Afagh Farhadi*1, Madhurima Patra1, Andrew Sivaprakasam1, Michael Heinz1
1 Purdue University
S28. Micro-Goldwire Electrode for Neural Signal Recording
Jordan Villa*1, Joaquin Cury1, Xiaodong Tan1, Claus-Peter Richter2
1Feinberg School of Medicine, Northwestern University, 2Northwestern University Medical School
S29. Effects of Auditory Learning on the Activity of Parvalbumin-Positive (PV +) Interneurons and Perineuronal Nets in the Auditory Cortex
Jessica Winne*1, Melissa L. Caras2
1University of Maryland, 2University of Maryland—College Park
S30. A Multimodal Convolutional Neural Network Reveals Position-Dependent Changes in Single-Neuron Representations of Natural Sounds during Free-Movement.
Jereme Wingert1, Brad Buran1, Stephen David*1
1 Oregon Health and Science University
S31. Murine GRXCR1 Has a Different Function Than GRXCR2 in the Morphogenesis of Stereocilia
Chang Liu*1, Bo Zhao1
1 Indiana University School of Medicine
S32. Ultrasonic Characteristics of Prestin Complex Nonlinear Capacitance (cNLC) in the Mouse: Mutation and Molecular Dynamics (MD)
Joseph Santos-Sacchi*1, Jun-Ping Bai1, Chenou Zhang2, Dominik Oliver3, Oliver Beckstein2, Dhasakumar Navaratnam1
1Yale University School of Medicine, 2Arizona State University, 3Marburg University
S33. Natural History of Vestibular Dysfunction in Mice With Mutations in Tmc1, Tmc2 and Tmie
Caroline Sit1, Zelma Iriarte1, Tianwen Chen1, Youguo Xu1, Meghan Patel2, Jeffrey Holt3, Gwenaelle Geleoc3, Hong Zhu1, Wu Zhou*1
1University of Mississippi Medical Center, 2School of Medicine, University of Mississippi Medical Center, 3Boston Children's Hospital, Harvard Medical School
S34. G-a Interacting Protein, C-terminus 3 (GIPC3) Regulates Vesicular Trafficking in Mammalian Auditory Hair Cells
Abigail Dragich*1, Savita Sharma1, Shadan Hadi1, Craig Vander Kooi2, Gregory Frolenkov1
1University of Kentucky, 2University of Florida, College of Medicine
S35. Does Chronic TRPA1 Deficiency Affect Auditory Hair Cell Ribbons?
Ava M. Kruse1, Doris Susana Llanes-Coronel1, D. Ysabella Calderon-Briceño1, A. Catalina Velez-Ortega1, Ava Kruse*1
1 University of Kentucky
S36. Integrating Experiments, AlphaFold2 Predictions, and Simulations to Investigate Inner-Ear Tip Links
Carter Wheat1, Elakkiya Tamilselvan1, Qurat Ashraf1, Yoshie Narui1, Jasanvir Sandhu1, Pedro De-la-Torre1, Joseph Sudar1, Travis Harrison-Rawn1, Marissa Boyer1, Daisy Alvarado1, Marcos Sotomayor*1
1 The Ohio State University
S37. Identification of a Novel Otoferlin Isoform and Its Role in Auditory Function
Huihui Liu*1, Hongchao Liu1, Cai Ruijie1, Lei Song1, Hao Wu1
1 Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
S38. The Transmembrane Channel 1 (TMC1) Interacts With the Piezo1 Mechano-Sensitive Channel and Function
Ebenezer Yamoah*1, Pauline Trinh2, Seojin Park1, Maria C. Perez-Flores1, Xiao-Dong Zhang2, Nipavan Chiamvimonvat2
1University of Nevada School of Medicine, 2University of California
S39. Intracochlear Morphology Quantified: Considerations for Cochlear Implant Surgery
Ashley Micuda*1, Sumit Agrawal1, Hanif Ladak1
1 Western University
S40. Effects of Acoustic Crossover Between Ears on ABR Thresholds and Waveform in Mice (Mus Musculus)
Luke Shaheen1, Quynh-Anh Fucci1, Joseph Goodliffe1, Kasey Jackson1, Yoojin Chung*1
1 Regeneron Pharmaceuticals
S41. Estimating Human Cochlear Health in Situ From the Basal High-Frequency Region With High Spatial Resolution Optical Coherence Tomography (OCT)
Paul Secchia*1, Nam Hyun Cho1, Christopher McHugh2, Jingxin Jessica Feng3, Sunil Puria1, Hideko Heidi Nakajima1
1Harvard Medical School, Mass. Eye and Ear Infirmary, 2Massachusetts Eye and Ear Infirmary, 3Smith College, Mass Eye and Ear Infirmary
S42. Single-Cell Analysis and Fate Mapping Studies Reveal Strong Heterogeneity of Cochlear Macrophages
Aude Chiot*1, Max Felgner2, Dillon Brownell1, Katherine H. Rott1, Alina Bogachuk1, Dennis-Dominik Rosmus3, Takahiro Masuda4, Audrey Ching5, Patrick J. Atkinson5, Marco Prinz6, Karen Sachs7, Alan G. Cheng5, Peter Wieghofer3, Bahareh Ajami1
1OHSU, 2Leipzig University, 3University of Augsburg, 4Kyushu University, 5Stanford University, 6University of Freiburg, 7Next Generation Analytics
S43. Cochlear Aqueduct Post-Natal Growth in Human: A Computed Tomography Study
Maha Abbas1, Nicolas Leboucq1, Jing Wang2, Michel Mondain1, Fabian Blanc*3
1Gui de Chauliac Hospital, CHRU Montpellier – Centre Hospitalier Régional Universitaire, Université de Montpellier, 2Institute for Neurosciences of Montpellier, INSERM U1298, 3Institute for Neurosciences of Montpellier (INM), University Montpellier, INSERM U1298
S44. Bmi1-Regulated Genome-Wide H3K27me3 Modification Pattern Modulates Auditory Sensory Epithelial Cell Proliferation and Cell Death in the Mouse Inner Ear
Xiaoling Lu*1, Kunkun Wang1, Yunzhong Zhang1, Liping Zhao1, Huiqian Yu1, Huawei Li1, Shan Sun1
1 Eye and ENT Hospital, Fudan University
S45. Aminoglycoside Triggers the Translocation of RIPOR2 and Phosphatidylserine Externalization by Different Mechanisms
Jinan Li*1, Bo Zhao1
1 Indiana University School of Medicine
S46. A Hybrid Fem and Experimental Study on the Relation Between Temporal Bone 3D Motion and Intracochlear Pressure Under Bone Conduction
Ivo Dobrev*1, Jongwoo Lim2, Flurin Pfiffner1, Christof Röösli1, Namkeun Kim3
1Head and Neck Surgery, University Hospital Zurich, University of Zurich, 2Korea Advanced Institute of Science and Technology, 3Sogang University
S47. Pou3f4 is Necessary for Normal Patterns of Cochlear Spontaneous Activity and IGF Signaling During Development
Yifan Zhou*1, Paige Brooks1, Kevin Rose2, Ronna Hertzano2, Thomas Coate1
1Georgetown University, 2NIDCD
S48. Single-AAV Packaged RNA Base Editor Cures Hearing Loss Induced by OTOF Gene Mutation
Yong Tao*1, Yuanyuan Xue2, Xueling Wang1, Hui Yang2, Hao Wu1
1Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 2HuidaGene Therapeutics Co., Ltd.
S49. Upregulation of Atoh1 by Crispr Activation Promotes Vestibular Hair Cell Regeneration and Function Recovery in Mice
Yong Tao*1, Chenxi Jin1, Hao Wu1
1 Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
S50. Mini-PCDH15b Gene Therapy Rescues Visual Deficits in a Zebrafish Model of Usher Syndrome Type 1F
Maryna Ivanchenko*1, Alex J Klein1, Daniel M Hathaway1, Xinlan Chen1, Jennifer B Phillips2, Kevin T Booth1, Corey Goldstein1, Andrew R Murphy1, Jeremy Wegner2, Artur Indzhykulian3, Sean G Megason1, Monte Westerfield2, David Corey1
1Harvard Medical School, 2Institute of Neuroscience, University of Oregon, 3Harvard Medical School / MEEI
S51. Preclinical Evaluation of the Efficacy and Safety of AAV1-HOTOF in Mice and Non-Human Primates
Longlong Zhang*1, Wang Hui2, Xun Mengzhao2, Tang Honghai2, Jinghan Wang3, Jun Lv1, Biyun Zhu4, Yuxin Chen1, Daqi Wang1, Hu Shaowei2, Ziwen Gao1, Jianping Liu1, Zheng-Yi Chen5, Bing Chen1, Huawei Li4, Yilai Shu3
1Eye and ENT Hospital of Fudan University, 2ENT Institute, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, 3Eye and ENT Hospital, Shanghai Medical College, Fudan University, 4ENT Institute and Otorhinolaryngology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, 5Massachusetts Eye and Ear/Harvard Medical School
S52. CHORD: A Phase 1/2 Open-Label, Multi-Center Trial to Evaluate Intracochlear Administration of DB-OTO Gene Therapy in Pediatric Patients With Profound Sensorineural Hearing Loss Due to Biallelic Otoferlin Mutations
Jeffery Anderson*1, Manohar Bance2, Robert Nash3, Manuel Manrique Rodriguez4, Ruben Polo5, Angel Ramos6, Lawrence Lustig7, Jay Rubinstein8, Akira Ishiyama9, Tera Quigley1, William Riggs1, Eduardo Corrales10, Vassili Valayannopoulos1
1Decibel Therapeutics, 2University of Cambridge, 3Great Ormond Street Hospital, 4Clinica Universidad de Navarra, 5Hospital Universitario Ramon y Cajal, 6Las Palmas University, 7Columbia University Medical Center, 8Seattle Children's Hospital, 9UCLA, 10Brigham and Women's Hospital
S53. Ultrastructure of Noise-Induced Cochlear Synaptopathy
Daniel Moverman1, Leslie Liberman1, Stephan Kraemer2, Gabriel Corfas3, Charles Liberman*4
1Eaton-Peabody Laboratories, Massachusetts Eye and Ear, 2Center for Nanoscale Systems, Harvard College, 3The University of Michigan, Kresge Hearing Research Institute, 4Eaton-Peabody Laboratories, Mass. Eye and Ear
S54. Development of Piezoelectric PVDF Device for Cochlear Implants
Pan Liao*1, Hajime Takano2, Deep Jariwala3, Daqing Li1
1Perelman School of Medicine University of Pennsylvania, 2The Children’s Hospital of Philadelphia, 3University of Pennsylvania
S55. Investigating the Role of Aryl Hydrocarbon Receptor Signaling in Protection and Regeneration of Cochlear Hair Cells
Sujata Pandey*1, Shelley Tischakau1, Brandon Cox1
1 Southern Illinois University School of Medicine
S56. Novel Electrophysiological Marker for Focal Spiral Ganglion Neuron Degeneration
Wiebke Konerding*1, Julie Arenberg2, Andrej Kral1, Peter Baumhoff1
1Hannover Medical School, 2Massachusettes Eye and Ear Infirmary, Eaton Peabody Laboratory
S57. Role of Lipid Mediators in Eosinophilic Otitis Media (EOM)-Associated Sensorineural Hearing Loss: An in Vitro and in Vivo Analysis
Takeshi Fujita*1, Toru Miwa2, Natsumi Uehara1, Mie Kubo1, Jun Yokoi1, Yukako Goto3, Katsumi Doi4, Masakazu Shinohara5, Akinobu Kakigi1, Ken-ichi Nibu1
Kobe University Graduate School of Medicine, 2Osaka Metropolitan University, Konan Medical Center, ISEIKAI International General Hospital, 5Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine
S58. Spatial Distribution and Relationship of PSD95, GluA2 and CtBP2 Puncta and Their Reorganization After Noise-Induced Cochlear Synaptopathy in Mice
Ning Hu*1, Steven Green1
1 University of Iowa
S59. Concussion-Induced Vestibular Peripheral Functional Deficits in Mice
Matthew Donald1, Tianwen Chen2, Caroline Sit2, Zelma Guisela Iriarte2, Youguo Xu2, Wu Zhou2, Hong Zhu*2
1University of Mississippi, School of Medicine, 2University of Mississippi Medical Center
S60. Immune Response in the Spiral Ganglion Following Aminoglycoside-Induced Hair Cell Loss
Adrianna Caro*1, Steven H. Green1
1 University of Iowa
S61. Early Players Involved in Both Cisplatin-Induced Ototoxicity and SENS-401 Protection in Intact Organ Cultures
Selma Dadak1, Anne-Gabrielle Harrus1, Audrey Broussy1, Vincent Descossy1, Laura Gallot1, Arnaud Giese1, Geraldine H. Petit1, Laurent Désiré*1
1 Sensorion
S62. Ubiquitin Protein Ligase NEDD4L is Essential for Hair Cell Maintenance and Hearing Function
Soo min Kim*1, Hyehyun Min1, Heiyeun Koo1, Yujin Choi1, Sung Huhn Kim2, Jinwoong Bok1
BK21 PLUS Project for Medical Science, Yonsei University College of Medicine, 2Yonsei University College of Medicine
S63. Changes in the Auditory Function of C57BL/6 Mice After Irradiation and Pathomory
Jiaqi Pang*1, Yiming Gao2, Yiqing Zheng2
1Sun Yat-sen University, Sun Yat-sen Memorial Hospital, 2Sun Yat-sen Memorial Hospital
S64. Gonadal Hormones Depletion Reduces Auditory Impacts of Lgals3 Knockout in Female Mice
Mengxiao Ye1, Jolie McCutcheon2, Bohua Hu*1
1University at Buffalo, 2Comparative Medicine and Laboratory Animal Facilities, University at Buffalo
S65. Synthesis and Characterization of Hyaluronan-Antioxidant Conjugates as Potential Therapeutics for Noise-Induced Hearing Loss
Elizabeth Arrigali*1, Joachim Veit1, Bhaskar Birru1, Jack Van Tine1, Emma Barrett-Catton1, Kole Sandau1, Zachary Tonnerre1, Philippe Diaz1, Monica Serban1
1 University of Montana
S66. Modulation of Hair Cell Synaptic Elements by Glutamate and Gaba Receptor Ligands
Noel Smith1, Isabella Moreno Stedman*1, Allison Coffin1
1 Washington State University Vancouver
S67. Partial-Reprogramming Contributes to an Anti-Inflammatory Associated Hearing Recovery in Acoustic Trauma
Yizhou Quan*1, Wei Wei1, Camilla Boschian1, Zhengyi Chen1
1 Mass Eye and Ear Infirmary/Harvard Medical School
S68. Cochlear Damage in the Mouse Model of Lassa Virus Infection
Delaney Clark*1, Rebecca Cook2, Junki Maruyama2, Slobodan Paessler2, Tomoko Makishima2
1 John Sealy School of Medicine, University of Texas Medical Branch at Galveston, University of Texas Medical Branch at Galveston
S69. Difference of Nestin Expression by Age After Noise Exposure in Mouse Cochlea
Marie Shimanuki*1, Takanori Nishiyama1, Makoto Hosoya1, Masafumi Ueno1, Hiroyuki Ozawa1, Naoki Oishi1
1 Keio University School of Medicine
S70. Hair Cells Are Preserved in Mice With Severe Hearing Loss Caused by Lassa Virus Infection
Marina Saito*1, Kenneth Egbuji1, Rebecca Cook1, Junki Maruyama1, Slobodan Paessler1, Tomoko Makishima1
1 University of Texas Medical Branch at Galveston
S71. The Potential of Mitochondrially-Targeted Tetrapeptide in Protecting Against Noise-Induced Hearing Impairment
Niranj Kumar1, Kumar Alagramam1, Ruben Stepanyan*1
1 Case Western Reserve University, University Hospitals Cleveland Medical Center
S72. Machine Learning-Driven in Silico Screening Reveals Novel Drug Hits Against Cisplatin-Induced Hearing Loss
Shaikh Emdadur Rahman1, Elizabeth Kara1, Xiaohan Fu1, Matthew Caylor1, Dong Xu1, Shaikh Emdadur Rahman*2
1Idaho State University, 2National Institute of Health
S73. Investigating the Protracted Inner-Ear Proteomic Signatures in Response to Systemic Lipopolysaccharide and Kanamycin
Jonathan Fleegel*1, Marisa Zallocchi1, Prashant Kaushal2, Iman Izzat1, Alex Rahn1, Alyssa Burd1, Nicole Rud1, Sarath Vijayakumar1, Jian Zuo3
1Creighton University School of Medicine, 2University of Nebraska Medical Center, 3Ting Therapeutics LLC
S74. Exploring the Role of Supporting Cells in Inner Hair Cell Survival During Cyclodextrin-Induced Ototoxicity
Dalian Ding1, Bohua Hu*1
1 State University of New York at Buffalo
S75. Mucoadhesive Nanoparticle-Mediated Inner Ear Drug Delivery
Subin Kim1, Seo Young Cheon2, Keum-Jin Yang1, Seong su Won1, Heebeom Koo2, Dong-Kee Kim*1
1College of Medicine, The Catholic University of Korea, 2Catholic Photomedicine Research Institute, College of Medicine, The Catholic University of Korea
S76. Kv7.4 Activator INT002-140 Protects Against Noise-Induced Hearing Loss
Min-A Kim*1, Dong-Woo Kim1, Seungbeom Lee1, Woongbin Kim1, Kyumin Kim2, Jinsei Jung2, Wan Namkung3, Jae Young Choi2, Chongdeok Park1
1iN Therapeutics Inc., Yongin-si, Gyeonggi-do, 2Yonsei University College of Medicine, Seoul, 3Yonsei University College of Pharmacy, Incheon
S77. Congenital Cytomegalovirus Infection: Assessing the Feasibility of Inner Ear Therapy for Hearing Loss Using Mice
Elise De Cuyper*1, Ingeborg Dhooge1, Frederic Acke1
1 Ghent University/Ghent University Hospital
S78. Gelatin Encapsulation Improves the Therapeutic Efficacy of Tetrahedral DNA in Inner Ear Drug Delivery
Xu Ke*1, Xu Baoying2, Yu Dehong2, Chen Yu2, Wang Xueling1
1 Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University 2 Materdicine Lab, School of Life Sciences, Shanghai University
S79. Bio-Responsive Nanoformulation Fabricated to Maintain Inner Ear Homeostasis via Redox and Calcium Ion Channel
Neeraj Thakur1, Iulia Rus1, Vibhuti Agrahari*2
1University of Oklahoma Health Sciences Center, 2University of Oklahoma
S80. Perilymph and Plasma Pharmacokinetics of Ebselen (SPI-1005) After Oral Dosing in Guinea Pig
Rende Gu1, Annie Jia1, G Michael Wall1, Jonathan Kil*1
1 Sound Pharmaceuticals, Inc.
S81. Assessing Factors Influencing the Efficiency of Drug Delivery via the Semicircular Canal
Jinkyung Kim1, Jesus Moldanado1, Samantha Zenteno1, Anthony Ricci*1
1 Stanford University
S82. Transcriptional Analysis of Early Cochlear Development and Proliferation at the Single Cell Level
Susumu Sakamoto*1, Matthew Kelley1
1 NIDCD
S83. Cochlear Deletion of Prox1 Results in Outer Hair Cell Loss and Profound Deafness in Adult Mice
Braulio Peguero*1, Matthew Kelley1
1 NIH/NIDCD
S84. Using Cochlear Explants as a Tool to Examine the Role of Tgfβr1 in the Developing Cochlea
Brianna Walters*1, Braulio Peguero2, Matthew Kelley2
1National Institute of Health, 2NIH/NIDCD
S85. Proper Time of Atoh1 Expression for Hair Cell Subtypes and Function
Wenli Ni1, Wenyan Li*2
1Fudan University, 2The EENT Hospital of Fudan University
S86. The Role of Flippase ATP8A2 in Developing Type II Spiral Ganglion Neurons
Katherine Nimchuk*1, David Lee1, Jung-Bum Shin1
1 University of Virginia
S87. In Vitro Organotypic Explants and Single Cell RNA Sequencing Provide a Novel Comparison Between the Neonatal and Adult Stria Vascularis
Matsya Thulasiram*1, Ryosuke Yamamoto2, Rafal Olszewski3, Shoujun Gu3, Michael Hoa4, Alain Dabdoub5
1University of Toronto, 2Sunnybrook Research Institute, 3Auditory Development and Restoration Program, NIDCD Otolaryngology-Surgeon-Scientist Program, NIDCD Neurotology Branch, Division of Intramural Research, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, 4Auditory Development and Restoration Program, NIDCD Otolaryngology-Surgeon-Scientist Program, NIDCD Neurotology Branch, Division of Intramural Research, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, Georgetown University School of Medicine, 5Sunnybrook Research Institute, University of Toronto
S88. Molecular Diversification of Zebrafish Inner Ear Hair Cells and Afferent Neurons
Selina Baeza-Loya*1, David Raible1
1 University of Washington
S89. Casz1 is Necessary for Cochlear Inner Hair Cell Development by Regulating Gata3 Expression
Yuwei Sun*1, Minhui Ren1, Yu Zhang2, Shunji He1, Guangqin Wang1, Lei Song2, Zhiyong Liu1
1Institute of Neuroscience, Chinese Academy of Sciences, 2Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
S90. Chd7-Sox2 Gene Regulatory Network in Development of the Inner Ear
Jingxia Gao*1, Jennifer Skidmore1, Jelka Cimerman1, Elaine Ritter1, Jingyun Qiu2, Lindsey Wilson3, Yehoash Raphael5, Kelvin Kwan2, Donna Martin1
1University of Michigan, 2Rutgers University, 3Medical Scientist Training Program, University of Michigan, 5Kresge Hearing Research Institute, Michigan Medicine
S91. SOX11 and CHD7 Act in the Same Gene Regulatory Network to Promote Inner Ear Development
Jelka Cimerman*1, Ethan Sperry2, Ronus Hojjati3, Donald L. Swiderski4, Yehoash Raphael4, Ksenia Gnedeva5, Lei Lei6, Donna Martin1
1University of Michigan, 2Medical Scientist Training Program, University of Michigan, 3College of Literature, Science, and the Arts, University of Michigan, 4Kresge Hearing Research Institute, Michigan Medicine, 5Keck School of Medicine, University of Southern California, 6 University of New England
S92. The Function of CaMKIV in Spiral Ganglion Neuron Development
Muthu Malavika Sugumar*1, Zhirong Wang1, Thomas Coate1
1 Georgetown University
S93. Inhibition of Retinoic Acid Signaling Increases Striolar Fate Specification in Inner Ear Organoids
Liqian Liu1, Ranya Dano1, R. Keith Duncan*1
1 University of Michigan
S94. A Type 1 Spiral Ganglion Neuron Subpopulation Originated From WNT1- And SOX10-Positive Cells
Ebenezer Yamoah1, Yingying Chen1, Thomas W. Gould1, Jeong Han Lee1, Seojin Park1, Cristina M. Perez-Flores1, Yingying Chen*2
1University of Nevada School of Medicine, 2Physiology and Cell Biology, School of Medicine, University of Nevada, Reno
S95. Thyroid Hormone Accelerates Hair Cell Maturation in Human Cochlear Organoids
Tsubasa Saeki1, Stephen Moore1, Isabel Aristizabal-Ramirez2, Gregory Frolenkov2, Eri Hashino1, Tsubasa Saeki*1
1Indiana University School of Medicine, 2University of Kentucky
S96. Exploring Tonotopic Gene Isoform Diversity in the Cochlea by Single-Cell Long-Read Sequencing
Sihan Li*1, Natchanon Sittipongpittaya1, Gloria Sheynkman1, Jung-Bum Shin1
1 University of Virginia
S97. Validation of Intercellular Interactions Between Epithelial and Mesenchymal Cells in the Postnatal Mouse Utricle by Single Cell RNAseq and in Situ Hybridization
Sushobhan Biswas*1, Abel David1, Macey Soltis1, Yasmin Eltawil2, Stefan Heller3, Alan Cheng3, Taha Jan1
1Vanderbilt University Medical Center, 2UCSF, 3Stanford University
S98. Open Board
S99. Single-Cell RNA-Sequencing of Stria Vascularis Cell Types in the Slc26a4-/- Mouse
Jin-Young Koh1, Corentin Affortit*1, Ranum T. Paul2, Cody West1, William D. Walls1, Hidekane Yoshimura3, Jian Shao4, Brian Mostaert5, Hela Azaiez1, Richard J.H. Smith1
1University of Iowa Hospitals and Clinics, Molecular Otolaryngology and Renal Laboratories, 2Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia Research Institute, Shinshu University School of Medicine,4Central Microscopy Research Facility, University of Iowa, 5Carver College of Medicine, University of Iowa
S100. Hyperacusis-Behavioral Changes by Cx26 (GJB2) Heterozygous Mutation
Tianying Zhai*1, Liman Liu1, Yiding Yu1, Yang Yang1, Guangdi Chen1, Hong-Bo Zhao1
1 Yale University Medical School
S101. Investigation of the Potential to Reverse Hearing Loss Caused by Whrn Mutations
Daniel R. Pentland*1, Nina Treder2, Shahd Najjar2, Karen P. Steel2
1Wolfson Sensory, Pain and Regeneration Centre, King's College London, 2Wolfson Centre for Age-Related Diseases, King's College London
S102. The Molecular Principles Underlying Diverse Functions of SLC26 Proteins
Satoe Takahashi*1, Kazuaki Homma1
1 Northwestern University Feinberg School of Medicine
S103. Success of Targeted Sequencing in the Search for Genetic Causes of Usher Syndrome Type 2
Dominika Ozieblo*1, Janine Reurink2, Natalia Baldyga1, Henryk Skarzynski3, Hannie Kremer4, Monika Oldak1
1Institute of Physiology and Pathology of Hearing, 2Radboud University Medical Center, 3Oto-Rhino-Laryngology Surgery Clinic, Institute of Physiology and Pathology of Hearing, 4Radboud University Medical Center; Radboud University Medical Center
S104. Identification of Cytotoxic Truncating MYO6 Variants
Haon Futamata*1, Satoe Takahashi2, Osamu Nureki1, Kazuaki Homma2
1The University of Tokyo, 2Northwestern University
S105. Unlocking Insights Into DFNA5 Hearing Disorder Using Inner Ear Organoids
Arun Prabhu Rameshbabu*1, Wenliang Zhu2, Karl Koehler3, Zheng-Yi Chen4
1Eaton-Peabody Lab, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 2Mass. Eye and Ear, 3Boston Children's Hospital/Harvard Medical School, 4Massachusetts Eye and Ear
S106. Cellular and Functional Avian Auditory Regeneration
Mitsuo Sato*1, Nesrine Benkafadar1, Stefan Heller1
1 Stanford University School of Medicine
S107. IP3 and RyR Signaling are Essential and Have Distinct Roles in Regulating Neurite Pathfinding in Response to Micropatterned Growth Cues
Joseph Vecchi*1, Madeline Rhomberg1, Marlan Hansen1
1 University of Iowa Hospitals and Clinics
S108. Comparison of Inner Ear Organoid Derived EVs at Different Developmental Stage
Jiwon Chang*1, Se Hee Lee2, Hee Soo Yoon3, Kang Hyeon Lim3, June Choi3, Gi Jung Im2
1Hallym University College of Medicine, Kangnam Sacred Heart Hospital, 2Korea University Anam Hospital, Korea University College of Medicine, 3Korea University College of Medicine
S109. The Role of Notch, Wnt, Shh and Fgf2 Signalling in the Differentiation of LGR5-Positive Progenitor Cells into Inner Ear Hair Cells
Nathaniel Carpena*1, So-Young Chang1, Seung Chul Ahn2, Ji-Eun Choi3, Jae Yun Jung3, Min Young Lee3
1Beckman Laser Institute Korea, Dankook University, 2Dankook University, 3Dankook University Hospital
S110. RNA-Seq Analysis of Early Transcriptional Genomic Changes of Alzheimer’s Disease in the Auditory System
Yang Yang*1, Li-Man Liu1, Tian-Ying Zhai1, Yi-Ding Yu1, Guang-Di Chen1, Yong Kong2, Hong-Bo Zhao1
1Yale University Medical School, 2Yale School of Public Health
S111. Fhod3 Dysregulation Affects Actin Polymerization in the Cuticular Plate, Leading to Progressive High-Frequency Hearing Loss: Insights Into Age-Related Hearing Decline
Yuzuru Ninoyu*1, Ely Boussaty2, Leo Andrade3, Qingzhong Li4, Ryu Takeya5, Hideki Sumimoto6, Takahiro Ohyama4, Karl Wahlin7, Uri Manor8, Rick Friedman2
1Kyoto Prefectural University of Medicine, 2 University of California San Diego, 3Salk Institute for Biological Studies, 4USC Keck School of Medicine, University of Southern California, 5University of Miyazaki, 6Kyushu University Graduate School of Medical Sciences, 7Shiley Eye Institute, University of California San Diego, 8School of Biological Sciences, University of California San Diego
S112. Neural Oscillatory Responses to Speech-In-Noise in Older Adults With Normal-Hearing, Hearing Loss, and Mild Cognitive Imparement
Ji-Hye Han*1, Jihyun Lee1, Seungik Jeon1, Hyo-Jeong Lee1
1 Hallym University College of Medicine
S113. Investigation of Afferent and Efferent Neuron Systems in Cochlea With Age-Related Hearing Loss Based on Three-Dimensional Imaging
Yiwei Du*1, Dian Jing1, Sidi Liu1, Yawing Cheng1, Lei Song1, Hao Wu1
1 Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
S114. Preventing Age-Related Hearing Loss Using Mitochondrial Function Improving Drugs
Teppei Kouga*1, Toru Miwa2
1Medical Corporation Fujii-kai Ishikiri Seiki Hospital, 2 Metropolitan University
S115. Progressive Changes in Central Gain in the Aging Human Auditory System
Emily Fabrizio-Stover*1, James Dias1, Carolyn McClaskey1, Jeffery Rumschlag1, Kelly Harris1
1 Medical University of South Carolina
S116. Investigating Loss of Pitch Information During Cochlear Implant Stimulation Using Network Modeling
Cynthia Steinhardt*1, Laurence Abbott1
1 Columbia University Center for Theoretical Neuroscience
S117. Computer Simulation of Combined Stimulation of the Cochlear and Vestibular Systems Employing Realistic Human Inner Ear Anatomy and Multi-Compartment Nerve Models
Björn Vey1, Michael Handler1, Daniel Baumgarten*1
1 UMIT TIROL
S118. Charge Threshold, Array Tilt, and Longitudinal Speech Perception in Exceptional Users of the Auditory Brainstem Implant (ABI)
Samantha Shave*1, Sonja Poe1, Barbara S. Herrmann1, Christine Carter1, Daniel J. Lee1
1 Massachusetts Eye and Ear
S119. Acute Focal Micro Lesions Reorganize Tonotopic Profiles Evoked by Cochlear Implant Stimulation
Peter Baumhoff*1, Wiebke Konerding1, Andrej Kral3
1Hannover Medical School, 2Hannover Medical School; DFG Exc 2177 "Hearing 4 All"
S120. All You See is an Electrode? Probing CI Electrode Array Properties for Optimizing Stimulation Parameters of Cochlear Implants
Mit Bhavsar*1, Merle Sehlmeyer2, Stefan Zimmermann2, Hannes Maier3
Hannover Medical School, 2Institute of Electrical Engineering and Measurement Technology, Leibniz University Hannover,3Medical University Hannover
S121. Consequences of the Use of Ramped Pulses in an Animal Model of Cochlear Implants on the Discriminative Abilities of Auditory Cortex Neurons
Elie Partouche1, Victor Adenis2, Pierre Stahl3, Chloe Huetz4, Jean-Marc Edeline*4
1Paris-Saclay Institut of Neurosciences, 2Neuro-PSI, UMR CNRS 9197, 3Oticon Medical/ Neurelec, 4NeuroPSI UMR CNRS 9197
S122. Towards Real-World Benefit With a Cochlear Implant Speech Coding Strategy That Leverages Temporal Masking Effects
Lidea Shahidi*1, Robert Carlyon1, Deborah Vickers1, Tobias Goehring1
1 University of Cambridge
S123. Towards the Optimal Preserving Cochlear Implant Stimulation
Dietmar Basta*1, Susanne Schwitzer1, Moritz Gröschel1, Patrick Boyle2, Arne Ernst1
1University of Berlin, Charité Medical School, 2Advanced Bionics European Research Center, Hannover
S124. The Role of Maximum Output and Necessary Dynamic Range for Active Middle Ear Implants
Hannes Maier*1, Thomas Lenarz2, Susan Busch1
1Medical University Hannover, 2 University Hannover and Cluster of Excellence “Hearing4all”
S125. Characterizing Localization of Stationary and Moving Sound in Children Using Bilateral Bone Conduction Devices and Bilateral Cochlear Implants
Robel Alemu*1, Alan Blakeman1, Sharon Cushing1, Blake Papsin1, Karen Gordon1
1 The Hospital for Sick Children, The University of Toronto
S126. Piston Diameter Influences the Output Efficiency in Oval Window Stimulation
Mohammad Ghoncheh*1, Daniel Schurzig2, David Stauske3, Ricardo Di Micco1, Nils Kristian Prenzler4, Thomas Lenarz4, Hannes Maier4
1Hannover Medical School, 2MED-EL Research Center Hannover, 3Business Unit Vibrant, MED-EL, Innsbruck, 4Hannover Medical School, DFG Cluster of Excellence Hearing4all
S127. Development of a Penetrating Electrode Array for Stimulation of the Auditory Nerve in a Non-Human Primate Model for Translation to Human Patients
Inderbir Sondh*1, Aaron Loveland1, Geoffrey Ghose1, Luke Johnson1, Brenna Knaebe1, Janet Choi1, Moritz Leber2, Joseph Crew3, Florian Solzbacher6, Hubert H. Lim1, Meredith E. Adams1
1University of Minnesota 2Blackrock Neurotech, 3University of Utah, Blackrock Neurotech,
S128. A Novel Prototype: The Hybrid Opto-Electrical Cochlear Implant for Hearing Restoration
Joaquin Cury*1, Matthew Joo-yoon Kim1, Xiaodong Tan1, Claus-Peter Richter1
1 Feinberg School of Medicine, Northwestern University
S129. Middle Ear Ossicular Joint Changes in Type 2 Diabetes Mellitus: A Histopathological Study
Tomotaka Shimura1, Rafael da Costa Monsanto*2, Dilshan Rajan2, Grace Sinae Song3, Nevra Keskin Yilmaz3, Sebahattin Cureoglu2
1University of Minnesota Otopathology Laboratory; Showa University Fujigaoka Hospital, 2The University of Minnesota, 3University of Minnesota Otopathology Laboratory,
S130. Immune Profiling of Secreted Factors From Human Vestibular Schwannoma Cells and Tumor-Associated Macrophages
Konstantina Stankovic1, Shelley Batts1, D. Bradley Welling2, Sasa Vasilijic*1
1Stanford University School of Medicine, 2Harvard
S131. Identification of Immune-Related Candidate Biomarkers in Plasma of Patients With Sporadic Vestibular Schwannoma
Sasa Vasilijic*1, Nadia Altai1, Hiroshi Hyakusoku3, Steven Worthington4, Yin Ren3, Jessica Sagers3, Mehmet Sahin3, Alyssa Brown3, Rohan Reddy5, Charvi Malhotra1, Takeshi Fujita3, Lukas Landegger3, Richard Lewis3, Bradley Welling3, Konstantina Stankovic1
1Stanford University School of Medicine, 2Massachusetts Eye and Ear and Harvard Medical School, 4Harvard Institute for Quantitative Social Science, Harvard University
S132. Changes in the Oral and Nasal Microbiota in Pediatric Obstructive Sleep Apnea
Xiaoman Zhang*1, Xinyi li1, Huajun Xu1, Shankai Yin1
1 Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
S133. Effectiveness of the Botulinum Toxin Injection for Facial Nerve Palsy in an Animal Model
Ji Hyung Lim*1, Young Jun Seo1, Ye Lin Kim1, Jae Sang Han1, So Young Park2, Shi Nae Park1
1Seoul St. Mary's Hospital, The Catholic University of Korea, 2College of Medicine, The Catholic University of Korea
S134. Open Board
S135. Reduced Auditory Thalamo-Cortical Connectivity (Acoustic Radiations) Due to Blast Exposure in Veterans With Auditory Deficits: A Diffusion Tensor Imaging Study
Oren Poliva*1, Christian Herrera Ortiz2, Kelli Sugai3, Nicole Whittle2, Marjorie Leek2, Samuel Barnes4, Barbara Holshouser4, Alex Yi2, Jonathan Venezia2
1VALLHCS, 2VA Loma Linda Healthcare System, 3Loma Linda Veterans Association Healthcare System, 4Loma Linda University
S136. Prestin as a Biomarker for Sensorineural Hearing Loss in Human Perilymph, Cerebrospinal Fluid, and Blood
Anselm Gadenstaetter*1, Paul Krumpoeck1, Alice Auinger1, Erdem Yildiz1, Aldine Tu1, Christian Matula1, Christoph Arnoldner1, Lukas Landegger1
1 Vienna General Hospital, Medical University of Vienna
S137. Effect of Yap Inhibition on Radiation Response in NF2-Mutant Schwann Cells and Primary Vestibular Schwannoma
Matthew Wiefels*1, Olena Bracho1, Mikhail Marasigan1, Cristina Fernandez-Valle2, Christine Dinh1
1Miller School of Medicine, University of Miami, 2Burnett School Biomedical Sciences, College of Medicine, University of Central Florida
S138. Eargenie—A Clinician-Friendly fNIRS System to Evaluate Infant Speech Detection and Discrimination
Gautam Balasubramanian1, Julia Wunderlich2, Darren Mao2, Linty McDonald2, Demi Gao*2, Colette McKay2
1Bionics Institute, 2The Bionics Institute of Australia
S139. Visually Evoked Potentials in Early and Late-Onset Hearing Loss
Siyu Zhu*1, Xiaohan Bao1, Stephen Lomber1
1 McGill University Faculty of Medicine
S140. Influence of Visual Speech Cues on Auditory Brainstem and Cortical Evoked Responses in Normal and Impaired Ears
Aditi Gargeshwari*1, Ananthanarayan Krishnan1
1 Purdue University
S141. Accessibility of Speech Used in Broadcast: Implications for Older Listeners With Hearing Loss
Rebecca Millman*1, Lorenza Zaira Curetti1, Trevor Cox2, Ben Shirley2, Lauren Ward3, Alan Archer-Boyd4, Matthew Paradis4, Michael Stone1
1University of Manchester, 2University of Salford, 3Royal National Institute for the Deaf, 4British Broadcasting Corporation
S142. Cross-Species Investigations of Place and Time Coding of Pitch Using Envelope-Following Responses
Andrew Sivaprakasam*1, Hari Bharadwaj2, Michael Heinz1
1Purdue University, 2University of Pittsburgh
S143. Loudness in the Normal Ear of Single-Sided Deaf Listeners
Nino Di Maio1, Jan van Heteren1, Jeroen Peters1, Ruben van Eijl1, Koenraad Rhebergen1, Huib Versnel*1
1 University Medical Center Utrecht
S144. Evaluation of the Benefits of Replacement Hearing Aids (HAs) and Cochlear Implant (CI) and Hearing Aid in a Bimodal Solution With Hearing in Noise Test (HINT), Pupillometry and the Speech, Spatial and Qualities of Hearing Scale (SSQ12)
Yeliz Jakobsen1, Jesper Hvass Schmidt2, Carl Pedersen3, Yeliz Jakobsen*3
1Research Unit for ORL – Head and Neck Surgery and Audiology, Odense University Hospital; University of Southern Denmark, 2Research Unit for ORL – Head and Neck Surgery and Audiology, Odense University Hospital; University of Southern Denmark, 3University of Southern Denmark
S145. The Noise Outcomes in Service Members Epidemiology Study – a 10-Year Cohort Profile Update
Hannah Famili1, Eduardo Veytia1, Emily Thielman2, Leah Barger1, Sarah Theodoroff2, Kathleen Carlson3, Charlotte Kaplan-Hughes4, Carlos Esquivel5, Kelly Reavis*2
1The Geneva Foundation, 2VA RR and D, National Center for Rehabilitative Auditory Research, 3VA HSR and D, Center to Improve Veteran Involvement in Care, 4Naval Medical Center San Diego, 5DHA, Hearing Center of Excellence
S146. Assessing Physiological Indicators of Subtle Auditory Trauma: ABRs and DPOAEs in Rhesus Macaques at 2 and 8 Months After Noise-Induced Temporary Threshold Shifts With Perceptual Changes
Amy Stahl*1, Swarat Kulkarni1, Aneesh Batchu1, Jane Mondul1, Katy Alek2, Troy A Hackett2, Ramnarayan Ramachandran2
1Vanderbilt University, 2Vanderbilt University Medical Center
S147. The Fudan Tinnitus Relieving System
Dongmei Tang*1, Huawei Li1, Shan Sun1
1 Fudan University, Eye and ENT Hospital
S148. Functional MRI Neurofeedback Versus Cognitive Behavioral Therapy for Reducing Tinnitus Distress: A Prospective Randomized Clinical Trial
Dimitrios Daskalou*1, Nicolas Gninenko2, Stéphanie Trznadel3, Luca Gramatica1, Julie Vanoy1, François Voruz1, Claudia Lardi Robyn1, Anne Spadazzi1, Aude Yulzari3, Ranganatha Sitaram4, Pascal Senn1, Dimitri Van De Ville2, Sven Haller5
1Geneva University Hospitals, 2École Polytechnique Fédérale de Lausanne (EPFL), 3Wyss Center for Bio and Neuroengineering, 4St. Jude Children's Research Hospital, 5Centre d’Imagerie Médicale de Cornavin (CIMC)
S149. Auditory Gating as a Function of Sensation Level
Lauren Ralston*1, Julia Campbell1, Lauren Daniels1
1 The University of Texas at Austin
S150. Neural Adaptation Model of Hyperacusis
Wei Sun*1, Fei Xu1
1 University of Buffalo
S151. Tinnitus Suppression and Enhancement of Cognitive Function Following High Definition tACS Using Cross Frequency Coupling Electrical Currents
Sunmi Ma*1, Nour Alsabbagh2, Sungkwang Hong1
1Hallym University College of Medicine, 2The University of Iowa
S152. The Size Analysis of Stapedius and Tensor Tympani Muscles in CT Scan in Patients With Middle Ear Myoclonic Tinnitus
Gianfranco Velasco*1, Hyun Jae Cho1, Jae Sang Han1, Ji Hyung Lim1, Young Jun Seo1, Jae-Hyun Seo1, Shi Nae Park1
1 Seoul St. Mary's Hospital, The Catholic University of Korea
S153. Applying an Unequal Variance Signal Detection Theory Model to Patient Decisions in the Tinnitus Patient Journey
Alexander Hoetink*1, Sarah Kaldenbach2, Arno Lieftink1, Huib Versnel1, Robert J. Stokroos1, Karin H. Wiefferink2
1University Medical Center Utrecht, 2Dutch Foundation for the Deaf and Hard of Hearing Child (NSDSK)
S154. Cortical Evoked Activity is Modulated by the Sleep State in a Ferret Model of Tinnitus
Linus Milinski1, Fernando R. Nodal1, Matthew K.J. Emmerson1, Andrew J. King1, Vladyslav V. Vyazovskiy1, Victoria Bajo*1
1 University of Oxford
S155. Tinnitus Clinical Research: Challenges with Recruitment, Eligibility, and Symptom Variability
Grace Conchas*1, Yezihalem Mesfin1, Yuan He1, Abigail Heiller1, Ali Stockness1, Meredith Adams1, Peggy Nelson1
1 University of Minnesota
S156. Exploring the Link between Low-Pass Speech in Noise and Tinnitus Distress
Pauline Devolder*1, Hannah Keppler2, Sarineh Keshishzadeh1, Baziel Taghon1, Ingeborg Dhooge2, Sarah Verhulst1
1Hearing Technology @ WAVES, Ghent University, 2Ghent University Hospital
S157. The Role of Ion Channels: From Misfiring to Misfolding
Oskar Markkula*1, Ian Forsythe2, Mihai Stancu1, Conny Kopp-Scheinpflug1
1Ludwig Maximilian University Munich, 2University of Leicester
S158. Effect of Reverberation on Interrupted Spatial Auditory Attention
Victoria Figarola*1, Wusheng Liang1, Christopher Brown2, Abigail Noyce1, Barbara Shinn-Cunningham1
1Carnegie Mellon University, 2University of Pittsburgh
S159. Sound Localization in Bimodal CI Users With Various Device Latencies
Mathias Dietz*1, Alina Kleinow1, Sabine Hochmuth1, Rebecca Felsheim1, Andreas Radeloff1
1 University of Oldenburg
S160. A Signal Detection Theory Model of Binaural Cue Reweighting
Udbhav Singhal*1, Norbert Kopco1
1 P.J. Safarik University, Kosice
S161. Perceptual Spatial Acuity in a 9th Order Ambisonic Array
Nima Zargarnezhad1, Bruno Mesquita*1, Ewan Macpherson1, Ingrid Johnsrude1
1 University of Western Ontario
S162. Differences in Sound Localization in Semi-Fossorial and Lab Reared Animals
Genesis Alarcon*1, Casey Sergott1, Peyton Williams1, Cameron Miller1, Ben-Zheng Li2, Luberson Joseph1, Elizabeth McCullagh1
1Oklahoma State University, 2University of Colorado Anschutz Medical Campus
S163. Characterizing Hearing Ability Using Acoustic Startle Response and Prepulse Inhibition in Prairie Voles (Microtus Ochrogaster)
Andrea Gensky*1, Casey Sergott1, Elizabeth McCullagh1
1 Oklahoma State University
S164. The Influence of Binaural Cues on Auditory Stream Segregation
Nathan Higgins*1, Carrie Secor1, Erol Ozmeral1
1 University of South Florida
S165. Examining Individual Variability in the Acoustic Effects of Hearing Protectors on Cues for Sound Source Localization
Aoi Hunsaker*1, David Audet1, Nathaniel Greene2, Mallory Butler2, Ted Argo3, Andrew Brown1
1University of Washington, 2University of Colorado Anschutz Medical Campus, 3Applied Research Associates, Inc.
S166. Auditory Competition and Coding of Salience Across Midbrain Space Maps of Barn Owls
Andrea Bae*1, Roland Ferger1, Jose Luis Pena1
1 Albert Einstein College of Medicine
S167. Wider Auditory Filters and Greater Overshoot in Children Than Adults for Brief Tones at Noise Onset
Samantha R. Glicken1, Ruijing Ning2, Beverly A. Wright*1
1Northwestern University, 2Linköping University
S168. Eye-Fixation and Speech Perception for Visual and Auditory Words in Age-Related Hearing Loss
Patricia V. Aguiar*1, Brandon T. Paul1
1 Toronto Metropolitan University
S169. Effect of Audiovisual Simultaneity Judgment Training on Speech Understanding and Neural Activity in Cochlear Implant Users
Ansley Kunnath*1, Mark Wallace2, Rene Gifford3
1Vanderbilt University School of Medicine, 2Vanderbilt University, 3Vanderbilt University Medical Center
S170. Effects of Electrical Stimulation Rate in Neuromodulating the Auditory System Through Non Invasive Paired Electrical and Acoustic Stimulation
Abigail Heiller*1, Yuan He1, Azaan Haider1, Hubert Lim1
1 University of Minnesota
S171. Extended High Frequency Thresholds, Evoked and Spontaneous Otoacoustic Emissions, and Medial Olivocochlear Reflex
W. Wiktor Jedrzejczak*1, Krzysztof Kochanek1, Edyta Pilka1, Malgorzata Pastucha1, Henryk Skarzynski1
1 Institute of Physiology and Pathology of Hearing, Warsaw
S172. Expanding the Objective Audiometric Test Battery for Studying Age-Related Hearing Loss and Novel Therapeutic Candidates in Rats
Mathieu Petremann*1, Valentina Kaden-Volynets2, Hubert Löwenheim1, Jonas Dyhrfjeld-Johnsen2
1Translational Hearing Research, University of Tübingen, 2Acousia Therapeutics
S173. Changes in Click Evoked Otoacoustic Emissions Reflect Cochlear Gain Changes That May Underlie Forward Masking
C. Evelyn Feld1, Daniela E. Matute1, Laurel H. Carney*1
1 University of Rochester
S174. Frequency Importance Functions in Simulated Bimodal Hearing
Maddie Arsenault*1, Naomi White1, Carrie Drew1, George Whitaker2, Yang-Soo Yoon1
1Baylor University, 2Baylor Scott and White Medical Center
S175. Spectral Processing in Simulated Electric Acoustic Stimulation Hearing
Naomi White*1, Maddie Arsenault1, Carrie Drew1, George Whitaker2, Yang-Soo Yoon1
1Baylor University, 2Baylor Scott and White Medical Center
S176. Modulation-Domain Psychophysical Tuning Curves Measured in Normal-Hearing and Cochlear-Implant Listeners
Shigeto Furukawa*1, Norishige Hattori1, Aya Matsubara1, Akira Takagi1
1 Shizuoka Graduate University of Public Health
S177. Effects of Salient Interruptions on Auditory Spatial Attention
Wusheng Liang*1, Christopher Brown2, Abigail Noyce1, Barbara Shinn-Cunningham1
1Carnegie Mellon University, 2University of Pittsburgh
S178. A Data-Driven Approach for Rapid Profiling of Loudness Perception
Erik Petersen*1, Stephen T. Neely2, Yi Shen1
1University of Washington, 2Boys Town National Research Hospital
S179. Initial Evaluations of a Rapid Psychophysical Procedure for Estimating Loudness Growth Across a Wide Frequency Range
Yi Shen*1, Erik A. Petersen1, Isabella E. Cunio1, Sara E. Harris2, Stephen T. Neely2
1University of Washington, 2Boys Town National Research Hospital
S180. Acoustic Constraints on Vocal Learning in Songbirds
Rawan Zayter*1, Loughlin Browne1, Moises Rivera1, Jacob Edwards1, Sarah Woolley2
1Columbia University, 2Zuckerman Institute, Columbia University
S181. What Frequency Was That Tone and When Did it Occur? A Pilot Experiment
Emily R. Gibson1, Beverly A. Wright1, Emily Gibson*1
1 Northwestern University
S182. The Effect of Signal Level and Signal-To-Noise Ratio on Adaptation to Noise in Spectral and Temporal Modulation Detection
David López-Ramos*1, Luis E. López-Bascuas2, Almudena Eustaquio-Martin1, Miriam I Marrufo-Pérez1, Enrique Lopez-Poveda1
1University of Salamanca, 2Complutense University of Madrid
S183. The Role of Temporal Coding in Hearing: Evidence From Task Optimization
Mark Saddler*1, Josh McDermott1
1 MIT
S184. Mapping the Timecourse of Adaptation to Noise Statistics During Localisation and Speech Discrimination Tasks
Louay Madanat*1, Maya Khalil1, Jennifer Bizley1
1 UCL
S185. Preferences for Loudness and Pitch Vary Across Cultures
Malinda McPherson*1, Eduardo Undurraga2, Bryan Medina3, Josh McDermott3
1University of California, San Diego, 2Pontificia Universidad Católica de Chile, 3MIT
S186. In Search of a Psychophysical Correlate of Dynamic Range Adaptation in Human Listeners: Intensity Discrimination within a Context
Coline Marché*1, Olivier Macherey1, Sabine Meunier1
1 Aix Marseille Univ, CNRS, Centrale Marseille, LMA UMR 7031
S187. Perception of Global Properties, Objects, and Settings in Natural Auditory Scenes
Margaret McMullin*1, Rohit Kumar2, Nathan Higgins3, Brian Gygi4, Mounya Elhilali2, Joel Snyder1
1University of Nevada, Las Vegas, 2Johns Hopkins University, 3University of South Florida, 4East Bay Institute for Research and Education
S188. Language Background and Attention to Speech in Complex Auditory Scenes
Anna Liu*1, Christina Vanden Bosch der Nederlanden1
1 University of Toronto
S189. Listening Effort and Disengagement During Story Listening
Madison Tutton*1, Björn Herrmann2, Ingrid Johnsrude1
1University of Western Ontario, 2Rotman Research Institute
S190. Using Computational Auditory Models to Explore the Impact of the Efferent System on Speech Coding
Daniel R. Guest*1, Afagh Farhadi2, Laurel H. Carney1
1University of Rochester, 2Purdue University,
S191. Open Board
S192. The Impact of Measurement Time on Speech Perception in Noise Among Morning and Evening Chronotypes
Nitza Horev*1, Hanna Putter-Katz1
1 Ono Academic College
S193. Investigating the Neural Tracking of Speech in Dialogue Listening Scenarios
Emily Ip*1, Aoife Igoe1, Amirhossein Chalehchaleh1, Benjamin Cowan2, Giovanni Di Liberto1
1Trinity College Dublin, 2University College Dublin
S194. Language-Agnosticism of Linguistics Research Tasks: A Feasibility Study for Application in Hearing Assessment
Natalie Riebe1, Tianyi Jia1, Jason Brant1, Jianjing Kuang1, Tiffany Hwa*2
1University of Pennsylvania, 2University of Pennsylvania Health System
S195. The Contribution of Spectrum and Modulation Statistics Towards Speech Recognition in Natural Environmental Noise
Alex Clonan1, Xiu Zhai2, Ian Stevenson1, Monty Escabi*1
1University of Connecticut, 2Wentworth Institute of Technology
S196. Transmission of Acoustic Cues in Vowel Perception and Its Relationship to Spectral Ripple Discrimination in Listeners With Cochlear Implants
Destinee Halverson*1, Olga Peskova2, Anisha Noble2, Mariette Broncheau2, David Horn3
1University of Washington; Virginia Merrill Bloedel Hearing Research Center; Seattle Children's Hospital, 2University of Washington; Virginia Merrill Bloedel Hearing Research Center, 3University of Washington; Virginia Merrill Bloedel Hearing Research Center; Seattle Children's Hospital
S197. Slow Build-Up of the Acoustic Reflex by Contralateral Noise
Jonathan Siegel*1, Jeffrey Wise1, Shayna Lavi1, Danielle Bassett1, Sophia Chan1, Abbie Baricevich1
1 Northwestern University
S198. Measurements of the Quasi-Static and Dynamic Stiffness of the Human Icudo-Malleal Joint
Merlin Schär1, Bastian Baselt2, Alexander Sander1, Alexander Huber1, Jae Hoon Sim*1
1University Hospital Zurich, 2University of Zürich
S199. Open Board
S200. Distinct and Simultaneous Neural Encoding of Speech and Music Expectations During Sung Speech Listening
Giorgia Cantisani*1, Giovanni Di Liberto2, Shihab Shamma3
1Laboratoire des Systémes Perceptifs, DEC, ENS, PSL University, CNRS, 2Trinity College Dublin, 3University of Maryland, College Park
S201. The Long-Term Stability of the Speech-To-Song Illusion and the Effects of Individual Differences
Rodica Constantine*1, Erin Hannon1
1 University of Nevada, Las Vegas
S202. Contribution of Vestibular Hair Cells to Function
Yan Chen1, Wenli Ni1, Wenyan Li*2
1Fudan University, 2The EENT Hospital of Fudan University
S203. Developmental Transcriptomic Profiling of Non-Sensory Vestibular Epithelium Reveals Ionic Contribution to Endolymph Formation
Sanghyun Kwak*1, Seong Hoon Bae2, Heon Yung Gee2, Jinwoong Bok2, Sung Huhn Kim2
1St. Vincents Hospital, The Catholic University of Korea, 2Yonsei University College of Medicine
S204. Sexual Dimorphism in cVEMP Latency
Max Gattie*1, Elena Lieven1, Karolina Kluk-de kort2
1University of Manchester, 2Manchester Centre for Audiology and Deafness
S205. Fast-Phase Nystagmus Enables Precise Evaluation on Vestibular Deficits
Shijie XIAO*1, Tong Zhao1, Fangyi Chen1
1 Southern University of Science and Technology
S206. Hyper-Response of Cervical Vestibular Evoked Myogenic Potential in Patients With Meniere Disease
Minbum Kim*1, Youn Jin Choy1
1 Catholic Kwandong University International St. Mary's Hospital
S207. Accelerated Degeneration in the Aging Utricle of an Alzheimer’s Mouse Model
Debbie Hamilton1, Jarnail Singh1, Bradley Walters2, Brandon Cox*1
1Southern Illinois University School of Medicine, 2University of Mississippi Medical Center
S208. A Finite Element Model of the Human Utricle in Response to Sound and Vibration
Nastaran Gholami*1, Hong Zhu2, Wu Zhou2, Christopher M. Smith3, Richard D. Rabbitt1
1University of Utah, 2University of Mississippi Medical Center, 3American Museum of Natural History
S209. Impact of Impaired Calcium Metabolism on Otolith Development in Zebrafish
Kazuma Sugahara*1, Makoto Hashimoto2, Junko Tsuda2, Mei Sakamoto3, Hiroshi Yamashita1
1Yamaguchi University Graduate School of Medicine, 2Yamaguchi University, 3Yamaguchi Prefectural Grand Medical Center
S210. Characterizing Postnatally Added Hair Cell Bundles in Adult Mouse Utricle
Tian Wang*1, Ahmad Mahmoudi1, Nathan Mohit1, Jun He1, Katharine Miller1, Kimberly Giffen1, Nicolas Grillet1, Alan G. Cheng1
1 Stanford University
S211. Long-Term Effects of Repeated Noise Exposure on the Rat Vestibular Periphery
Dylan Bartikofsky1, David Bauer2, Mikayla Hertz1, Richard Altschuler3, W. Michael King2, Courtney Stewart*1
1VA Ann Arbor Healthcare System, 2University of Michigan, Kresge Hearing Research Institute, 3University of Michigan, Kresge Hearing Research Institute and VA Ann Arbor Healthcare System
S212. Influence of Varying Positions and Orientations of Vestibular Implant Electrode Contacts on Simulated Neural Stimulation Outcome
Michael Handler*1, Björn Vey1, Elke Loos2, Elke Devocht3, Stan van Boxel3, Raymond van de Berg3, Daniel Baumgarten1
1UMIT Tirol, 2Maastricht University Medical Centre, University Hospitals Leuven, 3Maastricht University Medical Centre
S213. Characterizing Human Vestibular Sensory Epithelia from Vestibular Schwannoma Surgeries
Olivia Kalmanson1, Frances Meredith1, Tiffany Vu1, Samuel Gubbels1, Katie Rennie1, Anna Dondzillo*1
1 University of Colorado Anschutz Medical Campus
S214. Body Balance in Isolated Otolithic Vertigo—Differences Between Utricular Disorder and Saccular Disorder
Toru Seo*1, Izumi Koizuka2, Manabu Komori2
1St. Marianna University Yokohama Seibu Hospital, 2St. Marianna University School of Medicine
Symposium 1—Good Data In, Big Data Out
2:00 p.m.—4:00 p.m.
Platinum Salon 5
Good Data In, Big Data Out
Chair: Katharine Fernandez, NIDCD
Co-Chair: Carmen Brewer, National Institute on Deafness and Other Communication Disorders/NIH
Standardization of Threshold and Supra-Threshold Measures in Clinical Trials Assessing Investigational Inner Ear Medicines
Colleen Le Prell
University of Texas at Dallas
The Role of Consistent Clinical Practice Approaches for Data-Informed Hearing Care
Gayla Poling
National Institute on Deafness and Other Communication Disorders
Here Hear Share!
Ronna Hertzano
National Institutes of Health
From Club Good to Pure Public Good: Some Barriers and Solutions to Sharing Health-Related Data
Michael Cummings
University of Maryland
Big Data, Big Possibilities
Kelly Reavis
VA RR and D, National Center for Rehabilitative Auditory Research
Podium Session 1—Cochlear Mechanics: Physiology
2:00 p.m.—4:00 p.m.
Platinum Salon 6
Suppression of Basilar Membrane and Organ-of-Corti Responses Towards the Apex of the Cochlea
Sebastiaan Meenderink*1, Wei Dong1
1 VA Loma Linda Healthcare System
Cochlear Vibrations in Response to Frequency Sweeps
Karolina Charaziak*1
1 USC Keck School of Medicine
Organ of Corti Vibrations in the Basal Turn of the Chinchilla
Eric Verschooten1, Marcel Van Der Heijden*2, Philip X Joris1
1Laboratory of Auditory Neurophysiology, Medical School, Campus Gasthuisberg, University of Leuven, 2Erasmus MC
Resting Calcium Dependence of the Outer Hair Cell Hair Bundle
Rayan Chatterjee*1, Daibhid O Maoileidigh2
1Stanford University School of Medicine, 2Stanford University
Sound-Evoked Tonic Outer Hair Cell Length Changes in Mice With Impaired Mechanotransduction
James Dewey*1
1 University of Southern California
Variation of Cochlear Mechanical Responses at Micro- And Macro-Levels Post Acoustic Trauma
Wei Dong*1, Sebastiaan Meenderink1
1 VA Loma Linda Healthcare System
Robot-Assisted Multidimensional OCT Measurements of Cochlear Mechanics
Gabriel Alberts*1, Wiam Lahlou2, Sunil Puria3
1Harvard University, 2International University of Rabat, 3MEE
The Localized Action of OHC Activity in the Base of the Gerbil Cochlea
Elizabeth Olson*1, Clark Strimbu2, Lauren Chiriboga3, Brian Frost1
1Columbia University, 2College of Physicians and Surgeons of Columbia University, 3Columbia University
Podium Session 2—Primary Auditory Cortex
2:00 p.m.—4:00 p.m.
Grand Ballroom Salon E
Voice Patches in the Marmoset Auditory Cortex Revealed by Wide-Field Calcium Imaging
YANG ZHANG*1, Xingdong Song1, Yueqi Guo1, Chenggang Chen1, Xiaoqin Wang1
1 Johns Hopkins University
A Top-Down, Cingulate-to-Auditory Cortex Projection Facilitates Effortful Listening
Kelsey Anbuhl*1, Marielisa Diez Castro1, Nikki A. Lee1, Vivian S. Lee1, Dan H. Sanes1
1 Center for Neural Science, New York University
Orbitofrontal Cortex Modulates Auditory Cortical and Perceptual Sensitivity
Matheus Macedo-Lima*1, Lashaka Sierra Hamlette1, Melissa Caras1
1 University of Maryland—College Park
Dysfunction of Specific Auditory Fibers Impact Cortical Oscillations, Driving an Autism Phenotype Despite Near-Normal Hearing
Morgan Hess*1, Philine Marchetta1, Konrad Dapper1, Dila Calis1, Wibke Singer1, Jakob Wertz1, Stefan Fink1, Steffen Hage2, Mesbah Alam3, Kerstin Schwabe3, Robert Lukowski4, Jerome Bourien5, Jean-Luc Puel5, Michele Jacob6, Matthias Munk7, Rüdiger Land8, Lukas Rüttiger1, Marlies Knipper1
1University of Tuebingen, 2Hearing Research Center, University of Tübingen, Medical Center, 3Hannover Medical School, 4Institute of Pharmacy, Pharmacology, Toxicology and Clinical Pharmacy, University of Tübingen, 5Institute for Neurosciences Montpellier, University of Montpellier, Institut National de la Santé et de la Recherche Médical, 6Tufts University School of Medicine, Sackler School of Biomedical Sciences, 7University of Tübingen,, 8Institute of Audioneurotechnology, Hannover Medical School
Active vs. Passive Listening Reveals Neural Modulation Frequency Selectivity and Top-Down Control Over Entrainment
Sam Watson*1, Jens Hjortkjær1, Torsten Dau1
1 Technical University of Denmark (DTU)
Altered Auditory Cortical Representation of Context Specific Vocalization Sequences in a Mouse Model of Autism Spectrum Disorder
Srishti Jain*1, Purba Mandal2, Swapna Agarwalla3, Sharba Bandyopadhyay1
1Indian Institute of Technology, Kharagpur, 2Purdue University, 3University of Rochester
Social Experience Dependent Plasticity in Micro-Organization and Population Coding of Sequences of Mouse Vocalizations in the Mouse Auditory Cortex
Srishti Jain1, Sohini Gupta*1, Swapna Agarwalla2, Sharba Bandyopadhyay1
1IIT Kharagpur, 2University of Rochester
Spatial Tuning of Neurons in Marmoset Auditory Cortex is Dynamically Modulated by Spatial and Temporal Features of Background Noise
Yi Zhou*1, Katherine Doxey1, Sharon Crook1
1 Arizona State University
In Memoriam Symposium—Celebrating Arnold Starr: A Legacy of Discoveries in Basic and Clinical Auditory Research
4:15 p.m.—6:15 p.m.
Grand Ballroom Salon E
Celebrating Arnold Starr: A Legacy of Discoveries in Basic and Clinical Auditory Research
Chair: Fan-Gang Zeng, University of California Irvine
Co-Chair: Leonard Kitzes, University of California at Irvine
Co-Chair: Nina Kraus, Northwestern University
Arnold Starr’s Life and Achievements
Leonard Kitzes
University of California at Irvine
Cerebral Responses to the Speech Envelope
Terence Picton
University of Toronto
Site-of-Lesion in Auditory Neuropathy
Gary Rance
University of Melbourne
Neural and Receptor Cochlear Potentials in Patients With Genetic Auditory Neuropathy
Rosamaria Santarelli
University of Padova
A Synaptic Perspective on a Neurologist’s Journey in Hearing Research
Tobias Moser
University Medical Center Goettingen
Cochlear Synaptopathy: Auditory Neuropathy for the Rest of Us
Charles Liberman
Eaton-Peabody Laboratories, Mass. Eye and Ear
Crossmodal Plasticity in Hearing Loss
Andrej Kral
Medical University Hannover
Clinical Implications From Arnie Starr’s Work in Electrophysiology
Andrew Dimitrijevic
Sunnybrook Hospital ENT University of Toronto
Starr’s Legacy- Inspiring Research Beyond Otolaryngology
Nina Kraus
Northwestern University
Sunday, February 4, 2024
Young Investigator Symposium 2—Emerging Perspectives on Misophonia
8:00 a.m.—10:00 a.m.
Grand Ballroom Salon E
Emerging Perspectives on Misophonia
Chair: Emily Coffey, Concordia University
Co-Chair: Marie-Anick Savard, Concordia University
Clinical Validation of a New Diagnostic Test for Misophonia and Hyperacusis
Philippe Fournier
Universite Laval Faculty of Medicine
Effect of Misophonia on Cognitive and Social Processing
Heather Hansen
Concordia University
Selective Attention as a Means of Modulating Misophonic Responses
Marie-Anick Savard
Concordia University
Misophonia Reactions Increase During Childhood and are Associated With Musicality and Other Auditory Affective Experiences
Solena Mednicoff
University of Nevada, Las Vegas
Altering the Perceived Cause of Unpleasant and Misophonic Sounds With Videos and Words
Urszula Oszczapinska
Carnegie Mellon University
Reactions to Misophonic Trigger Sounds are Reduced by Visual Stimuli
Ghazaleh Mahzouni
UC Santa Cruz
Podium Session 3—Hair Cell Spiral Ganglia Synaptic Specializations in Normal and Pathological States
8:00 a.m.—10:00 a.m.
Platinum Salon 5
Dynamics of Noise-Induced Dopamine Upregulation in Lateral Olivocochlear Neurons
Jane Mondul*1, Catherine Graham1, Megan Wood2, Amanda Lauer1, Elisabeth Glowatzki2
1Johns Hopkins University, 2Johns Hopkins University School of Medicine
Ageing of Cochlear Hair Cells in Mice
Jing-Yi Jeng*1, Adam Carlton1, Piece Yen1, Walter Marcotti1
1 The University of Sheffield
Synaptic Ribbon Dynamics After Noise Exposure in the Hearing Cochlea
Peu Santra*1, Noura Ismail Mohamad1, Yesai Park1, Ian R. Matthews1, Emily Taketa1, Dylan K. Chan1
1 UCSF
BAI1 Localises AMPA Receptors at the Cochlear Afferent Postsynaptic Density and is Essential for Hearing
Adam Carlton*1, Jing-Yi Jeng1, Fiorella Grandi2, Francesca De Faveri1, Ana Amariutei1, Lara De Tomasi1, Andrew O'Connor1, Stuart Johnson1, David Furness3, Steve Brown4, Federico Ceriani1, Michael Bowl5, Mirna Mustapha1, Walter Marcotti1
1University of Sheffield, 2Sorbonne Université, 3Keele University, 4MRC Harwell Institute, 5UCL Ear Institute, University College London
Functional Development of Embryonic IHCs and SGNs in the Mouse Cochlea
Jingjing Zhao1, Yige Li1, Fang Wang1, Geng-Lin Li*1
1 Eye and ENT Hospital, Fudan University
The Biophysical Differences Between Murine Type I and Type II Spiral Ganglion Neurons
Nathaniel Nowak*1, Radha Kalluri1
1 University of Southern California
Objective Thresholding of the Auditory Brainstem Response Using Cross-Correlation Across Subaverages
Luke Shaheen*1, Yoojin Chung1, Brad Buran2, Seth Koehler1
1Regeneron Pharmaceuticals, 2Oregon Health and Science University
Encoding of Phasic and Tonic Signals by Non-Quantal and Quantal Transmission in the Vestibular Periphery
Dyllan Zhou1, Wesley Schoo1, Takashi Kodama2, Sascha du Lac1, Elisabeth Glowatzki1, Soroush Sadeghi*1
1Johns Hopkins University, 2Johns Hopkins University, Tokyo Women's Medical University
Podium Session 4—Clinical Otology and Pathology: Human and Animal Studies
8:00 a.m.—10:00 a.m.
Platinum Salon 6
Mouse Models of DFNA78 Demonstrate Importance of Exon 21 of SLC12A2 for Hearing
Hideki Mutai*1, Yukiko Kuroda2, Shinobu Noji2, Saki Ichikawa3, Koichi Matsuo2, Satoshi Tanaka3, Naoyuki Kataoka3, Tatsuo Matsunaga1
1NHO Tokyo Medical Center, 2Keio University School of Medicine, 3The University of Tokyo
Risk Factors Determining Congenital Hearing Loss and Hearing Evolution in Children With Congenital Cytomegalovirus Infection
Elise De Cuyper*1, Frederic Acke1, Annelies Keymeulen3, Els De Leenheer1, Helen Van Hoecke1, Elizaveta Padalko3, An Boudewyns4, Annick Gilles4, Marie Muylle5, Rudolf Kuhweide5, Liesbeth Royackers6, Christian Desloovere6, Margriet Verstreken7, Isabelle Schattemans7, Ingeborg Dhooge1
1Ghent University/Ghent University Hospital, 3Ghent University Hospital, 4Antwerp University Hospital, 5Sint Jan Hospital, Bruges, 6University Hospitals of Leuven, 7GZA Hospitals Campus Sint Augustinus
Molecular Specializations Underlying Phenotypic Differences in Hair Cells of Zebrafish and Mice
Kacey Yamane*1, Kim Giffen2, Huizhan Liu3, Yi Li4, Kenneth Kramer1, David He1
1Creighton University, 2Medical College of Georgia, 3Creighton University School of Medicine, 4Beijing Tongren Hospital
SPI-1005 Reduces Tobramycin Ototoxicity in a Phase 2 Randomized Controlled Trial of Cystic Fibrosis Patients
Jonathan Kil*1, Emily Harruff1, Joel Dermis2, Daniel Rosenbluth3, Perry Brown4, Douglas Conrad5, Raksha Jain6, Patrick Flume7
1Sound Pharmaceuticals, Inc., 2KUMC, 3Washington University, 4St Luke's Cystic Fibrosis Center, 5UCSD, 6UTSW, 7MUSC
Comparison of Round Window Electrocochleography Across Pediatric Subjects Receiving Cochlear Implants With Auditory Neuropathy Spectrum Disorder (ANSD), Enlarged Vestibular Aqueduct (EVA), and Sensorineural Hearing Loss (SNHL)
Douglas Fitzpatrick*1, William Dunn1
1 University of North Carolina at Chapel Hill
AC102-201: A Phase 2 Clinical Trial Comparing the Efficacy of AC102, an Innovative Small Molecule, to Corticosteroids in Patients With Idiopathic Sudden Sensorineural Hearing Loss
Christin Galetzka1, Ronald J.E. Pennings2, Cris Lanting2, Alena Meis1, Maika Friedrich1, Miroslawa Gachowska1, Stefan Plontke3, Reimar Schlingensiepen*1
1AudioCure Pharma GmbH, 2Radboud University Medical Center, 3Martin Luther University Halle-Wittenberg
Machine Learning-Based Prediction Model for Longitudinal Outcomes in GJB2-Related Sensorineural Hearing Impairment
Pey-Yu Chen*1, Ta-Wei Yang2, Yi-Shan Tseng2, Cheng-Yu Tsai3, Chiung-Szu Yeh2, Tien-Chen Liu4, Yen-Hui Lee5, Pei-Hsuan Lin4, Ting-Chun Lin2, Yu-Jen Wu2, Ting-Hua Yang4, Yu-Ting Chiang6, Jacob Shu-Jui Hsu2, Chuan-Jen Hsu7, Pei-Lung Chen4, Chen-Fu Chou2, Chen-Chi Wu5
1MacKay Memorial Hospital, 2National Taiwan University, 3National Taiwan University Hospital; National Taiwan University College of Medicine, 4National Taiwan University Hospital, 5National Taiwan University Hospital Hsin-Chu Branch; National Taiwan University Biomedical Park Hospital; National Taiwan University Hospital, 6National Taiwan University College of Medicine, 7Taichung Tzu-Chi Hospital
Longitudinal Variability in Vestibular Evoked Myogenic Potentials and Endolymphatic Hydrops for Patients With Hearing Instability
Julia Telischi*1, Jennifer Chisholm2, Christopher Zalewski2, Julie Christensen2, Noelle Allemang2, Anhelina Bilokon2, Hui Cheng3, John Butman4, Carmen Brewer2, Michael Hoa5
1University of Miami Miller School of Medicine, 2Audiology Unit, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 3Bioinformatics and Biostatistics Collaboration Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 4National Institutes of Health, 5Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
Young Investigator Symposium 3—Multisensory Signals Along the Auditory Processing Pathway
10:15 a.m.—12:15 p.m.
Grand Ballroom Salon E
Multisensory Signals Along the Auditory Processing Pathway
Chair: Rebecca Norris, UCL
Co-Chair: Nathan Vogler, University of Pennsylvania
Cortical Mechanisms for Integration of Auditory and Olfactory Information
Nathan Vogler
University of Pennsylvania
Behavioral Origin of Sound-Evoked Activity in Mouse Visual Cortex
Celian Bimbard
University College London
Temporal Integration of Audio-Visual Stimuli in the Mouse Superior Colliculus
Gaia Bianchini
The Francis Crick Institute
Functional Specificity of Auditory Inputs to the Visual Cortex
Alexander Egea Weiss
The Francis Crick Institute
Origin of Visual Information in Deep Layers of Mouse Auditory Cortex
Timothy Olsen
UCSF
Visual Signals in Ferret Auditory Cortex
Rebecca Norris
UCL
Podium Session 5—Aging
10:15 a.m.—12:15 p.m.
Platinum Salon 5
The Proteomic Changes of Mouse Cochlear Nucleus of Mice During Aging
Weijun Zhou1, Huihui Liu1, Ruijie Cai1, Ting Zhao1, Ling Tong1, Sidi Liu1, Yunge Gao1, Zhaoyan Wang1, Hao Wu1, Meijian Wang*1
1 Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Inhibitor of Mitosis Reduces Supporting Cell Regeneration in the Neonatal Mouse Cochlea
Julia Abitbol*1, Sungwon Choi1, Alan G. Cheng1
1 Stanford University
Age-Related Auditory Temporal Processing Deficits in Behavioral and Electrophysiological Measurements of Forward Masking
Chengjie Huang*1, Taylor M. Evans-Beinke1, Roksana Soleimanpour1, Milena Costantino1, Samira Anderson1, Matthew J. Goupell1
1 University of Maryland—College Park
Age-Related Changes in Neural Synchronization With Naturalistic Music
Yue Ren*1, Kristin Weineck2, Björn Herrmann1, Molly J. Henry2
1Rotman Research Institute, 2Max Planck Institute for Empirical Aesthetics
Probing the Role of Epigenetics Mechanisms in Presbycusis Using a Genome-Wide Methylation Analysis
Marie Roche*1, Denise Yan1, Katherina Walz1, Feng Gong1, Xue-Zhong Liu1
1 University of Miami Miller School of Medicine
Relevance of Supporting Cell Pairing for Hair Cell Resilience to Age and Noise
Ignacio Garcia-Gomez*1, Jemma L. Webber1, Yingjie Zhou1, Berta Soria Izquierdo1, Trevor D.M. Harriman1, Chloe G. Brink1, Xiaodong Tan1, Claus-Peter Richter1, Mary Ann Cheatham1, Jaime Garcia-Anoveros1
1 Northwestern University
Longitudinal Assessment of Auditory Nerve and Brainstem Function Older Adults
Kelly Harris*1, James Dias1, Carolyn McClaskey1, Jeffrey Rumschlag1, Judy Dubno1
1 Medical University of South Carolina
QuickSIN as a Predictor of Subsequent Clinical Hearing Loss: Insights From the Baltimore Longitudinal Study of Aging
Jiayue Liu*1, Haotian Zou1, Josh Stohl2, Tobias Overath1
1Duke University, 2MED-EL
Podium Session 6—Vestibular, Hearing and Brain Dysfunction: Diseases, Drugs and Genes
10:15 a.m.—12:15 p.m.
Platinum Salon 6
Evaluating the Vestibulotoxic Potential of Cisplatin in a Clinically Relevant Mouse Model of Cisplatin Ototoxicity
John Lee*1, Hong Zhu2, Wu Zhou2, Katharine Fernandez1, Lisa Cunningham1
1National Institute on Deafness and Other Communication Disorders, 2Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center
Superior Semicircular Canal Dehiscence and Subsequent Closure Through Osteoneogenesis Induces Reversible Impaired Decision-Making
Sean Hong1, P. Ashley Wackym1, Todd Mowery*2
1Rutgers Robert Wood Johnson Medical School, 2Rutgers University
Glucocorticosteroid Treatment in Acute Unilateral Vestibulopathy, a Multicentric, Randomized, Double-Blind, Placebo-Controlled Study
Rebecca Revol*1, Jean-philippe Guyot MD1, Honorata Crisan1, Raphaël Maire PD3, Raymond van de Berg MD PhD4, Angelica Perez Fornos PhD1, Nils Guinand MD PhD5
1Geneva University Hospital, 2Lausanne University Hospital, 3Maastricht University Medical Centre, 5Geneva University Hospitals and University of Geneva
Contribution of Mirror-Image Hair Cell Orientation to Mouse Otolith Organ and Zebrafish Neuromast Function
Amandine Jarysta*1, Kazuya Ono2, Natasha Hughes3, Alma Jukic4, Vanessa Chang3, Michael Deans5, Ruth Anne Eatock6, Kathleen E. Cullen3, Katie Kindt4, Basile Tarchini1
1The Jackson Laboratory, 2Osaka University, 3Johns Hopkins University School of Medicine, 4NIH/NIDCD, 5University of Utah, 6University of Chicago
The Transcription Factor Six2 Regulates Morphogenesis of Vestibular Epithelia and Maturation of Vestibular Hair Cells
Sumana Ghosh*1, Punam Thapa1, Vineel Vanga1, Beth Baker1, Steven. Gressett1, Bradley Walters1
1 University of Mississippi Medical Center
Dissecting the Divergent Impact of Cochleovestibular Tumors on Auditory and Vestibular Dysfunction in Neurofibromatosis Type 2
Christopher Zalewski*1, Jeff Kim1, Maxwell Laws2, Noelle Allemang1, Ihika Rampalli2, J. Dixon Johns3, Prashant Chittiboina2
1NIH—NIDCD, 2NIH—NINDS, 3Georgetown University Hospital—HNS
Data-Driven Analysis From Audiometric Profiles of 1045 Patients Consulting for Dizziness and Vertigo
Cécile Puel1, Jérôme Bourien1, Jean-Luc Puel1, Jean-Charles Ceccato*2
1INM, Inserm; University of Montpellier, Montpellier Hospital, 2Audiocampus, University of Montpellier
Reduced Saccular Function is Associated With Cortical Surface Growth in Broca’s Area
Dominic Padova*1, J. Tilak Ratnanather2, Andreia Faria1, Yuri Agrawal1
1Johns Hopkins School of Medicine, 2Johns Hopkins University
Poster Session 2
1:15 p.m.—3:15 p.m.
Marquis Ballroom
SU1. Recovery From Auditory Neuropathy Upon Induction of Schwann Cell Loss in Mature Adult DTA Mice
Shreeya Sawant*1, Nicole Zoghby1, Elizabeth Markuson1, Jessica Georgopulos1, Hongji Zhang1, Maria Traka1, Michael Ebeid1
1 Midwestern University
SU2. Representations of Relative Frequency in Human Auditory Cortex
Emily Allen*1, Juraj Mesik1, Anahita Mehta2, Kendrick Kay1, Andrew Oxenham1
1University of Minnesota, 2University of Michigan
SU3. Can Speech Induced Mismatch Negativity Used as a Biomarker for the Hidden Hearing Loss in Human Adults?
Lichun Zhang*1, Florian Schmidt1, David Mißler1, Karsten Ehrt1, Wilma Großmann1, Robert Mlynski1
1 Rostock University Medical Center
SU4. Compact and Explainable Decoding of Auditory Selective Attention
Jusung Ham*1, Jinhee Kim2, Kyogu Lee2, Inyong Choi1
1University of Iowa, 2Seoul National University
SU5. The Cortical Frequency-Following Response to Continuous Speech in Musicians and Non-Musicians
Jasmin Riegel*1, Alina Schüller1, Achim Schilling2, Patrick Krauss3, Stefan Rampp4, Tobias Reichenbach1
1Friedrich-Alexander-University Erlangen, 2Neuroscience Lab, University Hospital Erlangen, 3Neuroscience Lab, University Hospital Erlangen; Pattern Recognition Lab, Friedrich-Alexander-University Erlangen-Nürnberg, 4University Hospital Erlangen; University Hospital Halle (Saale)
SU6. Vasoactive Intestinal Peptide Signaling Within Auditory Cortex
Christine Junhui Liu*1, Cathryn MacGregor2, Carolyn Sweeney1, Lucas Vattino1, Kasey Smith2, Anne Takesian1
1Harvard Medical School, Eaton-Peabody Laboratories, Massachusetts Eye and Ear, 2Eaton-Peabody Laboratories, Massachusetts Eye and Ear
SU7. Cortical Synaptic Zinc Signaling Contributes to Increased Gain and Perceptual Recovery After Noise Trauma
Manoj Kumar*1, Thanos Tzounoupoulos2
1University of Pittsburgh, 2Pittsburgh Hearing Research Center, University of Pittsburgh
SU8. Dynamic Membrane Potential Responses to Complex Sound Features in Mouse Auditory Cortical Fields
Chung-Wei Chiang*1, Matthew McGinley1
1 Baylor College of Medicine
SU9. Spiral Ganglion Neurons Activation by pH Changes
Enrique Soto*1, Katya Rosas1, Esteban Urrieta1, Rosario Vega1
1 Universidad Autonoma de Puebla
SU10. Human Pluripotent Derived Neurons Survive in the Guinea Pig Cochlea
Lisa Beyer1, Diane Prieskorn1, Aleksandara Poole2, Rami Skaliter2, Dana Hayoun Neeman2, Ofer Wiser2, Olga Mizrahi2, Yehoash Raphael*1
1University of Michigan, 2Lineage Cell Therapeutics, Inc
SU11. Enhanced Gain at the Ribbon Synapse May Constitute a Mechanism to Compensate Auditory Nerve Fiber Loss After Excitotoxicity
Artem Diuba1, Jerome Bourien*1, Sharon Kujawa2, Jean-Luc Puel1
1Institute for Neurosciences Montpellier, University of Montpellier, Institut National de la Santé et de la Recherche Médicale, 2Eaton-Peabody Laboratories, Massachusetts Eye and Ear; Harvard Medical School, Harvard University
SU12. Encoding of Vowels in Gerbil Auditory Nerve
Daniil Kiselev1, Etienne Gaudrain2, Sarah Verhulst3, Jean-Luc Puel4, Jerome Bourien*4
1Institute for Neurosciences Montpellier, University of Montpellier, Institut National de la Santé et de la Recherche Médicale, 2Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM UMRS 1028, Université Claude Bernard Lyon 1, Université de Lyon, 3Hearing Technology @ WAVES, Ghent University, 4Institute for Neurosciences Montpellier, University of Montpellier, Institut National de la Santé et de la Recherche Médicale
SU13. Precision Medicine and Gene Therapy for Hearing Impairment: Big Data, 3D Structure, and AI
Zippora Brownstein*1, Lara Kamal1, Inbar Blech1, Yazeed Zoabi1, Shadi J. Khoury1, Tal Patalon2, Asaf Peretz2, Juan Fernandez-Recio3, Xavier de La Cruz4, Fabian Glaser5, Noam Shomron1, Karen B. Avraham1
1Tel Aviv University, 2Maccabi Healthcare Services, 3Instituto de Ciencias de la Vid y del Vino (ICVV), 4Vall d'Hebron Institute of Research (VHIR), 5THHI, Technion Human Health Initiative
SU14. Open Board
SU15. Myogenic Artifacts Masquerade as Neuroplasticity in the Auditory Frequency-Following Response (FFR)
Gavin Bidelman*1, Jessica MacLean1, Rose Rizzi1, Alexandria Sisson1, Kaitlin Baer2
1Indiana University 2University of Memphis
SU16. Examining Efferent Effects on Neural Processing of Concurrent Vowel Processing
Sarah Medina*1, Fan-Yin Cheng1, Olaedochim Obinna1, Spencer Smith1
1 The University of Texas at Austin
SU17. Three-Dimensional Mapping of Isofrequency Bands in the Mouse Cochlear Nucleus With c-fos Expression Upon Hierarchical Acoustic Stimulation
Sidi Liu*1, Dian Jing1, Yiwei Du1, Yaqiong Cheng1, Huihui Liu3, Lei Song1, Hao Wu1
1 Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine,
SU18. Enhancement of Phase-Locking in Bushy Cells Benefits Binaural Coding in the Auditory Brainstem
Go Ashida*1
1 University of Oldenburg
SU19. Unipolar Brush Cells Directly Target Fusiform and Cartwheel Cells and Can Drive Action Potential Firing
Christian Candler*1, Tim Balmer1
1 Arizona State University
SU20. Glial Glutamate Transporters are Essential for Auditory Coding in the Ventral Cochlear Nucleus
Tenzin Ngodup*1, Laurence O. Trussell1
1 Oregon Health and Science University, Oregon Hearing Research Center
SU21. Structure-Function Effects in the Auditory System After Impact Acceleration Traumatic Brain Injury in CBA/CaJ Mice
Amanda Lauer1, Vassilis Koliatsos1, Athanasios Alexandris1, Kali Burke1, Elennyel Correa*1
1 Johns Hopkins University
SU22. Effects of C1qa Deletion on Auditory Brainstem Development
Sima Chokr*1, Ashley Bui-Tran1, Kyle C. Arceo1, Karina S. Cramer1
1 University of California, Irvine
SU23. A Comparison of Auditory Brainstem Response for Chirp Stimuli Across Three Different Manufacturers
Zachary Abt1, Margaret Winter1, Miwako Hisagi1, Chandan Suresh*1
1 California State University, Los Angeles
SU24. Impact of Scn2a Haploinsufficiency on Auditory Processing Abnormalities in an ASD Mouse Model
Jorge Contreras*1, Jun Hee Kim1
1 University of Michigan
SU25. Inferior Colliculus Neurons are Sensitive to Sub-Millisecond Variations in Sound Onset Duration
Melissa Ryan*1, Siddhartha Joshi1, Hemant Kumar Srivastava1, Hong Jiang1, Matthew McGinley1
1 Baylor College of Medicine
SU26. Dynamic Changes in Pre- and Post-Synaptic Markers of Neurotransmission Across the Inferior Colliculus in a Model of Noise Induced Temporary Threshold Shift
Selin Yalcinoglu*1, Rod Braun1, Avril Genene Holt1
1 Wayne State University School of Medicine
SU27. Biochemical Diversity Amongst Calyx-Only Afferents in the Vestibular Nuclear Complex
Syed Naqvi*1, Shana King1, Rod Braun1, Avril Genene Holt1
1 Wayne State University School of Medicine
SU28. A Systems-Neurophysiologic Toolkit for Studying Dorsal Cochlear Nucleus’ Role in State-Dependent Spatial Saliency
Jessica Pfliger*1, Hong Jiang2, Hemant Kumar Srivastava2, Junzhan Jing1, Tenzin Ngodup3, Laurence O. Trussell3, Xiaolong Jiang1, Matthew McGinley2
1Rice University, 2Baylor College of Medicine, 3Oregon Health and Science University, Oregon Hearing Research Center
SU29. Behavioral Task Modulates Neural Activity in the Dorsal Inferior Colliculus Neurons of Mice
Gang Xiao*1, Brandon Li1, Grace Ledogar1, Daniel A. Llano1
1 University of Illinois at Urbana-Champaign
SU30. Predicting Auditory Midbrain Responses to Natural Sounds With Interpretable Gabor Integrate and Fire Receptive Field Models
Jenna Blain*1, Monty Escabi1, Ian Stevenson1
1 University of Connecticut
SU31. Effect of Spectro-Temporal Characteristics of Sound Sequences and Anesthesia on Sound Processing in the Inferior Colliculus
Chun-Jen Hsiao*1, Nikhil Harish1, Alexander Galazyuk1
1 Northeast Ohio Medical University
SU32. Lineage-Tracing Reveals an Expanded Population of NPY Neurons in the Inferior Colliculus
Marina Silveira*1, Nichole Beebe2, Yoani Herrera3, Michael Roberts3, Brett Schofield2
1University of Texas at San Antonio, 2Northeast Ohio Medical University, 3The University of Michigan, Kresge Hearing Research Institute
SU33. Cortical Responses Time-Locked to Continuous Speech in the High-Gamma Band Depend on Selective Attention
Vrishab Commuri*1, Joshua Kulasingham2, Jonathan Z. Simon3
1University of Maryland, 2Linköping University, 3Institute for Systems Research, University of Maryland.
SU34. Pioneering Cortical Assays of Gap Detection to Explore Temporal Processing in Chinchilla Using a Multi-Channel Mini-EEG Cap
Varsha M Athreya*1, Andrew Sivaprakasam1, Hannah Ginsberg1, Hari Bharadwaj2, Michael Heinz1
1Purdue University, 2University of Pittsburgh
SU35. Dissecting the Functional Connectome of the Lateral-Line System in Zebrafish
Zhengchang Lei*1, Qiuxiang Zhang2, Katherine Pinter2, Katie Kindt2
1Section on Sensory Cell Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 2NIH/NIDCD
SU36. Kif1aa-Based Transport and Microtubules Maintains Synaptic Vesicle Populations in Hair Cells
Sandeep David*1, Katherine Pinter1, Katie Kindt1
1 NIH/NIDCD
SU37. Characterizing the Functional and Molecular Features of Smpx in Cochlear Hair Cells
Andrew Paquette*1, Elizabeth Wagner1
1 University of Virginia School of Medicine
SU38. Kv1.8 Channels Enhance Vestibular Hair Cell Signaling and Performance on Challenging Vestibulomotor Tasks
Hannah Martin*1, Dana Silvian1, Emily Scott1, Ruth Anne Eatock1
1 University of Chicago
SU39. The 3D Morphology of the Outer-Hair-Cell Hair Bundle Increases Its Dynamic Range
Zenghao Zhu1, Wisam Reid2, Shefin Sam George1, Victoria Ou1, Daibhid O Maoileidigh*1
1Stanford University, 2Harvard Medical School
SU40. Exploring the Function of KLHDC7b, a Novel Gene Associated With Hearing Loss
Alexandra Kaufman*1, Sarah Cancelarich1, Alma Corona1, Kara Graham1, Jacqueline Copeland1, Daniela Di Battista Miani1, Elika Fallah1, Eva Morozko1, Daniel Johnson1, Roberto Donnianni1, Meghan Drummond1
Regeneron Pharmaceuticals, Inc.
SU41. Application of Synchrotron-Based Imaging in Visualization of the Spiral Ganglion and Outer Hair Cells in Mice
Seyed Alireza Rohani*1, Ashley Micuda1, Nastaran Shakourifar1, Hao Li2, Ning Zhu3, Sergey Gasilov3, Rafal Olszewski4, Helge Rask-Andersen2, Sumit Agrawal1, Hanif Ladak1, Michael Hoa4
1Western University, 2Uppsala University, 3Canadian Light Source, 4National Institute on Deafness and Other Communication Disorders, National Institutes of Health
SU42. The Cochlea is Built to Last a Lifetime
Jeffrey Savas*1, Miguel Ramirez1
1 Northwestern University Feinberg School of Medicine
SU43. Group 2 Innate Lymphoid Cells in the Mouse Cochlea
Megan Wood*1, Elisabeth Glowatzki1, Stephane Lajoie1
1 Johns Hopkins University School of Medicine
SU44. BK Channels are Required for Synchronized Response of Vestibular Nerve Afferents During Fast Head Movements in Vivo
Daniel Ballinas1, Wesley Schoo1, Soroush Sadeghi*1
1 Johns Hopkins University
SU45. Exploring HOMER1 as a Postsynaptic Marker for Ribbon Synapses in the Peripheral Vestibular Epithelia
Tyler Kramer*1, Kevin Wright2, Cassandra Franco-Barragan2, Larry Hoffman2
1University of California—Los Angeles, 2Geffen School of Medicine at UCLA
SU46. Manifestations of Critical Dynamical Behavior in an Isolated Segment of the Mammalian Cochlea
Rodrigo Alonso*1, Francesco Gianoli1, Brian Fabella1, Yuval Edri1, A. James Hudspeth2
1The Rockefeller University, 2The Rockefeller University; Howard Hughes Medical Institute
SU47. Outer Hair Cells (OHCs) Produce Cochlear Amplification via a Cortilymph Fluid Space Impedance That is Wavelength Dependent
John Guinan*1, Nam Hyun Cho2, Sunil Puria1
1Mass Eye and Ear, Harvard Medical School, 2Harvard Medical School
SU48. Transport of Therapeutic Agents Along the Cochlea by Acoustic Steady Streaming – an FEM Simulation Study
Xinyu Zhou1, Torsten Marquardt*1
1 University College London
SU49. Can the Spontaneous Otoacoustic Emissions Predicted by Coherent Reflection Models be Represented by Individual Van der Pol Oscillators?
Dani Agramonte*1, George Samaras1, Julien Meaud1
1 Georgia Institute of Technology
SU50. Srf is Required for Supporting Cell Cytoskeletal Architecture and Hearing
Ting-Ting Du*1, Wen-Xiao Wang2, Ling-Yun Zhou2, Hao Wu2
1 Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 2Shanghai Jiao Tong University School of Medicine
SU51. Reevaluating Cochlear Fluid Viscosity's Influence on Basilar Membrane Motion: A Finite Element Study
Soomin Lee*1, Jongwoo Lim2, Namkeun Kim1
1Sogang University, 2KAIST
SU52. Enhanced Cochlear Amplification in Response to Hearing Loss is Mediated by the Medial Olivocochlear Efferent Pathway
Patricia Quiñones*1, Michelle Pei2, Ariadna Cobo-Cuan1, Frank D. Macias-Escriva1, Juemei Wang1, James B. Dewey1, Hemant Kumar Srivastava3, Brian E. Applegate1, Matthew J. McGinley3, John S. Oghalai1
1Keck School of Medicine, University of Southern California, 2Miller School of Medicine, University of Miami,, 3Baylor College of Medicine
SU53. Refining Cochlear Impedance Representation in a Finite-Element Human Ear Model
Junfeng Liang1, Hamid Motallebzadeh*2, Xiying Guan1
1Wayne State University, 2California State University, Sacramento
SU54. S398 in Prestin is Critically Important for Cl- Binding
Chenou Zhang1, Jun-Ping Bai2, Joseph Santos-Sacchi2, Dhasakumar Navaratnam2, Oliver Beckstein*1
1Arizona State University, 2Yale University School of Medicine
SU55. Prestin and Slc26a9 Show Distinctly Different Responses to Voltage Change in Molecular Dynamic Simulations
Chenou Zhang*1, Richard Mariadasse2, Jun-Ping Bai2, Joseph Santos-Sacchi2, Oliver Beckstein1, Dhasakumar Navaratnam2
1Arizona State University, 2Yale University School of Medicine
SU56. Preclinical Development of SENS-501 as a Treatment for the Autosomal Recessive Non-Syndromic Deafness 9 (DFNB9) Using an Adeno Associated Vector-Based Gene Therapy
Guillaume Oliver1, Christophe Tran van Ba1, Lise Barrot1, Rafik Boudra1, Julie Duron Dos Reis1, Pierre Rambeau1, Charlene Vaux1, Charlene Vaux1, Sandra Pierredon1, Anais Pages1, Pauline Liaudet1, Audrey Broussy1, Anne-Gabrielle Harrus1, Selma Dadak1, Laura Gallot1, Geraldine H. Petit1, Jérôme Nevoux2, Ghizlene Lahlou2, Natalie Loundon3, Christine Le Bec1, Emilie Bousquet1, Marie-Jose Lecomte2, Saaid Safieddine2, Christine Petit2, Arnaud Giese1, Laurent Désiré*1
1Sensorion, 2Genetics and Physiology of Hearing Laboratory, Institut de l’Audition/Pasteur, 3Hôpital Necker-Enfants Malades
SU57. Surgical Approach for a Safe Intra-Cochlear Injection of AAVs in Macaca Fascicularis
Lise Barrot1, Jérôme Nevoux2, Ghizlene Lahlou2, Guillaume Olivier1, Audrey Broussy1, Anne-Gabrielle Harrus1, Natalie Loundon3, Arnaud Giese1, Laurent Désiré*1
1Sensorion, 2Genetics and Physiology of Hearing Laboratory, Institut de l’Audition/Pasteur, 3Hôpital Necker-Enfants Malades.
SU58. Gene Therapy Targeting Auditory and Vestibular Systems in Clic5 Mutant Mice
Roni Hahn*1, Shahar Taiber1, Olga Shubina-Oleinik2, Gwenaëlle S.G. Géléoc2, Jeffrey R. Holt2, Karen B. Avraham1
1Tel Aviv University, 2Boston Children's Hospital, Harvard Medical School
SU59. In Vivo Adenine Base Editing Ameliorates Auditory Function in a Mouse Model of Dominant Deafness
Yuxin Chen*1, Cheng Ye2, Bowei Huang1, Fang Wang1, Chong Cui1, Daqi Wang1, Yu Han1, Sen Zhang1, Jun Lv1, Geng-Lin Li1, Huawei Li1, Yilai Shu1
1Eye and ENT Hospital of Fudan University, 2Wenzhou Medical University
SU60. Gene Therapy With AAV.ie Rescues Auditory Function in a Mouse Model of DFNB111 Hearing Loss
Luoying Jiang*1, Shaowei Hu1, Zijing Wang1, Honghai Tang1, Yuxin Chen1, Daqi Wang1, Lei Han1, Yingzi He1, Yilai Shu1
1 Eye and ENT Hospital of Fudan University
SU61. Restoration of Auditory Function With Otoferlin Gene Transfer Therapy in Nonsense (Q828X) and Missense (R1934Q and Deaf5) Models of OTOF Deficiency
Yoojin Chung*1, Quynh-Anh Fucci1, Seth Koehler1, Ning Pan1, Yehree Kim2, Eunyoung Yi3, Min Young Kim2, Sangyong Jung4, Kyu-Hee Han5, Tyler Gibson1, Lars Becker1, Joseph Goodliffe1, Molly Kalker1, Madeline Barnes1, Luke Shaheen1, Vassili Valayannopoulos1, Byung Yoon Choi2
1Regeneron Pharmaceuticals, 2Seoul National University Bundang Hospital, 3Mokpo National University, 4National University of Singapore, 5Seoul National University Hospital
SU62. Novel Antisense Therapy to Durably Treat USH2A Patients
Stephanie Mauriac*1, Yu-Han Huang1, Jennifer B Phillips2, Jeremy Wegner2, Monte Westerfield2, Timothy Yu1, Gwenaelle Geleoc1
1Boston Children's Hospital, Harvard Medical School, 2Institute of Neuroscience, University of Oregon
SU63. Preventing Autosomal-Dominant Hearing Loss in Bth Mice With CRISPR/CasRx-Based RNA Editing
Chong Cui*1, Ziwen Zheng1, Guo Li2, Xingxu Huang3, Huawei Li1, Geng-Lin Li1, Yilai Shu1
1ENT Institute and Otorhinolaryngology Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, 2College of Biological Sciences, China Agricultural University, 3School of Life Science and Technology, Shanghai Tech University
SU64. Evaluation of Cannabidiol as a Therapeutic for Noise-Induced Hearing Loss
Erika Lipford*1, Benjamin Shuster2, Beatrice Milon2, Ronna Hertzano2
1University of Maryland School of Medicine, 2NIDCD/NIH
SU65. CX3CR1 Fate Mapping Reveals Heterogeneity in Cochlear Macrophages and Blood Circulating CCR2-Expressing Infiltrated Macrophages Promote Hair Cell and Neuron Survival After Acoustic Trauma.
Sree Varshini Murali*1, Andrew Stothert2, Elyssa Pereyra3, Vijayprakash Manickam2, Lyudmila Batalkina2, Astrid Cardona4, Tejbeer Kaur1
1Rutgers University, Rutgers Brain Health Institute, Piscataway, 2Creighton University, 3College of Arts and Sciences, Creighton University, 4University of Texas, San Antonio
SU66. REV-ERBα Agonist SR9009 Ameliorates Noise-Induced Hearing Loss and Reduces Cochlear Macrophage Infiltration
Chao-Hui Yang*1, Ming-Yu Yang2
1Kaohsiung Chang Gung Memorial Hospital, 2College of Medicine, Chang Gung University
SU67. Effects of Selective Inner Hair Cell Loss and Cochlear Synaptopathy Loss on Psychophysical Intensity Increment Detection Tasks in the Chinchilla Animal Model
Andie Zang*1, Monica Trevino2, Edward Lobarinas1
1University of Texas at Dallas, 2The University of Texas at Austin
SU68. CFTR Potentiator Ivacaftor Protects Against Noise-Induced Hair Cell Loss by Increasing Nrf2 and Reducing Oxidative Stress
Fan Wu1, Rui Hu2, Jintao Lou2, Ziyi Cai2, Guisheng Chen2, Wenji Zhao2, Hao Xiong2, Yiqing Zheng2, Suhua Sha*1
1Medical University of South Carolina, 2Sun Yat-Sen Memorial Hospital
SU69. Glucocorticoid Treatment Protects Inner Hair Cell Ribbon Synapses From Degeneration Following Kainic Acid-Induced Excitotoxicity in Neonatal Mouse Cochlear Explants
Elyssa Pereyra*1, Tejbeer Kaur2
1Creighton University, 2Rutgers University, Robert Wood Johnson School of Medicine, Rutgers Brain Health Institute
SU70. Patterns of Cochlear Neo-Ossification Following Cochlear Implantation in Mice
Alexander Claussen*1, Caridad Naanep1, Brian Mostaert1, Razu Ibrahim1, Mateo Salazar1, David Redhage1, Marlan Hansen1
1 University of Iowa Hospitals and Clinics
SU71. Characterizing Translational Rodent Noise Exposures in a Novel Dynamic, Ambient Noise Delivery Chamber
Kayla Minesinger*1, Federica M. Raciti1, Maria Fernanda Yepes2, Suhrud Rajguru3
1University of Miami, 2University of Miami Miller School of Medicine, 3University of Miami, Bruce W. Carter Department of Veterans Affairs Medical Center
SU72. Molecular and Morphological Changes in Hair Cell Stereocilia After Acoustic Trauma
Yujin Choi*1, Hyehyun Min1, Soomin Kim1, Jinwoong Bok1
1 Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine
SU73. A Study of Hearing Function and Histopathologic Changes in the Cochlea of the Type 2 Diabetes Model Mice
Junko Tsuda*1, Kazuma Sugahara1, Makoto Hashimoto1, Hiroshi Yamashita1
1 Yamaguchi University
SU74. Pathophysiological Assessment of Blast-Induced Perilymphatic Fistula
Yoshiaki Inuzuka*1, Kunio Mizutari1, Takaomi Kurioka1, Tomohiro Matsumura2, Han Matsuda3, Tetsuo Ikezono3, Akihiro Shiotani1, Koji Araki1
1National Defense Medical College, 2Nippon Medical School, 3Saitama Medical University
SU75. Proteomics Study in Cochlea of Chronic Suppurative Otitis Media
Ritwija Bhattacharya*1, Anping Xia1, Viktoria Schiel1, Peter Santa Maria1
1 Stanford University School of Medicine
SU76. Multiple Mechanisms of Aminoglycoside Ototoxicity in Zebrafish Hair Cells Distinguished by Subcellular Localization of Action
Patricia Wu*1, Francisco Barros Becker2, Esra Camci3, Tor Linbo1, Roberto Ogelman1, Julian Simon4, Edwin Rubel1, David Raible1
1University of Washington, 2University of Washington School of Medicine, 3Prime Medicine, 4Fred Hutchinson Cancer Research Center
SU77. Investigating Neuroprotective Bclw as a Preventative Measure Against Noise-Induced Hearing Loss
Joy Franco*1, Taylor Copeland1, Lucy Lee1, Ryan Merrow1, Maria Pazyra-Murphy1, Rosalind Segal1, Lisa Goodrich1
1 Harvard University
SU78. Biochemical and Bioenergetic Alterations in Cochlear Tissue: A Comparative Study in Wild Type and Alport Syndrome Knockout Mice Under Quiet and Noise Conditions
Brendan Smyth*1, Jared Hartsock2, Noa Yates Nelson3, Dominic Cosgrove1, Michael Anne Gratton1
1Boys Town National Research Hospital, 2Turner Scientific, 3Creighton University
SU79. Physiologic Otoprotection via Renin-Angiotensin System Blockade in Noise-Induced Hearing Loss Model
Tanner Kempton*1, Bryce Hunger2, Rhong Zhuo Hua2, Carolina Chu1, Miles Klimara3, Marlan Hansen4, Douglas Bennion2
1University of Iowa Carver College of Medicine, 2The University of Iowa, 3University of Iowa Hospitals and Clinics, Molecular Otolaryngology and Renal Research Laboratories, 4University of Iowa Hospitals and Clinics
SU80. Disruption of F-Actin Within the Shafts of Stereocilia is a Key Difference Between Temporary and Permanent Noise-Induced Hearing Loss
Shadan Hadi*1, Gregory Frolenkov1
1 University of Kentucky
SU81. Envelope following Response and Auditory Brainstem Response as Potential Biomarkers of Central Compensation Following Selective Inner Hair Cell Loss
Sean Kashiwagura*1, Andie Zang1, Kelly Jahn1, Edward Lobarinas1
1 The University of Texas at Dallas
SU82. Effects of Angiotensin Receptor Blockade on Cochlear Synaptopathy Following Noise Overexposure
Carolina Chu*1, Peter Eckard1, Rong Zhuo Hua2, Tanner Kempton1, Bryce Hunger2, Miles Klimara3, Marlan Hansen3, Douglas Bennion3
1University of Iowa Carver College of Medicine, 2University of Iowa, 3University of Iowa Hospitals and Clinics
SU83. A Novel Therapeutic Strategy of Mitochondrial Transplantation Into Cochlear Cells for the Treatment of Hearing Loss
Mustafa Okur*1, Arash Kheradvar1, Hamid Djalilian1
1 University of California Irvine
SU84. TTR is Not Required for Hearing
Daniel Johnson*1, Alexandra Kaufman1, Meghan Drummond1
1 Regeneron Pharmaceuticals, Inc.
SU85. Comparing Round Window Membrane Permeability Enhancers: An Animal Study
Jae Sang Han*1, Ye Lin Kim1, Kyusun Park1, Gianfranco Velasco1, Shi Nae Park1
1 Seoul St. Mary's Hospital, The Catholic University of Korea
SU86. The Transcription Factor Pou4f1 Regulates Spiral Ganglion Positioning and the Timing of Hair Cell Differentiation
Tessa Sanders*1, YeonSoo (Kelly) Kim1, Matthew Kelley1
1 NIDCD, National Institutes of Health
SU87. Varying Mechanical Forces Drive Sensory Epithelium Formation
Mingyu Xia1, Mingxuan Wu1, Yaoqian Liu1, Jiaoyao Ma1, Huawei Li1, Wenyan Li*1
1 The EENT Hospital of Fudan University
SU88. Illuminating the Depths of Auditory Cortex: The Role of Subplate Neurons in Developing Circuits
Travis Babola*1, Minzi Chang1, Yunru Chen1, Marina Cardoso de Oliveira1, Rachel Jun1, Sophia Nehs1, Patrick Kanold1
1 Johns Hopkins University
SU89. A Spatial Transcriptomic Atlas of the Developing Inner Ear at Single-Cell Resolution
Kwan Soo Kim*1, Jae Hwan Oh1, Jinwoong Bok1
1 Yonsei University College of Medicine
SU90. Investigation of the Gene Regulatory Network That Determines the Timing of Cell Cycle Exit and Developmental Patterning in the Organ of Corti
Yeeun Kim*1, Yun Ji Kim1, Eva Jahanshir1, Juan Llamas1, Rosa Sierra1, Ksenia Gnedeva1
1 Keck School of Medicine University of Southern California
SU91. Differential Regulation of Hair Cell Actin Cytoskeleton Mediated by SRF and MRTFB
Lingyun Zhou*1
1 Shanghai Jiao Tong University School of Medicine
SU92. Sox3 Deficiency Induces Stereocilia Core Damage and Hearing Loss
Wang Wen-Xiao*.1
1 Shanghai Jiao Tong University.
SU93. Degeneration of Supporting Cell Primary Cilia Within the Mouse Cochlea
Dennis Derstroff*1, Francesca Gehrt1, Dominik Oliver2, Katrin Reimann1
1University Hospital Marburg, Philipps-University Marburg, 2Institute of Physiology and Pathophysiology, Philipps‐Universität Marburg
SU94. GDF6 is the Master Regulator of Cochlear Duct Elongation
Jae Hwan Oh*1, Kwan Soo Kim1, Jinwoong Bok1
1 Yonsei University College of Medicine
SU95. Netrin-G1 Regulates Spiral Ganglion Neuron Axon Terminal Morphology
Katelyn C. Boulanger*1, Lauren J. Kreeger2, Lucy Lee2
1Harvard University, 2Harvard Medical School
SU96. Ccer2: An Upregulated Gene During Mammalian Hair Cells Development
Emilia Luca*1, Joanna F. Mulvaney1, Daniel Nouri Nejad1, Jacqueline M. Ogier1, Gianluca Sampieri1, Wiebke Schormann1, David W. Andrews2, Alain Dabdoub2
1Sunnybrook Research Institute, 2Sunnybrook Research Institute, University of Toronto
SU97. PCP-Autocount: A Novel ImageJ Plug-In for Automated Quantification of Planar Cell Polarity
Kendra Stansak*1, Luke Baum1, Bradley Walters1, Sumana Ghosh1, Punam Thapa1
1 University of Mississippi Medical Center
SU98. Neurotrophin Signaling Supports the Development of Neurons in the Avian Cochlear Nucleus
Kristine McLellan*1, Ann Lamptey1, Sandesh Mohan1, Hui Hong2, Jason Sanchez1
1Northwestern University, 2Oregon Health and Science University
SU99. The Role of Gata3 Transcriptional Programs in Aligning Afferent and Efferent Circuitry in the Cochlea
Austen Sitko*1, Lisa V. Goodrich1
1 Harvard Medical School
SU100. Molecular Mapping of the Cochlea Using the Xenium In Situ Platform
Christopher Shults*1, Yang Song2, Michael Hoa1, Ronna Hertzano1
1National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 2University of Maryland School of Medicine
SU101. A Jack of All Trades: POU3F4 Orchestrates Diverse Transcriptional Programs in the Developing Cochlea
Kevin Rose*1, Gabriella Manilla2, Beatrice Milon1, Rani Elkon3, Thomas Coate4, Ronna Hertzano2
1National Institutes of Health, NIDCD, 2University of Maryland School of Medicine, 3Tel Aviv University, 4Georgetown University
SU102. gEAR v2.0—A Redesigned Interface for Better User Experience, Plus New Features
Joshua Orvis*1, Yang Song2, Ricky Adkins1, Jayaram Kancherla3, Kevin Rose4, Beatrice Milon4, Daniel Lesperance1, Carlo Colantuoni5, Seth Ament2, Hector Bravo3, Anup Mahurkar1, Ronna Hertzano4
1Institute for Genome Sciences, 2University of Maryland School of Medicine, 3Genentech, 4National Institute for Deafness and Other Communication Disorders, National Institutes of Health, 5Johns Hopkins University School of Medicine
SU103. Bulk RNA-Sequencing Reveals the Spatial–Temporal Transcriptional Dynamics of Hearing Loss in a Mouse Model of Congenital CMV Infection
Daniel Romano*1, Song-Zhe Li1, Alexander Larson1, William Britt2, Keiko Hirose1
1Washington University School of Medicine, 2University of Alabama at Birmingham
SU104. Chromatin Remodeling Protein CHD7 Regulates Anti-Sense Transcription of Neurogenic Factor Sox11 During Neuronal Differentiation
Edward Martinez*1, Jihyun Kim1, Azadeh Jadali2, Julie Ni1, Jingyun Qiu1, Kelvin Kwan1
1Rutgers University, 2Sampled
SU105. Determining the Critical Window of Expression of Rfx1/3 in Hair Cell Development and Maintenance
Ningjin Wu*1, Kathleen Gwilliam2, Reza Amanipour2, Beatrice Milon2, Ronna Hertzano2
1National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 2Neurotology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
SU106. Exploring the Role of FOXJ1 in the Auditory System
Han Dewan*1, Lesly Umanzor2, Kathleen Gwilliam2, Ronna Hertzano2
1University of Maryland School of Medicine, 2Neurotology Branch, NIDCD/NIH
SU107. Reduced Expression Level of KCNE1 is Sufficient to Maintain Hearing
Darcey. A Kirwin*1, Elisa Martelletti1, Nina Treder1, Neil J. Ingham1, Karen P. Steel1
1 King's College London
SU108. FDXR Gene as a Cause of Adult-Onset Auditory Neuropathy Spectrum Disorder via a Mechanism of Mitochondrial Dysfunction
Bong Jik Kim*1, Yujin Kim2, Yehree Kim3, Jin Hee Han3, Chae-Seo Rhee4, Chun-Hyung Kim2, Byung Yoon Choi4
1Chungnam National University, 2Paean Biotechnology, 3Seoul National University Bundang Hospital, 4Seoul National University
SU109. Identifying Genetic Underpinnings Using Whole Exome Sequencing and Phenotype-Genotype Correlations in Patients With BOR Syndrome
Yen-Hui Lee*1, Cheng-Yu Tsai2, Yue-Sheng Lu3, Pei-Hsuan Lin3, Jacob Shu-Jui Hsu4, Pei-Lung Chen4, Tien-Chen Liu3, Chen-Chi Wu5
1National Taiwan University Biomedical Park Hospital, Hsinchu County, 2National Taiwan University Hospital, Taipei; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University College of Medicine, Taipei, 3National Taiwan University Hospital, Taipei, 4Graduate Institute of Medical Genomics and Proteomics, National Taiwan University College of Medicine, Taipei, National Taiwan University Hospital, Taipei, 5National Taiwan University Hospital, Taipei, National Taiwan University Hospital Hsin-Chu Branch
SU110. High Prevalence of Syndromic Hearing Loss in Mexican Children With Severe to Profound Hearing Loss Undergoing Cochlear Implantation
Shelby Redfield*1, Monica Rodriguez2, Adrian Pastolero1, Eliot Shearer3
1Boston Children's Hospital, 2ABC Medical Center, 3Harvard Medical School
SU111. Novel BCAP31 Variant Associated With Non-Syndromic Deafness Shows Mitochondrial Dysfunction and Higher Sensitivity to Cisplatin: Evidence for Amenability to Mitochondrial Replacement
Yehree Kim1, Yujin Kim2, Bong Jik Kim3, Shin-Hye Yu2, Jin Hee Han1, Mingyoung Kim1, Chae-Seo Rhee1, Ju Ang Kim1, Chun-Hyung Kim2, Byung Yoon Choi*1
1Seoul National University, 2Paean Biotechnlogy, Inc, 3Chungnam National University
SU112. Differential Expression of miR-210-3p and miR-23a-3p in Sudden Sensorineural Hearing Loss Patients' Serum
Reyhaneh Abgoon*1, Ru Guo1, Cole Needham1, Cathie Garnis1, Desmond Nunez2
1University of British Columbia, 2University of British Columbia Faculty of Medicine
SU113. Genetic Background of Hearing Loss in Patients With Inner Ear Malformations
Natalia Bałdyga1, Dominika Ozieblo1, Nina Gan1, Mariusz Furmanek2, Marcin L. Leja1, Henryk Skarzynski3, Monika Oldak*1
1Institute of Physiology and Pathology of Hearing, 2Bioimaging Research Center, Institute of Physiology and Pathology of Hearing, 3Oto-Rhino-Laryngology Surgery Clinic, Institute of Physiology and Pathology of Hearing
SU114. Enriched Proliferation of Hair Cells in Otic Organoids Using the Notch Pathway Inhibitor and Wnt Agonist
Jungho Ha*1, Hantai Kim2, Young Sun Kim1, Sivasubramanian Ramani1, Seong Jun So1, Siung Sung Sung1, Jeong Hyeon Yun Yun1, Miyoung Lee3, Oak-Sung Choo4, Jeong Hun Jang1, Yun-Hoon Choung1
1Ajou University School of Medicine, 2Konyang University College of Medicine, 4Kangnam Sacred Heart Hospital, Hallym University College of Medicine
SU115. Identifying and Characterizing Notch Target Genes Associated With Trans-Differentiation in the Mammalian Organ of Corti
Lama Khalaily*1, Shahar Kasirer2, Katherine Domb1, Shahar Taiber1, Michal Sperber1, Olga Loza2, Litao Tao3, Ran Elkon1, David Sprinzak2, Karen B. Avraham1
1Tel Aviv University, 3Creighton University
SU116. Long-Term Results after Cell Transplantation to the Inner Ear Using the Inner Ear Catheter in Cochlear Implant Recipients
Athanasia Warnecke*1, Rolf Benedikt Salcher2, Jurgita Ivanauskaite2, Thomas Lenarz2, Anke Lesinski-Schiedat3, Nils Kristian Prenzler2
1Hannover Medical School/Institute of Audioneurotechnology, 2Hannover Medical School, 3Hannover Medical School, German Hearing Center Hannover
SU117. From Facultative Stem Cells to Hair Cells: Understanding Avian Hair Cell Regeneration
Austin Huang*1, Mitsuo Sato1, Maggie Matern1, Stefan Heller1, Nesrine Benkafadar1
1 Stanford University School of Medicine
SU118. Urolithin A Counteracts Mitophagy Decline and Attenuates Auditory Cell Senescence
Sung Il Cho*1, Eu-Ri Jo1, Hee Sun Jang1
1 Chosun University
SU119. Age-Related Cellular and Molecular Changes Associated With Vestibular Sensory Epithelium
Samadhi Kulasooriya*1, David He2, Huizhan Liu2, Mi Zhou2, Sarath Vijayakumar2, Celia Bloom2, Litao Tao2, Zhenhang Xu2
1Creighton University School of Medicine, 2Creighton University
SU120. Auditory Nerve Function and Cortical White-Matter Structure Predict Age-Related Deficits in Speech Communication
Jeffrey Rumschlag*1, James Dias1, Carolyn McClaskey1, Kelly Harris1
1 Medical University of South Carolina
SU121. Exploring the Mechanisms of Age-Related Hearing Loss Using Transcriptomics
Luis Cassinotti*1, Beatriz Borges1, Matthew Finneran2, M. Charles Liberman4, Roman Giger2, Gabriel Corfas1
1Kresge Hearing Research Institute University of Michigan Medical School, 2University of Michigan Medical School, 4Eaton-Peabody Laboratories, Mass Eye and Ear, Harvard Medical School
SU122. Changes in Cortical Directional Connectivity During Difficult Listening in Younger and Older Adults
Behrad Soleimani1, I.M Dushyanthi Karunathilake*2, Proloy Das3, Vrishab Commuri1, Stefanie Kuchinsky4, Behtash Babadi1, Jonathan Simon1
1University of Maryland, 2University of Maryland, College Park, 3Massachusetts General Hospital, 4Walter Reed National Military Medical Center
SU123. Novelty Detection in an Auditory Oddball Task on TgF344-AD Rats
Laura Quintela Vega*1, Perez-González David2, Manuel Malmierca2
1Institute of Neuroscience of Castilla y León, Cognitive and Auditory Neuroscience, 2Institute of Neuroscience of Castilla y León, Cognitive and Auditory Neuroscience; Institute for Biomedical Research of Salamanca, Auditory Neuroscience; University of Salamanca
SU124. Neural Representation and Auditory Perception of Temporal Fine Structure Are Impaired by Age but not by Cochlear Synaptopathy
Rainer Beutelmann1, Henning Oetjen1, Christine Koeppl1, Georg Klump1, Friederike Könitz-Steenken*1
1 Carl von Ossietzky University Oldenburg
SU125. Age-Related Changes in the Physiological and Molecular Markers of Central Gain Assessed in the Mongolian Gerbil
Jennifer Klara1, Julia D. Lewis2, Kimberly Yurasits1, Victoria E. Cancel1, Christopher L. Cunningham2, Aravindakshan Parthasarathy*1
1University of Pittsburgh, 2Pittsburgh Hearing Research Center, University of Pittsburgh School of Medicine
SU126. Comodulation Masking Release in Neurons of the Inferior Colliculus of Young and Old Mongolian Gerbils
Sandra Tolnai1, Carolin Jüchter1, Constantin Paladi1, Rainer Beutelmann1, Georg Klump1, Katja Bleckmann*2
1Carl von Ossietzky University Oldenburg, 2Cluster of Excellence Hearing4all, Carl von Ossietzky University.
SU127. Effects of Age on Within-Channel and Across-Channel Temporal Processing and Relationship to Speech Perception in Noise
Varsha M Athreya*1, Ravinderjit Singh1, Hari Bharadwaj2
1Purdue University, 2University of Pittsburgh
SU128. Using Interaural Time Difference Thresholds to Create Individualized “Mixed-Rate” Processing Strategies for Sound Localization Among Bilateral Cochlear Implant Listeners
Agudemu Borjigin*1, Stephen Dennison2, Alan Kan3, Ruth Litovsky1
1University of Wisconsin Madison, 2MED-EL Corporation, 3Macquarie University
SU129. Combined Optogenetic and Electrical Stimulation for Spatially and Temporally Precise Stimulation of Cochlear Neurons
Ajmal Abdul Azees*1, Alex Thompson2, Elise Ajay2, Andrew Wise2, Patrick Ruther3, David Garret4, Anita Quiqley4, James Fallon2, Rachael Richardson2
1Bionics Institute and RMIT University, 2Bionics Institute, 3University of Freiburg, 4RMIT University
SU130. What is the Basis of the Binaural Benefit for Music Sound Quality in Single-Sided Deaf Cochlear Implant Users?
Mahta Marefat*1, John Galvin1, Natalia Stupak2, David Landsberger2
1The House Institute Foundation, 2New York University
SU131. Progress on an Implantable Microphone for Cochlear Implants
Emma Wawrzynek*1, John Zhang1, Aaron Yeiser1, Elizabeth Olson2, Jeffrey Lang1, Hideko Heidi Nakajima3
1MIT, 2Columbia University, 3Harvard Medical School, Mass. Eye and Ear Infirmary
SU132. An Open Platform for Cochlear Implant Research
Abraham Akinin*1, Michael Triplett1, Razi-ul Haque1
1 Lawrence Livermore National Laboratory
SU133. Cortical Haemodynamic Responses to Auditory-Speech and Visual-Speech Stimuli Predicts Future Speech Understanding Outcomes for Cochlear Implant Recipients
Tommy Peng*1, Maureen Shader2, Mica Haneman1, Jamal Esmaelpoor3, Colette McKay1
1The Bionics Institute of Australia, 2Purdue University, 3University of Melbourne
SU134. Hearing Through a Bone Conduction Headset
Sudeep Surendran1, Srdan Prodanovic1, Stefan Stenfelt*1
1 Linkoping University
SU135. Improved Parameterization of a Hybrid Phenomenological-Biophysical Model of Cochlear Implant Stimulation of the Auditory Nerve
Ian Bruce*1
1 McMaster University
SU136. Bilocated Intracochlear Electrocochleography During Cochlear Implantation to Provide Surgical Feedback
Leanne Sijgers*1, Rahel Bertschinger1, Marlies Geys1, Ahmet Kunut1, Christof Röösli1, Alexander Huber1, Flurin Pfiffner1, Adrian Dalbert1
1 University Hospital Zurich, University of Zurich
SU137. First-In-Human Neurophysiological and Electrode Impedance Results for a Novel Penetrating Auditory Nerve Implant During Acute Intraoperative Experiments
Thomas Lenarz1, Amir Samii2, Karl-Heinz Dyballa1, Waldo Nogueira1, Moritz Leber3, Robert Franklin3, Rolf Benedikt Salcher1, Inderbir Sondh*4, Florian Solzbacher5, Meredith E. Adams4, Hubert H. Lim6
1Hannover Medical School, 2International Neuroscience Institute, 3Blackrock Neurotech, 4University of Minnesota, 5University of Utah, Blackrock Neurotech, 6Institute for Engineering in Medicine, University of Minnesota
SU138. Contribution of Macrophages to Neural Survival and Intracochlear Tissue Remodeling Responses Following Cochlear Implantation
Muhammad Rahman*1, Brian Mostaert1, Bryce Hunger1, Utsow Saha1, Alexander Claussen1, Ibrahim Razu1, Farjana Nasrin1, Nashwaan Khan1, Peter Eckard1, Sarah Coleman2, Jacob Oleson2, Jonathon Kirk3, Keiko Hirose4, Marlan Hansen1
1University of Iowa Hospitals and Clinics, 2University of Iowa, 3Cochlear Limited, Sydney, 4Washington University
SU139. Pulsed Infrared Light Stimulates the Cochlea by Generating Pressure Waves that Are Detected by Hair Cells
Julien Azimzadeh*1, Patricia Quinones2, John Oghalai2, Anthony Ricci1
1Stanford University, 2University of Southern California
SU140. Post-Exposure Treatment of Noise-Induced Hearing Loss by Bk Channel Blockers
Hong-Bo Zhao*1, Liman Liu1, Auraemil Quinonez2, Rafael Roberts2
1Yale University Medical School, 2University of Kentucky Medical Center
SU141. Facilitating Molecular Studies on Archival Human Temporal Bone and Brain Sections Using Poly(ethylene Glycol)-Mediated Celloidin Removal
David Bächinger*1, Jennifer T. O'Malley2, Morris Wolf3, Stéphane Bernhard3, M. Charles Liberman4, Mark W. Tibbitt3, Andreas H. Eckhard4
1University Hospital Zurich, 2Otopathology Laboratory, Massachusetts Eye and Ear, 3Macromolecular Engineering Laboratory, Institute of Energy and Process Engineering, ETH Zurich, 4Otopathology Laboratory, Massachusetts Eye and Ear; Harvard Medical School
SU142. Quantitative 2-Dimensional Assessment of Endolymphatic Hydrops in the Aging Human Temporal Bone
Maria Hurtado*1, Yassine Bahli2, Bryan Ward2, Amanda Lauer2, Dianela Perdomo2
1University of Arizona College of Medicine, 2Johns Hopkins University
SU143. National Perspectives on the Management of Hearing Loss in Patients with Limited English Proficiency
Adina Singer1, Aparna Govindan2, Lily Zekavat1, James Naples3, Jianjing Kuang1, Tiffany Hwa4, Adina Singer*5
1University of Pennsylvania, 2Mount Sinai Medical Center, 3Harvard Medical School, Beth Israel Deaconess Medical Center, 4University of Pennsylvania Health System, 5Perelman School of Medicine University of Pennsylvania
SU144. Coupled Influence of Tympanic Membrane Perforation Parameters on Hearing Loss and Surgical Outcome
Bastian Baselt*1, Merlin Schär2, Alexander Huber2, Jae Hoon Sim2
1University of Zürich, 2University Hospital Zurich
SU145. Histopathological Study of the Distribution of Schwann Cells and Microglia in the Cochlea of Human Temporal Bones with Neurofibromatosis Type 2
Drew Montigny1, Reef Al-Asad1, Jennifer O'Malley1, David Jung2, Andreas Eckhard2, Judith Kempfle2, Drew Montigny*3
1Massachusetts Eye and Ear, 2Massachusetts Eye and Ear, Harvard Medical School, 3Harvard Medical School
SU146. Short- And Long-Term Effects of Hearing Aids on Speech Recognition in Older Adults With Age-Related Hearing Loss – Preliminary Findings
Liat Shechter-Shvartzman1, Limor Lavie1, Karen Banai*1
1 University of Haifa
SU147. Neurophysiological, Structural and Molecular Alterations in the Prefrontal and Auditory Cortices Following Noise-Induced Hearing Loss
Sarah Hayes*1, Salonee Patel2, Parinita Arora2, Lin Zhao2, Ashley Schormans2, Shawn Whitehead2, Brian Allman2
1University of Rochester, 2Western University
SU148. Comparison of Hearing Aid Fitting Effectiveness With Audiograms From Either User-Operated or Traditional Audiometry in a Clinical Setting
Carl Pedersen1, Ellen Raben Pedersen2, Søren Laugesen3, Raul Sanchez-Lopez4, Jacob Nielsen2, Chris Bang Sørensen2, Jesper Hvass Schmidt1, Carl Pedersen*5
1Research Unit for ORL – Head and Neck Surgery and Audiology, Odense University Hospital; University of Southern Denmark, 2The Maersk Mc-Kinney Moller Institute, University of Southern Denmark, 3Interacoustics Research Unit, 4Oticon, 5University of Southern Denmark
SU149. Preservation of Distortion Product Otoacoustic Emissions (DPOAEs) in Hearing-Impaired Patients With Mutations in OTOF Gene
Rosamaria Santarelli*1, Pietro Scimemi1, María Domínguez-Ruiz2, Montserrat Rodríguez-Ballesteros2, Ignacio del Castillo2
1University of Padova, 2Hospital Universitario Ramón y Cajal
SU150. The Relationship Between Tinnitus Annoyance and Work-Related Noise Exposure History in Older Adults With Sensorineural Hearing Loss
Sabina Sabina Storbjerg Houmøller1, Li-Tang Tsai1, Anne Wolff2, Sreeram K Narayanan1, Dan Dupont Hougaard2, Michael Gaihede2, Christian Godballe1, Jesper Hvass Schmidt1, Sabina Storbjerg Houmøller*3
1Research Unit for ORL, Head and Neck Surgery and Audiology, Odense University Hospital and University of Southern Denmark, 2, Aalborg University Hospital, 3Research Unit for ORL, Head and Neck Surgery and Audiology, University of Southern Denmark
SU151. Refinement of Inner Hair Cell (IHC) Dysfunction in a Phenomenological Auditory Nerve (AN) Model Using Physiological and Single-Unit Recordings Following Selective IHC Dysfunction
Madhurima Patra*1, Afagh Farhadi1, Andrew Sivaprakasam1, David Axe2, Michael Heinz1
1Purdue University, 2Mathworks
SU152. Cortical Extracellular Matrix Glycoprotein Density Increases After Acoustic Noise Trauma in Tinnitus Animals Only
Konstantin Tziridis*1, Holger Schulze2
1University Hospital Erlangen, 2ENT Hospital Erlangen
SU153. Insights Into Auditory Phantom Perception and the Beneficial Role of Intrinsic Neural Noise in Auditory Processing
Patrick Krauss*1, Achim Schilling2
1University of Erlangen-Nuernberg, 2Neuroscience Lab, University Hospital Erlangen
SU154. A Brain-Constrained Tinnitus Model Based on Stochastic Resonance and Predictive Coding
Achim Schilling*1, Patrick Krauss1
1 Neuroscience Lab, University Hospital Erlangen
SU155. Characterizing Functional Changes of the Central Auditory System in Tinnitus
Emily Antes*1, Victoria Organtini1, Lori Zitelli1, Hari Bharadwaj1
1 University of Pittsburgh
SU156. Effect of Photobiomodulation on Tinnitus Induced by Acoustic Overexposure
So-Young Chang*1, Min Young Lee2, Ilyong Park2, Ji-Eun Choi2, Jae Yun Jung2
1Beckman Laser Institute Korea, Dankook University, 2Dankook University
SU157. Exploring the Mechanisms of Stress-Induced Tinnitus: Transcriptomic Analysis of the Prefrontal Cortex and Hippocampus in a Rat Model
Jae Sang Han*1, Junseong Park2, Ji Hyung Lim1, Ye Lin Kim1, So Young Park3, Yeun-Jun Chung2, Shi Nae Park1
1Seoul St. Mary's Hospital, The Catholic University of Korea, 2Precision Medicine Research Center, College of Medicine, The Catholic University of Korea, 3College of Medicine, The Catholic University of Korea
SU158. Efficacy and Safety of Intratympanic Botulinum Toxin Injection on Middle Ear Myoclonic Tinnitus: Clinical Outcomes in a Large Case Series
Young Jun Seo*1, Ji Hyung Lim1, Dowoon Han1, Jae Sang Han1, Jae-Hyun Seo1, So Young Park1, Shi Nae Park1
1 St. Mary’s Hospital, College of Medicine, The Catholic University of Korea
SU159. Tinnitus Affects the Response to Sound in the Inferior Colliculus
Alice Burghard*1, Emily Fabrizio-Stover2, Christopher Lee1, Douglas Oliver1
1University of Connecticut Health Center, 2Medical University of South Carolina
SU160. Influence of Auditory Experience With Jittered Input on Spatial Hearing of Cochlear Implanted Rats
Tim Fleiner*1, Emily Becker1, Susan Arndt1, Jan W Schnupp2, Nicole Rosskothen-Kuhl1
1Medical Center – University of Freiburg, 2City University of Hong Kong
SU161. A Fast and Accurate Algorithm of Sound Localization for Smart Hearing Aids
Elizabeth Flad*1, Jakeh Orr2, Yan Gai2
1Saint Louis University, 2School of Science and Engineering, Saint Louis University
SU162. Accounting for Individual Variability in the Recovery of Sound Localization Performance Following Acute Spatial Cue Distortion
David Audet*1, Aoi Hunsaker1, Lani Curry1, Andrew Brown1
1 University of Washington
SU163. Measuring and Modeling Real-World Sound Localization
Sagarika Alavilli*1, Andrew Francl2, Preston Hess2, Josh McDermott2
1Harvard University, 2Massachusetts Institute of Technology
SU164. Performance on a Novel Combined Sound Localization and Speech-In-Noise Task in Bilateral Cochlear Implant Recipients
Obada Abdulrazza*1, Nadine Ibrahim2, Madison Epperson1, Gerilyn Jones3, Carolyn Kroger1, Jackson Graves3, Anahita Mehta1, Renee Banakis Hartl1
1University of Michigan, 2University of Michigan Hospitals, 3University of Michigan, Kresge Hearing Research Institute
SU165. Comparison of Vowel Fusion Percepts With Headphones and Loudspeakers
Michéla Mondesir*1, Michelle Molis2, Stephen David1, Lina Reiss1
1Oregon Health and Sciences University, 2VA RR and D Nat'l Center for Rehabilitative Auditory Research
SU166. Patient-Derived Organoids Modelling Human TMPRSS3-Related Hearing Loss
Nathaniel Carpena*1, So-Young Chang1, Jae Yun Jung2, Kwang Sung Ahn3, Hosup Shim3, Jin Hee Han4, Min Young Kim4, Bong Jik Kim4, Yahree Kim4, Byung Yoon Choi4, Min Young Lee2
1Beckman Laser Institute Korea, Dankook University, 2Dankook University Hospital, 3Institute of Tissue Regeneration Engineering (ITREN), Dankook University, 4Seoul National University Bundang Hospital
SU167. Changes in Subjective Verticality Under Optokinetic Flows and Related Pupil and Cortical Responses: Focusing on the Impact of Cognitive Impairment
Bohee Lee1, YoungGyu Lee1, Yongwook Chae1, June Choi2, Yoonchan Rah*2
1Looxidlabs, 2Korea University College of Medicine
SU168. Unveiling the Neural Circuitry of Salience: Rough Sounds Processing in Mice
Noémi Gonçalves*1, Sabrina Méchaussier2, Shéhanie Udugampolage1, Carolina de Campos Pina3, Typhaine Dupont4, Nicolas Michalski5, Luc Arnal1, Boris Gourévitch6
1Hearing Institute, 3Institut de l'Audition, Institut Pasteur, 4Institut de l'Audition, Institut Pasteur, INSERM, Université de Paris, 5Intitut Pasteur, 6Institut de l'Audition, INSERM, Institut Pasteur; CNRS
SU169. Musical Groove Listening Does Not Enhance Primary Motor Cortex Activation
Daniel Berkowitz*1, Samantha O'Connell2, Grace Wilson1, Erin Hannon1, Joel Snyder1
1University of Nevada, Las Vegas, 2Keck School of Medicine of USC
SU170. Cross-Modal Stimulation in Changing Hearing Sensitivity and Tinnitus in Humans
Yuan He*1, Abigail Heiller1, Azaan Haider1, Hubert Lim1
1 University of Minnesota
SU171. Otoacoustic Test of Middle Ear Transmission Changes Associated With Increased Intracranial Pressure
Arturo Moleti*1, Triestino Minniti1, Arnaldo D'Amico1, Renata Sisto3, Teresa Botti3, Filippo Sanjust3, Luigi Cerini3, Maria Patrizia Orlando4, Giorgio Pennazza5, Marco Santonico5, Alessandro Zompanti5, Gabriele Mascetti6, Monia Vadrucci6, Giovanni Valentini6, Rosa Sapone7, Maurizio Deffacis7, Alessandro Crisafi7, Dario Castagnolo8, Marco Lucertini9, Robert MacGregor10
1University of Roma Tor Vergata, 3Inail Dimelia, 4CNR–INM, 5Campus Biomedico, 6ASI, 7ALTEC, 8Telespazio, 9Italian Air Force—Aerospace Medicine Dept, 10Airbus DS Space Systems and NASA
SU172. Monitoring the Course of Endolymphatic Hydrops With a Joint Reflection-Distortion OAE Profile
Samantha Stiepan*1, Christopher Shera1, Carolina Abdala1
1 University of Southern California
SU173. Accuracy of the Joint Reflection-Distortion OAE Profile in Detecting Mild Hearing Loss: Preliminary Findings
Carolina Abdala*1, Tricia Benjamin1, Ping Luo1, Samantha Stiepan1, Christopher Shera1
1 University of Southern California
SU174. Enhanced Otoacoustic Emissions in College Musicians: Role Training Recency and Noise Exposure
Morgan Main1, Erika Skoe*2
1University of Connecticut, University of Rochester School of Medicine and Dentistry, 2University of Connecticut
SU175. Contributions to Otoacoustic Emission Amplitudes Beyond Outer Hair Cells: Effects of Sedation and Inner Hair Cell Dysfunction
Samantha Hauser*1, Hari Bharadwaj2, Michael Heinz1
1Purdue University, 2University of Pittsburgh
SU176. Components Identified in SFOAEs Derived From a Nonlinear Cochlear Model Composed of Fluid-Coupled Oscillators
Vaclav Vencovsky*1, Ales Vetesnik1
1 Czech Technical University in Prague
SU177. Perception of USVs by the BTBR Mouse Model of Autism
Payton Charlton*1, Sevda Abdavinejad1, Micheal Dent1
1 University at Buffalo, SUNY
SU178. Adaptation to Sentences and Melodies When Making Judgments Along a Voice/Non-Voice Continuum
Zi Gao*1, Andrew J. Oxenham1
1 University of Minnesota
SU179. Impact of Reduced Spectral Resolution on Temporal-Coherence-Based Source Segregation
Vibha Viswanathan*1, Michael Heinz2, Barbara Shinn-Cunningham1
1Carnegie Mellon University, 2Purdue University
predictions for CMR as a function of degree of simulated outer-hair-cell (OHC) dysfunction.
SU180. The Impact of Inharmonicity on Voice Denumerability and Discrimination in Polyphonic Music
Lisanne Bogaard*1, Andrew Oxenham.1
1 University of Minnesota.
SU181. Behavioural and Electrophysiological Measures of Hearing in the Abnormally Wobbly Gait (AWG) Mutant Mouse Strain
Shane Seheult*1, Nicholas Boehler2, Kazuma Hase1, Shakshi Saini1, Sierra D'Amico1, Hai-Ying Mary Cheng2, Paul Faure1
1McMaster University, 2University of Toronto Mississauga
SU182. Individual Differences in Vowel Spectral Contrast and Auditory Enhancement Effects
Ali Williams*1, Andrew Oxenham1
1 University of Minnesota
SU183. Incidental Learning Enhances Auditory Sensitivity in Real-World Soundscapes
Manda Fischer*1, Morris Moscovitch2, Claude Alain2
1University of Western Ontario, 2The Rotman Research Institute at Baycrest Hospital
SU184. Syllable-Rate-Adjusted-Modulation (SRAM) Predicts Clear and Conversational Speech Intelligibility
Ye Yang*1, Fan-Gang Zeng1
1 University of California, Irvine
SU185. No Learning Effect and Small Variations in Ripple Test Outcomes With Different Acoustic Conditions
Esmee van Breda1, Koenraad Rhebergen1, Alexander Hoetink1, Dyan Ramekers1, Huib Versnel*1
1 University Medical Center Utrecht
SU186. Long-Term Experience with Amplification May Contribute to Broad Binaural Fusion
Nicole Dean*1, Holden Sanders1, Morgan Eddolls1, Lina Reiss1
1 Oregon Health and Science University
SU187. The Interactions of Spatial and Pitch Cues in Auditory Scene Analysis
Nima Zargarnezhad1, Ingrid Johnsrude*1
1 University of Western Ontario
SU188. Training a Deep Neural Network to Analyze Mouse Facial Grimace as a Measure of Painful Perception of Sound
Anna Kohler1, Elisabeth Glowatzki1, Megan Wood1, Anna Kohler*1
1 Johns Hopkins University School of Medicine
SU189. The Circularity of Audition: Perceptual Similarity Underlies Memory Performance for Simple Tones
Jamal Williams*1, Malinda McPherson1, Timothy Brady1
1 University of California, San Diego
SU190. Neural Correlation of Speech Envelope Tracking for Background Noise in Normal Hearing
Hyunjung An*1, Jeewon Lee2, Myung-Whan Suh3, Yoonseob Lim1
1Korea Institute of Science and Technology, 2Ewha Womans University, 3Seoul National University Hospital
SU191. Analysis of Word Type Specific ERPs Obtained From Continuous Speech EEG
Nikola Kölbl*1, Achim Schilling1, Patrick Krauss1
1 Neuroscience Lab, University Hospital Erlangen
SU192. Sex-Based Differences in TEOAE Results and Reproducibility Rates in Newborns
Ogechukwu Anwaegbu*1, Tomoko Makishima1
1 University of Texas Medical Branch of Galveston
SU193. Speech Sound Discrimination by Mongolian Gerbils Before and After Noise Trauma
Carolin Jüchter*1, Rainer Beutelmann1, Georg Martin Klump1
1 Carl von Ossietzky University Oldenburg
SU194. The Effects of Temporal-Spectral Asynchrony on Speech Intelligibility in a Multi-Talker Listening Environment
Jaeeun Lee*1, Andrew Oxenham1
1 University of Minnesota
SU195. Feasibility of Continuous Speech-Evoked Electroencephalography to Understand Language Comprehension
Luong Do Anh Quan1, Le Thi Trang1, Hyosung Joo1, Dongseok Kim1, Inyong Choi2, Jihwan Woo*1
1University of Ulsan, 2University of Iowa
SU196. Recruitment of Latent Neural Resources During Speech Recognition in Blast-Exposed Veterans
Christian Herrera Ortiz*1, Nicole Whittle1, Kelli Sugai1, Marjorie Leek1, Samuel Barnes, Barbara Holshouser, Alex Yi1, Jonathan Venezia1
1VA Loma Linda Healthcare System, 2Loma Linda University
SU197. Decoding of Imagined Speech and Music
Maryam Maghsoudi Shaghaghi*1, Mohsen Rezaeizadeh1, Rupesh Chillale2, Guilhem Marion3, Ali Ibrahim Ali Mohammed1, Abhinav Uppal4, Gert Cauwenberghs4, Giovanni Di Liberto5, Jonathan Simon6, Shihab, A Shamma7
1University of Maryland, College Park, 2Institute for Systems Research, University of Maryland, College Park, 3Ecole Normale Superieure, 4University of California San Diego, 5Trinity College Dublin, 6University of Maryland, 7University of Maryland; École Normale Supérieure
SU198. Robust Evaluation of the Cortical Encoding of Word-Level Expectations Using the Temporal Response Function
Amirhossein Chalehchaleh1, Martin Winchester1, Giovanni Di Liberto*1
1 Trinity College Dublin
SU199. Individual Variability in Behavioral and Neural Measures of Categorical Perception
Bhamini Sharma1, Ashley Lombardi2, Emily Myers2, Erika Skoe*2
1University of Connecticut, Now at Brooklyn College, NYC, 2University of Connecticut
SU200. Multi-Session Training in the Evening Schedule Promotes Speech Learning
Akshay Maggu*1, Mansi Roy2, Tanaya Rowell2, Lydia Seiling2
1University of Connecticut, 2Hofstra University
SU201. Investigating Contributions of Temporal Processing on Speech-In-Noise Understanding in Middle-Aged Adults
Kailyn McFarlane*1, Jason Sanchez1
1 Northwestern University
SU202. The Human Middle Ear in Motion: Direct Visualization and Movement Quantification Using Dynamic Synchrotron-Based X-Ray Phase-Contrast Microtomography
Aleksandra Ivanovic*1, Margaux Schmeltz2, Wilhelm Wimmer3, Marco Caversaccio1, Christian Schlepütz2, Aaron Remenschneider4, Marco Stampanoni2, Anne Bonnin2, Lukas Anschuetz1
1University Hospital Bern, Inselspital, 2Paul Scherrer Institut, 3Technical University of Munich, 4Mass Eye and Ear, Harvard Medical School
SU203. Mechanical Impedance of the Human Head at Different Stimulation Position, Static Forces, and Interface Areas
Sudeep Surendran1, Stefan Stenfelt*1
1 Linkoping University
SU204. Assessing the Safety of Non-Invasive Electrical Stimulation in the External Auditory Canal
Dong-min Kang*1, TaeSoo Noh1, Chiheon Kwon2, Yunseo Ku3, Myung-Whan Suh1
1Seoul National University Hospital, 2Seoul National University, 3Chungnam National University
SU205. Deficits in Sensory and Neural Processing of Auditory/Vestibular Cues in Zebrafish Spen Mutants
Yan Gao*1, Eliot Smith1, Anna Shipman1, Itallia Pacentine2, Timothy Erickson3, Alex Nechiporuk2, Teresa Nicolson1
1Stanford School of Medicine, 2Oregon Health and Science University, 3East Carolina University
SU206. Developing and Validating a Calibration Method to Reduce Wave Peak Amplitude Variability in Auditory Evoked Potentials
Joseph Pinkl*1, John Hawks1, Jinsai Cheng2, Tao Shen2, Jianxin Bao1
1Gateway Biotechnology Inc., 2Kent State University
SU207. The Study on the Biomarkers of Specific Damage of Explosive Deafness
Ning Yu*1
1 Institute of Otolaryngology
SU208. Morphological and Behavioral Alterations in Sprague Dawley Rats Following Single Intraperitoneal 3′3-Iminodipropionitrile Administration
John Patrick Cuenca*1, Nataniel Carpena2, So-Young Chang3, Min Young Lee2, Ji-Eun Choi2, Jae Yun Jung2
1Dankook University, 2Dankook University Hospital, 3Beckman Laser Institute Korea, Dankook University
SU209. Vestibular Perceptual Thresholds Correlate With Endolymphatic Volume in Patients With Meniere’s Disease
Kimberly Ramirez*1, Cameron Fattahi1, Faisal Karmali2, Andreas H. Eckhard2, Steven D. Rauch2, Amy F. Juliano2, Richard F. Lewis2, Divya A. Chari2
1UMASS Medical School, 2Massachusetts Eye and Ear Infirmary, Harvard Medical School
SU210. Modernizing Vestibular Function Testing Through Multi-Frequency Examination of the Vertical Vestibulo-Ocular Reflex
Erin Williams*1, Fumihiro Mochizuki1, Alexander Kiderman2, Michael Hoffer1
1University of Miami Miller School of Medicine, 2Neurolign, Inc.
SU211. Oculomotor, Vestibular, and Reaction Time (OVRT) Assessment in Parkinson Patients
Devin McCaslin*1, Simon David1, Stiven Roytman1, Kanel Prabesh1, Rebecca Paalanen1, Alexis Griggs1, Kevin Kerber2, Fay Pongmala1, Austin Luker1, Robin Ashmore3, Alex Kiderman3, Nicolaas Bohnen1
1University of Michigan, 2The Ohio State University, 3Neurolign Technologies
SU212. Vestibular Dysfunction in Individuals With Parkinson Disease With Freezing of Gait
Devin McCaslin*1, Simon David1, Stiven Roytman1, Kanel Prabesh1, Alexis Griggs1, Kevin Kerber2, Fay Pongmala1, Austin Luker1, Nicolaas Bohnen1
1University of Michigan, 2The Ohio State University
SU213. Age-Dependent Changes in Sound-Evoked Vestibular Myogenic Potentials in Preclinical Models of Noise Overexposure
Federica M. Raciti*1, Kayla Minesinger2, Hillary Snapp1, Suhrud Rajguru3
1University of Miami Miller School of Medicine, 2University of Miami, 3University of Miami, Restor-Ear Devices LLC,
SU214. Natural History of Vestibular Dysfunction in USH1C Mice
Jessica Landry*1, Zelma Guisela Iriarte2, Caroline Sit2, Aaron McCullough1, Matthew Ward1, Youguo Xu2, Tianwen Chen2, Gwenaelle S.G. Geleoc3, Hong Zhu2, Wu Zhou2, Jennifer Lentz4
1Louisiana State University School of Medicine, 2University of Mississippi Medical Center, 3Boston Children's Hospital, Harvard Medical School, 4LSU Health Sciences Center
SU215. Effects of Lifetime Noise Exposure on Irregular Afferent Function and the Near VOR Response
Natela Shanidze*1, Anca Velisar1
1 The Smith-Kettlewell Eye Research Institute
Young Investigator Symposium 4—New Approaches and Technologies in Auditory Neuroscience
1:45 p.m.—3:45 p.m.
Grand Ballroom Salon E
New Approaches and Technologies in Auditory Neuroscience
Chair: Bonnie K. Lau, University of Washington
Co-Chair: Giovanni Di Liberto, Trinity College Dublin
Understanding Speech Processing in Children and Adolescents Using Intracranial Recordings
Liberty Hamilton
The University of Texas at Austin
Using EEG, Pupillometry and Information Modelling to Track Musical Expectations in Non-Human Primates
Roberta Bianco
Istituto Italiano di Tecnologia
From Whole-Brain Decoding to Single Neuron Spiking: Uncovering the Code of Speech Comprehension
Laura Gwilliams
Stanford University
Hierarchical Encoding of Natural Sound Mixtures in Ferret and Human Auditory Cortex
Yves Boubenec
Ecole Normale Superieure
The Organization of Neural Integration Windows in the Human Auditory Cortex
Samuel Norman-Haignere
University of Rochester
Investigating Auditory Cognition With Natural Speech and Music
Giovanni Di Liberto
Trinity College Dublin
Investigating Maturation of Auditory Cortical Processing in Infants Using Magnetoencephalography
Bonnie K. Lau
University of Washington
Podium Session 7—Regeneration
1:45 p.m.—3:45 p.m.
Platinum Salon 5
Endogenous Progenitor Cells in the Adult (Human and Mouse) Cochlea
Natalia Smith-Cortinez*1, Joep Kuppers1, Huib Versnel1, Hans G.X.M. Thomeer1, Robert J. Stokroos1, Louise Straatman1
1 University Medical Center Utrecht
“Turning off” Hippo Signaling Induces Cochlear Hair Cell Regeneration Primarily via Direct Trans-Differentiation
Huiqian Yu*1, Xiaoling Lu1, Jiaoyao Ma1, Kunkun Wang1, Shan Sun1, Huawei Li1, Xiaoling Lu1
1 Eye and ENT Hospital, Fudan University
The Phoenix Platform as Novel Tool to Unveil Regenerative Pathways in Presenescent Auditory Neuroprogenitors
Francis Rousset*1, Stéphanie Sgroi1, Lucie Oberhauser1, Rebecca Sipione1, Giulia Schilardi2, Sonja Kleinlogel2, Vincent Jaquet1, Pascal Senn1
1University of Geneva, 2University of Bern
Mechanistic Insights Into the Regenerative Ability of Greater Epithelial Ridge Cells.
Marie Kubota*1, Paul K. Lee1, Taha A. Jan2, Stefan Heller1
1Stanford University School of Medicine, 2Vanderbilt University Medical Center
Progenitor Cell Pools in the Chick Auditory Epithelium and Their Response to Hair Cell Loss
Marie Takeuchi*1, Mami Matsunaga2, Ryosuke Yamamoto2, Tomoko Kita2, Koichi Omori2, Takayuki Nakagawa2
1Kyoto University, 2 School of Medicine, Kyoto University
Combinatorial Transcription Factor Gene Therapy Induces Hair Cell Regeneration on Both Sides of the Basilar Membrane
Yujie Liu1, Lin Yang1, Sunita Singh2, Lisa Beyer1, Diane Prieskorn1, Donald Swiderski1, Hanna Erhardt1, Andrew Groves2, Yehoash Raphael*1
1University of Michigan, 2Baylor College of Medicine
Unexpected Dynamics of Vestibular Hair Cell Differentiation During Normal Development and Local Regeneration
Shahar Kasirer1, Olga Loza1, David Sprinzak*1
1 Tel Aviv University
analysis of the morphological and regulatory events (delaminations, divisions, and differentiation) in the
Lsd1 Knockout Promotes Atoh1-Mediated Conversion of Supporting Cells to Hair Cells in Mouse Cochleae
Jackson Diers*1, Yan Zhang1, Shu Tu1, Zhenhang Xu1, June Li1, Huizhan Liu1, Mi Zhuo1, Guanfang Xie1, Litao Tao1, Jian Zuo2
1Creighton University School of Medicine, 2Creighton University School of Medicine and Ting Therapeutics LLC
Podium Session 8—Binaural Hearing and Sound Localization
1:45 p.m.—3:45 p.m.
Platinum Salon 6
Does Hearing Experience With Jittered Input Affect the Temporal Weighting of Binaural Stimuli in Cochlear Implanted Rats?
Nicole Rosskothen-Kuhl*1, Tim Fleiner1, Emily Becker1, Alexa N Buck2, Susan Arndt1, Jan W Schnupp3
1University of Freiburg,, 2City University of Hong Kong
How Sensitive is the Deaf, Cochlear Implanted Auditory System for Interaural Time and Interaural Level Differences and How Do They Interact in Spatial Hearing?
Sarah Buchholz*1, Heika Hildebrandt-Schoenfeld1, Theresa A Preyer1, Henrike Budig1, Susan Arndt1, Jan W Schnupp2, Nicole Rosskothen-Kuhl1
1University of Freiburg, 2City University of Hong Kong
Role of Inhibition in Shaping Interaural Time Difference Tuning in the Medial Superior Olive
Ben-Zheng Li*1, Matthew Ridenour1, Tim Lei2, Achim Klug1
1University of Colorado Anschutz Medical Campus, 2University of Colorado Denver
Binaural-Bimodal (Electric/Acoustic) Stimulation Degrades Neural Coding of Interaural Time Differences
Maike Vollmer*1, Merle Berents1, Andreas Schulz2, Frank W. Ohl2
1University Hospital Magdeburg; Systems Physiology of Learning, Leibniz Institute for Neurobiology, Magdeburg, 2Systems Physiology of Learning, Leibniz Institute for Neurobiology
Speech-In-Noise and Sound Localization in Single Sided Deafness and Cochlear Implantation: Differences in Complex Head Movements, Localization, and Speech Performance in Noise
Nadine Ibrahim*1, Gerilyn Jones2, Obada Abdulrazzak2, Madison Epperson1, Chioma Anidi2, Carolyn Kroger2, Jackson Graves2, Renee M. Banakis Hartl1
1University of Michigan Hospitals, 2University of Michigan
Effects of Preceding Exposure on Distance Perception in Varying and Fixed Virtual Environments
Norbert Kopco*1, Myroslav Fedorenko1
1 P.J. Safarik University, Kosice
Providing a Binaural Advantage by Improving the Signal-To-Noise Ratio in the Acoustically Better Ear
Enrique Lopez-Poveda*1, Almudena Eustaquio-Martín1, Milagros J Fumero1, Fernando M. San-Victoriano1
1 University of Salamanca
Cortical Patches and Map of Auditory Space
Chenggang Chen*1, Xindong Song1, Yueqi Guo1, Xiaoqin Wang1
1 Johns Hopkins University
Workshop: DMA Supportive Allyship and STEM
4:00 p.m.—6:00 p.m.
Platinum Salon 5
Supportive Allyship in STEM
Chair: Jeffrey Cheng, Mass. Eye and Ear/Harvard Medical School
Co-Chair: Tejbeer Kaur, Rutgers University, Robert Wood Johnson School of Medicine, Rutgers Brain Health Institute
Presenters: Samantha O'Connell, Keck School of Medicine of USC
Meg Warren, Western Washington University
Samantha O'Connell, Keck School of Medicine of USC
Matheus Macedo-Lima, University of Maryland
Jeffrey Cheng, Mass. Eye and Ear/Harvard Medical School
In Memoriam Symposium—Mechanics and Physiology of the Inner Ear Vestibular Organs: A Tribute to J. Wally Grant
4:00 p.m.—6:00 p.m.
Platinum Salon 6
Mechanics and Physiology of the Inner Ear Vestibular Organs: A Tribute to J. Wally Grant
Chair: Jong-Hoon Nam, University of Rochester
Ultrafast Non-Quantal Vestibular Synaptic Transmission Probably Differentiates Vestibular From Cochlear Responses to Sound and Vibration: A Tribute to Wally Grant
Ian Curthoys
University of Sydney
Vestibular Biomechanics in Health and Disease
Richard Rabbitt
University of Utah
Does the Distribution of Hair Cell Morphologic Polarization Vectors Provide Evidence of Spatial Tuning in the Mammalian Utricle?
Larry Hoffman
Geffen School of Medicine at UCLA
Transduction in Mammalian Otolith Organs: In Memory of Wally Grant
Ruth Anne Eatock
University of Chicago
Activity of the Efferent Vestibular Nucleus Neurons in Mice During Self-Generated, High Acceleration Head Movements
Alan Brichta
The University of Newcastle
Understanding the Effects of Vestibular Efferent Stimulation on Afferent Responses to Vestibular Stimuli: A Nod to Wally Grant
Joseph Holt
University of Rochester
Engineering in a Dish: A Hokie Journey From Mechanics to Molecules
R. Keith Duncan
University of Michigan
Monday, February 5, 2024
Symposium 5—Advanced Imaging Methods and Applications for Inner Ear Studies
8:00 a.m.—10:00 a.m.
Platinum Salon 5
Advanced Imaging Methods and Applications for Inner Ear Studies
Chair: Katie Kindt, NIH/NIDCD
Co-Chair: Uri Manor, University of California, San Diego
How Does Maturation and Aging Change the Morphological Vesicle Pools of Auditory Synapses?
Carolin Wichmann
Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience, InnerEarLab and Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen
Dynamic Structural Plasticity Determines Developmental Maturation of the Cochlear Inner Hair Cell Ribbon Synapse
Roos Voorn
Medical University Innsbruck, Auditory Neuroscience Group
Longitudinal Quantification of Inner Ear Fluid Spaces and Endolymphatic Hydrops on Contrast-Enhanced Delayed Flair MRI: Reliability and Correlation With Changes in Hearing
Julia Telischi
University of Miami Miller School of Medicine
High-Resolution Imaging of Human Inner Ear
Konstantina Stankovic
Stanford School of Medicine
A Population of Short Actin Filaments Contributes to Stereocilia Widening
Benjamin Perrin
Indiana University, Purdue University
A Deep-Learning Approach at Mitochondria Morphological Analysis in the Outer Hair Cell
Christopher Buswinka
Harvard University
New Uses for Local Shape Descriptors in Image Analysis
Uri Manor
University of California
Podium Session 9—Auditory Research Insights: Ear Morphology, Hearing Tests, and Tinnitus Treatments in Animal Models
8:00 a.m.—10:00 a.m.
Platinum Salon 6
Efficacy of AC102 in a Noise-Induced Tinnitus Model in Mongolian Gerbils
Konstantin Tziridis1, Monika Kwiatkowska2, Holger Schulze1, Reimar Schlingensiepen*2
1University Hospital Erlangen, ENT Hospital, Experimental Otolaryngology, 2AudioCure Pharma GmbH
Differences in External Morphology and Implications for Auditory Function in Two Closely Related Mouse Species (Peromyscus Leucopus and Peromyscus Maniculatus)
Casey Sergott*1, Katelynn Rodman1, Luberson Joseph1, Emily Margaret New1, Genesis Alarcon1, Elizabeth McCullagh1
1 Oklahoma State University
Audiometric and Vestibular Testing of a Murine Model of Down Syndrome
Cong Tian1, Gabrielle Merchant2, Sarath Vijayakumar1, Gini George1, Katherine Waugh3, Kelly Sullivan3, Joaquin Espinosa3, Peter Steyger*1
1Translational Hearing Center, School of Medicine, Creighton University, 2Center for Hearing Research, Boys Town National Research Hospital, 3Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
Up-Regulation of Gaba Type a Receptor α1 in the Dorsal Cochlear Nucleus of Rats With Noise-Induced Tinnitus and Evidence of Therapeutic Mitigation With NHPN-1010
Xiaoping Du*1, Weihua Cheng1, Qunfeng Cai1, Jianzhong Lu1, Zachary Yokell1, Don Nakmali1, Richard D. Kopke1, Matthew West1
1 Hough Ear Institute
Ebselen Attenuates Noise-Induced Tinnitus in Older Mice With Age-Related Hearing Loss
Annie Jia1, Ryan Longenecker1, Rende Gu1, Celia Escabi2, Jonathan Kil*1
1Sound Pharmaceuticals, Inc., 2UT Dallas, Sound Pharma
Bone Conducted Ossicular Sound Transmission in Elephant and Human Middle Ears
Caitlin O'Connell-Rodwell*1, Jodie Berezin1, Xiying Guan2, Anbuselvan Dharmarajan1, Alessio Pignatelli4, Sunil Puria5
1Harvard Medical School, Eaton Peabody Lab, Massachusetts Eye and Ear Infirmary, 2Wayne State University, 4Johns Hopkins University, 5Harvard Medical School, Mass. Eye and Ear Infirmary
Therapeutic Effects of Near-Infrared Light (NIR) on Tinnitus in Rats
Jinsheng Zhang*1, Po Hung Chiang1, Paul Morse1, Tasnim Arroum1, Maik Huttemann1
1 Wayne State University
In-Vivo Middle Ear Imaging via Transbullar Approach for Topical Delivery of Rhodamine Liposomes
Ki Wan Park*1, Stella Yang1, Roya Sadabad1, Tulio Valdez1
1 Stanford University School of Medicine
Podium Session 10—Brainstem: Structure and Function
8:00 a.m.—10:00 a.m.
Grand Ballroom Salon E
Spatial Transcriptomic Analysis of Mouse Cochlear Nucleus
Huihui liu*1, Weijun Zhou1, Xingle Zhao1, Cai Ruijie1, Hongchao Liu1, Hao Wu1
1 Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Heksor: A Novel Framework for Conceptualizing Olivo-Cochlear Efferent System Functions
Anthony Cacace*1
1 Wayne State University.
A Striking Source of Giant Synapses in the Auditory Thalamus: The Olivo-Thalamic Projections
Héctor Rincón*1, Mario Gómez-Martínez1, Marcelo Gómez-Álvarez1, Enrique Saldana1
1 University of Salamanca
Discovering Neuron Types and Constructing Synaptic Maps Utilizing High Throughput Segmentation of Volume Electron Microscopy Images
Timothy Fawcett*1, Emily Amick*1, Audrey Gabbard1, Matthew Madany2, Christine Kim2, Mark Ellisman2, Paul Manis3, George Spirou*1
1University of South Florida, 2University of California, San Diego, 3University of North Carolina, Chapel Hill
A Critical Period for Synaptic Refinement in Octopus Cells of the Mammalian Cochlear Nucleus
Lauren J. Kreeger*1, Sydney Maeker1, Lisa V. Goodrich1
1 Harvard Medical School
Perinatal Nicotine Exposure Disrupts nAChR Functional Expression and Impairs Glutamatergic Synaptic Transmission in the Mouse Auditory Brainstem
Mackenna Wollet*1, Abram Hernandez, Kaila Nip1, Jason Pugh1, Jun Hee Kim3
1UT Health Science Center at San Antonio, 3University of Michigan
Ipsilateral Noise Effect on Human Electrocochleography Latencies
Lavinia Slabu*1, Grégory Gerenton1, Céline Quinsac1, Paul Avan1
1 Institut Pasteur, Université Paris Cité, Inserm, Institut de l’Audition
Serotonin Excites Medial Olivocochlear Efferent Neurons
Kirupa Suthakar*1, Catherine JC Weisz1
1 National Institute on Deafness and Other Communication Disorders (NIH/NIDCD)
Symposium 6—The Leaky Pipeline: How Can Mentors Better Support, Advocate, and Encourage Women and Underrepresented Minorities to Remain in the Sciences?
10:15 a.m.—12:15 p.m.
Platinum Salon 6
The Leaky Pipeline: How Can Mentors Better Support, Advocate, and Encourage Women and Underrepresented Minorities to Remain in the Sciences?
Chair: Tejbeer Kaur, Rutgers University, Robert Wood Johnson School of Medicine, Rutgers Brain Health Institute
Co-Chair: Jeffrey Cheng, Mass. Eye and Ear/Harvard Medical School
Podium Session 11—Inner Ear: Ototoxicity and Otoprotection
10:15 a.m.—12:15 p.m.
Platinum Salon 5
Live Imaging of Intracellular Calcium Waves in Mature Hearing Cochlea After Noise Exposure
Yesai Park1, Noura Ismail1, Ian Matthews1, Peu Santra1, Dylan Chan*1
1 University of California, San Francisco
Age-Related Hair Cell Loss in Zebrafish: Decoupling of Homeostasis Vs. Regeneration
Allison Coffin*1, Emily Dale1, Olivia Molano1, Alexandra Pederson1
1 Washington State University
Macrophage Ablation Protects Against Cisplatin-induced Hearing Loss Without Affecting the Tumor Efficacy of Cisplatin in Mice
Cathy Yea Won Sung*1, Bryce Hambach2, Haley Ogbemudia3, Katharine Fernandez1, Mark Warchol4, Lisa Cunningham1
1National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 2Sidney Kimmel Medical College at Thomas Jefferson University, 3New York University, 4Washington University School of Medicine
Pharmacological Downregulation of TRPV1 Channels Protects From Aminoglycoside-Induced Hearing Loss
Marisa Zallocchi*1, Jonathan Fleegel1, Dhaval Shukal1, Jian Zuo2, Ali Sajid3, Abdul-Rizaq Ali Hamound3, Robert McCullumsmith4, Lyudmila Batalkina1, Martin Conda-Sheridan5, Luana De Campos5, Sarath Vijayakumar1
1Creighton University, 2Ting Therapeutics LLC, 3University of Toledo, 4University of Toledo and Neurosciences Institute, ProMedica, 5College of Pharmacy, University of Nebraska Medical Center
Higher Platinum Signal is Detected in the Inner Hair Cells Than in the Outer Hair Cells After Systemic Cisplatin Administration
Xiaodong Tan*1, Prerita Pandya1, Devin Thomas1, Robert Fuentes1, Chail Koo1, Olga Antipova2, Luxi Li2, Yang Yang3, Claus-Peter Richter1
1Feinberg School of Medicine, Northwestern University, 2Advanced Photon Source, Argonne National Laboratory, 3Brookhaven National Laboratory, National Synchrotron Light Source II
Exploring Protective Strategies Against Aminoglycoside-Induced Ototoxicity Using Molecular Dynamics Simulations and Transcriptomic Analyses
Cheng Yu Hsieh*1, Cheng-Yu Tsai2, Chen-Chi Wu3
1Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 2Graduate Institute of Medical Genomics and Proteomics, National Taiwan University College of Medicine, 3National Taiwan University Hospital; National Taiwan University Hospital Hsin-Chu Branch
Vesicular Compartmentalization of Aminoglycosides in Zebrafish Lateral Line Hair Cells
Francisco Barros Becker*1, Patricia Wu2, David Raible2
1University of Washington School of Medicine, 2University of Washington
Designing a Tumor-Bearing Mouse Model of Cisplatin-Induced Hearing Loss to Test Potential Therapeutics
Bryce Hambach*1, Cathy Yea Won Sung2, Haley Ogbemudia3, Katharine Fernandez4, Lisa Cunningham4
1Sidney Kimmel Medical College at Thomas Jefferson University, 2National Institute of Health, 3New York University, 4National Institute on Deafness and Other Communication Disorders
Podium Session 12—Hearing Loss: Implication for Cochlear Implantation and Cross-Modal Plasticity
10:15 a.m.—12:15 p.m.
Grand Ballroom Salon E
Impact of Inner Ear Malformation and Cochlear Nerve Deficiency on the Development of Auditory-Language Network in Children With Profound Sensorineural Hearing Loss
Yaoxuan Wang*1, Mengda Jiang1, Yuting Zhu1, Lu Xue1, Wenying Shu1, Xiang Li1, Hongsai Chen1, Yun Li1, Ying Chen1, Yongchuan Chai1, Yu Zhang1, Xiaofeng Tao1, Zhaoyan Wang1, Hao Wu1
1 Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Hearing Loss in Adult Rats Leads to Less Ultrasound Vocalization During Social Interaction, Cognitive Disturbances in Visuospatial Attention and Learning Behavior
Mariele Stenzel1, Mesbah Alam1, Jonas Jelinek1, Joachim K. Krauss1, Kerstin Schwabe1, Marie Johne*1
1 Hannover Medical School
Visual and Auditory Implicit Learning in Adult Cochlear Implant Users: A Cross-Modal Contribution to Speech Recognition?
Ranin Khayr1, Riyad Khnifes1, Talma Shpak2, Karen Banai*3
1University of Haifa and Bnai-Zion Medical Center, 2Bnai-Zion Medical Center, 3University of Haifa
Differences in Neural Correlates of Auditory Working Memory Between Cochlear Implant Users and Typical Hearing Controls
Priyanka Prince*1, Joseph Chen2, Trung Le2, Vincent Lin2, Andrew Dimitrijevic3
1Sunnybrook Health Sciences Center, Sunnybrook Health Sciences Centre; University of Toronto, 3Sunnybrook Hospital ENT, University of Toronto.
Neural Entrainment of a Naturalistic Conversation in Varying Working Memory Loads
Priyanka Prince*1, Joseph Chen2, Trung Le2, Vincent Lin2, Andrew Dimitrijevic.3
1Sunnybrook Health Sciences Center, 2Sunnybrook Health Sciences Centre; University of Toronto, 3Sunnybrook Hospital ENT University of Toronto
Characterization and Mitigation of Hearing Damage Induced by Repeated Mild Blast TBI in Chinchillas
Shangyuan Jiang*1, Rong Gan1
1 University of Oklahoma
Localizing Cross-Modal Plasticity: Sensory Border Dynamics and Implications for Cochlear Implantation in Adult-Onset Deafness
Mariele Stenzel1, Alam Mesbah1, Marie Johne1, Peter Baumhoff2, Wiebke Konerding2, Kerstin Schwabe1, Andrej Kral2, Rüdiger Land*2
1Hannover Medical School, 2Institute of Audioneurotechnology, Hannover Medical School
Effects of Cognitive Load and Spatial Hearing on Postural Sway and Associations With Fall Risk in Older Adults With and Without Hearing Aids
Alexander Francis*1, Shirley Rietdyk1, Jeffrey Haddad1, Sarah Burgin2, Sharon Christ1, Melissa Newell1, Mia Schmetter1, Abigail Foley1
1Purdue University, 2Indianapolis University School of Medicine
Poster Session 3
1:15 p.m.—3:15 p.m.
Marquis Ballroom
M1. Auditory Attention Decoding Using Epidural Electrodes
Desmond Mehta*1, Vishal Choudhari2, Nima Mesgarani2
1Cold Spring Harbor High School, 2Columbia University
M2. Exploring a Possible EEG Marker of Anticipatory Processing in a Natural Speech-Based Selective Attention Task
Thomas Stoll*1, Ross Maddox1
1 University of Rochester
M3. Neural Correlates of Auditory Figure-Ground Segregation in Cochlear Implant and Hearing Aid Users
Nour Alsabbagh*1, Phillip Gander2, Bob McMurray1, Timothy Griffiths3, Inyong Choi1
1The University of Iowa, 2University of Iowa Hospitals and Clinics, 3Biosciences Institute, Newcastle University
M4. Analyzing Sub-Groups of People Living With HIV in Tanzania Who Perform Below Average in Central Auditory Tests
Titilayo Mabogunje*1, Christopher Niemczak2, Samantha Leigh2, Linda Zhang2, Albert Magohe3, Enica Massawe3, Jay Buckey2
1Geisel School of Medicine at Dartmouth, 2Dartmouth-Hitchcock, Geisel School of Medicine, 3Muhimbili University of Health and Allied Sciences
M5. Decoding Maintenance and Replay Activity in the Human Auditory Cortical Mnemonic System
Ryan Calmus*1, Zsuzsanna Kocsis2, Yukiko Kikuchi3, Hiroto Kawasaki1, Timothy D. Griffiths3, Matthew A. Howard III1, Christopher I. Petkov4
1University of Iowa, 2Carnegie Mellon University, 3Newcastle University, 4University of Iowa and Newcastle University
M6. Comparison of Speech in Noise Processing in Hearing Impaired Populations Using O-15 Water Pet
Phillip Gander*1, Laura Kiskunas2, Joel Berger1, Bob McMurray2, Inyong Choi2, Laura Ponto1, Timothy Griffiths3
1University of Iowa Hospitals and Clinics, 2University of Iowa, 3Biosciences Institute, Newcastle University Medical School
M7. Hearing Impairment Exacerbates Cognitive Dysfunction and Accelerates the Progression of Alzheimer’s Disease by Increasing Inflammation in the Brain
Yoo-Seung Ko1, Young Mi Choi1, Hyong-Ho Cho1, Sungsu Lee2, Yoo-Seung Ko*1
1Chonnam National University Medical School, Chonnam National University Hospital, 2Chonnam National University Hospital, Gwangju
M8. Similar Abstract Coding Properties of Frontal Cortex Neurons in Appetitive and Aversive Auditory Discrimination Tasks in Ferrets
Pingbo Yin*1, Jonathan Fritz2, Shihab, A Shamma3
1University of Maryland, 2New York University, 3University of Maryland, École Normale Supérieure
M9. Auditory Cortex Subplate Neurons Form Distinct Molecular and Functional Classes During Early Postnatal Development
Minzi Chang*1, Zheng Xu1, Patrick O. Kanold1
1 Johns Hopkins University.
M10. Role of Oxidative Stress in Excitotoxicity Induced Auditory Synaptopathy: Implication for Molecule Screening
Anissa Rym Saidia*1, Florence François1, François Casas2, Jean Luc Puel1, Jing Wang1
1Institute for Neurosciences of Montpellier- INSERM_U1298, 2INRAE, Montpellier
M11. Optogenetic Activation of Single Spiral Ganglion Neurons Using ChReef
Anna Vavakou*1, Victoria Hunniford2, Maria Zerche3, Bettina Wolf4, Thomas Mager3, Tobias Moser1
1University Medical Center Göttingen, 2University of Goettingen, 3Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 4Institute for Auditory Neuroscience, University Medical Center Göttingen
M12. Comparing Spiral Ganglion Neuron Subtypes: Synaptic Properties and in Vivo Responses at Targets in the Anteroventral Cochlear Nucleus
Nicole Wong1, Sydney Brongo1, Evan Forero1, Connor Cook1, Shuohao Sun2, Amanda Lauer2, Ulrich Mueller2, Matthew Xu-Friedman*1
1University at Buffalo, SUNY, 2Johns Hopkins University
M13. Aging Effects on Human Auditory Nerve Myelination: Morphological and Clinical Associations
Shelby Payne*1, Jeffrey Rumschlag1, Kelly Harris1, Hainan Lang1
1 Medical University of South Carolina
M14. Correlation Study of Astrocytes and Noise-Induced Cochlear Nucleus Damage and Regeneration
Weijun Zhou*1, Sidi Liu2, Meijian Wang3, Huihui Liu2
1Shanghaijiaotong University, 2Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 3The Ohio State University
M15. The Impact of Small Arms Fire-Like Noise on Temporal Processing of Simple and Complex Stimuli
Meredith Ziliak*1, Emily Bell1, Andres Navarro1, Edward L. Bartlett1
1 Purdue University
M16. Discrimination Between Natural Vocalizations in Challenging Conditions: Relationships Between Behavioral Performance of CBA Mice and the Responses of Inferior Colliculus Neurons
Alexandra Martin*1, Chloe Huetz1, Jean-Marc Edeline1
1 NeuroPSI UMR CNRS 9197
M17. Molecular Profiling of Tonotopy in the Developing Auditory Brainstem
Daniel Pederick*1, Yunming Wu1, Stephen Quake1, Liqun Luo1
1 Stanford University
M18. Acoustic Trauma Reduces Sound-Offset Responses in Superior Paraolivary Nucleus Neurons
Mihai Stancu1, Ezhilarasan Rajaram1, Joseph Kroeger1, Benedikt Grothe1, Conny Kopp-Scheinpflug1, Mihai Stancu*1
1 Ludwig-Maximilian University
M19. Descending Projections From the Inferior Colliculus to the Superior Olivary Complex in Mice
Brian E. Barral1, Nichole L. Beebe1, William A. Noftz1, Brett Schofield*1
1 Northeast Ohio Medical University
M20. Effect of Precursor Level Statistics on Adaptation to Noise Measured With Electroencephalography
Miriam I Marrufo-Pérez1, Deborah Vickers2, Enrique Lopez-Poveda1, Miriam I Marrufo-Perez*3
1University of Salamanca, 2University of Cambridge, 3University of Cambridge, University of Salamanca
M21. D-Stellate Neurons of the Ventral Cochlear Nucleus Are Predominantly Innervated by Calretinin-Deficient Auditory Nerve Synpases
Chuangeng Zhang1, Meijian Wang1, Shengyin Lin1, Ruili Xie*1
1 Ohio State University
M22. Mechanisms Underlying Frequency Sweep Selectivity in Inferior Colliculus Neurons
Audrey Drotos*1, Marina Silveira1, Sarah Wajdi1, Michael Roberts1
1 University of Michigan, Kresge Hearing Research Institute
M23. The Influence of Spectrum and Modulation Cues on the Neural Representation of Vocalizations in Natural Background Sounds
James Dion*1, Monty Escabí1, Ian Stevenson1
1 University of Connecticut
M24. How Speech is Coded in the IC of Gerbils and Affected by Hidden Hearing Loss
Warren Bakay*1, Ana Belen Lao-Rodríguez1, Etienne Gaudrain2, Sarah Verhulst3, Manuel S. Malmierca1
1Institute of Neuroscience Castilla y Leon, University of Salamanca, 2Lyon Neuroscience Research Center, Université Claude Bernard Lyon 1, CNRS UMR5292, Inserm U1028, 3Ghent University
M25. Changes in Spatial Response Properties of Inferior Colliculus Neurons During Behavioural Adaption to Unilateral Conductive Hearing Loss
Ana Sanchez-Jimenez1, Victoria Bajo1, Ben Willmore1, Andrew King1, Fernando Nodal*1
1 University of Oxford
M26. Monaural and Binaural Level Tolerance of Duration Tuning in the Inferior Colliculus
Kazuma Hase*1, Paul Faure1
1 McMaster University
M27.Synthetic Vowel Encoding in the Inferior Colliculus of Awake Rabbits: Effect of Formant Bandwidth
Swapna Agarwalla*1, Laurel H. Carney1
1 University of Rochester
M28. Synapse-Specific Plasticity Mechanisms in Cortical Excitatory Synapses After Noise Trauma
Martha Canto-Bustos*1, Thanos Tzounoupoulos1
1 Pittsburgh Hearing Research Center, University of Pittsburgh
M29. LHFPL5 Transmits Force From the Tip Link to the Hair Cell Mechanotransducer Channel
Robert Fettiplace*1, Maryline Beurg1, Evan Schwalbach1
1 University of Wisconsin-Madison
M30. In Vivo Calcium Imaging in the Developing Mouse Cochlea
Walter Marcotti*1, Francesca De Faveri1, Federico Ceriani1
1 University of Sheffield
M31. Elucidating the Role of the Potential Mechanosensor Protein CRIP3 in Hair Cell Repair
Henry De Hoyos*1, Alyssa Luz-Ricca2, Daniel Morrison3, Jung-Bum Shin2
1University of Virginia Medical Scientist Training Program, 2University of Virginia School of Medicine, 3University of Virginia
M32. Multiple Modes of Motion and the Effectiveness of Outer Hair Cells
Kuni Iwasa*1
1 NIDCD/NIH
M33. A Revised Biophysical Inner Hair Cell Model for the Meddis Model of the Auditory Periphery
Daniela Schwarz*1, Go Ashida1
1 University of Oldenburg
M34. Localization of PIEZO2 in Vestibular Hair Cells in Mice
Tianwen Chen1, Caroline Sit1, Zelma Iriarte-Oporto1, Kendra Stansak1, Kathleen T. Yee1, Douglas E. Vetter1, Bradley Walters1, Hong Zhu1, Wu Zhou*1
1 University of Mississippi Medical Center
M35. ATP-Dependent Signaling Activity in Mouse Developing Inner Hair Cells
Regis Nouvian*1, Anne-Gabrielle Harrus, Jean-Charles Ceccato1, Jérôme Bourien1, Jean-Luc Puel1
1 INM, Univ Montpellier, Inserm, CNRS
M36. Determining the Mechanical Properties of Inner Hair Cell Hair Bundles by Measuring Their Motions
Riccardo Marrocchio*1, Dáibhid Ó Maoiléidigh1
1 Stanford University
M37. Importance of the Mitochondrial Protein ACO2 for Hearing and Sensory Hair Cells
Sophie Lear*1, Lubriel Sambolin-Escobales2, Oraya Zinder2, Laura Reinholdt2, Basile Tarchini2, Katie Kindt1
1NIH/NIDCD, 2The Jackson Laboratory
M38. In Vivo Study of Truncated and Zero Layer Mutations of the C-Terminus of SNAP-25 Reveals Its Direct Role in Auditory Hair Cell Ribbon Synaptic Exocytosis
Maxence Cornille1, Najate Benamer1, Charlotte Calvet1, Mauricio Saenz-Roldan1, Marie-José Lecomte1, Didier Dulon2, Saaid Safieddine3, Maxence Cornille*1
1Institut de l'Audition, Institut Pasteur, INSERM, Université de Paris, 2Bordeaux NeuroCampus, Université de Bordeaux, 3CNRS/Institut de l'Audition
M39. Exploring the Role of Exon-47 Encoded (Brain-Splicing Isoform) of Otoferlin in Cochlear and Central Sound Processing
Yohan Bouleau1, Steven Condamine1, Didier Dulon*1
1 INSERM, Institut Pasteur—Institut de l'Audition
M40. On the Identity of Spectrin Subtypes in the Sub Plasma Membrane Space Responsible for eM-NLC Uncoupling in Outer Hair Cells
Jun-Ping Bai1, Michael Stankewich1, Joseph Santos-Sacchi1, Dhasakumar Navaratnam*1
1 Yale University School of Medicine
M41. A Unique Collection of Animal Temporal Bone Specimens: Otopathology Laboratory at the University of Minnesota
Nevra Keskin Yilmaz*1, Grace Sinae Song1, Tomotaka Shimura2, Emre Abdullah Cureoglu1, Michael Mauro Paparella1, Rafael da Costa Monsanto3, Sebahattin Cureoglu1
1University of Minnesota Otopathology Laboratory, 2University of Minnesota Otopathology Laboratory; Showa University Fujigaoka Hospital, 3The University of Minnesota
M42. Role of the RNA-Binding Protein FMRP in Spiral Ganglion Maturation
Danah Alquraish*1, Jenna Blair2, Brett Winter2, Yuan Wang2
1Florida State University, 2College of Medicine, Florida State University
M43. Structural Basis of G-A Interacting Protein, C-Terminus 3 (GIPC3) Function as an Adaptor for Myosin-6-Dependent Transport
Savita Sharma1, Abigail Dragich1, Shadan Hadi1, Gregory Frolenkov1, Craig Vander Kooi*2
1University of Kentucky, 2University of Florida, College of Medicine
M44. Exploring the Role of Microfractures in Sensorineural Hearing Loss Among Otosclerosis Patients
Grace Song*1, Dilshan Rajan1, Rafael da Costa Monsanto1, Nevra Keskin Yilmaz2, Sebahattin Cureoglu1, Michael Paparella1
1University of Minnesota Otopathology Laboratory, 2The University of Minnesota, Ankara University Veterinary Faculty Department of Internal Medicine
M45. Peripheral Vestibular Dysfunction in Shank3 Mouse Model of Autism
Daniel Ballinas1, Soroush Sadeghi*1, Tara Deemyad1
1 Johns Hopkins University
M46. Refractive Correction and Calibration of 3D OCT Vibrometry: Reconstruction of the Vector of Motion in the Mouse Cochlea
Julianna Bordas*1, Michael Serafino2, Patricia M. Quiñones2, Wihan Kim2, Frank D. Macias-Escriva2, John S. Oghalai2, Brian Applegate2
1USC, 2Keck School of Medicine, University of Southern California
M47. Improving Resolution of OCT Vibrometry in the Cochlea With Compressed Sensing
Brian Frost*1, Nikola Janjušević2, C. Elliott Strimbu1, Christine Hendon1
1Columbia University, 2New York University Tandon School of Engineering
M48. Effects of a Low-Side Suppressor on Vibrations in the Base of the Gerbil Cochlea
Clark Strimbu*1, Elizabeth Olson2
1College of Physicians and Surgeons of Columbia University, 2Columbia University
M49. Influence of the Head Boundary Conditions on the Skull Bone Motion Under Bone Conduction: A Hybrid Fem and Experimental Approach
Ivo Dobrev*1, Jongwoo Lim2, Yves Hottiger1, Flurin Pfiffner1, Christof Röösli1, Namkeun Kim3
1University Hospital Zurich, University of Zurich, 2Korea Advanced Institute of Science and Technology, 3Sogang University
M50. Comparing Kinematic Gains of the Mouse and Gerbil Cochlea
Anes Macić1, Wei-Ching Lin1, Jong-Hoon Nam1, Anes Macic*1
1 University of Rochester
M51. Cubic Distortion Product Within the Cochlear Partition in the Basal Turn of Sensitive Gerbil Cochleae
Wenxuan He1, Tianying Ren*1
1 Oregon Health and Science University
M52. Protein Profile of Endolymph in the Cochlea of Mouse Inner Ear
Masatoshi Fukuda*1, Daisuke Ino1, Hiroki Okanishi1, Eri Wakai1, Kazuya Ono1, Yumi Ohta1, Takashi Sato1, Hidenori Inohara1, Yoshikatsu Kanai1, Hiroshi Hibino1
1 Graduate School of Medicine, Osaka University
M53. HAP1 Regulates KCNQ4 Surface Expression and Channel Current
Jung Ah Kim*1, Kyung Seok Oh1, Young Ik Koh1, Heon Yung Gee2
1Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, 2Yonsei University College of Medicine
M54. The Tectorial Membrane Buffers Gentamicin in Vitro, in Situ, and in Vivo
George Burwood*1, Pierre Hakizimana2, Wajiha Zaidi2, Rubing Xing1, Teresa Wilson1, Alfred Nuttall1, Anders Fridberger2
1Oregon Health and Science University, 2Linköping University
M55. Aberrant Endocochlear Potential is Associated With Early-Onset but Not Late-Onset TMPRSS3 Hearing Loss
Eliot Shearer*1, Stephanie Rouse2, Janmaris Marin Fermin3, Xiaohan Wang2, Jeffrey Holt2
1Harvard Medical School, 2Boston Children's Hospital, Harvard Medical School, 3Boston Children's Hospital
M56. Computational Insights Into the Generation of Endocochlear Potential: Role of Potassium Channels and Tight Junctions
Lucas Garcia Camargo*1, Aravind Govindaraju1, Robert Raphael1
1 Rice University
M57. Gene Therapy Restores Auditory Functions in an Adult Vglut3 Knockout Mouse Model
Xingle Zhao*1, Yunge Gao1, Hao Wu1
1 Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine
M58. AAV Variant ShH10 for Selective and Efficient Gene Delivery to Mammalian Inner Ear Supporting Cells
Yun Ji Kim*1, Yeeun Kim1, Rosa Sierra1, Juan Llamas1, Ksenia Gnedeva1
1 Keck School of Medicine University of Southern California
M59. Peripheral Gene Augmentation Therapy Restores Hearing and Central Auditory Processing in a Preclinical Model of DFNB9 Auditory Synaptopathy
Najate Benamer*1, Hélène Le Ribeuz1, Charlotte Calvet1, Chloé Felgerolle1, Olivier Postal1, Mauricio Saenz-Roldan2, Baptiste Plion1, Marie Giorgi1, Nicolas Michalski1, Boris Gourévitch3, Omar Akil4, Saaid Safieddine5
1Institut de l'Audition, Institut Pasteur, INSERM, Université de Paris, 2Institut de l'Audition, Institut Pasteur, INSERM, Sorbonne Université, 3Institut de l'Audition, INSERM, Institut Pasteur; CNRS, 4University of California San Francisco, 5CNRS/Institut de l'Audition
M60. In Vivo Cellular Tropism of Adeno-Associated Viruses (AAVs) Within the Inner Ear: From Embryonic to Adult Stages
Sepideh Iranfar*1, Mauricio Saenz-Roldan2, Marie-José Lecomte3, Saaid Safieddine4, Ghizlène Lahlou5
1Pasteur Institute, 2Institut de l'Audition, Institut Pasteur, INSERM, Sorbonne Université, 3Institut de l'Audition, Institut Pasteur, INSERM, Université de Paris, 4CNRS/Institut de l'Audition, 5Institut de l'Audition, Institut Pasteur, INSERM, Université de Paris; Unité Fonctionnelle Implants Auditifs, Groupe Hospitalo-Universitaire Pitié-Salpêtrière, APHP Sorbonne Université
M61. Developmental Impact on AAV-DJ-GFP Expression Profile
Sriram Hemachandran*1, Jinkyung Kim2, Hayden Reynso2, Evi Scheinbinger2, Samantha Zenteno2, Anthony Ricci2
1Stanford Medical School, 2Stanford University
M62. In Vivo Characterization of Supporting Cell Responses to Hair Cell Damage in the Zebrafish
Elizabeth Cebul*1, Miyakla Hady2, Katherine Pinter2, Katie Kindt2
1NIDCD, 2NIH/NIDCD
M63. A Common Variant in AAK1 Reduces Risk of Noise-Induced Hearing Loss
Qixuan Wang*1, Xueling Wang1, Zhiwu Huang1, Hao Wu1
1 Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
M64. Development of the Auditory Pathway Depends on the Strength of the Transient Efferent Synapse and is Altered by Early Noise Exposure
Valeria Castagna*1, Mariano Di Guilmi2, Paul Fuchs3, Ana Belen Elgoyhen4, Maria Gomez-Casati1
1Instituto de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, 2Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr. Héctor N. Torres, Consejo Nacional de Investigaciones Científicas y Técnicas, 3Johns Hopkins University of Medicine, 4Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr. Héctor N. Torres, Consejo Nacional de Investigaciones Científicas y Técnicas
M65. Lead Exposure Induces Synaptopathy and Alters the Abundance of Synaptosomal Proteins in the Cochlea
Pankaj Bhatia*1, Rita Rosati1, Paul Stemmer1, Samson Jamesdaniel1
1 Wayne State University
M66. Repurposing Therapies Against Cisplatin-Induced Hearing Loss
Elise Kiszla*1, Marisa Zallocchi1
1 Creighton University School of Medicine
M67. Genetic Polymorphisms in Human Fractalkine Receptor CX3CR1 Expressed by Macrophages is Associated With Weakened Immune Response and Impaired Recovery of Loss of Hearing and Ribbon Synapses After Noise-Induced Cochlear Synaptopathy: Study in a Humanized Mouse Model
Dinesh Gawande*1, Ben Borgmeier2, Lyudmila Batalkina2, Tejbeer Kaur1
1Rutgers University, Robert Wood Johnson School of Medicine, Rutgers Brain Health Institute, 2Creighton University
M68. Variants in the vWFA2 Domain of the COCH Gene Cause Proteinopathy
Kyung Seok Oh*1, Heon Yung Gee2
1Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 2Yonsei University College of Medicine
M69. AMPA Receptor Plasticity and Proteomics-Based Identification of Biological Pathways of Macrophage-Dependent Restored Inner Hair Cell Ribbon Synapses Following Noise-Induced Cochlear Synaptopathy
Dinesh Gawande*1, Kanika Sharma2, Vikas Kumar2, Tejbeer Kaur1
1Rutgers University, Robert Wood Johnson School of Medicine, Rutgers Brain Health Institute, 2University of Nebraska Medical Center
M70. Outer Hair Cell Motor Protein Prestin is Not a Reliable Biomarker for Mouse Cochlear Damage
Jing Zheng*1, Yingjie Zhou1, Robert Fuentes1, Xiaodong Tan1
1 Northwestern University
M71. Protective Effects of Y-27632 on Cisplatin‐Induced Ototoxicity in Zebrafish
Kang Hyeon Lim*1, Hee Soo Yoon1, Yoon Chan Rah1, June Choi1
1 Korea University College of Medicine
M72. The Impact of Estrogen on Lateral Line Hair Cells in Adult Zebrafish
Leila Farbod*1, Coty Jasper1, Allison Coffin1
1 Washington State University
M73. Real-Time Measurement of Basilar Membrane Motion During Blast Exposure – A Preliminary Study
Alexander Bien1, Shangyuan Jiang*2, Rong Gan2
1University of Oklahoma Health Sciences Center, 2University of Oklahoma
M74. Challenges of Rat Explant Culture for a Reliable Ototoxic Ex Vivo Model for Drug Screening
Carolanne Coyat*1, Gaëlle Naert1, Sylvie Pucheu1, Karine Toupet1
1 CILCARE
M75. A Corticotropin Releasing Factor Response in the Contralateral Cochlea Following Monaural Cochlear Ablation
Walter Moore*1, Sarah Hayek1, Lauren Kate Storm1, Douglas Vetter1, Kathleen Yee1
1 University of Mississippi Medical Center
M76. The Role of MyD88 Signaling in Cochlear Ototoxin Trafficking and Ototoxin-Induced Hearing Loss
Cong Tian1, Sadie Keesler1, Aimee Schreiner1, Kylee Sutton1, Peter Steyger*1
1 Translational Hearing Center, School of Medicine, Creighton University
M77. Viral Mediated Selective and Timed Ablation of Spiral Ganglion Neurons in Parvalbumin-Cre Mice
Nhi Nguyen*1, Miti Parikh2, Joshua Lin2, Seiji Shibata1
1University of Southern California, 2Keck School of Medicine, University of Southern California
M78. Synaptopathic Insults Cause Degradation of Axonal-Coat-Like Extracellular Matrix Structures Around the Junction of Auditory Nerve Fibers and Inner Hair Cells
Punam Thapa*1, Garner Fincher1, Sung-Ho Huh2, Kathleen Yee1, Douglas Vetter1, Brad Walters1
1University of Mississippi Medical Center, 2University of Nebraska Medical Center
M79. Thin Film Zwitterionic Hydrogel Coatings of Cochlear Implants Minimize Insertion Trauma and the Foreign Body Response
Nir Ben-Shlomo*1, Christine Etler1, Emily Petersen1, George Barrera1, Douglas Fredericks1, C. Allen Guymon1, Marlan Hansen1
1 University of Iowa Hospitals and Clinics
M80. Optimization of Pharmacological Interventions in the Guinea Pig Animal Model – A New Approach to Calculate the Perilymph Volume of the Scala Tympani
Marleen Grzybowski*1, Kathrin Malfeld2, Thomas Lenarz3, Verena Scheper2, Daniel Schurzig4
1Hannover Medical School, German Hearing Center Hannover, 2Hannover Medical School, Lower Saxony Center for Biomedical Engineering, Implant Research and Development (NIFE), 3Hannover Medical School, German Hearing Center Hannover Lower Saxony Center for Biomedical Engineering, Implant Research and Development (NIFE), 4Hannover Medical School, MED-EL Research Center Hannover
M81. Intracochlear Drug Delivery in Combination With Dexamethasone Eluting Electrode Provides Efficient Otoprotection for Cochlear Implant Trauma
Jaimee Cooper*1, Maria-Pia Tuset1, Jeenu Mittal1, Teresa Melchionna2, Carolyn Garnham2, Soren Schlip2, Dimitri Godur1, Keelin McKenna1, Max Zalta1, Rahul Mittal1, Adrien Eshraghi1
1Cochlear Implant and Hearing Research Laboratory, University of Miami Miller School of Medicine, 2MED-EL GmbH, Innsbruck
M82. Investigations on Safety and Biodistribution of Vesicle-Enriched Secretome Fraction in Mice After Cochlear Implantation Trauma
Odett Kaiser*1, Susanne Sasse1, Jennifer Harre1, Mario Gimona2, Eva Rohde2, Hinrich Staecker3, Thomas Lenarz1, Athanasia Warnecke1
1Hannover Medical School, 2Paracelsus Medical University Salzburg, 3University of Kansas Medical Center
M83. Biosafety and Biodistribution Study of Vesicle-Enriched Secretome Fraction for Prevention of Cochlear Implantation Trauma
Susanne Sasse*1, Odett Kaiser2, Jennifer Harre1, Mario Gimona3, Eva Rohde3, Hinrich Staecker4, Thomas Lenarz1, Athanasia Warnecke1
1Hanover Medical School, 2Hanover Medical School and Cluster of Excellence “Hearing4all”, 3Paracelsus Privat Universität Salzburg, 4School of Medicine, University of Kansas
M84. Implanted Injection Port for Chronic Drug Delivery to the Middle Ear in Mice
Isabel Held*1, Niranj Kumar1, Azmi Marouf1, Kumar Alagramam1
1 Case Western Reserve University
M85. The Impact of Proteostasis on Neuronal Diversity in the Developing Inner Ear
Mona Veithen*1, Brigitte Malgrange2, Laurence Delacroix2
1University of Liege, 2GIGA-Neurosciences, University of Liege, C.H.U. Sart Tilman
M86. Development Expression of Proteins in Neurons to Innervate Brainstem and Hair Cells
Bernd Fritzsch*1, Ebenezer N Yamoah2, Jeong Han Lee2
1University of Nebraska Medical Center, 2School of Medicine, University of Nevada, Reno
M87. A Novel Cytoskeletal Regulator That Blocks Cell Proliferation in the Mammalian Cochlea
Vidhya Munnamalai*1, Caryl Young2
1The Jackson Laboratory, 2University of Maine
M88. Expression of Ebf1 and Ebf3 in the Vestibule and Semicircular Canals During Mouse Development
Norio Yamamoto*1, Hiroki Kagoshima2, Hiroe Ohnishi2, Takayuki Nakagawa2, Koichi Omori2
1Kobe City Medical Center General Hospital, 2Graduate School of Medicine, Kyoto University
M89. Ebf1 is Necessary for Sensory Domain Establishment Within the Organ of Corti and Essential for Hearing in Mice
Kathryn Powers*1, Brent Wilkerson2, Sophie Seo1, Jose Rodriguez1, Olivia Bermingham-McDonogh1
1University of Washington, 2Medical University of South Carolina
M90. Time of Delamination of Inner Ear Neurons Specifies Their Topography and Target Innervation
Surjit Singh Saini*1
1 NCBS
M91. TMEM30A is Essential for Hair Cell Polarity Maintenance in Postnatal Mouse Cochlea
Yazhi Xing*1, Guang Yang1, Haibo Shi1, Shankai Yin1
1 Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
M92. Epithelial Morphogenesis Begins With the Cochlear Progenitors
Caryl Young*1, Vidhya Munnamalai2
1University of Maine, 2The Jackson Laboratory
M93. TUBB4B, a Protein Linked to Sensorineural Hearing Loss, is Needed for the Development of Motile Cilia in the Middle Ear and for the Cytoskeleton Architecture of Supporting Cells in the Inner Ear
Urikhan Sanzhaeva*1, Helen Boyd-Pratt1, Philip T.R. Bender1, Christopher L. Cunningham2, Charles T. Anderson1, Visvanathan Ramamurthy1
1West Virginia University, 2Pittsburgh Hearing Research Center, University of Pittsburgh School of Medicine
M94. Characterizing the Role of Stereocilia Links During Early Hair-Bundle Development in Mouse Inner and Outer Hair Cells
Paroma Chatterjee*1, Jocelyn Krey2, Peter Barr-Gillespie2
1Oregon Hearing Research Center, OHSU, 2Oregon Hearing Research Center and Vollum Institute, OHSU
M95. P2RX4 Signaling in Auditory System Maturation and Alzheimer’s Disease-Related Sensorineural Hearing Loss
Mehmet Alp Demirhan*1, Thomas Coate1
1 Georgetown University
M96. Molecular Characterization of Vestibular-Like Hair Cell Formation in Inner Ear Organoids
Maggie Matern*1, Stefan Heller1
1 Stanford University School of Medicine
M97. The Common Marmoset as Suitable Non-Human Alternative for the Analysis of Primate Cochlear Development
Makoto Hosoya*1, Marie Shimanuki2, Masafumi Ueno2, Takanori Nishiyama2, Hiroyuki Ozawa2, Naoki Oishi2
1Keio University, 2Keio University School of Medicine
M98. Regulation of YAP/ERM Signaling Cascade by Itga8 During Inner Ear Development
Dhaval Shukal*1, Vijayprakash Namakkal Manickam1, Lyudmila Batalkina1, Marisa Zallocchi1
1 Creighton University School of Medicine
M99. Phospho-Regulation of PCDH15 Plays a Role in Inner Ear Hair Cell Planar Polarity
Aray Adylkhan*1, Anna Andreeeva2, Alison Lim1, Ulrich Mueller3, Xiaowei Lu1
1University of Virginia, 2Nazarbayev University, 3Johns Hopkins University
M100. The Role of AQP4 in Developmental Spontaneous Activity
Trinh Nguyen*1, Dwight Bergles2
1Johns Hopkins School of Medicine, 2Johns Hopkins University
M101. Exploring Sex-Based Differences in the Constitutive Expression of Cochlear Genes Linked to Auditory Dysfunction: Findings From a Mouse Study
Mengxiao Ye1, Henry J. Adler1, Rania Sharaf1, Bohua Hu*1
1 University at Buffalo
M102. A Gene Regulatory Landscape and Network That Drives Hair Cell Regeneration in Zebrafish
Jeremy Sandler*1, Malcolm Cook1, Shiyuan Chen1, Tatjana Piotrowski1
1 Stowers Institute for Medical Research
M103. Multiomic Changes in Sensory Hair Cells After Ablation of Chromatin Remodeling Protein CHD4
Jihyun Kim*1, Edward Martinez1, Azadeh Jadali2, Kelvin Kwan1
1Rutgers University, 2Sampled
M104. Rare Coding Variants in Patients With Non-Syndromic Vestibular Dysfunction
Regie Lyn Santos-Cortez*1, Angelo Augusto Sumalde1, Melissa Scholes1, Olivia Kalmanson1, Elizabeth Terhune1, Lidia Frejo2, Cambria Wethey1, Pablo Roman-Naranjo2, Patrick Carry1, Samuel Gubbels1, Jose Antonio Lopez-Escamez2, Nancy Hadley-Miller1
1University of Colorado Anschutz Medical Campus, 2University of Granada-Junta de Andalucia
M105. Audiologic Measures in an Indigenous Community With A2ML1- And FUT2-Related Otitis Media
Regie Lyn Santos-Cortez*1, Kimberly Mae Ong2, Angeli Carlos-Hiceta2, Ma. Leah Tantoco2, Talitha Karisse Yarza2, Ma. Luz San Agustin2, Melquiadesa Pedro2, Teresa Luisa Cruz2, Eva Maria Cutiongco-de la Paz2, Generoso Abes2, Erasmo Gonzalo Llanes2, Abner Chan2, Charlotte Chiong2, Maria Rina Reyes-Quintos2
1University of Colorado Anschutz Medical Campus, 2University of the Philippines Manila
M106. HDAC Inhibitor, Trichostatin a Inhibits Hearing Loss in a Model of Alport Syndrome
Sungsu Lee*1, Sujin Han1, Yoon Seok Nam1, Eun-Ji Gi1, Hyong-Ho Cho1
1 Chonnam National University Medical School and Chonnam National University Hospital
M107. Reinterpretation of Pathogenic Variants Associated With Hearing Loss in Korean Population
Sun Young Joo*1, Seung Hyun Jang1, Jinsei Jung1, Heon Yung Gee1
1 Yonsei University College of Medicine
M108. MYH1 Variants Cause Autosomal Recessive Hearing Loss by Disrupting Outer Hair Cell Electromotility
Jae Won Roh*1, Jinsei Jung1, Sun Young Joo1, Hyehyun Min1, Jinwoong Bok1, Jae Young Choi1, Heon Yung Gee1
1 Yonsei University College of Medicine
M109. PKHD1L1, a Gene Involved in the Stereociliary Coat, Causes Autsomal Recessive Nonsyndromic Hearing Loss
Shelby Redfield1, Pedro de la Torre2, Mina Zamani3, Hina Khan4, Tyler Morris2, Reza Maroofian5, Majid Karimi6, Margaret Kenna7, Go Hun Seo8, Sadaf Naz4, Hamid Galehdari3, Barbara Vona9, Eliot Shearer7, Artur Indzhykulian2, Shelby Redfield*1
1Boston Children’s Hospital, 2Harvard Medical School, MEEI, 3Shahid Chamran University of Ahvaz, 4University of the Punjab, Quaid-e-Azam Campus, 5UCL Queen Square Institute of Neurology, University College London, 6Khuzestan Cochlear Implantation Center (Tabassom), 7Harvard Medical School, 83billion, Inc., 9Tübingen Hearing Research Centre, Eberhard Karls University
M110. Defects in Exosome Biogenesis Are Associated With Deficits in Auditory Sensorimotor Transformation in Zebrafish VPS4A Mutants
Anna Shipman*1, Yan Gao1, Matthew Hill2, Eliot Smith1, Timothy Erickson3, Teresa Nicolson1
1Stanford School of Medicine, 2Oregon Health and Science University, 3East Carolina University
M111. The Pathogenesis of Common Gjb2 Mutation Associated With Human Hereditary Deafness in Mice
Chong Cui*1, Qing Li2, Daqi Wang1, Jingsong Li2, Huawei Li1, Yilai Shu1
1ENT Institute and Otorhinolaryngology Department of Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, 2State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
M112. Identifying CHD4 Enrichment at Enhancers During Inner Ear Stem Cell Differentiation
Jingyun Qiu*1, Jihyun Kim1, Edward Martinez1, Kelvin Y. Kwan1
1 Rutgers University—New Brunswick
M113. Overexpression of SIRTUIN1 Protein by N1-Methylnicotinamide (MNAM) Promotes Age-Related Cochlear Damage
Toru Miwa*1, Teppei Kouga1
1 Osaka Metropolitan University
M114. Impact of Aging and Temporal Salience on Unit Responses to SAM Stimuli in the Inferior Colliculus of the Awake Rat
Rui Cai*1, Lynne Ling1, Donald Caspary1
1 Southern Illinois University School of Medicine
M115. Electrophysiological Insights Into Age-Related Neural Changes in the Aging Auditory System and Speech-In-Noise Decline
So Eun Park*1
1 East Tennessee State University
M116. Speech Discrimination in Aging: MMN Study
Miwako Hisagi*1, Burgundy Bisson1, Susan Lee1, Alessandro Presacco2
1California State University, Los Angeles, 2Keck School of Medicine of the University of Southern California
M117. A Machine-Learning-Based Approach to Predict Early Hallmarks of Progressive Hearing Loss
Federico Ceriani*1, Jing-Yi Jeng1, Walter Marcotti1
1 University of Sheffield
M118. Voice Familiarisation Delivered Online Improves Speech Intelligibility for Older and Younger Adults
Wansu Zhu1, Emma Holmes*1
1 UCL
M119. Purinergic Signalling in the Supporting Cells of the Ageing Cochlea
Sarah Hool*1, Jing-Yi Jeng1, Daniel Jagger2, Walter Marcotti1, Federico Ceriani1
1University of Sheffield, 2University College London
M120. Silence, Solitude, and Serotonin: Combined Effects of Noise-Induced Hearing Loss and Social Isolation in Older Mice
Megan Lampert1, Kate Steiner1, Jessica Bush1, Laura Hurley*1
1 Indiana University
M121. Mitochondrial Dysfunction in Strial Marginal Cells of Middle-Aged Mice
Tyreek Jenkins*1, Hainan Lang1
1 Medical University of South Carolina
M122. Contrasting Intra-Cochlea Neural Health Variability Assessed Using Psychophysical Thresholds and Panoramic Evoked Compound Action Potentials
Tommy Peng*1, Mica Haneman1, Charlotte Garcia2, Maureen Shader3, Robert Carlyon4, Colette McKay1
1The Bionics Institute of Australia, 2University of Cambridge, 3Purdue University, 4Cambridge Hearing Group, MRC Cognition and Brain Sciences Unit, University of Cambridge
M123. Speech Encoding in the Midbrain of Normal Hearing Cats in Noisy Environments
Anu Sabu*1, Dexter Irvine2, David Grayden3, James Fallon1
1Bionics Institute, 2Monash University, 3University of Melbourne
M124. Cortex Developmental Plasticity and Relations to Behavior Outcomes of Congenital Deafness Children With Auditory Brainstem Implantations
Hao Wu*1
1 The Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine
M125. Exploring Temporal Mechanisms of Pitch Perception Using the Apical Electrodes of a Cochlear Implant
Evelien de Groote1, Olivier Macherey2, John M. Deeks1, Robert Carlyon*1
1Cambridge Hearing Group, MRC Cognition and Brain Sciences Unit, University of Cambridge, 2Aix-Marseille University, CNRS, Centrale Marseille, LMA
M126. Acute Speech Perception in Optimized Dynamically Focused Cochlear Implant Stimulation
Dietmar Wohlbauer*1, Charles Hem2, Caylin McCallick3, Julie Arenberg1
1Harvard Medical School, Massachusetts Eye and Ear, 3Massachusetts Eye and Ear
M127. A Study on the Development of Middle-Ear Microphone Package for Fully Implantable Hearing Devices Using Piezoresistive Sensor
Woonhoe Goo*1, Jongwoo Lim2, Keedong Yang3, Namkeun Kim4, Jae Hoon Sim5, Seung Ha Oh1, Juyong Chung6
1Seoul National University Hospital, 2Korea Advanced Institute of Science and Technology, 3Korea Electrotechnology Research Institute (KERI), 4Sogang University, 5University Hospital Zurich, 6Wonkwang University Hospital
M128. Tonal Language Experience is Associated With Utilization of Spatial Cues for Segregating Competing Speech in Bimodal Cochlear Implant Listeners
John Galvin*1, Biao Chen2, Jingyuan Chen2, Yongxin Li2, Qian-Jie Fu3
1House Intitute Foundation, 2Beijing TongRen Hospital, Capital Medical University, Ministry of Education of China, 3David Geffen School of Medicine at UCLA
M129. Effects of Older Age and Steroid Treatment on Inflammation and Survival of Neural Structures in the Aging Guinea Pig Cochlea After Cochlear Implantation
Farshid Taghizadeh*1, Jeffrey Hyzer1, Teresa Wilson1, Lina Reiss1
1 Oregon Health and Science University
M130. Improved Tactile Speech Perception Using Audio-To-Tactile Sensory Substitution With Formant Frequency Focusing
Mark Fletcher*1, Esma Akis1, Carl Verschuur1, Samuel Perry1
1 University of Southampton
M131. Relationship Between Cochlear Implant Electrode Position and Postoperative Residual Hearing
Max Meuser*1, Susanne Schwitzer1, Patrick Boyle2, Arne Ernst1, Dietmar Basta1
1University of Berlin, Charité Medical School, 2Advanced Bionics European Research Center
M132. The Effect of Pulse Phase Duration on the Electrically Evoked Compound Action Potential and Its Relation to Auditory Nerve Health
Henk A. Vink1, Dyan Ramekers1, Huib Versnel*1
1 University Medical Center Utrecht
M133. Determination of Implant Dynamic Range to Predict Speech Performance of Vibrant Soundbridge Users
Susan Busch*1, Thomas Lenarz2, Hannes Maier3
1Medical University Hannover, 2Medical University Hannover, Cluster of Excellence “Hearing4all”, 3Hannover Medical School, DFG Cluster of Excellence Hearing4all
M134. Modelling Consonant Discrimination by Users of Cochlear Implants
Peter Johannesen*1, Yue Zhang2, Manuel Segovia-Martínez2, Enrique Lopez-Poveda3
1Salamanca University, 2Oticon Medical, Vallauris, 3University of Salamanca
M135. Development of Stimulation Strategies for a New Auditory Nerve Implant for Hearing Restoration in a Guinea Pig Model
Inderbir Sondh*1, Hubert H. Lim2
1University of Minnesota, 2Institute for Engineering in Medicine, University of Minnesota
M136. Design Optimization of Piezoelectric Accelerometers for Totally Implantable Auditory Prostheses
Panagiota Kitsopoulos*1, Alison E. Hake1, Karl Grosh1
1 University of Michigan
M137. Modeling and Assessment of a Vowel Identification Task in Cochlear Implants Using Machine Learning: Preliminary Results
Andres Llico Gallardo*1, Thomas Talavage1
1 University of Cincinnati
M138. Optical Properties of the Human Cochlea Bone
Joaquin Cury*1, Xiaodong Tan1, Claus-Peter Richter1
1 Feinberg School of Medicine, Northwestern University
M139. Visualization System for Real-Time Monitoring of Electrode Array Insertion into the Human Cochlea
Joaquin Cury*1, Arnaldo Rivera2, R Schneider2, Xiaodong Tan1, Ray Tan1, Claus-Peter Richter1
1Feinberg School of Medicine, Northwestern University, 2School of Medicine, Missouri University
M140. Ensuring the Future of Otitis Media Research: Interest in and Feasibility of a Mentoring Network Program Within the Otitis Media Research Community
Sonja Ziniel*1, Regie Lyn Santos-Cortez2, Diego Preciado3, Rita Lee2, Joseph Kerschner4, Allen Ryan5
1University of Colorado Anschutz Medical Campus, Children's Hospital, 2University of Colorado Anschutz Medical Campus, 3George Washington University School of Medicine, 4Medical College of Wisconsin, 5University of California San Diego
M141. Open Board
M142. Examination of Aspiration Prevention Surgery in Our Department
Mei Sakamoto*1, Junko Tsuda2, Makoto Hashimoto2, Kazuma Sugahara2, Hiroshi Yamashita2
1Yamaguchi Prefectural Grand Medical Center, 2Yamaguchi University
M143. Potential Overestimation of Cognitive Decline in Older Adults With Hearing Loss
Eun Jin Son*1, Seung Ho Shin1, Yuri Ko1, Seon Joo Lee1
1 Yonsei University College of Medicine
M144. Characteristics of Pure Tone Audiogram in Patients With Untreated Sporadic Unilateral Vestibular Schwannoma
Nobuyoshi Tsuzuki*1, Tsubasa Kitama2, Koichiro Wasano3, Takeshi Wakabayashi2, Makoto Hosoya2, Takanori Nishiyama2, Hiroyuki Ozawa2, Naoki Oishi2
1National Hospital Organization Tokyo Medical Center, 2Keio University School of Medicine, 3Tokai University School of Medicine
M145. Oto-Pathology of Sickle Cell Disease
Dianela Perdomo1, Alice Li*1, Diane Jung1, Yassine Balhi2, Julie Winston2, Amanda Lauer2, Bryan Ward1, Nicholas Andresen1
1Johns Hopkins School of Medicine, 2Johns Hopkins University
M146. Investigating the Association Between SSHL Etiology and Hearing Outcomes Following Intratympanic Steroid Injection
Addison Lana*1, Devin Kennedy1, Matthew Wiefels1, Valerie Yunis1, Michael Hoffer1, Erin Williams1
1 Miller School of Medicine, University of Miami
M147. Performance on the Triple Digit Test Relates to a Blood Marker of Brain Injury in Patients With Alzheimer’s Disease
Miranda Bacon*1, Christopher Niemczak2, Nesrine Rahmouni2, Alyssa Stevenson2, Jenna Stevenson2, Samantha Leigh2, Linda Zhang2, Pedro Rosa-Neto3, Jay Buckey1
1Dartmouth Hitchcock Medical Center, 2Dartmouth-Hitchcock, Geisel School of Medicine
M148. Sensory Transduction Contributes to Synapse Maturation During Auditory Hair Cell Development
Thibault Peineau*1, John Lee1, Hong Zhu2, Wu Zhou2, Jeffrey Holt1, Gwenaelle Geleoc1
1Boston Children's Hospital, Harvard Medical School, 2University of Mississippi Medical Center
M149. Open-Source Music Playlist for Cochlear Implant Users: An Accessible Tool for Clinicians
Jonghwa Park*1, Wonwoo Lee2, Jiyeon ha2, Jeong Mi Park2, Byung Yoon Choi1
1Seoul National University, 2Bell Therapeutics Inc.
M150. Machine Learning-Based Prediction of Hearing Recovery Prognosis in Canal Wall Down Mastoidectomy Patients
Hee Soo Yoon*1, EunSong Bang2, June Choi1, Hwamin Lee2
1Korea University Ansan Hospital, 2Korea University College of Medicine
M151. Analysis of Receiver Operating Characteristics to Evaluate the Performance of Predictor Variables for the Diagnosis of Cochlear Synaptopathy
JoAnn McGee*1, Xiaohui Lin1, Ashley Vazquez1, Hongzhe Li1, Jonathan H. Venezia1, Marjorie R. Leek1, Edward J. Walsh1
1 VA Loma Linda Healthcare System
M152. Longitudinal Study of Dietary Intake and Risk of Incident Persistent Tinnitus
Sharon Curhan*1, Oana Zeleznik1, Gary Curhan1
1 Brigham and Women's Hospital, Harvard Medical School
M153. Effects of Sound Therapy Using Hearing Aids Fitted With Utsunomiya Method in Unilateral Tinnitus Patients With Acquired Ipsilateral Sensorineural Hearing Loss
Masafumi Ueno*1, Seiichi Shinden1, Daisuke Suzuki2, Marie Shimanuki1, Makoto Hosoya1, Takanori Nishiyama1, Hiroyuki Ozawa1, Naoki Oishi1
1Keio University School of Medicine, 2Saiseikai Utsunomiya Hospital
M154. Biomarker Profiles of Cochlear Injury in Tinnitus
Victoria Organtini*1, Emily Antes1, Aravindakshan Parthasarathy1, Lori Zitelli1, Hari Bharadwaj1
1 University of Pittsburgh
M155. Daily Sound Exposure Patterns After Tinnitus Onset
Erika Skoe*1, Rachel Corsetti1, Janet Desmarais1, Annalise Kieley1, David Wilson2, Patrick Adamcyzk2, Daniel Roberts2, Kourosh Parham2
1University of Connecticut, 2UConn Health
M156. Reduced Sizes of Efferent Nerve Termini in the Cochleae of Rats With Noise-Induced Tinnitus and Evidence of Therapeutic Mitigation With NHPN-1010
Qunfeng Cai*1, Xiaoping Du2, Weihua Cheng2, Jianzhong Lu2, Zachary Yokell2, Wei Li2, Don Nakmali2, Richard D. Kopke2, Matthew West2
1State University of New York at Buffalo, 2Hough Ear Institute
M157. Distinctive Trends of Masking Release Effect in Frequency Following Response
Won So*1, Sungmin Lee2
1Grand Valley State University, 2Tongmyong University
M158. Impact of Acute Impairment on Adaptive Head Movements Individuals With Single-Sided Hearing Loss
Gerilyn Jones*1, Obada Abdulrazzak2, Nadine Ibrahim2, Madison Epperson2, Carolyn Kroger2, Jackson Graves2, Anahita Mehta2, Renee M. Banakis Hartl2
1University of Michigan, Kresge Hearing Research Institute, 2University of Michigan
M159. Aging Impairs Binaural Processing and Spatial Hearing, While Increasing Synaptopathy, in the Mongolian Gerbil
Matthew Sergison*1, John Peacock1, Monica Benson1, Achim Klug1, Nathaniel Greene1, Daniel Tollin1
1 University of Colorado Anschutz Medical Campus
M160. Quantifying Anatomical Myelination Changes in Fragile X Syndrome Mice During Development in the Auditory Brainstem
Amita Chawla*1, Elizabeth McCullagh1
1 Oklahoma State University
M161. Open Board
M162. Older Adults Rely on the Structural and Functional Connectivity Between Auditory and Visual Cortex When Identifying Audiovisual Speech
James Dias*1, Jeffrey Rumschlag1, Carolyn McClaskey1, Kelly Harris1
1 Medical University of South Carolina
M163. Audiovisual Decision-Making Deficits After Hearing Loss
Madeline Berns*1, Xingeng Zhang1, Chase Hintelmann1, Genesis Nunez1, Anindita Chavan1, Divyanjali Raskonda1, Prisha Patel1, Klavdia Zemlianova2, Sharon G. Kujawa3, Justin Yao1
1Rutgers University, 2New York University, 3Eaton-Peabody Laboratories, Massachusetts Eye and Ear; Harvard Medical School; Harvard University
M164. Hearing With Hands: Vibrotactile Stimulation Generates a Frequency-Following Response
Emily Coffey*1, Ana Carbajal Chávez2, Loonan Chauvette3, Marcel Farrés-Franch4, Andréanne Sharp3, Robert Zatorre4
1Concordia University, 2University of Leuven, 3Laval University, 4Montreal Neurological Institute, McGill University
M165. The Role of Sensory Loss and Plasticity in Auditory and Audiovisual Speech Recognition in Noise in Older Adults
Kelly Harris*1, Carolyn McClaskey1, Jeffrey Rumschlag1, James Dias1
1 Medical University of South Carolina
M166. Lateral Line Contributes to Locomotion in Depth by Sensing Vertical Drift
Samantha Davis*1, Yunlu Zhu2, David Schoppik3
1New York University, 2NYU School of Medicine, 3NYU School of Medicine, Neuroscience Institute
M167. Does the Gender of the Tester and Subject or a Change in Olfactory Function Affect Auditory Function in Mice?
Amy Wang*1, Ayush Singh1, Kenneth Egbuji1, Rebecca Cook1, Tomoko Makishima1
1 University of Texas Medical Branch
M168. Case Study: Audible Fluttering Sounds Associated With Eye Movements in a Patient With Palatal and Possible Tensor Tympani Myoclonus
Cynthia King*1, Tingan Zhu1, Jennifer Groh1
1 Duke University
M169. Relationship Between Stimulus Frequency Otoacoustic Emission Estimates of Cochlear Tuning and Speech-In-Noise Recognition
Monica Trevino*1, Sai Vaibhav Batchu1, Diksha Kurwa1, Srikanta Mishra1
1 The University of Texas at Austin
M170. Development of Novel Auditory Alerts That Foster Efficient Detection and Discrimination in Complex Auditory Environments
Mabel Cummins*1, Michael Schutz2, Leslie R. Bernstein3, Joshua Shive4, Joseph J. Schlesinger5
1Vanderbilt University Medical Center, 2School of the Arts, McMaster University, 3University of Connecticut Health Center, 4Tennessee State University, 5Vanderbilt University Medical Center
M171. Cross-Frequency Spectral Integration in Electro-Acoustic Stimulation and Bimodal Hearing
Priyanka Jaisinghani*1, Yang-Soo Yoon1
1 Baylor University
M172. Multiple Pitch Perception With Rate-Place Metamers
Jackson Graves*1, Daniel R. Guest2, Anahita Mehta1
1Kresge Hearing Research Institute, University of Michigan, 2University of Rochester
M173. Influences of Pitch and Spatial Trajectories on Relative Timing Judgments in Auditory Sequences
Carolyn Kroger*1, Renee M. Banakis Hartl1, Anahita Mehta1
1 University of Michigan
M174. CAT-Egorical Perceptual Similarity Does Not Explain Memory Organization of Auditory Sequences
Yuhang Li*1, Eli Bulger1, Abigail Noyce1, Barbara Shinn-Cunningham1
1 Carnegie Mellon University
M175. Modeling Auditory Attention With Machine Learning
Ian Griffith*1, Preston Hess2, Josh McDermott2
1Program in Speech and Hearing Biosciences and Technology, Harvard University, 2Massachusetts Institute of Technology
M176. Phasic Pupillary Response Traces Salient Auditory Events in a Multidimensional Feature Space
Hsin-I Liao*1, Nahaleh Fatemi2, Mounya Elhilali2
1NTT Communication Science Laboratories, 2Johns Hopkins University
M177. Cues for Tone-In-Noise Detection: Evidence From Constant-Stimuli and Adaptive Approaches
Braden Maxwell*1, Andrew Oxenham1
1 University of Minnesota
M178. Noise Schemas Aid Hearing in Noise
Jarrod Hicks*1, Josh McDermott1
1 MIT
M179. Hearing Impairment Causes Different Saccade Errors Than Normal Hearing in Multisensory Localization Tasks
Colton Clayton1, Yi Zhou*2
1Grand Valley State University, 2Arizona State University
M180. Cortical and Subjective Measures of Individual Noise Tolerance Predict Noise-Reduction Outcomes
Susan Arzac*1, Natalie Dokic1, Jenn Donnelly1, Nicole Genser1, Kristen Nortwich1, Alexis Rooney1, Subong Kim1
1 Montclair State University
M181. The Effect of Second Language Acquisition on Central Auditory Processing Abilities
Abby Kambhampaty*1, Christopher Niemczak1, Jay Buckey1
1 Dartmouth College
M182. Pupillometry and Eye Movements Indicate Listening Effort Differently in Both Younger and Older Adults
Björn Herrmann*1, Jennifer Ryan1
1 Rotman Research Institute
M183. Perceptual Learning of Temporally Degraded and Spectrally Degraded Speech in Children and Adults
Saja Khalaili1, Karen Banai*1, Hanin Karawani1
1 University of Haifa
M184. Event Processing During Story Listening in Background Noise
Ryan Panela*1, Alexander Barnett1, Morgan Barense1, Björn Herrmann2
1University of Toronto, 2Baycrest Health Sciences
M185. Source Analysis of the Neural Response at the Fundamental Frequency of Speech
Jonas Auernheimer*1, Tobias Reichenbach1
1 Friedrich-Alexander-University Erlangen-Nürnberg
M186. Decoding Cortical and Frequency-Following Responses to Speech Using Deep Neural Networks
Michael Thornton*1, Danilo Mandic1, Tobias Reichenbach2
1Imperial College London, 2Friedrich-Alexander-University Erlangen-Nürnberg
M187. Extending Subcortical EEG Responses to Continuous Speech to the Sound-Field
Florine L. Bachmann*1, Joshua P. Kulasingham2, Kasper Eskelund3, Martin Enqvist2, Emina Alickovic1, Hamish Innes-Brown1
1Eriksholm Research Centre, 2Linköping University, 3Oticon A/S
M188. Simulated Bimodal Speech Perception Among Bilingual Speakers
Can Xu*1, Chang Liu2, Spencer Smith2
1California State University, Sacramento, 2The University of Texas at Austin
M189. Speech-Perception Training For Older Adults With Hearing Loss Increases the Consistency Of Cortical Activity During A Speech-In-Noise Task
Carolyn McClaskey*1, Stefanie Kuchinsky2, Kenneth Vaden1, Stephanie Cute1, Jayne Ahlstrom1, Larry Humes3, Judy R. Dubno1, Mark Eckert1
1Medical University of South Carolina, 2Audiology and Speech Pathology Center, Walter Reed National Military Medical Center, 3Indiana University
M190. Impact of Hearing Protection Devices on Speech Perception in Noise
Mallory Butler*1, Carol Sammeth2, Andrew Brown3, David Audet3, Aoi Hunsaker3, Ted Argo4, Greg Rule4, Nathaniel Greene2
1University of Colorado Anschutz Medical Campus, Children’s Hospital, 2University of Colorado School of Medicine, 3University of Washington, 4Applied Research Associates, Inc.
M191. Ossicular Chain Mobility Evaluation by OCT Vibrometry in Normal Ears
Harry de Vries*1, Coen Greidanus1, Ruben Niemantsverdriet1, Koenraad Vermeer1, Mick Metselaar2
1Acoustic Insight, 2Erasmus Medical Center
M192. Association Between Earwax-Determinant Genotypes and Acquired Middle Ear Cholesteatoma in a Japanese Population
Satoshi Hara*1, Satoshi Hara2, Takeshi Kusunoki2, Yu Toyoda3, Hiroshi Nakagawa4, Shuko Nojiri2, Kazusaku Kamiya2, Masayuki Furukawa2, Yusuke Takata2, Hiroko Okada2, Takashi Anzai2, Fumihiko Matsumoto2, Katsuhisa Ikeda2
1Johns Hopkins University, 2Juntendo University, 3Tokyo University, 4Chubu University
M193. Development of an Intensimetric Probe for Wideband Acoustic Immittance
Gabrielle Merchant*1, Matt Ueckermann2, Sara Harris1, Ryan McCreery1, Christopher Wichman3, Odile Clavier2
1Boys Town National Research Hospital, 2Creare LLC, 3University of Nebraska Medical Center
M194. Comparison of Healing of Acute Total Tympanic Membrane Perforation Between Rats With and Without Excision of the Mallear Handle
Zihan Lou*1, Zhengcai Lou2, Zhengnong Chen1
1Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 2 YiWu Hospital
M195. Clinical Assessment of Eustachian Tube Dysfunction Through Questionnaire and Immittance Audiometry
Amina Khan*1, Karolina Charaziak1
1 Keck School of Medicine, USC
M196. Machine Learning Aid for Middle Ear Disease
Jae Ho Chung*1, Hayoung Byun2, Hee Won Seo1, Seung Hwan Lee1, Tae Hyun Kim1, Jaehoon Oh1
1Hanyang University, 2Kangbuk Samsung Hospital
M197. Music Listening Habits and Auditory Function in Young Adults
Jun Suzuki*1, Tomoyasu Ishida1, Tetsuya Oishi1, Takeshi Sato1, Yohei Honkura1, Ryoukichi Ikeda2, Yukio Katori1
1Tohoku University Graduate School of Medicine, 2Iwate Medical University
M198. Protocol for Supervised Automation of Cell Counting in Confocal Microscopic Cochlear Imaging Datasets Using Macro and Batch Processing
Muhammad Rahman*1, Nashwaan Khan1, Mobin Mokbul2, Cristina Garcia1, Ibrahim Razu1, Peter Eckard1, Bryce Hunger1, Shakila Fatima1, Marlan Hansen1
1University of Iowa Hospitals and Clinics, 2Dhaka Medical College
M199. Stimulus-Specific Adaptation in the Hippocampus of the Anesthetized Rat
Jazmin Sanchez Sanchez*1, Perez-González David2, Manuel Malmierca3
1INCyL, Universidad de Salamanca, 2Cognitive and Auditory Neuroscience Laboratory (CANELAB), Institute of Neuroscience of Castilla y León (INCYL), 3Institute of Neuroscience Castilla y Leon, INCYL
M200. An Integrated System for Comprehensive Mouse Vestibular Function Evaluation Based on Vestibulo-Ocular Reflexes
Tong Zhao*1, Shijie Xiao1, Fangyi Chen1
1 Southern University of Science and Technology
M201. Could Stimulus-Evoked Changes in Extracellular [K +] and Electrical Potential Beyond the Synaptic Cleft Affect Encoding by Vestibular Calyx Afferents?
Aravind Chenrayan Govindaraju*1, Anna Lysakowski2, Ruth Anne Eatock3, Rob Raphael1
1Rice University, 2University of Illinois at Chicago, 3University of Chicago
M202. Development of a Reliable and Portable Pediatric Oculomotor and Vestibular Tool for Objective Evaluation of Concussion
Jennifer Coto*1, Erin Williams1, Valerie Yunis2, Alexander Kiderman3, Angela Flamm Finamore4, Michael Hoffer5
1University of Miami Miller School of Medicine, 2University of Miami, 3Neurolign, Inc, 4Allegheny General Hospital, 5University of Miami School of Medicine, University of Miami Ear Institute
M203. Multiple Noise Exposures to Intense Noise (110 dB) Cause Persistent Vestibular Deficits
W. Michael King*1, David Bauer1, Mamiko Niwa1, Katharine Keller1, Richard Altschuler1, Courtney Stewart2
1University of Michigan, Kresge Hearing Research Institute, 2Ann Arbor VA Health Care System
M204. Vestibular Function After Simultaneous Bilateral Cochlear Implantation in Adults
Jun Yokoi*1, Takeshi Fujita1, Natsumi Uehara1, Shinobu Iwaki1, Akinobu Kakigi1, Ken-ichi Nibu1
1 Kobe University Graduate School of Medicine
M205. Investigating Gait Kinematic Variability in Patients With Chronic Vestibulopathy
Angelica Perez Fornos*1, Gautier Grouvel1, Anissa Boutabla2, Stéphane Armand1, Julie Corre1, Rebecca Revol1, Samuel Cavuscens2, Maurizio Ranieri2, Raymond van de Berg3, Nils Guinand1
1Geneva University Hospitals, 2University of Geneva, 3Maastricht University Medical Center
M206. Constant “Baseline” Electrical Stimulation of Vestibular Nerve Afferents Improves Function in Human Patients Implanted With Cochleo-Vestibular Implants
Angelica Perez Fornos*1, Gautier Grouvel1, Anissa Boutabla2, Stéphane Armand1, Julie Corre1, Samuel Cavuscens2, Maurizio Ranieri2, Raymond van de Berg3, Nils Guinand1
1Geneva University Hospitals, 2University of Geneva, 3Maastricht University Medical Center
M207. Na/K-ATPase Alpha Subunit Heterogeneity in the Glial Cells of the Mammalian Vestibular Ganglion
Koji Nishimura*1, Sosuke Ono1, Koichi Omori1
1 Kyoto University
M208. In Vivo Calcium Imaging of Efferent Vestibular Nucleus Neurons Reveals Activity During Self-Generated Movements but Not During Moderate Passive Motion
David Lorincz*1, Elizabeth E. Manning1, Hannah R. Drury1, Hengning Xu1, James S. Welsh1, Rebecca Lim1, Alan M. Brichta1
1 The University of Newcastle
M209. Simulation of Semicircular Canal Cupulae Deflections Evoked by Head Impulse Tests and Orientation Relative to Gravity in Control and BPPV Conditions
Richard Rabbitt*1, Janet Helminski2
1University of Utah, 2Rosalind Franklin University
M210. Infant Vestibular Evoked Myogenic Potentials: A Scoping Review
Alaina Bassett1, Chandan Suresh*1
1 California State University, Los Angeles
M211. Synaptic Activity in Embryonic Vestibulo-Ocular Reflex (VOR) Neurons in a Chick Model for Congenital Vestibular Disorders
Elizabeth Bogin*1, Rossella Conti2, June Hirsch1, Anastas Popratiloff3, Kenna Peusner1
1George Washington University School of Medicine, 2University of Paris, 3George Washington University
M212. The Role of Glutamatergic Input in Shaping the Biophysical Properties of Developing Vestibular Ganglion Neurons
Katherine Regalado*1, Daniel Bronson1, Radha Kalluri1
1 University of Southern California, Keck School of Medicine
M213. Exploring Age-Related Balance Dysfunction in Rodent Peripheral Vestibular System
Mohammad Al-Amin*1, Tiffany Vu1, Brandon Gehrke1, Anna Dondzillo1, Frances Meredith1, Nesrien Mohamed1, Anthony Peng1, Katie Rennie1
1 University of Colorado Anschutz Medical Campus
M214. Hair Bundle Measurement During Mouse Utricle Development and Maturation
Ahmad Mahmoudi1, Tian Wang1, Nathan Mohit1, Kimberly Giffen1, Alan Cheng1, Ahmad Mahmoudi*1
1 Stanford University
M215. Are the Factors Driving Expression of Calcium Binding Proteins Conserved in Mammalian Otolithic Epithelia?
Tyler Kramer*1, Larry Hoffman2
1University of California—Los Angeles, 2Geffen School of Medicine at UCLA
Symposium 7—What Can We Learn From Chicken, Fish, and Stem Cells for Regenerating Hair Cells?
2:15 p.m.—4:15 p.m.
Platinum Salon 6
What can we Learn From Chicken, Fish, and Stem Cells for Regenerating Hair Cells?
Chair: Takayuki Nakagawa, Graduate School of Medicine, Kyoto University
Co:Chair: Stefan Heller, Stanford University School of Medicine
Quo Vadis, Hair Cell Regeneration?
John Brigande
Oregon Hearing Research Center, Oregon National Primate Research Center, Oregon Health and Science University
A Roadmap for Human Ectoderm Development From Pluripotent Stem Cells
Kyle Loh
Stanford University
Generating Cochlear Hair Cells From Human Pluripotent Stem Cells
Eri Hashino
Indiana University School of Medicine
Mapping and Functionally Testing the Gene Regulatory Network During Zebrafish Inner Ear Regeneration
Shawn Burgess
National Human Genome Research Institute
Building a Gene Regulatory Network of Zebrafish Hair Cell Regeneration
Tatjana Piotrowski
Stowers Institute for Medical Research
Direct Conversion From Supporting Cells to Hair Cells in the Chicken Auditory Epithelium
Mami Matsunaga
Graduate School of Medicine, Kyoto University
An Essential Signaling Cascade for Auditory Hair Cell Regeneration
Nesrine Benkafadar
Stanford University School of Medicine
Podium Session 13—Emerging Gene Therapies in Mice, Monkeys, Men, and Women
2:15 p.m.—4:15 p.m.
Platinum Salon 5
First-In-Human Cochlear Implant Neurotrophin Gene Therapy Clinical Trial Directed to Close the ‘Neural Gap’
Gary D Housley*1, Catherine S Birman2, Fadwa Alnafjan3, Jeremy L Pinyon4, Georg von Jonquieres1, Mayryl Duxbury1, WaiKong Lai5, Catherine McMahon6, David McAlpine6, Rachelle Hassarati5, Jaime Undurraga6, Edward N Crawford1, Cherylea J Browne7, Halit Sanli5, Daniel Scherman8, Corinne Marie9, James B Fallon10, Andrew K Wise10, Robert Shepherd10, Ya Lang Enke11, Robert D Gay11, Paul M Carter11, James F Patrick11, Amr Al Abed12, Matthias Klugmann1, Nigel H Lovell12
1School of Biomedical Sciences, UNSW Sydney, 2NextSense, Faculty of Medicine and Health, Sydney Medical School, Sydney University; Faculty of Medicine and Health Science, Macquarie University; Royal Prince Alfred Hospital, 3School of Biomedical Sciences, UNSW Sydney; NextSense, The Hearing Hub, Faculty of Medicine, Health and Human Sciences, Macquarie University, 4School of Biomedical Sciences, UNSW Sydney; School of Medical Sciences, University of Sydney, 5NextSense, 6The Hearing Hub, Faculty of Medicine, Health and Human Sciences, Macquarie University, 7School of Biomedical Sciences, UNSW Sydney; Medical Sciences—School of Science, Western Sydney University, 8Laboratory of Chemical and Biological Technologies for Health, Université Paris Cité, UMR 8258 CNRS – UMR-S 1267, 9Unité de Technologies Chimiques et Biologiques pour la Sante, UTCBS INSERM u1267—CNRS UMR8258 – Université Paris Cité; Faculté des Sciences Pharmaceutiques et Biologiques, 10Bionics Institute, St Vincent's Hospital, Melbourne; University of Melbourne, 11Cochlear Ltd, 12Tyree Institute of Health Engineering (IHealthE), UNSW Sydney; Graduate School of Biomedical Engineering, UNSW Sydney
Assessment of an Adeno Associated Vector-Based Gene Therapy (GJB2-GT) for the Non-Syndromic Deafness 1 (DFNB1) in Cynomolgus Monkeys
Guillaume Olivier1, Lise Barrot1, Christophe Tran van Ba1, Rafik Boudra1, Julie Duron Dos Reis1, Pierre Rambeau1, Charlene Vaux1, Sandra Pierredon1, Anais Pages1, Pauline Liaudet1, Audrey Broussy1, Anne-Gabrielle Harrus1, Selma Dadak1, Jérôme Nevoux2, Arnaud Giese1, Laurent Désiré*1
1Sensorion, 2Genetics and Physiology of Hearing Laboratory, Institut de l’Audition/Pasteur
Initial Characterization of a Naturally-Arising Otoferlin Frameshift Mutation in the Rhesus Macaque
John Brigande*1, Samuel Peterson2, Santhosh Verghese3, Junghyun Ryu2, Edward Porsov3, Beth Kempton3, Fernanda Burch2, Emily Mishler2, Nadine Piekarski2, Carol Hanna2, Jon Hennebold2, Betsy Ferguson2, Meghan Drummond4
1Oregon Hearing Research Center, 2Oregon National Primate Research Center, Oregon Health and Science University, 3Oregon Hearing Research Center, Oregon Health and Science University, 4Regeneron Pharmaceuticals, Inc.
Cerebrospinal Fluid Delivered Cochlear AAV Gene Therapy Enabled by Hair-Cell-Specific Payload
Paul Ranum*1, Ellie Carrell1, Jenna Devare1, Luis Tecedor1, Megan Keiser1, Yong Hong Chen1, David Leib1, Alex Mas Monteys1, Stephen Chorney1, Robert O'Reilly1, Beverly Davidson1
1 Children's Hospital of Philadelphia
The Effects of Epigenetic Modifications on the Efficacy of Inner Ear Gene Therapy
Kevin Isgrig*1, Jianliang Zhu2, Talah Wafa3, Zarek Fasoranti1, Inna Belyantseva4, Mhamed Grati5, Tracy Fitzgerald3, Thomas B. Friedman6, Wade Chien7
1NIH/NIDCD, 2Neurotology Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health, 3Mouse Auditory Testing Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 4Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders NIDCD, National Institutes of Health, 5Inner Ear Gene Therapy Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health, 6Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders NIDCD, National Institutes of Health, 7Neurotology Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health; Johns Hopkins School of Medicine
PIK3CD Overexpression Boosts Neurite Outgrowth and Excitability in Spiral Ganglion Neurons
Ilkem Sevgili*1, Sarantos Mantzagriotis1, Bart Nieuwenhuis1, Manohar Bance1
1 University of Cambridge
Virally-Mediated Enhancement of MOC Feedback Reduces Noise-Induced Damage in Wild Type Cochleas
Eleftheria Slika*1
1 Johns Hopkins University
Cellular and Circuit Mechanisms of Auditory Cortex Recovery After TOMT Gene Therapy for Hearing Loss
Laura Marinos*1, Alicia M. Frank2, Thanos Tzounopoulos1, Christopher L. Cunningham1
1Pittsburgh Hearing Research Center, University of Pittsburgh, Center for Neuroscience at the University of Pittsburgh, 2Pittsburgh Hearing Research Center, University of Pittsburgh
Podium Session 14—Auditory Cortex: Human and Animal Studies
2:15 p.m.—4:15 p.m.
Grand Ballroom Salon E
How Does the Brain of Sleeping Infants Respond to Auditory Stimuli?—The Influence of Stimulus-Induced Brain Arousal
Colette McKay*1, Onn Wah Lee1, Demi Gao1, Tommy Peng1, Julia Wunderlich1, Darren Mao1, Gautam Balasubramanian1, Linty McDonald1
1 The Bionics Institute of Australia.
Implicit Learning of Statistical Structure of Music in Ferret Auditory Cortex
Rupesh Chillale*1, Guilhem Maron2, Claire Pleofi3, Shihab Shamma1
1Institute for System Research, University of Maryland, College Park, 2Laboratoire des Systèmes Perceptifs (CNRS UMR 8248), PSL Research University, 3Center for Language, Music and Emotion, New York University
Neural Tracking of Different Cognitive Tasks in Human EEG
Moira-Phoebe Huet*1, Mounya Elhilali1
1 Johns Hopkins University
Neural Correlates of Learning the Social Meaning of Sounds in an Innate Behavior
Kai Lu1, Kelvin Wong1, Lin Zhou1, Yike Shi1, Chengcheng Yang1, Robert Liu*1
1 Emory University
Different Modes of Attention in Dynamic Multi-Speaker Auditory Scenes
Stephanie Graceffo*1, David Little1, Emine Merve Kaya1, Mounya Elhilali1
1 Johns Hopkins University
Modeling Speech-To-Language Transformations in the Human Brain
Edmund Lalor*1, Jin Dou1, Ole Bialas1, Andrew Anderson2
1University of Rochester, 2Medical College of Wisconsin
Intracranial Electrophysiology of Spectrally Degraded Speech in the Human Cortex
Kirill Nourski*1, Mitchell Steinschneider2, Ariane Rhone1, Joel Berger1, Emily Dappen1, Hiroto Kawasaki1, Matthew Howard1
1The University of Iowa, 2Albert Einstein College of Medicine, The University of Iowa
EEG as an Indicator for Perceptual Difficulties in Noise?
Jiayue Liu*1, Josh Stohl2, Tobias Overath1
1Duke University, 2MED-EL
In Memoriam Symposium—Emotional Connections to Speech and Music Throughout Life : In Memory of Dr. Sandra Trehub
4:30 p.m.—6:30 p.m.
Grand Ballroom Salon E
Emotional Connections to Speech and Music Throughout Life: In Memory of Dr. Sandra Trehub
Chair: Karen Gordon, The Hospital for Sick Children
Infants’ Emotional Responses to Music and Song
Laura Cirelli
University of Toronto Scarborough
The Experience of Musical Chills Emerges Gradually During Development and Depends on Musicality and Auditory Perceptual Skills
Erin Hannon
University of Nevada Las Vegas
Music Listening Skills of Deaf Children With Cochlear Implants: Triumphs and Challenges
Tara Vongpaisal
MacEwan University
Somewhere Between Music and Speech: Communicating Emotions With Cochlear Implants
Monita Chatterjee
Boys Town National Research Hospital
Considering the Valence and Arousal of Sounds Including Music in Cochlear Implant Users
Erin Picou
Vanderbilt University Medical Center
Tuesday, February 6, 2024
Symposium 8—Insights into Regulation of Hair Cell Mechanotransduction Complex Composition and Environment
8:00 a.m.—10:00 a.m.
Grand Ballroom Salon E
Insights Into Regulation of Hair Cell Mechanotransduction Complex Composition and Environment
Chair: Shefin George, Stanford University
Co-Chair: Christopher L. Cunningham, Pittsburgh Hearing Research Center, University of Pittsburgh School of Medicine.
Architecture of the C. Elegans TMC-1 Complex
Sarah Clark
Oregon State University
Investigating Contributions of the Deafness-Associated Protein TOMT to Localization of the Mechanotransduction Channel Subunit TMC1
Christopher L. Cunningham
Pittsburgh Hearing Research Center, University of Pittsburgh School of Medicine
LOXHD1 is Required for TMC1 Localization at the Lower Tip-Link Insertion Area
Pei Wang
Stanford Medicine
Myosin XVA Isoforms are Required for the Mechanotransduction-Dependent Remodeling of the Stereocilia Actin Cytoskeleton
A. Catalina Velez-Ortega
University of Kentucky
Stepwise Activation Mechanism of a Calcium-Activated Lipid Scramblase nhTMEM16
Valeria Kalienkova
University of Bergen
Regulation of Membrane Homeostasis by TMC1 Mechanoelectrical Transduction Channels is Essential for Hearing
Angela Ballesteros
NIDCD-NIH
TMCs Regulate Membrane Viscosity in Mammalian Cochlear Hair Cells
Shefin George
Stanford University
Unveiling the Role of Glycine Residues in Prestin: Insights Into Voltage and Mechanosensitivity in Mammalian Cochlear Amplification
Navid Bavi
University of California, Los Angeles, UCLA School of Medicine
Podium Session 15—Speech Perception: Hearing Loss, Noise, and Other Challenges
8:00 a.m.—10:00 a.m.
Platinum Salon 6
Audiometric Markers of Cochlear Synaptopathy and Speech in Noise Deficits in Humans
Lukas Rüttiger*1, Jakob Schirmer1, Stephan Wolpert1, Konrad Dapper1, Moritz Rühle1, Jakob Wertz1, Marjoleen Wouters2, Jerome Bourien3, Etienne Gaudrain4, Deniz Başkent5, Sarah Verhulst2, Matthias H. J. Munk6, Ernst Dalhoff7, Christoph Braun8, Marlies Knipper1
1Hearing Research Centre Tübingen, Molecular Physiology of Hearing, University of Tübingen, 2Ghent University, 3Institute for Neurosciences Montpellier, University of Montpellier, Institut National de la Santé et de la Recherche Médicale, 4Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM UMRS 1028, Université Claude Bernard Lyon 1, Université de Lyon, 5University of Groningen, University Medical Center Groningen, 6University Hospital Tübingen; Technical University Darmstadt, 7University of Tübingen, 8MEG-Center, University of Tübingen; Hertie Institute for Clinical Brain Research
Changes in the Fundamental Frequency of Speech in Response to Background Noise and Hearing Loss
Paolo Mesiano*1, Johannes Zaar1, Helia Relaño-Iborra2, Lars Bramsløw1, Torsten Dau2
1Eriksholm Research Centre, Denmark, 2Technical University of Denmark
Predicting the Effect of Hearing Loss on Speech Intelligibility Using a Physiologically Inspired Auditory Model
Johannes Zaar*1, Laurel H. Carney2
1Eriksholm Research Centre, 2University of Rochester
Predicting Supra-Threshold Speech Reception Deficits Using the Audible Contrast Threshold Test
Johannes Zaar*1, Peter Ihly2, Takanori Nishiyama3, Søren Laugesen4, Sébastien Santurette5, Chiemi Tanaka6, Gary Jones7, Marianna Vatti5, Daisuke Suzuki8, Tsubasa Kitama3, Kaoru Ogawa9, Jürgen Tchorz2, Seiichi Shinden8, Tim Jürgens2
1Eriksholm Research Centre, 2University of Applied Sciences Lübeck, 3Keio University School of Medicine, 4Interacoustics Research Unit, 5Oticon A/S, 6Oticon Japan, 7Demant A/S, 8Saiseikai Utsunomiya Hospital, 9OTO Clinic Tokyo
The Effect of Fundamental-Frequency Dynamics on Speech Intelligibility in Competing-Talker Scenarios for Normal-Hearing and Hearing-Impaired Listeners
Paolo Mesiano*1, Johannes Zaar1, Helia Relaño-Iborra2, Lars Bramsløw1, Torsten Dau2
1Eriksholm Research Centre, Denmark, 2Technical University of Denmark
The Role of Periodicity in Speech-on-Speech Understanding in Normal-Hearing and Hearing-Impaired Listeners
Paolo Mesiano*1, Hamish Innes-Brown1, Tobias May2, Johannes Zaar1
1Eriksholm Research Centre, 2Technical University of Denmark
The Effect of Age in Normal Hearing and the Use of Cochlear Implants on Voice Discrimination in the Background of Noise
Yael Zaltz1, Liat Kishon-Rabin*1
1 Tel-Aviv University
Decoding Selective Attention in Cochlear Implant and Normal Hearing Individuals’ Single-Trial EEG
Jinhee Kim*1, Jusung Ham2, Inyong Choi2, Kyogu Lee1
1Seoul National University, 2University of Iowa
Podium Session 16—Inner Ear Development
8:00 a.m.—10:00 a.m.
Platinum Salon 5
POU4F3 Deletion Causes Developmental Arrest of Utricular Hair Cells
Beatrice Mao*1, Matthew W. Kelley1
1 National Institute on Deafness and Other Communication Disorders, NIH
GJB2-Mediated Transcriptional Genomic Changes in the Postnatal Development of the Cochlea Analyzed by RNA-Seq
Yiding Yu*1, Yang Yang2, Liman Liu2, Tianying Zhai2, Yong Kong3, Hongbo Zhao2
1Yale University, 2Yale University Medical School, 3Yale School of Public Health
Revisiting the Potency of Tbx2 Expression in Transforming Outer Hair Cells Into Inner Hair Cells at Multiple Ages in Vivo
Zhiyong Liu*1, Zhenghong Bi1, Minhui Ren1, Yu Zhang2, Shunji He1, Lei Song2, Xiang Li1
1Institute of Neuroscience, Chinese Academy of Sciences, 2Ninth Affiliated Hospital, Shanghai Jiaotong University
HMGA2 Integrates Tonotopic Morphogen Signaling and is Required for Low-Frequency Hearing in Mice
Saikat Chakraborty1, Jack Ruhala1, Luis Cassinotti1, Shuze Wang1, Gabriel Corfas1, Joerg Waldhaus*1
1 University of Michigan
Notch1 is Required for Sensory Maturation in the Mammalian Vestibular System
Alison Heffer*1, Choongheon Lee1, Anjali Sinha2, J. Chris Holt2, Amy Kiernan1
1University of Rochester Medical Center, 2University of Rochester
Deciphering the Contribution of Wnt Ligands From Cochlear Epithelium and Periotic Mesenchyme During Cochlear Development
Ippei Kishimoto*1, Erin Su1, Abel David2, Kevin Rose3, Sara Billings1, Wuxing Dong1, Taha A. Jan4, Ronna Hertzano3, Alan Cheng1
1Stanford University, 2Mass Eye and Ear, Harvard University, 3NIDCD/NIH, 4Vanderbilt University Medical Center
The Transcription Factor TOX Potentiates ATOH1 Activity and Regulates Hair Cell Maturation in the Hearing Organ
Yoko Nakano1, Susan Wiechert1, Botond Banfi*1
1 University of Iowa
Development of the Fetal Human Utricle Revealed by Single-Nucleus Multiomics
Weisheng Liang*1, Ryosuke Yamamoto2, Emilia Luca2, Alain Dabdoub3
1University of Toronto, 2Sunnybrook Research Institute, 3Sunnybrook Research Institute; University of Toronto
Symposium 9—Plasticity of the Central Auditory System During the Life-Time
10:15 a.m.—12:15 p.m.
Grand Ballroom Salon E
Plasticity of the Central Auditory System During the Life-Time
Chair: Josef Syka, Institute of Experimental Medicine, ASCR
Co-Chair: Nina Kraus, Northwestern University
The Plasticity of the Auditory System in the Early Developmental Period
Josef Syka
Institute of Experimental Medicine, ASCR
Plastic Changes in the Auditory Cortex Caused by Unilateral Hearing Loss
Oliver Profant
Charles University
Hormones Impact Sexual Dimorphism of Subcortical Auditory Processing in Humans and Rodents
Jennifer Krizman
Northwestern University
Neural Plasticity Over the Lifetime: The Beams Hypothesis
Nina Kraus
Northwestern University
On the Interaction Between Speech, Age-Related Hearing Loss, and Brain Atrophy
Martin Meyer
University of Zurich
Evidence of Neuroplasticity in the Aging Brainstem and Cortex
Samira Anderson
University of Maryland
Podium Session 17—New Frontiers in Auditory Research: Exploring Middle Ear Dynamics and Tinnitus Pathophysiology
10:15 a.m.—12:15 p.m.
Platinum Salon 6
Acoustic Trauma Measured via Intracochlear Pressure Changes During Mastoidectomy
Emily Bacalao1, Nam Lee1, Juanantonio Ruiz1, Brian Herrmann1, Nathaniel Greene1, Emily Bacalao*2
1University of Colorado School of Medicine, 2University of Colorado
Defining Exclusion Criteria for GAP Inhibition of Acoustic Startle Reflex: Critical Factors for Assessment
Rod Braun1, Selin Yalcinoglu*1, Antonela Muca1, James Warila1, Aaron Apawu1, Anthony Cacace2, Avril Genene Holt1
1Wayne State University School of Medicine, 2Wayne State University
Acoustic Estimation of Middle-Ear Input Impedance
Joshua Hajicek*1, James Lewis2, Stephen Neely1
1Boys Town National Research Hospital, 2University of Tennessee Health Science Center
Metabolic Dysregulation and Risk of Developing Persistent Tinnitus in Two US Cohorts
Oana Zeleznik*1, Raji Balasubramanian2, D. Bradley Welling3, Konstantina Stankovic4, Gary Curhan5, Sharon Curhan5
1Brigham and Women's Hospital, Harvard Medical School, 2University of Massachusetts, 3Massachusetts Eye and Ear, Harvard Medical School, 4Stanford School of Medicine, 5Brigham and Women's Hospital, Harvard Medical School
An Integrated High-Speed 3D-Digital Image Correlation and Schlieren Methodology for Studying Tympanic Membrane Exposed to Blast
Anahita Alipanahi*1, Jonathan Oliveira Luiz1, Cosme Furlong2, Jeffrey Cheng1
1Mass. Eye and Ear, Harvard Medical School, 2Worcester Polytechnic Institute
Dynamics and Fluid–Solid Interaction of Human Tympanic Membrane Exposed to Blast
Jonathan Oliveira Luiz*1, Anahita Alipanahi1, Cosme Furlong2, Jeffrey Cheng1
1Mass. Eye and Ear, Harvard Medical School, 2Worcester Polytechnic Institute
Middle-Ear Sound Transmission in Cadaveric Temporal Bones: Fresh Versus Fresh-Frozen Human Temporal Bones
Bastian Baselt*1, Merlin Schaer2, Alexander Huber2, Jae Hoon Sim2
1University of Zürich, 2University Hospital Zurich
Rapid Evaluation of Middle Ear Muscle Reflex Level Growth Functions Using a Swept Elicitor
Shawn Goodman*1, Ehsan Khalili1, Julia Roemen1, Rachel White1, Megan Wright1, Daniel Tay1, Jeffery Lichtenhan2
1University of Iowa, 2University of South Florida
Podium Session 18—Cochlear Mechanics: Modelling
10:15 a.m.—12:15 p.m.
Platinum Salon 5
Using a Cochlear Model to Evaluate the Correlation Between Intracochlear Tuning Sharpness and Stimulus Frequency Otoacoustic Emission Group Delays
George Samaras*1, Yiwei Xia1, Julien Meaud1
1 Georgia Institute of Technology
3D Finite Element Modeling of Blast Wave Transmission to the Organ of Corti in Human Ear
John Bradshaw*1, Marcus Brown1, Alexander Bien2, Rong Gan1
1University of Oklahoma, 2University of Oklahoma Health Sciences Center
Steep Cochlear Filters, Noise Squelching and Spatial Filtering: Everywhere, All at Once in Your Ears!
Alessandro Altoe*1, Christopher Shera1
1 University of Southern California
Did Constraints Imposed by Outer Hair Cell Electromechanics Drive Cochlear Evolution?
Richard Rabbitt*1, Nastaran Gholami1
1 University of Utah
A Radial-Slice Model of the Gerbil Cochlea With Reticular Lamina Motion Amplification
Julius Kraut*1, Sunil Puria2
1Massachusetts Eye and Ear, 2Harvard Medical School, Mass. Eye and Ear Infirmary
Analyzing Cochlear Amplification Through a Two-Dimensional Organ of Corti Micro-Electro-Mechanical Model
Wen Cai*1, Karl Grosh1
1 University of Michigan
The Role of the Osseus Spiral Lamina on Human Cochlear Mechanics Examined With a Finite-Element Model
Andrew Tubelli*1, Paul Secchia2, Hideko Heidi Nakajima2, Sunil Puria2
1Mass. Eye and Ear Infirmary, 2Harvard Medical School, Mass. Eye and Ear Infirmary
Modeling the Effect of Intracellular Calcium on Hair Bundle Adaptation
Varun Goyal*1, Karl Grosh1
1 University of Michigan
Poster Session 4
1:15 p.m.—3:15 p.m.
Marquis Ballroom
T1. A Multi-Lab EEG Replication and Extension of “Tagging the Neural Entrainment to Beat and Meter”
Karli Nave1, Erin Hannon2, Joel Snyder*2
1University of Western Ontario, 2University of Nevada, Las Vegas
T2. Interactions Between Fundamental Frequency and Spectral Centroid in the Cortical Encoding of Pitch and Timbre
Yongtian Ou*1, Kendrick N. Kay1, Andrew J. Oxenham1
1 University of Minnesota
T3. Chimeric Music: Exploring Pitch-Time Interaction on the Neural Encoding of Music Expectation
Tong Shan*1, Edmund Lalor2, Ross Maddox1
1University of Rochester, 2Del Monte Institute for Neuroscience, University of Rochester
T4. Minimal Background Noise Enhances Neural Speech Tracking
Björn Herrmann*1
1 Rotman Research Institute
T5. Photobiomodulation Alters Cell Proportions in Auditory Cortex in Photo-Thrombosis Hearing Loss in Vivo Model
Ji On Park*1, So-Young Chang2, Jin-Chul Ahn3, Ji-Eun Choi1, Min Young Lee1, Jae Yun Jung1
1Dankook University Hospital, 2Beckman Laser Institute Korea, Dankook University, 3Medical Laser Research Center, Dankook University
T6. Characterizing the Morphology of Auditory Evoked Loudness Dependent fNIRS Responses in Sleeping Infants
Demi Gao*1, Julia Wunderlich1, Onn Wah Lee1, Darren Mao1, Tommy Peng1, Gautam Balasubramanian1, Linty McDonald1, Colette McKay1
1 The Bionics Institute of Australia
T7. Neural Correlates of Periodicity Pitch Perception in Mouse Auditory Cortex
Jason Putnam*1, Nikolas Francis1
1 The University of Maryland
T8. Myeloarchitecture of the Feline Auditory Cortex
Austin Robertson1, Daniel Miller2, Blake Butler*1
1University of Western Ontario, 2University of Illinois Urbana Champaign
T9. A Novel Approach for the Automation of Spiral Ganglion Neuron Quantification Using an ADARB1 Antibody
Garner Fincher*1, Sumana Ghosh1, Punam Thapa1, Cody Gresset1, Bradley Walters1
1 University of Mississippi Medical Center
T10. Auditory Phenotype in a Mouse Model of Neurofibromatosis Type 2 is Associated With Proliferation of Glial Cells and Peripheral Myelinopathy
Judith Kempfle*1, Luis Cassinotti2, Andrea Zhang3, Richard Kuang3, Sina Schwinn3, Drew Montigny3, Zhi Xuan Gao3, D. Bradley Welling1, Gabriel Corfas2, David Jung1
1Massachusetts Eye and Ear, Harvard Medical School, 2The University of Michigan, Kresge Hearing Research Institute, 3Massachusetts Eye and Ear
T11. Lateral Olivocochlear Efferent Inputs Contribute to Setting Auditory Nerve Fiber Spontaneous Firing Rates in Vitro
Philippe Vincent*1, Elisabeth Glowatzki1
1 Johns Hopkins School of Medicine
T12. Molecular Subtypes of Bushy Cells in Mouse Cochlear Nucleus
Junzhan Jing*1, Ming Hu1, Tenzin Ngodup2, Qianqian Ma1, Natalie Lau1, Cecilia Ljungberg1, Matthew J. McGinley1, Laurence O. Trussell2, Xiaolong Jiang1
1Baylor College of Medicine, 2Oregon Health and Science University, Oregon Hearing Research Center
T13. Bilateral and Symmetric Glycinergic and Glutamatergic Projections From the LSO to the IC in the Mouse
Isabella Williams*1, David Ryugo2
1University of Technology Sydney, 2Garvan Institute of Medical Research; School of Medical Sciences, UNSW Sydney, Kensington; St. Vincent's Hospital
T14. FMRP Regulation of Axon Targeting and Synaptogenesis for Binaural Processing
Sima Sabbagh*1, Yong Liu1, Yuan Wang1
1 College of Medicine, Florida State University
T15. Calcium Signaling During Development of Mouse MNTB Neurons
Tasmuna Tanmy*1, Yong Lu1
1 Northeast Ohio Medical University
T16. Sex Differences in Young Adult Frequency Following Responses to Speech and Musical Sounds
Joseph Luetkehans*1, Trent Nicol1, Jennifer Krizman1, Nina Kraus1
1 Northwestern University
T17. Noise-Induced Hearing Loss Increases Ca2 + Channel Conductances Underlying Burst Firing Pattern of Lateral Olivocochlear Neurons
Hui Hong*1, Laurence O. Trussell2
1Oregon Health and Science University, 2Oregon Health and Science University, Oregon Hearing Research Center
T18. Impact of KCC2 Phosphorylation on Synaptic Development in the Lateral Superior Olive (LSO)
Tamara Radulovic*1, Lena Ebbers1, Michael Winklhofer1, Christian Keine1, Hans Gerd Nothwang1, Ivan Milenkovic1, Anna-Maria Hartmann1
1 University of Oldenburg
T19. In Utero Exposure to Paracetamol Disrupts Auditory Brainstem Responses in Rats
Randy Kulesza*1, Meghan Graeca1
1 Lake Erie College of Osteopathic Medicine
T20. Sources and Termination Patterns of Cholinergic Input to the Ventral Nucleus of the Lateral Lemniscus
Emily E. Echols1, Rhea H. Mehta2, William A. Noftz2, Nichole L. Beebe2, Brett Schofield*2
1University of Akron, 2Northeast Ohio Medical University
T21. Diversity of Subthreshold and Action Potential Properties in Octopus Cells of the Posteroventral Cochlear Nucleus: Implications for Temporal Coding
Shobhana Sivaramakrishnan*1, Aaron Hardman1, Nace Golding1
1 University of Texas at Austin
T22. Mapping Vasculature in Human Midbrain With MRI
Kevin Sitek*1, O. Faruk Gulban2
1Northwestern University, 2Brain Innovation
T23. ABR + : Combining Click and Neurophonic Stimulus Types to Assess Multifaceted Neural Function in a Single Test
Gabriella Musacchia*1, Jiong "Joe" Hu1, Matthew Fitzgerald3
1University of the Pacific, 3Stanford University
T24. Central Auditory Deficits in Post-Acute COVID Syndrome
Christopher Niemczak*1, Erika Skoe2, Annalise Kieley2, Samantha Leigh1, Megan Dotzenrad2, Christin Ealer1, Linda Zhang1, Robert Roth1, Jay Buckey1
1Dartmouth-Hitchcock, Geisel School of Medicine, 2University of Connecticut
T25. Developmental Spontaneous Activity Drives the Maturation of the Calyx of Held Nerve Terminal and Its Synaptic Target in the Medial Nucleus of the Trapezoid Body
Daniel Heller*1, Nikollas Moreira Benites1, Emily Amick1, Andre Dagostin2, Samuel Young3, Henrique von Gersdorff4, George Spirou1
1University of South Florida, 2Oregon Health and Science University—Vollum Institute, 3University of Iowa, 4Oregon Health and Science University
T26. Differential Cortical Modulation of Inferior Colliculus Sub-Circuits
Hannah Oberle*1, Esther Choi1, Clara Martinez-Voigt1, Pierre Apostolides2
1University of Michigan, 2Kresge Hearing Research Institute, University of Michigan
T27. Auditory Hyperexcitability: Central Auditory Processing in the Inferior Colliculus of a Genetic Mouse Model Susceptible to Audiogenic Seizures
Carolina de Campos Pina*1, Olivier Postal2, Sabrina Méchaussier2, Mathilde Gagliardini2, Typhaine Dupont2, Boris Gourévitch3, Nicolas Michalski2
1Institut de l'Audition, Institut Pasteur, 2Institut de l'Audition, Institut Pasteur, INSERM, Université de Paris, 3Institut de l'Audition, INSERM, Institut Pasteur; CNRS
T28. Timbre Encoding in the Inferior Colliculus: Exploring Neural Mechanisms
Johanna Fritzinger*1, Laurel H. Carney2
1University of Rochester Medical and Dental School, 2University of Rochester
T29. Recruitment of Local Inhibitory Circuits in the Inferior Colliculus by Ascending Input From the Cochlear Nucleus
Yoani Herrera*1, Ananda Lewis1, Michael Roberts2
1University of Michigan, 2The University of Michigan, Kresge Hearing Research Institute
T30. Recovery of Neural Modulation Tuning in the Midbrain After Kainic-Acid-Induced Cochlear Synaptopathy in the Budgerigar
Yingxuan Wang*1, Kristina S. Abrams2, Margaret R. Youngman2, Kenneth S. Henry2
1University of Rochester, 2University of Rochester Medical Center
T31. Brain State-Dependent Modulation of Sound Responses in the Inferior Colliculus
Hemant Kumar Srivastava*1, Kathy Liang1, Hong Jiang1, Matthew McGinley1
1 Baylor College of Medicine
T32. Mapping Neural Excitation and Suppression During Sound Processing in the Awake Mouse Inferior Colliculus
Patrick Parker*1, Dwight Bergles2
1Johns Hopkins School of Medicine, 2Johns Hopkins University
T33. Prefrontal Cortex Inhibition Reduces Prediction Error in the Auditory Cortex
Adam Hockley*1, Manuel S. Malmierca1
1 Cognitive and Auditory Neuroscience Lab, Institute of Neuroscience of Castilla y León, Universidad de Salamanca
T34. Mice Got Rhythm: Sound-Evoked Whisker, Nose and Pinna Movements in the Awake Mouse and Their Relationship to Auditory Cortical Activity
Marios Akritas1, Sonali Sriranga1, Alex G. Armstrong1, Jules M. Lebert1, Arne F. Meyer2, Jennifer Linden*3
1Ear Institute, University College London, 2Sainsbury-Wellcome Centre for Neural Circuits and Behaviour, University College London, 3University College London
T35. LOXHD1 is Required for TMC1 Localization at the Lower Tip-Link Insertion Area
Pei Wang*1, Katharine Miller1, Enqi He1, Siddhant S. Dhawan1, Christopher L. Cunningham2, Nicolas Grillet1
1Stanford Medicine, 2Pittsburgh Hearing Research Center, University of Pittsburgh School of Medicine, Pittsburgh
T36. The Effect of Estrogen on Hair Cells in Larval Zebrafish
Coty Jasper*1, Leila Farbod1, Isabella Morena-Stedman1, Noel Smith1, Bella Williams1, Isabella Honsowetz1, Allison Coffin1
1 Washington State University
T37. Technical Details of Single-Molecule Microscopy to Visualize Protein Molecule Dynamics in a Stereocilium of Live Hair Cells
Mrudhula Sajeevadathan1, Takushi Miyoshi2, Harshad Vishwasrao3, Inna Belyantseva2, Yasuko Ishibashi2, Samuel Adadey2, Narinobu Harada4, Hari Shroff5, Thomas Friedman2, Mrudhula Sajeevadathan*1
1Southern Illinois University, 2NIDCD/NIH, 3NIBIB/NIH, 4Harada Ear Institute, 5Janelia Research Campus
T38. Sound Encoding in the Cochlear Apex: Is the Place Principle Misplaced?
Pierre Hakizimana*1, Anders Fridberger1
1 Linköping University
T39. Pigment Epithelium-Derived Factor in Human Cochlea, a Study Using IF, RNAscope, Confocal and Super-Resolution Structured Illumination Microscopy
Wei Liu*1, Jesper Edvardsson Rasmussen1, Helge Rask-Andersen2, Per-Olof Eriksson3, Göran Laurell3
1Uppsala University, 2Uppsala University Hospital, 3Akademiska Sjukhuset
T40. Improvements in the Immunofluorescence Staining of Human Ear Celloidin Sections
Ivan Lopez*1, Gail Ishiyama2, Akira Ishiyama1
1David Geffen School of Medicine at UCLA, 2UCLA
T41. Mortui Vivos Docent: A Modern Revival of Temporal Bone Plug Harvests
Varun Sagi*1, Nikitha Kosaraju2, Lindsay Moore3, Jip Mulders3, Mehmet Solyali4, Xiaojie Ma5, Donald Regula3, Jody Hooper3, Konstantina Stankovic3
1Stanford University, 2David Geffen School of Medicine at UCLA, 3Stanford School of Medicine, 4Stanford University School of Humanities and Sciences, 5Massachusetts Eye and Ear Infirmary, Harvard Medical School
T42. Haploinsufficiency for the Long Isoform of Myosin XVA Leads to Heightened Susceptibility to Cochlear Insults
Ana I. Lopez-Porras*1, Abigail Dragich1, Ava Kruse1, A. Catalina Velez-Ortega1
1 University of Kentucky
T43. Sem Analysis of Macrophages Along the Cochlear Spiral in Mice
Celia Zhang*1, Mengxiao Ye2, Bo Hua Hu3, Peter Bush4
1University of the Pacific, 2University at Buffalo, 3Center for Hearing and Deafness, University at Buffalo, 4South Campus Instrument Center, University at Buffalo
T44. Dysregulation of Fetal-Derived Resident Tissue Macrophages Mediate CMV-Associated SNHL
Kelly Otsuka*1, Emilio Trujillo1, Jordan Stout1, Peter Kfoury1, Albert H. Park1, Anna E. Beaudin2
1University of Utah, 2Division of Hematology and Hematologic Malignancies, University of Utah School of Medicine
T45. Do TRPA1-Deficient Mice Develop Age-Related Changes in Hearing?
Doris Susana Llanes-Coronel*1, Ava M. Kruse1, D. Ysabella Calderon-Briceño1, A. Catalina Velez-Ortega1
1 University of Kentucky
T46. Characterizing the Role of CGRP on OHC Function During Stimulation of Medial Olivocochlear Neurons
Choongheon Lee1, Anne Luebke2, Joseph Holt*2
1University of Rochester Medical Center, 2University of Rochester
T47. Exploring Human Cochlear Masking and OAE Suppression at Different Cochlear Locations Using Frequency Sweeps
William Salloom*1, Christopher Shera1, Karolina Charaziak1
1 University of Southern California
T48. Investigation of the Skull Bone Sound Waves Under Bone Conduction In-Vivo
Aikaterini Dimitrakopoulou1, Ivo Dobrev*1, Flurin Pfiffner1, Christof Röösli1
1 University Hospital Zurich, University of Zurich
T49. Motion of Cochlear Partition Structures of Intact Human Cadaveric Specimens Measured With Optical Coherence Tomography Vibrometry
Paul Secchia*1, Nam Hyun Cho1, Christopher McHugh2, Andrew Tubelli2, Aleksander Zosuls2, John Guinan1, Sunil Puria1, Hideko Heidi Nakajima1
1Harvard Medical School, Mass. Eye and Ear Infirmary, 2Mass Eye and Ear Infirmary
T50. Intracochlear Motion Measurements in the Basal Turn of the Guinea Pig Cochlea: A Comparison Across Species and Cochlear Locations
Lauren Chiriboga*1, C.Elliott Strimbu1, Brian Frost1, Elizabeth Olson1
1 Columbia University
T51. Assessment of AAV-Mediated Innate and Adaptive Immunity in the Mammalian Inner Ear
Yasuko Ishibashi*1, Jianliang Zhu2, Kevin Isgrig2, Mhamed Grati2, Rafal Olszewski3, Gwladys Gernoux4, Yunkai Yu5, Liang Cao5, Michael Hoa3, Thomas B. Friedman6, Oumeya Adjali4, Wade Chien7
1Laboratory of Molecular Genetics, Inner Ear Gene Therapy Program, National Institute on Deafness and Other Communication Disorders, National Institute of Health, 2Inner Ear Gene Therapy Program, National Institute On Deafness and Other Communication Disorders (NIDCD), National Institutes of Health, 3Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 4Nantes Université, CHU de Nantes, INSERM, TaRGeT—Translational Research in Gene Therapy, UMR 1089, 5Genetics Branch, The Center for Cancer Research, National Cancer Institute, National Institute of Health,, 6Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders NIDCD, National Institutes of Health, 7Inner Ear Gene Therapy Program, National Institute On Deafness and Other Communication Disorders (NIDCD), National Institutes of Health, Johns Hopkins School of Medicine
T52. Open Board
T53. Optimization of the AAV-Compatible Hair Cell-Specific Mini-Myo15 Promoter for Gene Therapy in the Inner Ear
Shao Wei Hu*1, Jun Lv1, Zijing Wang1, Honghai Tang1, Hui Wang1, Fang Wang1, Daqi Wang1, Juan Zhang1, Longlong Zhang1, Qi Cao1, Yuxin Chen1, Ziwen Gao1, Yu Han1, Wuqing Wang1, Geng-lin Li1, Yilai Shu1, Huawei Li1
1 Eye and ENT Hospital of Fudan University
T54. AAV1-HOTOF Gene Therapy for Autosomal Recessive Deafness 9 (DFNB9)
Yilai Shu*1, Jun Lv1, Hui Wang1, Xiaoting Cheng1, Yuxin Chen1, Daqi Wang1, Longlong Zhang1, Qi Cao1, Honghai Tang1, Shaowei Hu1, Kaiyu Gao2, Wuqing Wang1, Zheng-Yi Chen3, Huawei Li1
1ENT Institute and Otorhinolaryngology Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, 2Shanghai Refreshgene Therapeutics Co., Ltd., 3Graduate Program in Speech and Hearing Bioscience and Technology and Program in Neuroscience, Harvard Medical School
T55. In Vivo Adenine Base Editing Restores Long-Term Auditory Function in a Mouse Model of Recessive Profound Deafness
Chong Cui*1, Shengyi Wang1, Daqi Wang1, Jingjing Zhao1, Bowei Huang1, Biyun Zhu1, Yuxin Chen1, Honghai Tang1, Yu Han1, Cheng Ye1, Dan Mu1, Jun Lv1, Shuang Han1, Geng-Lin Li1, Huawei Li1, Yilai Shu1
1 ENT Institute and Otorhinolaryngology Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University
T56. Targeted Brainstem Delivery of Adeno-Associated Viral Vectors Significantly Improves Gene Delivery to Spiral Ganglion Neurons in Adult Rats
Jerusha Naidoo*1, Eric Bielefeld1, Yin Ren1, Hsuan-Chih Kuo1, Matthew Avenarius1, Nathan McFarland1, Allison Clark1, Matthew Rocco1, Manpreet Thakar1, Geneva Frank1, Victor Van Laar1, Krystof Bankiewicz1
1 The Ohio State University
T57. Rational Design and Predicted Elasticity of Mini-PCDH15 Proteins Used for Usher-1F Gene Therapy
Pedro de la Torre*1, Haosheng Wen2, Karina Martínez-Pérez3, Joseph Brower4, Yoshie Narui5, Maryna Ivanchenko6, David Corey6, Marcos Sotomayor2, Artur Indzhykulian4
1Harvard University and Massachusetts Eye and Ear Infirmary, 2The Ohio State University, 3Universidad del Atlántico, 4Harvard Medical School, MEEI, 5Ohio State Center for Electron Microscopy and Analysis, 6Harvard Medical School
T58. Stereocilin Gene Therapy Rescues Hearing in Mature STRC Knockout Mice
Antonio Bon-Nieves*1, Peixin Huang2, Juliane Schott3, Axel Schambach3, Hinrich Staecker2
1KUMC, 2University of Kansas Medical Center, 3Institute of Experimental Hematology, Hannover Medical School
T59. Cellular Study of the Protective Effect on Sensorineural Hearing Loss Using Cyclophilin D Inhibitor
Sujin Jun1, Ye-Ri Kim1, Byeonghyeon Lee2, jeong-In Baek3, Kyu-Yup Lee4, Un-kyung Kim1, Tae-Jun Kwon*2
1Kyungpook National University,2Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub), 3Daegu Haany University, 4Kyungpook National University Hospital
T60. Evaluating the Protective Effects of Raloxifene in a Mouse Model of Noise-Induced Hidden Hearing Loss
Reza Amanipour*1, Benjamin Shuster1, Beatrice Milon1, Ronna Hertzano1
1 Neurotology Branch, National Institute on Deafness and Other Communication Disorders
T61. Predicting Strial Atrophy From Audiogram Shape
Charanjeet Kaur*1, Peizhe Wu2, Jennifer O'Malley2, Charles Liberman3
1Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Harvard Medical School, 2Mass. Eye and Ear, Harvard Medical School, 3Eaton-Peabody Laboratories, Mass. Eye and Ear
T62. Repair of the Stereocilia F-Actin Core is Mediated by the Mechanosensitive Protein XIRP2
Alyssa Luz-Ricca*1, Elizabeth Wagner1, Stefano Sala2, Patrick Oakes2, Henry De Hoyos1, Jung-Bum Shin1
1University of Virginia School of Medicine, 2Loyola University Chicago
T63. Screening of FDA-Approved Drug Library Against Acquired Hair Cell Loss in Zebra Fish (Danio rerio)
Vijayprakash Namakkal Manickam*1, Lyudmila Batalkina1, Marisa Zallocchi1
1 Creighton University
T64. Evaluation of the Effects of Rock Inhibitors on Auditory Damage Model Caused by Blast Exposure in CBA/J
Yutaka Koizumi*1, Aaron Remenschneider2, Jeffrey Cheng3, Christopher J. Smalt4, Kunio Mizutari5, Seiji Kakehata6
1Eaton-Peabody Laboratories, Massachusetts Eye and Ear; Harvard Medical School; Yamagata University Faculty of Medicine, 2Eaton-Peabody Laboratories, Massachusetts Eye and Ear; Harvard Medical School, 3Eaton-Peabody Laboratories, Massachusetts Eye and Ear; Harvard Medical School; Harvard University, 4Human Health and Performance Systems Group, MIT Lincoln Laboratory, 5National Defense Medical College, 6Yamagata University Faculty of Medicine
T65. Endothelin a Receptor-Mediated Induction of Laminin α2 and Collagen α1(III) in Strial Capillary Basement Membranes Directly Damage Strial Cells Contributing to Progressive Loss of Strial Function in Alport Mice
Dominic Cosgrove*1, Daniel T. Meehan1, Julia Brockhouse1, Michael Anne Gratton1
1 Boys Town National Research Hospital
T66. Local Delivery of Soluble Fractalkine (CX3CL1) Peptide Restores Ribbon Synapses and Hearing in a Mouse Model of Noise-Induced Cochlear Synaptopathy
Tejbeer Kaur*1, Vijayprakash Manickam2, Sibaprasad Maity2, Sree Varshini Murali1, Dinesh Gawande1, Lyudmila Batalkina2, Astrid Cardona3
1Rutgers University, Robert Wood Johnson School of Medicine, Rutgers Brain Health Institute, 2Creighton University 3University of Texas San Antonio
T67. Pharmacological Chaperones Attenuate Sustained PERK Activation, Providing Protective Effects Against Noise-Induced Hearing Loss
Ji Won Hong*1, Hyehyun Min1, Jinwoong Bok1, Heon Yung Gee1
1 Yonsei University College of Medicine
T68. ROS-Related Disruptions to Cochlear Hair Cell and Stria Vascularis Consequently Leading to Radiation-Induced Sensorineural Hearing Loss
Yiming Gao*1, Fan Wu1, Jiaqi Pang1, Yiqing Zheng1
1 Sun Yat-Sen Memorial Hospital
T69. Loss of Synaptic Ribbons is an Early Cause in ROS-Induced Acquired Sensorineural Hearing Loss
Hiroaki Mohri*1, Shunkou Kurasawa2, Keiji Tabuchi2, Takehiko Ueyama3
1Kyoto Prefectural University of Medicine, 2University of Tsukuba, 3Biosignal Research Center, Kobe University
T70. miR-431 Secreted by Human Vestibular Schwannomas Increases the Mammalian Inner Ear’s Vulnerability to Noise Trauma
Takeshi Fujita*1, Richard Seist2, Shyan-Yuan Kao2, Vitor Soares2, Lorena Panano3, Radhika S Khetani3, Lukas D. Landegger2, Shelley Batts4, Konstantina M. Stankovic4
1Kobe University Graduate School of Medicine, 2Massachusetts Eye and Ear Infirmary, Harvard Medical School, 3Harvard T.H. Chan School of Public Health, Stanford University School of Medicine
T71. CC Chemokine Receptor 2 Protects Outer Hair Cells in CSOM Mouse
Anping Xia*1, Ankur Gupta2, Ritwija Bhattacharya2, Viktoria Schiel2, Peter Santa Maria2
1Stanford University, 2Stanford University School of Medicine
T72. Dynamics of Tissue-Resident Macrophages in the Acoustic Overstimulation in Mice Cochlae
Norihiro Usukura*1, Hirotaka Suzuki1, Kimihiro Okubo1, Takeshi Matsunobu1
1 Nippon Medical School
T73. The NLRP3 Inflammasome in Macrophages Causes Sensory Hearing Loss in Chronic Suppurative Otitis Media (CSOM)
Viktoria Schiel*1, Anping Xia2, Ankur Gupta2, Ritwija Bhattacharya2, Kourosh Efthekarian2, Peter Santa Maria2
1Stanford University, 2School of Medicine, Stanford University
T74. Hyaluronic Acid Conjugates for Therapeutic Management of Noise Induced Hearing Loss Specific Inner Ear Inflammation
Bhaskar Birru*1, Elizabeth Arrigali1, Joachim Veit1, Jack Van Tine1, Emma Barrett-Catton1, Zachary Tonnerre1, Philippe Diaz1, Monica Serban1
1 University of Montana
T75. After the Music: Factors Affecting Concert-Induced Temporary Threshold Shift
Carlyn Murray*3, Garreth Prendergast1, Hannah Guest1, Stephen Roberts2, Kevin Munro1, Rebecca Millman1, Karolina Kluk-de kort1, Chris Plack1
1Manchester Centre for Audiology and Deafness, 2The University of Manchester Centre for Biostatistics, 3The University of Manchester
T76. A Comprehensive Characterizations of Zebrafish Rheotactic Behaviors and Its Application to Otoprotective Drug Screening
June Choi*1, Kang Hyeon Lim1, Hee Soo Yoon1, Yoonchan Rah1, Jiwon Chang2
1Korea University College of Medicine, 2Hallym University College of Medicine, Kangnam Sacred Heart Hospital
T77. AC102 Outperforms Dexamethasone in the Treatment of Functional Hearing Loss and Synaptopathy in a Guinea Pig Model of Noise-Induced Hearing Loss
Reimar Schlingensiepen*1, Monika Kwiatkowska1, Rachael Ward1, Tomasz Zygmunt1, Benedikt Brommer1, Sujoy Bera1, Hans Rommelspacher1
1 AudioCure Pharma GmbH
T78. Subclinical Effects of Noise Exposure: A Pre-Registered Longitudinal Study
Hannah Guest1, Kevin Munro1, Garreth Prendergast1, Carlyn Murray1, Stephen Roberts2, Karolina Kluk-de kort1, Rebecca Millman1, Rebecca Dewey3, Michael Stone1, Richard Baker1, Chris Plack*1
1Manchester Centre for Audiology and Deafness, 2University of Manchester Centre for Biostatistics, 3University of Nottingham
T79. Pesticide Induces Hearing Impairments in Exposed Rural Inhabitants
Gonzalo Terreros*1, Felipe Munoz2, Felipe Paredes-Aravena3, Pedro Jilberto1, Cristian Aedo4, Enzo Aguilar4
1Instituto de Ciencias de la Salud, Universidad de O'Higgins, 2Doctorado en Ciencias de la Ingenieria para la Salud, Universidad de Valparaíso, 3Escuela de Salud, Universidad de O'Higgins, 4Universidad de Chile
T80. Hearing Impairment and Cochlear NLRP3 Inflammasome Activation Induced by High-Fat Diet Consumption in Mice
Amanda D'Espessailles*1, Manuel Soto-Donoso2, Matias Magdalena-Porma2, Gonzalo Terreros1
1Instituto de Ciencias de la Salud, Universidad de O’Higgins, 2Instituto de Ciencias de la Salud, Universidad de O’Higgins; Escuela de Salud, Universidad de O’Higgins
T81. Examining the Therapeutic Potential of Cell-Derived Exosomes in Hair Cell Protection
Jaylen Mumphrey*1, Melanie Barzik1, Tucker Costain1, Lizhen Wang1, Lisa Cunningham1
1 National Institute on Deafness and Other Communication Disorders
T82. Mild Frequency-Selective Synaptopathy After Multiday Gentamicin Treatment
Liana Sargsyan1, Alisa Hetrick1, Brian Bi1, Hongzhe Li*1
1 VA Loma Linda Healthcare System
T83. Regulators of Phagocytosis in the Vestibular Maculae of Mice
Mark Warchol*1
1 Washington University School of Medicine
T84. Rapid Cochlear Hair Cell Loss in Adult Mice After Single Aminoglycoside Infusion
Ayse Maraslioglu Sperber*1, Fabian Blanc2, Stefan Heller1, Nesrine Benkafadar1
1Stanford University School of Medicine, 2University of Montpellier
T85. New Molecular Entities Protect Hair Cells Against Aminoglycosides-Induced Ototoxicity
Elizabeth Kara*1, Shaikh Emdadur Rahman1, Caleb Leach2, Ken Cornell2, Dong Xu1
1Idaho State University, 2Boise State University
T86. Time-Course of MHCII Expression in Rat Spiral Ganglion After Hair Cell Loss
Zhenshen Zhang*1, Steven H. Green1
1 University of Iowa
T87. Sound Conditioning Strategy Promoting Paracellular Permeability of the Blood-Labyrinth-Barrier Benefits Inner Ear Drug Delivery
Xueling Wang1, Jiayi Gu*1, Ke Xu1, Baoying Xu2, Dehong Yu2, Hao Wu1
1Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 2School of Life Sciences, Shanghai University
T88. Detection and Quantification of Gentamicin in the Inner Ear Using Different Liquid Chromatography Methods
Shreshtha Dash*1, David D Smith2, E. Jeffrey North2, Molly T. McDevitt2, Peter S. Steyger1
1Translational Hearing Center, School of Medicine, Creighton University, 2Creighton University
T89. Novel Transcanal Device for Delivery of Cochlear Hypothermia
Maria Fernanda Yepes*1, Michael Hoffer2, Juan Armando Chiossone2, Kaelan Groves3, Curtis King3, Suhrud Rajguru4
1University of Miami, 2University of Miami School of Medicine, University of Miami Ear Institute, 3Restor-Ear Devices LLC, 4University of Miami; Bruce W. Carter Department of Veterans Affairs Medical Center
T90. Membranous Labyrinth Alteration and Functional Evaluation After a Posterior Semicircular Canal Injection in Adult Mice
Fabian Blanc*1, Renaud Lebrun2, Michel Mondain3, Jing Wang1
1Institute for Neurosciences of Montpellier (INM), University Montpellier, INSERM U1298, 2ISEM, University of Montpellier, CNRS, EPHE, IRD, 3Gui de Chauliac Hospital, CHRU Montpellier – Centre Hospitalier Régional Universitaire, Université de Montpellier
T91. Liposomal Nanoparticle for Non-Invasive in Vivo Drug Delivery to the Inner Ear
Stella Yang*1, Ki Wan Park1, Tulio Valdez1, Roya Sadabad1
1 Stanford University School of Medicine
T92. Outer Hair Cell Innervation by Type II Spiral Ganglion Neurons Depends on Eph/Ephrin Signaling
Deborah George*1, Aileen Cui1, Shankar Thiru1, Michael Deans2, Thomas Coate1
1Georgetown University, 2University of Utah
T93. Lef1 and Tcf7l2 are Wnt Signalling Effectors With Contrasting Functions During Inner Ear Sensory Organ Formation
Magdalena Zak*1, Javier de Andres1, Stephen Terry1, Nicolas Daudet1
1 UCL Ear Institute
T94. PRDM16 Deletion Reveals Novel Roles for Kölliker's Organ in Mouse Cochlear Development and Hearing
Hongji Zhang1, Timothy Papiernik1, Amal Yaghmour1, Ahmad Alzain1, James Benjamin Lennon1, Rahul Maini1, Xiaodong Tan2, Ava Niazi3, Joosang Park3, Sungjin Park3, Claus-Peter Richter2, Michael Ebeid*1
1Midwestern University, 2Feinberg School of Medicine, Northwestern University, 3University of Utah
T95. Incorporating Novel Audiogram Classification Strategies to Identify Genes and Pathways Involved in Subtype Components of Age-Related Hearing Loss
Samah Ahmed*1, Kenneth Vaden2, Judy R. Dubno2, Britt Drogemoller1
1University of Manitoba, 2Medical University of South Carolina
T96. The Importance of Phenotyping in Large-Scale Genomic Analyses of Hearing Impairment in Older Adults
Morag Lewis*1, Bradley A. Schulte2, Judy R. Dubno2, Karen P. Steel1
1King's College London, 2Medical University of South Carolina
T97. Identifying the Gene Regulatory Network Required for Hearing Regeneration in Zebrafish
Erin Jimenez*1, Wei Song2, Ivan Ovcharenko2, Shawn Burgess3
1Johns Hopkins University, 2National Center for Biotechnology Information, 3National Human Genome Research Institute
T98. Open Board
T99. Epigenetic Characterization of Vestibular Hair Cells and Type II-To-Type I Hair Cell Conversion
Sarath Vijayakumar*1, MI ZHOU1, Amanda Ciani Berlingeri2, Neil Segil3, Jennifer Stone2, Litao Tao1
1Creighton University, 2The University of Washington, Virginia Merrill Bloedel Hearing Resource Center, 3Keck School of Medicine, University of Southern California
T100. Transcriptomic Characterization of Vestibular Hair Cells and Type ll-to-Type l Hair Cell Conversion in Adult Mice
Amanda Ciani Berlingeri*1, Sarath Vijayakumar2, Mi Zhou2, Neil Segil3, Litao Tao2, Jennifer Stone4
1The University of Washington, 2Creighton University, 3Keck School of Medicine, University of Southern California, 4The University of Washington, Virginia Merrill Bloedel Hearing Resource Center
T101. Biallelic p.V37I Variant in GJB2 is Associated with Increasing Incidence of Hearing Loss With Age
Ying Chen*1, Zhili Wang1, Yi Jiang1, Yun Lin1, Xueling Wang1, Zhentao Wang1, Yunge Gao1, Zhiwu Huang1, Yun Li1, Junbo Shi1, Xue Wang1, Qiongfei Yu1, Yunqian MA1, Jin Zhou1, Tao Yang1, Hao Wu1
1 Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
T102. A New Allele of Otoferlin Allows Reversal of Hearing Loss
Elisa Martelletti*1, Nina Treder2, Alishba Saleemi2, Darcey. A Kirwin2, Neil J. Ingham2, Karen P. Steel2
1King's College London, 2Wolfson Centre for Age-Related Diseases, King's College London
T103. Zfp719 is a Transcription Factor Important for Maintenance of Hearing in Mice
Morag Lewis*1, Jing Chen1, Neil J. Ingham1, Maria Lachgar-Ruiz1, Karim Boustani1, Karen P. Steel1
1 King's College London
T104. Pathogenicity of Intronic Variants in Deaf Patients Identified by Transcriptome Sequencing of Whole Blood
Daqi Wang*1, Dan Mu1, Jun Lv1, Honghai Tang1, Chong Cui1, Yu Han1, Huawei Li1, Yilai Shu1
1 Eye and ENT Hospital of Fudan University
T105. A Variant in MUC5B, a Gene Which is Upregulated in the Middle Ears of Transgenic or Infected Mice, is Associated With Increased Biodiversity in the Middle Ears of Children With Otitis Media
Helen Gomez*1, Christina Elling1, Nam Lee2, Elizabeth Davidson1, Mahmood F. Bhutta3, Scott D. Hirsch1, Wasyl Szeremeta4, Melissa A. Scholes1, Jennifer M. Kofonow1, Harold S. Pine4, Sven-Olrik Streubel5, Elisabet Einarsdottir6, Todd Wine1, Juha-Pekka Vasama7, Jeremy D. Prager1, Patricia J. Yoon1, Charles E. Robertson1, Kenny H. Chan8, Petri S. Mattila9, Norman R. Friedman1, Daniel N. Frank1, Lena Hafren9, David A. Schwartz1, Tasnee Chonmaitree4, Ivana V. Yang1, Allen F. Ryan10, Regie Lyn Santos-Cortez1
1University of Colorado Anschutz Medical Campus, 2University of Colorado School of Medicine, 3UCL Ear Institute, 4University of Texas Medical Branch, Galveston, 5Children’s Hospital Colorado; Johnson and Johnson, 6Folkhälsan Institute of Genetics and Molecular Neurology Research Program, University of Helsinki; Science for Life Laboratory, KTH-Royal Institute of Technology, 7Helsinki University, 8The Children's Hospital Colorado, 9University of Helsinki; Helsinki University Hospital, 10University of California, San Diego; VA Medical Center, La Jolla
T106. Identification of a Novel Copy Number Variant in EYA4
Jacquelyn DeVries*1, Miles Klimara1, Amanda M Schaefer1, Diana L Kolbe1, Paige Harlan1, Hela Azaiez1, Richard JH Smith1
1 Molecular Otolaryngology and Renal Research Labs, University of Iowa Carver College of Medicine
T107. Tonsil-Derived MSC`s Anti-Oxidative Response Against Magnetically Charged Iron Oxide Nanoparticle
Temuulen Batsaikhan*1, Yeji Ahn1, Sun Mok Ha1, Young Joon Seo1
1 Yonsei University, Wonju College of Medicine
T108. Rho Kinase or DNA Methyltransferase Inhibitors Produce Ectopic Hair Cells After Aminoglycoside-Induced Damage in Neonatal Mouse Cochlear Explants
Jarnail Singh*1, Melanie Bedolli1, Hannah Johnson1, Becky Rose1, Brandon Cox1
1 Southern Illinois University, School of Medicine
T109. Neural Correlates of Memory-Guided Attention in Age-Related Hearing Loss
Dominica Pec*1, Claude Alain2, Brandon Paul1
1Toronto Metropolitan University, 2Baycrest Centre
T110. 5xFAD-Induced Hearing Loss in AHL-Corrected C57BL/6 Mice (FAD2) Does Not Correlate With Amyloid Deposition
Suhua Sha*1, Hongguo Su1, Khujista Haque1, Kumar Sambamurti1
1 Medical University of South Carolina
T111. Association Between Fractalkine Levels and Cochlear Inflammation, Immune Response and Hearing Loss as a Function of Aging
Tejbeer Kaur*1, Shailee Parekh2, Vijayprakash Manickam3, Dinesh Gawande1, Lyudmila Batalkina3, Grady W. Phillips4, Michael Anne Gratton5
1Rutgers University, Robert Wood Johnson School of Medicine, Rutgers Brain Health Institute, 2Creighton University, School of Medicine, 3Creighton University, 4Washington University in St. Louis, 5Boystown National Research Hospital
T112. Gap Detection Ability Declines in an Early Stages of Age-Related Hearing Impairment
Takaomi Kurioka*1, Kunio Mizutari1, Akihiro Shiotani1
1 National Defense Medical College
T113. Abnormal Cholesterol Metabolism and Lysosomal Dysfunction Induce Age-Related Hearing Loss by Inhibiting mTORC1-TFEB-Dependent Autophagy
Seongjun So*1, Jungho Ha1, Yun Yeong Lee1, Young Sun Kim1, Sivasubramanian Ramani1, Siung Sung1, Jeong Hyeon Yun1, Miyoung Lee1, Oak-Sung Choo2, Jeong Hun Jang1, Yun Hoon Choung1
1Ajou University School of Medicine, 2Kangnam Sacred Heart Hospital, Hallym University College of Medicine
T114. Neural Correlates of Temporal Processing Improve Following Treatment With Aldosterone: A Behavioral and Neurophysiological Approach
Dimitri Brunelle*1, Elliot Brecht1, Robert Frisina1, Timothy Fawcett1, Joseph Walton1
1 University of South Florida
T115. Loss of POU4f3 From Adult Vestibular Hair Cells Leads to Reduced Vestibular Function and Hair Cell Death
Kendra Stansak1, Tianwen Chen1, Tian Wang2, Caroline Nall1, Tierah Macon1, Wu Zhou1, Hong Zhu1, Alan Cheng2, Brandon Cox3, Brad Walters*1
1University of Mississippi Medical Center, 2Stanford University, 3Southern Illinois University School of Medicine
T116. Understanding Cochlear Implants Using Machine Learning
Annesya Banerjee*1, Mark Saddler2, Josh McDermott2
1Harvard University, 2MIT
T117. Machine Learning and Cochlear Implant Performance Outcome Predictions: A Systematic Review
Jonathan Mo*1, Davis Chong1, Nicole Jiam2
1University of California, Davis School of Medicine, 2Massachusetts Eye and Ear, Harvard Medical School
T118. Predicting Cochlear Implant Outcomes Using Resting-State Functional Near-Infrared Spectroscopy Recordings
Jamal Esmaelpoor1, Tommy Peng*2, Beth Jelfs3, Maureen Shader4, Colette McKay2, Darren Mao2
1University of Melbourne, 2The Bionics Institute of Australia, 3University of Birmingham, 4Purdue University
T119. Temporal Acuity of Electric Hearing Enhanced by a Chronic Penetrating Auditory-Nerve Electrode
Matthew Richardson*1, Harrison Lin1, Robert Carlyon2, John Middlebrooks1
1University of California, Irvine, 2Cambridge Hearing Group, MRC Cognition and Brain Sciences Unit, University of Cambridge
T120. Relationship Between Electrode Position, Electrode Impedance and Electrophysiological Thresholds in an Animal Model of Cochlear Implantation
Susanne Schwitzer*1, Moritz Gröschel1, Mario Thiele2, Horst Hessel3, Arne Ernst1, Dietmar Basta1
1UKB, University of Berlin, Charité Medical School, 2Julius Wolff Institute, Center for Musculoskeletal Surgery, Charité-Universitätsmedizin Berlin, 3Cochlear Deutschland GmbH and Co. KG
T121. Frequency Modulated Phase Coding – Patient Performance
Claus-Peter Richter*1, Christopher Boven2, Reagan Roberts2
1Feinberg School of Medicine, Northwestern University, 2Soundwave Hearing, LLC
T122. Dexamethasone-Eluting Cochlear Implants Reduce Intracochlear Foreign Body Response and Electrical Impedance for Extended Period Following Surgery in a Murine Model
Muhammad Rahman*1, Brian Mostaert1, Peter Eckard1, Bryce Hunger1, Alexander Claussen1, Ibrahim Razu1, Cristina Garcia1, Shakila Fatima1, Nashwaan Khan1, Douglas Bennion1, Jonathon Kirk2, Keiko Hirose3, Marlan R. Hansen1
1University of Iowa Hospitals and Clinics, 2Cochlear Limited, 3Washington University School of Medicine
T123. Chirp-Evoked Electrocochleography During Cochlear Implantation
Rachel Scheperle*1, Rustin Kashani1, Alexander Claussen1, Bruce Gantz1, Marlan Hansen1
1 University of Iowa Hospitals and Clinics
T124. Cochlear Insertion of Neuronal-Based Living Electrodes
Jason Brant*1, Oladayo Adewole2, Kacy Cullen2
1University of Pennsylvania, 2Corporal Michael J. Crescenz VA Medical Center
T125. Residual Hearing Mechanics and Fibrotic Burden in a Rodent Model of Cochlear Implantation
George Burwood*1, Wenxuan He1, Julia Dietlmeier2, Teresa Wilson1, Jordan Hill1, Rubing Xing1, Kevin O'Leary2, Noel O'Connor2, Lina Reiss.1
1Oregon Health and Science University, 2Dublin City University
T126. Hearing Loss and Cochlear Implantation in Patients With Usher Syndrome
Anselm Gadenstaetter*1, Paul Krumpoeck1, Maximilian Armstorfer2, Dominik Riss1, Wolf-Dieter Baumgartner1, Wolfgang Gstoettner1, Christoph Arnoldner1, Sebastian Roesch2, Lukas Landegger1
1Vienna General Hospital, Medical University of Vienna, 2Paracelsus Medical University
T127. Dexamethasone-Eluting Cochlear Implants Reduce Intracochlear Foreign Body Response Compared to Perioperative Topical Dexamethasone Treatment Following Surgery in a Murine Model.
Peter Eckard*1, Muhammad Rahman2, Brian Mostaert2, Bryce Hunger2, Alexander Claussen2, Ibrahim Razu2, Cristina Garcia2, Shakila Mahmuda Fatima2, Nashwaan Khan2, Douglas Bennion2, Jonathon Kirk3, Keiko Hirose4, Marlan Hansen2
1University of Iowa Carver College of Medicine, 2The University of Iowa, 3Cochlear Limited, 4Washington University, St. Louis
T128. Paraganglioma Presenting as Cervical Neck Radiculopathy
Kayla Martinez*1, Noorulann Sherwani1, Gurvir Mangat1, Juleen Elizee1, Adesuwa Inneh1, Cameron Dowlatshahi2, Samer Bahu2
1Ross University School of Medicine, 2Trinity Health Oakland Hospital
arotid artery. This tumor has tissue that is red-pink to brown in appearance with (zellballen) nests of round.
T129. Functional and Biological Effects of Systemic Dexamethasone After Facial Nerve Crush Injury in Mice
Seong Hoon Bae*1, Haeng Ran Park1, Hyunseo Lim1, Young-Min Hyun1
1 Yonsei University College of Medicine
T130. Comparative Study of Tympanoplasty Type I Using Fibrous Layer Versus Chondrogenic Layer of Tragal Cartilage
Jiwon Seo*1
1 Sungkyunkwan University School of Medicine, Samsung Changwon Hospital
T131. Association Between Fatty Liver Disease and Hearing Impairment in Korean Adults
Da Jung Jung*1
1 Kyungpook National University Hospital
T132. Proteomics and Immunophenotyping of Patients With Hearing Instability Disorders
Samuel Adadey*1, Alison Benner2, Rafal Olszewski2, Shoujun Gu2, Dillon Strepay2, Julia Telischi3, Jennifer Chisholm4, John Butman5, Michael Hoa1
1National Institute on Deafness and Other Communication Disorders, 2Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 3Miller School of Medicine, University of Miami, 4Audiology Unit, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5National Institutes of Health
T133. Preliminary Study of an Adaptive Algorithm for Efficient Estimation of Auditory Brainstem Response Threshold in Humans
Erik Petersen*1, Isabella E. Cunio1, Yi Shen1
1 University of Washington
T134. Intractable Chronic Otitis Media as First Manifestation of ANCA Associated Vasculitis
Jisong Hong1, Dajung Jung1, Myung Hoon Yoo*1
1 Kyungpook National University, Daegu
T135. From the Lab to the Clinic: Using fNIRS to Accelerate Early Intervention for Infants With Hearing Loss
Julia Wunderlich1, Linty McDonald1, Onn Wah Lee1, Gautam Balasubramanian1, Darren Mao1, Demi Gao1, Colette McKay*1
1 The Bionics Institute of Australia
T136. Risk of Otologic Symptom Onset Following mRNA COVID-19 Vaccination: An Institutional Cohort Study With High-Dimensionality Propensity Score Matching
Tina Munjal*1, Saurabh Gombar1, Konstantina Stankovic1
1 Stanford University School of Medicine
T137. Effect of Radiation on Viabilities of Schwann and Squamous Cell Carcinoma Cell Lines
Michelle Pei*1, Mikhail Marasigan2, Olena Bracho2, Erin Kaye2, Zoukaa Sargi2, Donald Weed2, Christine Dinh2
1University of Southern California, 2Miller School of Medicine, University of Miami
T138. Effectiveness of Cartilage Conduction Hearing Aids in Patients With Unilateral Hearing Loss
Takeshi Sato*1, Jun Suzuki1, Yohei Honkura1, Syunsuke Takai1, Masayuki Shirakura1, Yukio Katori1
1 Tohoku University Graduate School of Medicine
T139. Sensorineural Hearing Loss as a Complication of Type-2 Diabetes Mellitus: Evidence of Several Cellular and Neural Impairments
Carolanne Coyat*1, Sylvie Pucheu1, Mathieu Schué1, Gaëlle Naert1, Karine Toupet1
1 CILcare
T140. Hearing Screening in Private Practice Family Medicine
Maria El Mouahidine1, Arnaud Genin2, Frédéric Venail3, Jean-Luc Puel2, Jean-Charles Ceccato*4
1Medical School, Montpellier, 2INM, Inserm, Univ Montpellier, 3INM, Inserm, Otology and Neurotology Unit, Univ Montpellier, CHU, 4Audiocampus, University of Montpellier
T141. Characterizing Sudden Sensorineural Hearing Loss Outcomes With Associated Socioeconomic Status and Comorbidities Across the SARS-CoV-2 Pandemic
Devin Kennedy*1, Addison Lana1, Matthew Wiefels1, Valerie Yunis1, Michael Hoffer1, Erin Williams1
1 Miller School of Medicine, University of Miami
T142. Assessing the Impact of the COVID-19 Pandemic on Risk Factors for Sudden Sensorineural Hearing Loss
Matthew Wiefels*1, Devin Kennedy1, Addison Lana1, Valerie Yunis1, Michael Hoffer1, Erin Williams1
1 Miller School of Medicine, University of Miami
T143. Auditory and Balance Manifestations in Fabry Disease Patients: A Comprehensive Evaluation in Taiwan
Yen-Fu Cheng*1, Man-Ling Jao1, Hoi-Shan Lai1, Dau-Ming Niu1
1 Taipei Veterans General Hospital
T144. Therapeutic Effect of Intraperitoneal Dexamethasone on Noise-Induced Permanent Threshold Shift in Mice Model
Byeonghyeon Lee*1, Seong Tae Cho2, Ha Hyun Song2, Jong Su Hwang3, EunHye Cha3, Ye Eun Jeong3, Da Jung Jung4, Un-Kyung Kim2, Kyu-Yup Lee4
1New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (KMEDI-hub), 2College of Natural Sciences, Kyungpook National University; School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, 3College of Natural Sciences, Kyungpook National University; Advanced Bio-Resource Research Center, Kyungpook National University, 4Kyungpook National University Hospital, Kyungpook National University School of Medicine
T145. Clinical Characteristics and Hearing Impairment in 42 Patients With Mitochondrial Disease
Natsumi Uehara*1, Takeshi Fujita1, Jun Yokoi1, Akinobu Kakigi1, Ken-ichi Nibu1
1 Kobe University Graduate School of Medicine
T146. Noise Exposure Profiles of 100 College Students Who Participate in Musical Activities
Erika Skoe*1, Morgan Main2, Travis White-Schwoch3, Jennifer Tufts1
1University of Connecticut, 2University of Connecticut, Now at University of Rochester School of Medicine and Dentistry, 3University of Connecticut, Insight Management, LLC
T147. Exploring Level Effects on Auditory Enhancement: Implications for Hearing Loss
Elaea Purmalietis*1, Andrew J. Oxenham1
1 University of Minnesota
T148. Functional Hearing Difficulties in Veterans: Interactive Contributions of Traumatic Brain Injury, Age, and Cognitive Ability
Nicole Whittle1, Kelli Sugai*1, Christian Herrera Ortiz1, Marjorie Leek1, Grace Lee2, Eric Christopherson2, Caleb Barcenas2, Jonathan Venezia1
1VA Loma Linda Healthcare System, 2Loma Linda University
T149. Is Temporal Processing Crucial to Improve Hearing Thresholds in Tinnitus Patients?
Holger Schulze*1, Konstantin Tziridis2
1University of Erlangen-Nuremberg, 2University Hospital Erlangen
T150. Neural Signatures of Tinnitus in Subjects With Normal Hearing
Viacheslav Vasilkov1, Benjamin Caswell-Midwinter1, Yan Zhao2, Victor de Gruttola3, David Jung1, Charles Liberman1, Stéphane Maison*1
1Harvard Medical School, Mass Eye and Ear, 2Mass Eye and Ear, 3Harvard T.H. Chan School of Public Health
T151. Early Markers of Hidden Hearing Loss in Patients With Acute and Chronic Tinnitus
Pauline Devolder*1, Hannah Keppler2, Ingeborg Dhooge3, Sarah Verhulst1
1Hearing Technology @ WAVES, Ghent University, 2Ghent University, 3Ghent University Hospital
T152. Optimisation of Operant Silent Gap-In-Noise Detection in Humans to Avoid Ceiling Effect by Reducing Predictability and Saliency of the Silent Gap
Louis Negri1, Patrick Oliver1, Rebecca Mitchell1, Lavanya Sinha1, Jacob Kearney1, Dominic Said1, Fernando Nodal1, Victoria Bajo*1
1 University of Oxford
T153. Supra-Threshold Hearing Characteristics in Chronic Tinnitus Patients
Mie Joergensen*1, Torsten Dau1
1 Technical University of Denmark
T154. Binaural Temporal Fine Structure Sensitivity Development in Children With Developmental Dyslexia
Sheila Flanagan*1, Brian Moore1, Angela Wilson1, Fiona Gabrielczyk1, Kanad Mandke1, Usha Goswami1
1 University of Cambridge
T155. Effects of Contextual Cues on Speech Recognition and Spatial Release From Masking in Children With Typical Hearing Using Vocoded Speech
Nimesha Dantanarayana*1, Shelly Godar1, Sara Misurelli1, Ruth Litovsky1
1 University of Wisconsin-Madison
T156. Head-Related Transfer Functions of Rabbits Within the Front Horizontal Plane
Mitchell Day*1
1 Ohio University
T157. Investigating Sound-Localization in Head-Fixed Mice Using Two-Alternative Forced Choice Behavior
Meike Rogalla*1, Gunnar Quass1, Clara Martinez-Voigt1, Harry Yardley1, Pierre Apostolides1
1 Kresge Hearing Research Institute, University of Michigan
T158. Electrophysiological Indicators of an Aging Auditory System
Kerry Walker1, Carol Sammeth1, Nathaniel Greene1, Achim Klug1, Daniel Tollin*1
1 University of Colorado School of Medicine
T159. Human Sensitivity to Interaural Time and Level Differences Conveyed via Bilateral Bone Conduction
William Gray*1, Aoi Hunsaker1, Andrew Brown1
1 University of Washington
T160. Fine-Structure Interaural-Time-Difference Sensitivity as a Function of Frequency and Level
Matthew Goupell*1, G. Christopher Stecker2, Daniel Tollin3, Mathias Dietz4
1University of Maryland-College Park, 2Boys Town National Research Hospital, 3University of Colorado School of Medicine, 4University of Oldenburg
T161. Effects of Spatial Attention on Localization of Moving Sounds
Lemira Esparza*1, Jeffrey Mock1, Edward Golob1
1 The University of Texas at San Antonio
T162. Expression of BDNF and its Associated Receptors in the Fetal Development of the Human Inner Ear
Claudia Steinacher*1, Shin-ichi Usami2, Shin-ya Nishio2, Dietmar Rieder1, Christoph Seifarth1, Jasmin E. Turner3, Nita Solanky4, Rudolf Glueckert1, Anneliese Schrott-Fischer1, Jozsef Dudas1
1Medical University of Innsbruck, 2Shinshu University School of Medicine, 3Newcastle University, 4University College London
T163. Neural Signatures of Stream Segregation: From Childhood to Adulthood
Elena Benocci*1, Axelle Calcus2
1Université Libre de Bruxelles, CRCN, LCLD, 2Université Libre de Bruxelles
T164. Developmental Effects of Concurrent Auditory and Vestibular Impairments on Working Memory, Language, and Academic Abilities in Children With Bilateral Cochlear Implants
Melissa Hazen*1, Sharon Cushing2, Karen Gordon2
1The Hospital for Sick Children, 2University of Toronto, Hospital for Sick Children
T165. Development of Factors Underlying Spectral Resolution in Normal Hearing Infants
David Horn*1, Destinee M Halverson1, Anisha Noble2, Jay Rubinstein3, Lynne Werner1
1University of Washington, 2Cincinnati Children's Hospital, 3Virginia Merrill Bloedel Hearing Research Center
T166. A Matched Comparison Across Different Sensory Pairs of Cross-Modal Temporal Integration in Balance Maintenance
Yonghee Oh1, Ji Hyung Lim2, Min Jeong Shin2, Jae-Hyun Seo*2
1University of Louisville, School of Medicine, 2Seoul St. Mary's Hospital, The Catholic University of Korea
T167. Different Cortical Activities Associated With Susceptibilities in Audiovisual Integration in Normal Hearing Subjects
Yota Tobe*1, Hiroshi Yamazaki1, Kengo Oe1, Koichi Omori1
1 Kyoto University Graduate School of Medicine
T168. Parameters of Paired Stimulation Change Coding Properties in the Auditory Cortex of Guinea Pigs
Kevin Jiang*1, Kaden Li1, Dilshan Rajan1, Hubert Lim1
1 University of Minnesota
T169. Open Board
T170. Associations of Distortion- and Reflection-Based Otoacoustic Emissions With Metabolic and Sensory Components of Age-Related Hearing Loss
Kenneth Vaden*1, Stephen Neely2, Sara Harris2, Judy Dubno1
1Medical University of South Carolina, 2Boys Town National Research Hospital
T171. Temporal Correlations of Medial Olivocochlear Reflex With Auditory Brainstem and Cortical Responses
Yuki Ishizka*1, Sho Otsuka1, Seiji Nakagawa1
1 Chiba University
T172. Temperature Dependence of Spontaneous Otoacoustic Emissions From Lizards With Free-Standing Hair Cell Bundles
Rebecca Whiley*1, Daibhid O Maoileidigh2, Christopher Bergevin1
1York University, 2Stanford University
T173. Mechanisms of Frequency Modulation Perception Across the Adult Lifespan
Kelly Whiteford*1, Neha Rajappa1, Penelope Corbett1, Andrew Oxenham1
1 University of Minnesota
T174. Simulating Psychophysical Modulation Masking Experiments in an Artificial Neural Network Trained for Sound Classification
Takuya Koumura*1, Hiroki Terashima1, Shigeto Furukawa2
1NTT Communication Science Laboratories, 2Shizuoka Graduate University of Public Health
T175. Optimization Under Ecological Realism Reproduces Signatures of Human Speech Perception
Annika Magaro*1, Erica Shook2, Alex Kell1, Mark Saddler1, Josh McDermott1
1MIT, 2Zuckerman Institute, Columbia University
T176. The Role of Perceptual Grouping in Auditory Enhancement Effect
Magdalena Wojtczak*1, PuiYii Goh1, Andrew J. Oxenham1
1 University of Minnesota
T177. Mid-Level Auditory Computations Predict Human Speech Recognition in Natural Environmental Noise
Alex Clonan*1, Xiu Zhai2, Ian Stevenson1, Monty Escabi1
1University of Connecticut, 2Wentworth Institute of Technology
T178. Auditory Processing: Effects of Silent Intervals on the Extraction of Human Frequency-Following Responses Using Non-Negative Matrix Factorization
Fuh-Cherng Jeng*1, Allison T. Giordano1, Taylor R. Black1, Sydney W. Bauer1, Amanda E. Carriero1, Kalyn McDonald1, Tzu-Hao Lin2, Ching-Yuan Wang3
1Ohio University, 2Academia Sinica, Taiwan, 3China Medical University Hospital, Taiwan
T179. Individualized White Matter Connectivity of the Articulatory Pathway: An Ultra-High Field Study
Qiyuan Tian1, Ruopeng Wang2, Kaisu Lankinen1, Qing Mei Wang3, Jordan Green4, Teresa Kimberley5, Jyrki Ahveninen1, Shasha Li*1
1Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, 2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 3Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, Affiliate of Harvard Medical School, Charlestown, 4MGH Institute of Health Professions, 5School of Health and Rehabilitation Sciences, MGH Institute of Health Professions
T180. Semantic and Acoustic Ambiguity: An fMRI Investigation of Speech Perception Under Challenging Conditions
Jaimy Hannah*1, Jenni Rodd2, Ingrid Johnsrude1, Richard Binney3
1University of Western Ontario, 2University College London, 3Bangor University
T181. A Concussion Signature Without the Need of a Baseline: Comparison to Healthy Athlete Norms
Silvia Bonacina*1, Jennifer Krizman1, Matt Nerrie1, Trent Nicol1, Nina Kraus1
1 Northwestern University
T182. Central Auditory Processing Differences in Presbycusis Patients With Cognitive Impairment: An Audiometric Assessment Study
Jakub Fuksa*1, Oliver Profant2, Dora Čapková1, Zbyněk Bureš2, Aleš Bartoš3, Josef Syka2
13rd Faculty of Medicine, Charles University in Prague, Faculty Hospital Královské Vinohrady, 2Institute of Experimental Medicine of the Czech Academy of Sciences, 33rd Faculty of Medicine, Charles University, Faculty Hospital Královské Vinohrady
T183. Can Narrower Frequency Allocation Improve Speech Perception in Korean Cochlear Implant Users?
Euyhyun Park*1, Bongil Park1, Jaehyung Park1, Soo Jeong Choi1, Gi Jung Im1, Hak Hyun Jung1
1 Korea University Anam Hospital, Korea University College of Medicine
T184. A Comparison of Pupillometric, Cortical-Alpha, and Self-Report-Based Measures of Listening Effort During Speech-in-Speech Recognition Task
Juraj Mesik*1, PuiYii Goh1, Magdalena Wojtczak1
1 University of Minnesota
T185. Estimation of Speech Recognition Threshold in Noise From High-Frequency Pure Tone Threshold in Normal-Hearing
Tatsuya Oka*1, Takeshi Nakaichi1, Kao Yamaoka2, Yumi Sakai2, Yasuhide Okamoto3
1Rion Co., LTD., 2FANCL Corporation, 3Keio University
T186. Relationships Between Spectral Cues and Consonant Perception Errors in Pediatric Cochlear Implant Users
Olga Peskova*1, Destinee M Halverson2, Anisha Noble1, Mariette S Broncheau1, David L Horn3
1University of Washington; Virginia Merrill Bloedel Hearing Research Center, 2University of Washington; Virginia Merrill Bloedel Hearing Research Center; Seattle Children’s Hospital, 3University of Washington; Virginia Merrill Bloedel Hearing Research Center; University of Washington; Seattle Children’s Hospital
T187. Cochlear, Neural, Cognitive, and Linguistic Contributions to Speech-In-Noise Perception in Middle-Aged Adults
Anoop Basavanahalli Jagadeesh*1, Chaitra Venkataramana Nayak1, Courtney Baker1, Nina Kraus1, Trent Nicol1, Jennifer Krizman1
1 Northwestern University
T188. Phase Coding in Phoneme Processing Slows With Age
Konrad Dapper1, Jakob Schirmer1, Lukas Rüttiger1, Etienne Gaudrain2, Densie Başkent3, Sarah Verhulst4, Christoph Braun5, Ernst Dalhoff1, Stephan Wolpert1, Marlies Knipper*1, Matthias H. J. Munk6
1University Hospital Tuebingen, 2Lyon Neuroscience Research Center, Université Claude Bernard Lyon 1, CNRS UMR5292, 3University Medical Center Groningen (UMCG), 4Hearing Technology @ WAVES, Ghent University, 5MEG-Center, University of Tübingen; Hertie Institute for Clinical Brain Research, 6University of Tübingen
T189. Decoding Speech From Cochlear Implant Users' EEG
Francis Smith*1, Laura Kiskunas1, Phillip Gander1, Joel Berger1, Bob McMurray1, Timothy Griffiths2, Inyong Choi1
1University of Iowa, 2Newcastle University
T190. Non-Native and Noise-Masked Speech Rely on Different Auditory Processes in NH and SNHL Middle-Aged Adults
Jennifer Krizman*1, Ann Bradlow1, Anoop Basavanahalli Jagadeesh1, Nina Kraus1
1 Northwestern University
T191. Porosity and Bone Density Distribution in the Human Ossicular Chain: A Synchrotron-Based Microtomography Study
Aleksandra Ivanovic*1, Fabian Schallbetter1, Margaux Schmeltz2, Wilhelm Wimmer3, Marco Caversaccio1, Marco Stampanoni2, Anne Bonnin2, Lukas Anschuetz1
1University Hospital Bern, Inselspital, 2Paul Scherrer Institut, 3Technical University of Munich
T192. Human Middle-Ear Forward and Reverse Transfer Functions: A Finite-Element Modeling Study
Sunil Puria1, Hamid Motallebzadeh*2
1Harvard Medical School, Mass. Eye and Ear Infirmary, 2California State University, Sacramento
T193. Shelf-Life Studies on a Single Application Otitis Externa Drug Delivery System
Emma Barrett-Catton1, Kole Sandau1, Bogdan Serban*1, Monica Serban1
1 University of Montana
T194. Auditory Steady-State Response Elicited by Rising-Frequency Silent Interval Embedded Within Broadband Noise
Takashi Morimoto*1, Seiichi Kadowaki2, Toshimasa Ebina1, Hidehiko Okamoto3
1Rion Co., Ltd., 2Tokyo-Kita Medical Center, University of Tukuba, 3International University of Health and Welfare
T195. Cerebellar Activity for Compensatory Saccade During the Head Impulse Test in the Vestibular Impaired Monkey
Yoshiko Kojima*1, Leo Ling1, James Phillips1
1 University of Washington
T196. Photodynamic Therapy-Induced Precise Attenuation of Targeted Semicircular Canals for Treating Intractable Vertigo
Yingkun Yang1, Tong Zhao1, Hongzhe Li2, Pingbo Huang3, Fangyi Chen*1
1Southern University of Science and Technology, 2VA Loma Linda Healthcare System, Loma Linda University School of Medicine, 3Hong Kong University of Science and Technology
T197. Effects of Galvanic Vestibular Stimulation on Vestibular System in Hypergravity-Induced Motion Sickness Animal Model
Hyun Ji Kim*1, Ji Eun Hong1, Kyu-Sung Kim1
1 Inha University College of Medicine
T198. Assessment of Vertical Semicircular Canal Function: The Case for Computerized Rotational Head Impulse Testing
Fumihiro Mochizuki*1, Erin Williams1, Alexander Kiderman2, Michael Hoffer1
1University of Miami Miller School of Medicine 2Neurolign, Inc.
T199. Sex Differences in Vestibular Function in Mice
Jed Janecek*1, Tomoko Makishima1, Zachary Baca1
1 The University of Texas Medical Branch
T200. Noise Exposure Alters Head Stability and Orientation With Respect to Gravity in Rats
Mamiko Niwa*1, David Bauer2, Marie Anderson2, Ariane Kanicki2, Katharine Keller2, Courtney Stewart3, Richard Altschuler2, W. Michael King2
1University of Michigan, 2Kresge Hearing Research Institute, University of Michigan, 3VA Ann Arbor Healthcare System
T201. Measuring the Effect of Self-Reported History of Noise Exposure and Noise-Induced Hearing Deficits on Verticality Perception
Christian Sinnott*1, Catherine Agathos1, Anca Velisar1, Natela Shanidze1
1 The Smith-Kettlewell Eye Research Institute
T202. Mechanical Stimulation-Induced ATP Secretion Through Gap Junction Hemichannels and Vesicular Release in the Vestibular System
Yoo Young Ahn*1, Hyun Jin Lee2, Jeon Mi Lee3, Yesai Park2, Sung Huhn Kim1
1Yonsei University, 2Catholic University, 3Inje University
T203. Enhancement of Vestibular Compensation by Retigabine
Kang Yoon Park1, Gyu Cheol Han2, Sung Huhn Kim1, Park Kang Yoon*3
1Yonsei University, 2Gacheon University, 3Yonsei University College of Medicine
T204. A Novel Deep Learning Approach Enable to Evaluate Sensorimotor System During Quiet Standing in Patients With Peripheral Vestibular Disorders
Jaehyung Park*1, Ahnryul Choi2, Euyhyun Park1, Tae Hyong Kim3, Soo Jeong Choi1, Hak Hyun Jung1, Joung Hwan Mun3, Gi Jung Im1
1Korea University College of Medicine, 2College of Medical Convergence, Catholic Kwandong University, 3College of Biotechnology and Bioengineering, Sungkyunkwan University
T205. KCNQ4 Dysfunction Causes Dizziness and Imbalance After Excessive Rotational and Gravitational Stimulation due to Vestibular Hair Cell Loss
Dong Chul Cheap1, Hansol Hong1, Jinsei Jung1, Jae Young Choi1, Gyu Cheol Han2, Sung Huhn Kim1, Dong Chul Chon*3
1Yonsei University, 2Gacheon University, 3Yonsei University College of Medicine
T206. Development of Real-Time 3D Video-Oculography Using High Quality Infrared Video Frenzel and Galvanic Evoked Vestibulo-Ocular Response
Makoto Hashimoto*1, Kazuma Sugahara2, Okinaka Yosuke2, Junko Tsuda2, Hiroshi Yamashita1
1Yamaguchi University Graduate School of Medicine, 2Yamaguchi University
T207. Effects of Fluoxetine on Ionic Currents in Vestibular Calyces
Nesrien Mohamed*1, Frances Meredith2, Katie Rennie3
1University of Colorado Anschutz Medical Campus, 2University of Colorado School of Medicine, 3University of Colorado Denver
T208. Characterizing Oculomotor, Vestibular, and Reaction Time Testing (OVRT) in Acute Pediatric mTBI
Valerie Yunis*1, Erin Williams2, Alexander Kiderman3, Michael Hoffer4, Jennifer Coto2
1University of Miami, 2University of Miami Miller School of Medicine, 3Neurolign, Inc, 4University of Miami School of Medicine, University of Miami Ear Institute
T209. Postural Sway in Autism (ASD) CNTNAP2 Mouse Model
Shafaqat Rahman1, Anna Guo2, Anne Luebke*1
1University of Rochester, 2Eaton-Peabody Laboratories, Massachusetts Eye and Ear
T210. Postural Sway in a Mouse Model of Alzheimer's Disease (AD)
Baisar Alamiri1, Shafaqat Rahman1, Anna Lysakowski2, Anne Luebke*1
1University of Rochester, 2University of Illinois at Chicago
T211. Semicircular Canal Function Assessment Using Video Head Impulse Test (vHIT) in Pregnant Females
Melissa Castillo Bustamante*1, Maria Nazareth Campo-Campo1, Daniel Peña-Tobón1, Johanna Marcela Vanegas-Munera1, Jorge Madrigal2
1Universidad Pontificia Bolivariana, 2Centro de Vértigo y Mareo
T212. Transmembrane Channel-Like (Tmc) Subunits Contribute to Frequency Sensitivity in the Zebrafish Utricle
Peng Sun*1, Eliot Smith1, Teresa Nicolson1
1 Stanford University School of Medicine
T213. Interaction Between Noise Exposure and Aging on Rat Vestibular Sensory Epithelia
Marie Anderson1, Ariane Kanicki1, Richard Altschuler2, W. Michael King1, Courtney Stewart*3
1University of Michigan, Kresge Hearing Research Institute, 2University of Michigan, Kresge Hearing Research Institute and VA Ann Arbor Healthcare System, 3VA Ann Arbor Healthcare System
T214. Role of Vestibular Insults on Peripheral and Central Vestibular Function
Syed Naqvi1, Sukesh Gupta*1, Rod Braun1, Alejandro Ponce-Sepulveda1, Avril Genene Holt1
1 Wayne State University School of Medicine
T215. Frequency Tuning Characteristics of Bone-Conduction Ocular Vestibular-Evoked Myogenic Potentials in Healthy Individuals
Chandan Suresh*1, Isabel Valdovinos1, Arthur Ni1, Alaina Bassett1
1 California State University, Los Angeles
Symposium 10—Activity-Driven Mechanisms of Auditory Development, Regeneration, and Repair
1:45 p.m.—3:45 p.m.
Grand Ballroom Salon E
Activity-Driven Mechanisms of Auditory Development, Regeneration, and Repair
Chair: Thomas Coate, Georgetown University
Co-Chair: Zoe Mann, King's College London
Co-Chair: Travis Babola, JHMI
Diverse Roles of Developmental Spontaneous Activity in Maturation of the Auditory System
Dwight Bergles
Johns Hopkins University
SEMA5A Regulates Spontaneous Neural Firing in the Prehearing Cochlea
Satish Ghimire
Georgetown University
Metabolic Tuning of Positional Identity in the Developing Chick Cochlea: A Sweet Story
Zoe Mann
King's College London
Illuminating the Depths of Auditory Cortex: The Role of Subplate Neurons in Developing Circuits
Travis Babola
JHMI
Activity Regulates Mitochondria Morphology in Hair Cells and Afferent Neurons of the Zebrafish Lateral Line
Andrea McQuate
University of New Mexico
Visualizing Ribbon Synapse Maturation In Vivo Using Zebrafish
Saman Hussain
NIH/NIDCD
Supporting Cell Activity and the Regulation of Inner Ear Sensory Epithelial Repair
Jonathan Gale
UCL Ear Institute
Podium Session 19—A Bundle of Mechanisms Contributing to Stereocilia Development and Function
1:45 p.m.—3:45 p.m.
Platinum Salon 6
ER Stress-Induced Outer Hair Cell Stereocilia Fusion – Molecular Changes Involved
Ulla Pirvola*1, Saija Leinonen1, Tuuli Lankinen1, Kuu Ikäheimo1
1 University of Helsinki
Enzymatic Characterization of MYO7A Isoforms Localized to the Stereocilia Upper Tip-Link Density
Jinho Park*1, Sihan Li2, Jung-Bum Shin2, Jonathan Bird1
1University of Florida, 2University of Virginia
Myosin 15 Isoform 3 Traffics the Elongation Complex to the Tips of Row 1 Stereocilia and is Required for Their Maintenance in the Adult Hair Cells
Ghazaleh Behnammanesh*1, Shadan Hadi2, Abigail Dragich2, Xiayi Liao3, Mi-Jung Kim1, Lijin Dong4, Benjamin Perrin3, Shinichi Someya1, Gregory I Frolenkov2, Jonathan Bird1
1University of Florida, 2University of Kentucky, 3Indiana University—Purdue University Indianapolis, 4National Eye Institute, NIH
Proteins Required for Stereocilia Elongation During Hair Cell Development Ensure Precise and Steady Heights in Adult Life
Elli Hartig*1, Matthew Day1, Amandine Jarysta1, Basile Tarchini1
1 The Jackson Laboratory
Staircase Formation During Embryonic Development of Mouse Inner Hair Cells
Jocelyn Krey*1, Paroma Chatterjee1, Peter Barr-Gillespie1
1 Oregon Hearing Research Center and Vollum Institute, OHSU
The Endolymphatic Potential Can Control the Gating Force of the Hair Cell’s Transduction Channels.
Achille Joliot1, Pascal Martin*2
1Institut Curie Recherche, 2Institut Curie Recherche, Laboratoire Physico-Chimie Curie
Single-Molecule Microscopy in Live Hair Cells Reveals a Regulatory Mechanism of MYO7A-Driven Cargo Transport in a Stereocilium
Takushi Miyoshi*1, Harshad Vishwasrao2, Inna Belyantseva3, Yasuko Ishibashi3, Samuel Adadey3, Mrudhula Sajeevadathan4, Narinobu Harada5, Hari Shroff6, Thomas Friedman3
1Southern Illinois University School of Medicine, 2NIBIB/NIH, 3NIDCD/NIH, 4Sourthern Illinois University, 5Harada Ear Institute, 6Janelia Research Campus
The Role of MYO7A Isoforms in Tuning Hair Cell Function
Sihan Li*1, Andrew Mecca2, Jeewoo Kim1, Guisy Caprara3, Jinho Park4, Jonathan Bird4, Anthony Peng2, Jung-Bum Shin1
1University of Virginia, 2University of Colorado Anschutz Medical Campus, 3University of Colorado, 4University of Florida
Podium Session 20—Inner Ear: Drug Delivery
1:45 p.m.—3:45 p.m.
Platinum Salon 5
Rational Design of Magnetic Nanoparticles as Cochlear Drug Delivery Vehicles
Daniel Sun*1, Mukund Madhav Goyal2, Sarek Shen3, Mohamed Lehar3, Zimin He2, Chao Wang2
1University of Cincinnati College of Medicine, 2Johns Hopkins University, 3Johns Hopkins School of Medicine
Magnetic Nanoparticles for Cochlear Drug Delivery: Mechanisms and Modulation of Epithelial Transport in the Round Window Membrane
Sarek Shen*1, Mukund Madhav Goyal2, Zimin He2, Mohamed Lehar1, Chao Wang2, Daniel Sun1
1Johns Hopkins School of Medicine, 2Johns Hopkins University
Surgical Procedure of Transtratympanic Injection and Inner Ear Drug Kinetic Simulation in Domestic Pigs
Adele Moatti*1, Shannon Conard1, Novietta De Beritto1, William Dunn2, Ken Hutson2, Douglas Fitzpatrick2, Alec Salt3, Carlton Zdanski2, Alon Greenbaum1
1North Carolina State University, 2University of NC at Chapel Hill, 3Turner Scientific
Novel Microneedle Device for Transcanal Round Window Membrane Access via Endoscope and Flexible Actuation Mechanism
Aykut Aksit*1, Sharon Feng2, Stephen Leong2, Daniella Hébert2, Jeffrey Kysar2, Anil Lalwani2
1Haystack Medical, 2Columbia University
Development of Laser-Activated Nanoparticles for Controlled Release of Neural Differentiation Factors in Inner Ear Regenerative Therapy
Celine Abueva1, Sung Ryeong Yoon*1, Nathaniel Carpena1, So-Young Chang2, Jin-Chul Ahn1, Ji-Eun Choi3, Jae Yun Jung3, Min Young Lee3
1Dankook University, 2Beckman Laser Institute Korea, Dankook University, 3Dankook University Hospital
Magnetic Field-Enhanced Delivery of Mesenchymal Stem Cells in a Mouse Model of Ototoxic Hearing Loss
Yeji Ahn*1, Seonmin Choi2, Jaehong Key2, Young Joon Seo1
1Yonsei University Wonju College of Medicine, 2Yonsei University Mirae
Intracochlear Distribution and Accumulation of Locally Applied Dexamethasone Formulations in a Large Animal Model
Matthias Gerlitz*1, Anselm Joseph Gadenstaetter1, Lukas Landegger1, Clemens Honeder1, Eric Lehner2, Arne Liebau2, Stefan Plontke2, Erdem Yildiz1, Christoph Arnoldner1
1Medical University of Vienna, 2Martin Luther University of Halle-Wittenberg
Manipulation of Notch Signaling to Regenerate Type I and Type II Hair Cells With Restoration of Vestibular Function
Hanae Lahlou*1, Hong Zhu2, Wu Zhou2, Albert S. B. Edge1
1Massachusetts Eye and Ear Infirmary—Harvard Medical School, 2University of Mississippi Medical Center
Honorary Symposium—Mechanisms of Neural Encoding in the Inferior Colliculus and Beyond, A Symposium in Honor of George D. Pollak
4:00 p.m.—6:00 p.m.
Platinum Salon 6
Mechanisms of Neural Encoding in the Inferior Colliculus and Beyond: A Symposium in Honor of George D. Pollak
Chair: R. Michael Burger, Lehigh University
Co-Chair: Achim Klug, University of Colorado School of Medicine
Co-Chair: Laura Hurley, Indiana University
Cholinergic Input Modulates Sound Encoding in the Superior Olive
R. Michael Burger
Lehigh University
Beyond Just Localization: How Fast Glycinergic Inhibition Helps Us Survive a Cocktail Party
Achim Klug
University of Colorado School of Medicine
What is Serotonin Doing in the Auditory System? The Social Feedback Model of Auditory Neuromodulation
Laura Hurley
Indiana University
Cholinergic Circuitry and the Inferior Colliculus
Brett Schofield
Northeast Ohio Medical University
Regulation of Recurrent Excitation in the Auditory Midbrain
Michael Roberts
University of Michigan
Brain Mechanisms of Acoustic Communication and Emotion
Jeffrey Wenstrup
Northeast Ohio Medical University
Identification of Functional Circuits in the Inferior Colliculus Using Intersectional AAV Viruses
Nace Golding
University of Texas at Austin
Wednesday, February 7, 2024
Symposium 11—Circuits and Function of Auditory Midbrain and Auditory Brainstem
8:00 a.m.—10:00 a.m.
Grand Ballroom Salon E
Circuits and Function of Auditory Midbrain and Auditory Brainstem
Chair: Marina Silveira, University of Texas at San Antonio
Co-Chair: Alexandria Lesicko, University of Pennsylvania
Neuropeptide Y Signaling Regulates Recurrent Excitation in the Auditory Midbrain
Marina Silveira
University of Texas at San Antonio
Past, Present, and Future? What the Barn Owl's Inferior Colliculus Teaches us About Experience-Dependent Plasticity
Roland Ferger
Albert Einstein College of Medicine
Functional Implications of a Patch/Matrix-Like Compartmental Organization in the Mouse Inferior Colliculus
Alexandria Lesicko
University of Pennsylvania
Central Feedback From Lateral Olivocochlear Neurons Protects the Cochlea From Acoustic Trauma
Gabriel Romero
Harvard Medical School
Shell Inferior Colliculus Population Activity Encodes Behavioral Choice During an Operant Task
Gunnar Quass
University of Michigan
Spatially Clustered Neurons Encode Vocalization Categories in the Bat Midbrain
Jennifer Lawlor
Johns Hopkins University
Top-Down Modulation of the Dorsal Cochlear Nucleus by Descending Projections From Inferior Colliculus Neurons
Tim Balmer
Arizona State University, School of Life Sciences
Podium Session 21—Transduction and Channels and More, Oh My!
8:00 a.m.—10:00 a.m.
Platinum Salon 5
Novel Heterozygous USH1C Mutation Impacts Hair Cell Mechanotransduction and Causes Progressive Hearing Loss
Yanyan Jia1, Wenyan Li*1
1 The EENT Hospital of Fudan University
Evaluation of Lhfpl5b Loss-Of-Function on Lateral Line Mediated Behavior, Hair Cell Synapse Morphology, Mitochondrial Homeostasis, and Vulnerability to “Noise” Damage
Keziah-Khue Nguyen*1, Melanie Holmgren1, Lavinia Sheets1
1 Washington University School of Medicine
The Speed of Activation of Mechanotransducer Channels in Mammalian Auditory Hair Cells Depends on Intracellular Potential
Isabel Aristizabal*1, Ana I. Lopez-Porras1, A. Catalina Velez-Ortega1, Gregory I. Frolenkov1
1 University of Kentucky
Phospholipid PIP2 is the Key Mediator of Mammalian Hair Cell Slow Adaptation
Giusy Caprara1, Ye-Ri Kim1, Sujin Jun1, Anthony Peng*1
1 University of Colorado Anschutz Medical Campus
In Silico Insights into TMC Function in Sensory Perception
Wei-Hsiang Weng1, Harsha Mandayam Bharathi1, Shounak Mukherjee1, Travis Harrison-Rawn1, Marcos Sotomayor*1
1 The Ohio State University
Voltage-Dependent Movements of Mammalian Inner Hair Cell Bundles
Jamis McGrath*1, Anthony Ricci1
1 Stanford University
LOXHD1 Interacts With Subunits of the Mechanotransduction Complex
Katharine Miller*1, Pei Wang1, Nicolas Grillet1
1 Stanford Medicine
Piezo 1 and 2 May Constitute Part of the Mechano-Sensitive Channel Complex in Hair Cells
Ebenezer Yamoah*1, Jeong Han Lee1, Maria C. Perez-Flores1, Seojin Park1, Hyo Jeong Kim1, Yingying Chen1, Mincheol Kang1, Jennifer Kersigo1, Jinsil Choi1, Phung N. Thai1, Ryan Woltz1, Dolores Columba Perez-Flores1, Guy Perkins1, Choong-Ryoul Sihn1, Pauline Trinh1, Xiao-Dong Zhang1, Padmini Sirish1, Yao Dong1, Wayne Wei Feng1, Isaac N. Pessah1, Rose E. Dixon1, Bernd Sokolowski1, Bernd Fritzsch1, Nipavan Chiamvimonvat1
1 University of Nevada School of Medicine
Podium Session 22—Attention, Cognition, and Learning in Speech Perception
8:00 a.m.—10:00 a.m.
Platinum Salon 6
Attentional Modulation of the Cortical Contribution to the Frequency-Following Response Evoked by Continuous Speech
Alina Schüller*1, Achim Schilling2, Patrick Krauss3, Stefan Rampp4, Tobias Reichenbach1
1Friedrich-Alexander-University, 2Neuroscience Lab, University Hospital Erlangen, 3Neuroscience Lab, University Hospital Erlangen; Pattern Recognition Lab, Friedrich-Alexander-University, 4University Hospital Erlangen; University Hospital Halle (Saale); University Hospital Erlangen
Short- And Long-Term Experience-Dependent Neuroplasticity Interact During the Perceptual Learning of Concurrent Speech
8:00 a.m.—10:00 a.m.
Jessica MacLean*1, Jack Stirn1, Alexandria Sisson1, Gavin Bidelman1
1 Indiana University
Examining the Benefits of Categorical vs. Continuous Listening Strategies on Speech in Noise Perception
Rose Rizzi*1, Gavin Bidelman1
1 Indiana University
Influence of Social and Semantic Context in Processing Speech in Noise
Etienne Abassi*1, Robert Zatorre1
1 McGill University, Montreal Neurological Institute
Investigating the Hierarchical Neural Mechanisms Underlying Auditory Attention Switching
Sara Carta1, Emina Alickovic2, Johannes Zaar2, Alejandro López Valdes1, Giovanni Di Liberto*1
1Trinity College Dublin, 2Eriksholm Research Centre
Effect of Crossmodal Divided Attention on Continuous Speech Processing in Noise
Grace Frerking1, Anya Chatani1, Zilong Xie*1
1 Florida State University
Effects of Cognitive Ability and Semantic Context on Word Report in Noise
Joseph Rovetti*1, Stephen Van Hedger2, Ingrid Johnsrude1
1Western University, 2Huron University
The Effect of Voice Identity Training and Talker Identity Information on Speech in Noise Perception
Aditi Nayak*1, Joseph Rovetti1, Ingrid Johnsrude1
1 Western University
Podium Session 23—Inner Ear: Noise Induced Hearing Loss, Models and Therapies
10:15 a.m.—12:15 p.m.
Platinum Salon 5
Evaluation of Metformin as a Noise-Induced Hearing Loss Therapeutic
Benjamin Shuster*1, Catherine L. Kennedy2, Beatrice Milon1, Reza Amanipour1, Priya Patel3, Ran Elkon4, Ronna Hertzano1
1Neurotology Branch, National Institute on Deafness and Other Communication Disorders, 2University of Minnesota, 3University of Maryland School of Medicine, 4Tel Aviv University
A Cell-Penetrating Peptide Containing a Neurotrophin Receptor TrkB-FL Sequence as a Novel Therapeutic Approach for Sensorineural Hearing Loss
Elena Torres Campos*1, Margarita Díaz-Guerra González1, Isabel Varela-Nieto1
1 IIBSM , CSIC-UAM
Combinatorial Protection of Cochlear Hair Cells: Not too Little , but not too Much
Allen F. Ryan*1, Clara Draf1, Kwang Pak1, Arwa Kurabi1
1 University of California San Diego
ERK1/2 Inhibitor, Tizaterkib, Protects Mice From Noise-Induced Hearing Loss While Modulating the Innate Immune Response
Richard Lutze*1, Matthew Ingersoll1, Alena Thotam1, Anjali Joseph1, Joshua Fernandes1, Kristina Ly1, Tal Teitz1
1 Creighton University
Sleep Fragmentation Increases Noise-Induced Hearing Damage via Reductions in Cochlear Efferent Signaling to Outer Hair Cells
Lingchao Ji1, Beatriz Borges1, Marina Silveira1, Alejandra Mondino2, Giancarlo Vanini2, Ana Belen Elgoyhen3, Michael Roberts1, Gabriel Corfas*1
1The University of Michigan, Kresge Hearing Research Institute, 2The University of Michigan, 3Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas
Prestin and FOXO3 May Interact Genetically in the Recovery of Hearing After Mild Noise Exposure
Patricia White*1, Leah Sheppard1, Andrea Campbell1, Holly Beaulac1, Dorota Piekna-Przybylska2
1 University of Rochester Medical Center
Exploring Synaptopathy in Swine Models of Noise and Blast-Induced Hearing Loss
Wei Wei*1, Ying Wang2, Yizhou Quan1, Zhilin Liao2, Yanling Wei2, Victor Adenis1, MengYu Zhu1, Andreas Eckhard1, Zheng-Yi Chen1
1Mass Eye and Ear, Harvard Medical School, 2Blast-Induced Neurotrauma Branch, Center for Military Psychiatry and Neuroscience, WRAIR
ECochG Measurements in the Course of Cochlear Implantation to Evaluate the Insertion Trauma in a Large Animal Model With an Extended Follow-Up
Erdem Yildiz*1, Matthias Gerlitz1, Anselm Joseph Gadenstaetter1, Rudolf Glueckert2, Hinrich Staecker3, Lukas D. Landegger1, Clemens Honeder1, Christoph Arnoldner1
1Vienna General Hospital, Medical University of Vienna, 2Medical University Innsbruck, 3School of Medicine, University of Kansas
Podium Session 24—Clinical Otology: Pediatric Diseases and Animal Models
10:15 a.m.—12:15 p.m.
Platinum Salon 6
Unraveling the Phenotypic Spectrum of ACTG1-Related Disorders: Insights From Genotype Associations
Miles Klimara*1, Amanda Schaefer1, William Walls1, Paige Harlan1, Hela Azaiez1, Richard JH Smith1
1 Molecular Otolaryngology and Renal Research Labs, University of Iowa Carver College of Medicine
Patients With Pathogenic MYO15A Variants Presenting Phenotypes Mimicking Auditory Neuropathy Spectrum Disorders
Pei-Hsuan Lin*1, Pey-Yu Chen2, Cheng-Yu Tsai3, Yu-Ting Chiang4, Tien-Chen Liu1, Chuan-Jen Hsu5, Pei-Lung Chen6, Chen-Chi Wu7
1National Taiwan University Hospital, 2MacKay Memorial Hospital, 3National Taiwan University Hospital; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University College of Medicine, 4Graduate Institute of Medical Genomics and Proteomics, National Taiwan University College of Medicine, 5National Taiwan University Hospital; Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation; School of Medicine, Tzu Chi University, 6Graduate Institute of Medical Genomics and Proteomics, National Taiwan University College of Medicine; National Taiwan University Hospital, 7National Taiwan University Hospital; National Taiwan University Hospital Hsin-Chu Branch
The Effect of (val)Ganciclovir on Hearing in Children With Symptomatic Congenital Cytomegalovirus Infection: A Prospective Controlled Trial
Elise De Cuyper*1, Frederic Acke1, Annelies Keymeulen2, Els De Leenheer1, Helen Van Hoecke1, Elizaveta Padalko2, An Boudewyns3, Annick Gilles3, Marie Muylle4, Rudolf Kuhweide4, Liesbeth Royackers5, Christian Desloovere5, Margriet Verstreken6, Isabelle Schatteman6, Ingeborg Dhooge1
1Ghent University, Ghent University Hospital, 2Ghent University Hospital, 3Antwerp University Hospital, 4Sint Jan Hospital, Bruges, 5University Hospitals of Leuven, 6GZA Hospitals Campus Sint Augustinus
GWAS of Sensorineural Hearing Loss by Clinical Diagnosis Elicits Multiple Cochlear-Related Hits
Royce Clifford*1, Elizabeth Mikita1, Kelleigh Hogan1, Adam X. Maihofer1, Allen Ryan2, Caroline Nievergelt1
1University of California, San Diego, 2University of California, San Diego and VA Medical Center, La Jolla
Predominance of Auditory but Not Vestibular Deficits in the Mouse Model of Congenital Cytomegalovirus Infection
Chi-Chieh Chang1, Ying-Chang Lu1, Pei-Hsuan Lin1, Tien-Chen Liu1, Po-Nien Tsao1, Chun-Yi Lu1, Chen-Chi Wu*1
1 National Taiwan University Hospital
How Low Can You Go? Feasibility of Dose Reduction in Preoperative Imaging With the New Photon Counting Detector CT and AI Improved Images
Thore Schade-Mann*1, Frederike Bärhold1, Sven Becker1, Tobias Albrecht1, Andreas Brendlin2, Saif Afat2, Hubert Löwenheim3
1University of Tübingen, 2University of Tübingen Medical Center, 3Translational Hearing Research, University of Tübingen
Quantitative Imaging of the Healthy and Pathological Tympanic Membrane With a Hand-Held Optical Coherence Tomography (HHOCT) Device
Marcela Moran Mojica*1, Zihan Yang1, Ryan Long1, Wihan Kim1, Frank D. Macias-Escriva1, John S. Oghalai2, Brian E. Applegate2
1Keck School of Medicine University of Southern California 2Keck School of Medicine, University of Southern California; University of Southern California, Denney Research Center (DRB)
The Transcription Factor Prdm1a is at the Core of the Hair Cell Evolutionary and Developmental Gene Regulatory Network
Jeremy Sandler*1, Shiyuan Chen1, Logan Sabin1, Malcolm Cook1, Nhung T.T. Tran1, Tatjana Piotrowski1
1 Stowers Institute for Medical Research
Podium Session 25—Exploring the Auditory Nerve: Spontaneous Firing, Efferent Modulation, and Advanced Imaging
10:15 a.m.—12:15 p.m.
Grand Ballroom Salon E
Multiscale Three-Dimensional Imaging of Neural Projection From Cochlea to Cochlear Nucleus
Dian Jing*1, Yiwei Du1, Sidi Liu1, Yaqiong Cheng1, Lei Song1, Hao Wu1
1 Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
An MRI Protocol to Assess the Effects of Noise Exposure on the Peripheral and Central Auditory Pathway
Rebecca Dewey*1, Hannah Guest2, Garreth Prendergast2, Rebecca Millman2, Christopher Plack3, Susan Francis4
1Sir Peter Mansfield Imaging Centre, University of Nottingham, 2Manchester Centre for Audiology and Deafness (ManCAD), University of Manchester, Manchester Academic Health Science Centre; National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, 3Manchester Centre for Audiology and Deafness (ManCAD), University of Manchester, Manchester Academic Health Science Centre; National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust; Lancaster University, 4Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham; National Institute for Health and Care Research (NIHR) Nottingham Biomedical Research Centre
Evidence of a Non-Linear Relationship Between Cochlear Deafferentation and Speech Perception in Noise
Naomi Bramhall*1, Elizabeth Flores2, Garnett McMillan3
1VA NCRAR, 2University of Tennessee Health Science Center, 3VA RR and D NCRAR
Frequency Selectivity in Monkey Auditory Nerve Studied With Suprathreshold Multicomponent Stimuli
Philip Joris*1, Eric Verschooten1, Myles Mc Laughlin1, Corstiaen Versteegh2, Marcel Van Der Heijden2
1KU Leuven, 2Erasmus MC
Efferent Effects on Low-Frequency Auditory Nerve Neurophonic in Chinchilla
Eric Verschooten*1, Philip Joris1
1 KU Leuven
Lateral Olivocochlear Efferent Inputs Contribute to Setting Auditory Nerve Fiber Spontaneous Firing Rates in Vitro
Philippe Vincent*1, Elisabeth Glowatzki1
1 Johns Hopkins School of Medicine
The Link Between Auditory Nerve Dysfunction and Cochlear Macrophage Activation to Endocochlear Potential Declines
Cindy Wang1, Jeffrey Rumschlag1, Tyreek Jenkins1, Kelly Harris1, Hainan Lang*1
1 Medical University of South Carolina
Investigating Single-Unit Auditory Nerve Fiber Responses in the Budgerigar
Leslie Gonzales*1, Margaret Youngman2, Kenneth S. Henry1
1University of Rochester Medical Center, 2University of Rochester
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